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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 443 Documents
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Formulasi Tablet Hisap Yang Mengandung Ekstrak Akar Ginseng Korea (Panax ginseng C. A. Meyer) Dan Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza ROXB.) Gozali, Dolih; Susilawati, Yasmiwar; Simorangkir, T.P.H.; Utami, Nadya Firdianna
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.474 KB) | DOI: 10.35617/jfi.v8i1.233

Abstract

ABSTRACT: The aims of this research is to find the best organoleptically acceptable formula of lozenges that contain ginseng and curcuma extract. Lozenges were prepared using wet granulation method with variation in concentration of sweetener (aspartame) and citric acid, i.e. for formula I aspartame 1% and citric acid 3%, formula II aspartame 0,75% and citric acid 4%, formula III aspartame 0,5% and citric acid 5%, and formula IV without aspartame and citric acid. The result of quality test of the tablets showed that tablets have a good quality and complied with the requirement. Thin Layer Chromatography indicated that all formulas still contain active ingredients from ginseng and curcuma extract after formulation process. Organoleptic test showed that formula II is the most suitable compared to the other three formulas. Keywords: formulation, lozenges, ginseng, temulawak, Panax ginseng, Curcuma xanthorrhiza ABSTRAK : Penelitian ini dilakukan dengan tujuan untuk menentukan formula tablet hisap yang mengandung ekstrak Ginseng Korea (Panax ginseng C. A. Meyer) dan Temulawak (Curcuma xanthorrhiza ROXB.) yang dapat diterima oleh masyarakat. Tablet dibuat dengan metode granulasi basah dengan variasi konsentrasi pemanis (aspartam) dan asam sitrat, yaitu untuk formula I aspartam 1% dan asam sitrat 3%, formula II aspartam 0,75% dan asam sitrat 4%, formula III aspartam 0,5% dan asam sitrat 5%, dan formula IV tanpa aspartam dan asam sitrat. Pengujian kualitas tablet menunjukan bahwa tablet memiliki kualitas yang baik dan memenuhi persyaratan. Hasil uji kromatografi lapis tipis menunjukan bahwa senyawa aktif yang terdapat dalam ekstrak ginseng dan temulawak masih terdapat dalam tablet hisap. Hasil uji kesukaan yang dilakukan terhadap 30 responden menunjukan bahwa formula II lebih disukai dibandingkan ketiga formula lainnya. Kata kunci: formula, tablet hisap, ginseng, temulawak, Panax ginseng, Curcuma xanthorrhiza 
KAJIAN KEAMANAN ANTIHIPERTENSI PASIEN GAGAL GINJAL KRONIK LANJUT USIA DI UNIT HEMODIALISA RSUP DR. SARDJITO YOGYAKARTA Setyaningrum, Ndaru; Pramantara, I Dewa Putu
Jurnal Farmasi Indonesia Vol 9, No 1 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.783 KB) | DOI: 10.35617/jfi.v9i1.563

Abstract

ABSTRACT : The growth of elderly population increase fastest among the other age group. The elderly population been related to decrease renal function and other comorbidity as consequence of aging. The aim of this study is to know how about adverse drug reaction (ADR) and potential interaction of antihypertension drug in chronic kidney disease patient. This is a descriptive study about elderly patient with chronic kidney disease on period October 22th 2012 â?? January 22th 2013. This study use Naranjo scale to evaluate ADR and Tatro Drug Interactions Fact to evaluate potential drug interaction. There were 38 subjects analized, age < 70 years old (24 patients) and â?¥ 70 years old (14 patients); gender men (26 patients) and women (12 patients); duration hemodialysis < 8 months (8 patients) and â?¥ 8 months (30 patients); comorbidity DM (23 patients) and non DM (15 patients). There were probable ADR 4 events (10,8%) consist of nifedipine (2 events), lisinoprile (1 event) and captoprile (1 event). There were 14 events (37,8%) potential drug interactions consist of minor interaction (12 events) 32,4% and major interaction (2 events) 5,4%. This study show that there were actual probable ADR 10,8% and potential drug interaction 37,8%.  
PROFIL FARMAKOKINETIKA RADIOFARMAKA ETAMBUTOL BERTANDA TEKNESIUM-99m SEBAGAI SEDIAAN SIDIK TUBERKULOSIS Wangsaatmadja, Hanafiah; Kartini, Nanny
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.55

Abstract

The invention of Ethambutol labeled technetium-99m as a radiopharmaceutical for early detection of Mycobacterium tuberculosis gave a significant role in managing of pulmonary as well as extra pulmonary tuberculosis diseases. The clinical studies indicated that the application of this diagnostic agent was very specific and very accurate to determine not only for pulmonary TB infection, but also the existing of TB in abdomen, head, bone, and even in the fingertips. Physicochemical characteristics of this agent have been reported by the previous researcher; however the pharmacodynamic and pharmacokinetic studies as a parameter required in order to fulfill of good manufacturing practice is still necessary to be investigated.  In this study, the observation of pharmacokinetic profile in animal through the organ bio-distribution, blood kinetic, and renal clearance/urinary excretion have been carried out. The maximum blood concentration (46%) of 99mTc-Ethambutol was found less than 5 minutes after intra venous injection, and decreased by 0.04% in the next 24 hours. From the kinetic data interpretation, the biological half life of 99mTc-Ethambutol was found out around 0.26 hours for the distribution time and 3.19 hours for the elimination.   ABSTRAK Penemuan Etambutol bertanda teknesium-99m sebagai sediaan radiofarmasi untuk mendeteksi secara dini keberadaan Mycobacterium tuberculosis, menjadi penting artinya bagi program penatalaksanaan penyakit TBC paru dan non-paru. Uji coba klinis, telah menunjukkan bahwa penggunaan sediaan diagnostik ini spesifik dan sangat akurat dalam menentukan tidak hanya infeksi tuberkulosis (TB) paru, tetapi juga TB yang terdapat di daerah abdomen, kepala, tulang, bahkan di ujung jari sekalipun. Karakteristik fisiko-kimia sediaan ini telah dilaporkan oleh peneliti terdahulu, namun demikian, kajian farmakodinamika dan farmakokinetika sebagai parameter yang disyaratkan dalam rangka penyediaan obat yang baik masih perlu diteliti. Dalam penelitian ini telah dilakukan pengamatan profil farmakokinetika pada hewan percobaan melalui uji biodistribusi, studi kinetika darah, dan ekskresi uriner. Kadar maksimum (sekitar 46%) radiofarmaka 99mTc-Etambutol dalam darah hewan uji ditemukan kurang dari 5 menit setelah penyuntikan intra-vena, dan menurun hingga 0,04% dalam waktu 24 jam kemudian. Dari interpretasi data kinetika, diperoleh waktu paruh biologis 99mTc-Etambutol sebesar 0,26 jam untuk biodistribusi dan 3,19 jam untuk eliminasi.
EFEK SITOTOKSIK DAN ANTIPROLIFERATIF EKSTRAK KLOROFORM BUAH MAHKOTA DEWA TERHADAP SEL KANKER PAYUDARA T47D Nurulita, Nunuk Aries; Siswanto, Agus
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.87

Abstract

The study on anticancer activity of P. macrocarpa fruit extract had been done. This study was aimed to know cytotoxic and antiproliferative activity of P. macrocarpa Chloroform extract to T47D cell. Cytotoxic and antiproliferative assay of it was done by MTT method. The doubling time and AgNORs staining were used to identify proliferative inhibition of it. Apoptosis of T47D phenomenon wa identified by doubling time method with ethidium bromide-acridyne orange. The result showed than LC50 of P. macrocarpa fruit extract was 103,03 μg/ml. it has antiproliferative effect and prolong doubling time. It also induced apoptosis of T47D cell.   ABSTRAK Telah dilakukan penelitian mengenai efek antikanker ekstrak buah mahkota dewa terhadap sel kanker payudara. Penelitian ini bertujuan untuk mengetahui efek sitotoksik, dan antiproliferasi ekstrak kloroform P. macrocarpa pada sel T47D.  Uji sitotoksik dan antiproliferatif ekstrak kloroform buah mahkota dewa dilakukan dengan metode MTT. Untuk melihat penghambatan proliferasinya dilakukan dengan metode doubling time dan pengecatan AgNORs. Fenomena apoptosis sel T47D yang diberi perlakuan ekstrak kloroform P. macrocarpa dilihat dengan metode double stainning dengan etidium bromida-akridin oranye. Hasil penelitian menunjukkan nilai LC50  sebesar 103,03 μg/ml. ekstrak ini mempunyai efek antiproliferasi dan mampu memperpanjang waktu doubling time. Pengamatan apoptosis dengan double staining menggunakan etidium bromida-akridin oranye, menunjukkan dapat memacu apoptosis sel T47D.
Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC) Sunarni, Titik; Prastiwi, Rini; Kuncahyo, Ilham; Mardiyono, .; Rinanto, Yudi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.28 KB) | DOI: 10.35617/jfi.v6i4.144

Abstract

Formulation of chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda citrifolia L fruits and investigation of the activity towards liver damage induced by tuberculosis drugs has been performed. The rats were devide into six groups. The normal control without any treatment, negatif control were given INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol, and the treatment group were given INH-RIF with chewable tablets of papaya extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and 28th day. The study showed that the group that given chewable tablets of combination of papaya extract 120mg/200g and morinda extract 20mg/200g can prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%) and 19,90 (PVP1%), compared to the negative control of 41.78% as well as reducing the value of ALT, AST and bilirubin. The tablet formula that can be received on the best of taste and most effective as hepatoprotektor is the chewable tablet with PVP 3%.Keywords : Hepatoprotector, Carica papaya L., Morinda citrifolia L., Isoniazid, Rifampicin
Peningkatan Resistensi Kultur Bakteri Staphylococcus aureus terhadap Amoxicillin Menggunakan Metode Adaptif Gradual Setiawati, Agustina
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.295 KB) | DOI: 10.35617/jfi.v7i3.167

Abstract

Resistensi antibiotik masih menjadi perhatian dalam pengobatan penyakit infeksi. Penggunaan antibiotik yang tidak sesuai meningkatkan kasus terjadinya resistensi antibiotik. Penelitian ini didesain untuk membuat metode yang dapat digunakan untuk membuat kultur Staphycoccus aureus (S.aureus) yang resisten terhadap amoxicillin. Selanjutnya, bakteri tersebut dapat digunakan sebagai model bakteri resisten adaptif dalam penelitian mikrobiologi. Penelitian ini menggunakan metode adaptif gradual dengan sub kultur bakteri pada media mengandung amoxicillin sub-MIC. Konsentrasi sub-MIC ditingkatkan setiap minggu selama tiga minggu. MIC amoxicillin diuji kembali setiap akhir sub kultur sub-MIC pada satu konsentrasi. Amoxicillin bersifat bakterisidal terhadap S.aureus dengan MIC 0,25µg/mL. Konsentrasi amoxicillin sub MIC yang digunakan adalah 0,10; 0,15 dan 0,20 µg/mL. Metode ini berhasil membuat S.aureus resisten dengan meningkatkan MIC 300x pada akhir sub kultur 0,10 µg/mL  dan meningkatkan MIC 400x pada akhir sub kultur 0,15 µg/mL MIC tidak meningkat. Metode adaptif gradual berhasil meningkatkan resistensi S.aureus terhadap amoxicillin.
Ekstrak Daun Binahong Mencegah Kenaikan Kolesterol Darah pada Tikus yang Diberi Pakan Lemak Tinggi Rahman, Asep Abdul; Kurniati, Neng Fisheri; Sukandar, Elin Yulinah
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.021 KB) | DOI: 10.35617/jfi.v8i2.516

Abstract

Binahong (Anredera cordifolia (Ten.) v. Steenis) leaves empirically have been used to lower cholesterol levels. In this study, preventive activity of ethanol extracts will be tested on the animals fed with a high-cholesterol chow. Hypercholesterolemic animal model established by orally administering high-cholesterol chow, pure cholesterol, cholic acid, and propiltiourasil. The test animals were divided into 5 groups, including the positive control group, ethanol extract of binahong leaves at doses of 50 mg/kg bw, 100 mg/kg bw, and 200 mg/kg bw; and simvastatin at dose of 36 mg/kg bw. Extract was given at the same time as hypercholesterol induction. Lipid profiles were measured at the time before the induction, 15 days and 29 days after induction. Index of atherogenic was also calculated. The results showed that level of cholesterol and LDL of extract binahong at dose of 50 mg/kg (109.17±26.60 mg/dL and 55.78±23.92 mg/dL, respectively) had significant difference compared to a positive control group (p < 0.05). Furthermore, binahong extract at dose of 50 mg/kg bb had the lowest atherogenic index (0,68±0,27) and aorta thickening (150.60±41.72 μm) compared to other extracts at day 15 of induction. In conclusion, extract binahong at dose of 50 mg/kg bw rat gives the best effect to prevent the increase of cholesterol and LDL level on wistar male rats fed with a high-cholesterol chow.
KAJIAN INTERAKSI OBAT PADA PASIEN GAGAL JANTUNG KONGESTIF DI RSUP DR. SARDJITO YOGYAKARTA TAHUN 2005 Yasin, Nanang Munif; Widyastuti, Herlina Tri; Dewi, Endah Kusuma
Jurnal Farmasi Indonesia Vol 4, No 1 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i1.4

Abstract

This study was conduct to observe the drug adverse event in congestif heart failure management at DR. Sardjito Hospital in 2005. Data was collected retrospectively from 237 medical records, 110 in-patient and 127 out-patient. Data analysis was done descriptively. Result of study showed that potential drug interaction occured on 99 (90%) in-patient and 126 (99,26%) out-patient. 20 types (50%)of pharmacokinetic interaction and 6 types (15%) of pharmacodynamic interaction was found on in-patient, with interaction of furosemide and ACE inhibitor as the most frequent (84 cases/76.36%), followed by furosemide-acetosal (66 cases/60%), and ACE inhibitor-acetosal (57 cases/51,82%). 25 types (36%) of pharmacokinetic interaction and 11 types (32%) of pharmacodynamic interaction was found on out-patient, with interaction of acetosal-ACE inhibitor as the most frequent (90 cases/70,87%), followed by furosemide-ACE inhibitor (85 cases/66,93%), and ACE inhibitor-potassium supplementation ( 85 cases/66,93%). ABSTRAK Penelitian ini dilakukan untuk mengetahui angka kejadian interaksi obat pada penatalaksanaan pasien gagal jantung kongestif di RSUP DR. Sardjito tahun 2005. Data diambil secara retrospektif dari sampel berupa 110 rekam medik pasien rawat inap dan 127 resep pasien rawat jalan. Analisis data dilakukan secara deskriptif. Hasil penelitian menunjukkan bahwa interaksi obat potensial terjadi pada 99 (90%) pasien rawat inap dan 126 (99,26%) pasien rawat jalan. Pada pasien rawat inap ditemukan interaksi farmakokinetika sebanyak 20 jenis (50%), interaksi farmakodinamik sebanyak 6 jenis (15%), dan interaksi dengan mekanisme yang tidak diketahui sebanyak 14 jenis (35%). Jenis interaksi yang memiliki insidensi kejadian paling tinggi secara berurutan adalah furosemid dengan ACE inhibitor yang terjadi pada 84 pasien (76,36%), furosemid dengan asetosal pada 66 pasien (60%), dan ACE inhibitor dengan asetosal pada 57 pasien (51,82%). Pada pasien rawat jalan ditemukan interaksi farmakokinetika sebanyak 25 jenis (36%), interaksi farmakodinamik sebanyak 11 jenis (32%), dan interaksi dengan mekanisme yang tidak diketahui sebanyak 8 jenis (32%). Jenis interaksi yang memiliki insidensi kejadian paling tinggi secara berurutan adalah asetosal ACE inhibitor yang terjadi pada 90 pasien (70,87%), furosemid dengan ACE inhibitor pada 85 pasien (66,93%), dan ACE inhibitor dengan suplemen kalium pada 85 pasien (66,93%).
UJI SITOTOKSISITAS BUAH MERAH, MAHKOTA DEWA DAN TEMU PUTIH TERHADAP SEL KANKER SERVIKS Radji, Maksum; Aldrat, Hendri; Harahap, Yahdiana; Irawan, Cosphiadi
Jurnal Farmasi Indonesia Vol 5, No 1 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i1.36

Abstract

The cytotoxic effect of herbal medicines has been examined using HeLa cells line (cervical cancer cell culture). The result showed that the LC50 value of buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] extracts were  421 µg/ml, 835µg/ml and 58,9 µg/ml after 24 hour incubation, whereas the LC50 of each extract were 276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml after 48 hour incubation respectively. The cytotoxic activity of temu putih [Curcuma zedoaria (Berg.)] extract to HeLa cells was stronger than buah merah [Pandanus conoideus Lam.] and mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] extracts.   ABSTRAK Telah dilakukan penelitian efek sitotoksisitas ekstrak buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] terhadap sel HeLa (kultur sel kanker serviks). Hasil penelitian menunjukkan bahwa nilai LC50 dari ketiga ekstrak tersebut masing-masing adalah 421 µg/ml, 835µg/ml and 58,9 µg/ml, setelah waktu inkubasi selama 24 jam, sedangkan LC50 setelah diinkubasi selama 48 jam adalah  276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml. Aktivitas sitotoksik  temu putih [Curcuma zedoaria (Berg.)] terhadap sel HeLa  lebih kuat dibandingkan dengan buah merah [Pandanus conoideus Lam.] dan mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.]
PENENTUAN ISOFORM SITOKROM P450 POTENSIAL PADA METABOLISME OBAT DENGAN MODEL OBAT GLIKLAZID Suharjono, .
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.68

Abstract

With the advancement of molecular biology techniques and extended use of human liver microsomes (HLM), we have known the specific isoform of cytocrome P450 (CYP450) involved in human drug metabolisms. The specific isoform need certain physicochemistry characteristic of the drug to be metabolized, e.g. log P, pKa, log D7.4, a/d2, l/w, SA, vol,  E , ELUMO and μ , which theoriticaly can be measured from its chemical structure using COMPACT software. There are, at least, 8 human liver microsomal CYP450 isoforms involved in drug metabolism. In this experiment we use gliclazide as drug model which will be metabolized into 3 main metabolites; inhbitor will inhibit the formation of the 3 metabolites and can be calculated further the value of % inhibition. From the inhibitor concentration and the greatest % inhibition compare to control, we can predict the specific CYP450 isoform involved in the metabolism of drug model.  From the results of the experiment we can conclude that CYP2C9 isoform is the potential CYP450 isoform involved in the formation of glicazide metabolites. There are suitable physicochemistry characteristic of the inhibitor sulfafenazol and the substrate glicazide with CYP450 isoform enzymeâ??s specificity. ABSTRAK Dengan majunya ilmu dan teknologi biologi molekuler dewasa ini, maka sudah dapat diketahui jenis isoform sitokrom P450 (CYP450) yang spesifik pada manusia yang terlibat dalam metabolisme obat dengan menggunakan human liver microsomes (HLM). Untuk metabolisme obat oleh isoform CYP450 spesifik diperlukan kesesuaian sifat kimia-fisika substrat terhadap isoform CYP450. Sifat kimia fisika substrat tersebut, meliputi log P, pKa, log D7.4, a/d2, l/w, SA, vol,  E , ELUMO dan μ , yang secara teoritis dapat diperhitungkan dari struktur kimianya dengan software COMPACT. Setidaknya ada 8 isoform CYP450 mikrosomal hati manusia yang diduga dapat ikut mempengaruhi metabolisme obat. Pada penelitian ini digunakan model obat gliklazid yang akan dimetabolisme menjadi 3 metabolit utama dan inhbitor akan menghambat pembentukan ke tiga metabolit dan dapat dihitung % inhibisinya. Dari kecilnya kadar inhibitor yang digunakan dan % inhibisi terbesar  pembentukan metabolit dibanding kontrol dapat diprediksi isoform CYP450 spesifik.  Isoform CYP2C9 merupakan isoform CYP450 yang potensial  terlibat dalam pembentukan ketiga metabolit Gz dengan ditunjukkan % inhibisi terbesar dan kadar yang kecil dari sulfafenazol yang digunakan.Ada kesesuaian sifat kimia fisika inhibitor sulfafenazol  dan substrat  Gz dengan spesifisitas enzim metabolisme isoform CYP450.

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