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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 443 Documents
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Efek penambahan parasetamol pada terapi ketorolak terhadap nyeri akut pascaoperasi orthopedi Santoso, Agustinus; Huwae, Thomas Erwin CJ; Idha, Arofa; Suprapti, Budi
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.224 KB) | DOI: 10.35617/jfi.v8i1.224

Abstract

ABSTRACT : The aim of this research is to analyze pain control of paracetamol addition to ketorolac compared with ketorolac alone on patientâ??s pain response. Ketorolac group (K group) recieved ketorolac 10 mg i.v every 8 hours and Ketorolac and Paracetamol group (KP group) recieved ketorolac 10 mg i.v and paracetamol 1,000 mg orally every 8 hours. Observation of pain intensity with Face Scale at ½ hours before and after administration at the first, the fourth and the seventh analgesics. Observation quality of pain management with QUIPS at ½ hours after administration the seventh analgesics. As the results, paracetamol addition to ketorolac provide better pain control, shown at the mean pain intensity KP group was lower at post to 4, pre to 7 and post to 7 than K group, and the QUIPS results were side effects of paracetamol additional well tolerated, reduce needs for additional analgesics, but no difference at patient satisfactions. These results suggest that paracetamol addition to ketorolac had better pain control than ketorolac alone in patients with orthopedic postoperative acute pain.Keywords : ketorolac, paracetamol, postoperative, face scale, QUIPS ABSTRAK: Penelitian ini bertujuan untuk mengetahui pengendalian nyeri oleh penambahan parasetamol pada ketorolak dibandingkan dengan ketorolak tunggal berdasarkan respon nyeri pasien. Kelompok Ketorolak (Kelompok K) mendapatkan ketorolak 10 mg i.v setiap 8 jam dan kelompok Ketorolak dan Parasetamol (kelompok KP) mendapatkan ketorolak 10 mg i.v dan parasetamol 1000 mg per oral setiap 8 jam. Penilaian intensitas nyeri dengan Face Scale pada 30 menit sebelum (pre) dan sesudah (pasca) pemberian dosis analgesik pertama, ke empat dan ke tujuh. Pengamatan kualitas manajemen nyeri dengan QUIPS pada 30 menit setelah pemberian analgesik dosis ke tujuh. Hasil pengamatan menunjukkan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri yang lebih baik, ditunjukkan oleh rerata intensitas nyeri kelompok KP pada pasca dosis ke 4, pre dosis ke 7 dan pasca dosis ke 7 lebih rendah dari kelompok K, serta hasil QUIPS bahwa efek samping penambahan parasetamol dapat ditoleransi, menurunkan kebutuhan analgesik tambahan, namun tidak berbeda pada kepuasan pasien. Hasil diatas menyatakan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri lebih baik dari ketorolak tunggal pada pasien nyeri akut pascaoperasi orthopedi. Kata kunci: ketorolak, parasetamol, pascaoperasi, QUIPS  
MOLECULAR IDENTIFICATION OF ENDOPHYTIC FUNGI ISOLATED FROM Garcinia porrecta AND Garcinia forbesii Radji, Maksum; Nugraheni, Femi Arifah; Sumiati, Atiek
Jurnal Farmasi Indonesia Vol 4, No 4 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i4.22

Abstract

Penelitian ini dilakukan untuk mengidentifikasi isolat-isolat kapang endofit yang telah diisolasi dari tanaman Garcinia porrecta dan Garcinia forbesii yang dikoleksi di Laboratorium Mikrobiologi dan Bioteknologi Departemen Farmasi Universitas Indonesia. Lima galur isolat yang telah terbukti menunjukkan bioaktivitasnya sebagai antimikroba dan antioksidan diidentifikasi secara molekuler menggunakan profil sekuen DNA yang berasal dari gen penyandi ribosomal RNA. Identifikasi isolat kapang endofit dilakukan dengan metode Polymerase Chain Reaction (PCR) menggunakan primer NS1 dan NS4. Hasil amplifikasi dengan PCR selanjutnya dianalisis dengan sekuensing DNA yang kemudian dibandingkan dengan data pada GenBank dengan program BLAST (Basic Local Alignment Search Tools). Berdasarkan hasil analisis sekuens DNA, 5 isolat berhasil diidentifikasi. Empat isolat kapang endofit teridentifikasi sampai tingkat spesies yaitu: Penicillium purpurogenum, Zasmidium cellare, Colletothricum gloeosporioides, dan Nectria curta. Sedangkan satu isolat lain teridentifikasi sampai tingkat genus yaitu Pestalotiopsis sp. ABSTRACT The objective of this study was to identify the endophytic fungi isolated from Garcinia porrecta and Garcinia forbesii deposited in Laboratory of Microbiology and Biotechnology, Department of Pharmacy, University of Indonesia by using molecular tools. Five isolates of endophytic strains which were displayed the strongest antibacterial and antioxidant activities were identified based on ribosomal RNA (rRNA) gene sequence analysis. The Polymerase Chain Reaction (PCR) was used to identify these endophytic fungi by using primer NS1 and NS4. Amplicon or PCR product was analyzed by sequencing method to determine the DNA sequence. The result of sequencing DNA then compared with GenBankâ??s database using Basic Local Alignment Search Tool (BLAST). The results revealed that five isolates of endophytic strains had been successfully identified by this method. Four of them were identified up to the level of species as Penicillium purpurogenum, Zasmidium cellare, Colletothricum gloeosporioides, and Nectria curta, while the other one was identified up to the level of genus namely Pestaloptiosis sp.
OPTIMASI FORMULA TABLET LEPAS LAMBAT IBUPROFEN Sumargo, Fredy; Hadisoewignyo, Lannie
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.56

Abstract

Ibuprofen was one type of antiinflammation drug that is often used so frequently in a day. Therefore, ibuprofen should be formulated in the form of sustained release tablet and find the optimum formula using factorial design. Factors used are a concentration of combination locust bean gum â?? xanthan gum matrix at 5% - 10% and concentration PVP K-30 at 3% - 5%. Preferred response Banakar follow the criteria was percent of dissolved drug in 3 hours at 25% - 50% and the percent of dissolved drug in 6 hours at 45% - 75%. The purpose of this study was to determine the effect of both factors and their interactions and get the optimum formula for the disposal of the following criteria Banakar. Concentration of combination xanthan gum-locust bean gum and concentration of PVP K-30 factor inhibit dissolved ibuprofen from tablets. While their interaction increase dissolved ibuprofen from tablet. Based on Design-Expert program optimation, optimum formula was obtained using a concentration of combination locust bean gum â?? xanthan gum matrix 7.58% and concentration of PVP K-30 3.09% would be result dissolved drug in 3 hours amounted to 49.3137% and dissolved drug in 6 hours amounted to 51.7607%.   ABSTRAK Ibuprofen merupakan obat  antiinflamasi yang digunakan dengan frekuensi penggunaan berulang kali dalam sehari. Oleh karena itu, ibuprofen perlu diformulasikan dalam bentuk lepas lambat dan dicari formula optimumnya dengan menggunakan metode factorial design. Faktor yang digunakan adalah faktor konsentrasi kombinasi matriks locust bean gum â?? xanthan gum pada konsentrasi 5% â?? 10% dan faktor konsentrasi PVP K-30 pada konsentrasi 3% - 5%. Respon yang dipilih mengikuti kriteria Banakar yaitu persen obat larut 3 jam 25 â?? 50% dan persen obat larut 6 jam 45 â?? 75%. Tujuan penelitian ini adalah mengetahui pengaruh kedua faktor dan interaksinya serta untuk memperoleh formula optimum yang pelepasannya mengikuti kriteria Banakar. Faktor konsentrasi kombinasi matriks locust bean gum â?? xanthan gum dan faktor konsentrasi PVP K-30 menghambat jumlah ibuprofen yang larut. Interaksi kedua faktor meningkatkan jumlah ibuprofen yang larut. Berdasarkan program optimasi Design Expert diperoleh formula optimum menggunakan konsentrasi kombinasi matriks xanthan gum-locust bean gum 7,5775% dan konsentrasi PVP K-30 3,09%,menghasilkan persen obat terlepas 3 jam sebesar 49,3137% dan persen obat terlepas 6 jam sebesar 51,7607%.
ANALISIS KADAR GENDARUSIN A PADA TANAMAN BUDIDAYA Justicia gendarussa Burm. f. E.W, Bambang Prajogo; S, Dudy; HS, Mulja
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.88

Abstract

As an effort to provide raw material for male contraceptive phytoprmaca, an agricultural experiment had been done to revealed the influence of fertilizer on gendarucin A content in the leaves extract of Justicia gendarussa Burm.f. The fertilizers used were animal manure, humus, and inorganic fertilizer. The leaves were harvested at 5, 6, 7, 8 and 9 months after planting. The leaves were extracted with n-hexane and ethanol 60%, and then gendarucin A content was assayed using HPLC. Results showed that the highest gendarucin A content was found in the leaves which were harvested at 9 months of age. Fertilizers gave negative influence, i.e. plants grew without fertilizer gave the highest gendarucin A content (4,9761 % w/w), followed by plants which used animal manure (2,6010 % w/w, humus (2,5058 % ww), and the least was plants with inorganic fertilizer (2,2093 % w/w). ABSTRAK Sebagai upaya penyediaan bahan baku untuk fitofarmaka kontrasepsi pria dari daun Justicia gendarussa Burm.f. maka telah dilakukan percobaan budidaya dengan berbagai macam pupuk yang berbeda. Hal ini dimaksudkan untuk mengetahui kadar senyawa aktif gendarusin A pada berbagai kondisi sebelum dilakukan penanaman masal. Adapun media tanam terdiri dari empat sampel antara lain : pupuk kandang, pupuk humus, pupuk anorganik dan sampel tanpa pupuk. Panen daun masing-masing dilakukan pada usia tanam 5, 6, 7, 8 dan 9 bulan. Selanjutnya pada simplisia daun tersebut dilakukan ekstraksi bertingkat dengan n- heksana dan etanol 60% Dari ekstrak etanol 60% daun J.gendarussa dilakukan penetapan kadar gendarusin A dengan menggunakan metode HPLC. Hasil penelitian didapatkan bahwa kadar gendarusin A tertinggi diperoleh dari panen daun gendarussa pada usia 9 bulan. Urutan kadar Gendarusin A dari yang terbesar sampai yang terkecil adalah sampel tanpa pupuk, sampel dengan pupuk kandang, sampel denganpupuk humus, dan yang terkecil adalah sampel dengan pupuk anorganik. Besarnya kadar gendarusin A dalam daun yang dipanen pada usia 9 bulan untuk masing-masing sampel adalah :, (1) sampel dengan pupuk kandang = 2,6010 %b/b, (2) sampel dengan pupuk humus = 2,5058 %b/b, (3) sampel dengan pupuk anorganik = 2,2093 %b/b, (4) sampel tanpa pupuk = 4,9761 % b/b.
Aktivitas Antibakteri dan Toksisitas Teripang Stichopus sp. Rasyid, Abdullah
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.008 KB) | DOI: 10.35617/jfi.v6i4.145

Abstract

Sea cucumber Stichopus sp. is one of the marine life that has the potential to be developed as a source of antibacteriak agents. Research on the antibacterial activity and toxicity test of sea cucumber Stichopus sp. aims to determine the antibacterial activity and the toxicity level of sea cucumber Stichopus sp. extract against Artemia salina. The method used for antibacterial activity test was the agar diffusion method, while toxicity tests using the Brine Shrimp Lethality Test (BSLT). The result showed that the extract of sea cucumber Stichopus sp. has antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Vibrio eltor. Extracts of sea cucumber Stichopus sp. are active against BSLT test marked with LC50 values of less than 1000 ppmKeywords : Sticopus sp., antibacterial activity, toxicity test.
Studi Prevalensi Penggunaan Alat dan Obat Kontrasepsi di Masyarakat Kabupaten Bandung Weking, J. M.; Sutrisno, Entries; Kamilla, Gladdis
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.349 KB) | DOI: 10.35617/jfi.v7i3.307

Abstract

Governmentâ??s efforts in controlling the populationâ??s family planning program (KB) is using contraception. Contraception is a devices or a drug that is used to prevent conception (pregnancy). The purpose of this study was to determine the prevalence use of contraceptive drugs and devices (Alokon) in the community of Bandung Regency in July-August of 2013. This research uses the observation method with the cross sectional eksional questionnaire contain- ing questions related to knowledge, attitudes, and behaviors of 290 respondents about the use of Alokon. Results of the study showed that 87% of respondents know the Government program in terms of the number of children is recommended (two children). Respondents understand Alokon as a means of pregnancy prevention (78%) and can be used as requirements (42%). This type of contraception is the most known and used by the respondents are: Implants (5%), IUD (19%), birth control pills (20%) and injection (23%). In addition, respondents believed that it is not effective to delay pregnancy (82%). The existence of the respondentâ??s concern with respect to side effects(56%), Alokon among others obesity(42%). Alokon used more by women (75%) than men (4%). Alokon more chosen (43%) compared to devices (19%). Based on the results of the study it can be concluded that the respondents have a good knowledge in terms of Alokon and its use. Considering the type of medication Alokon (birth control pills) are chosen by many respondents, the required role of pharmacists in pharmaceutical care in giving right information about how to use to achieve their effectiveness as contraceptives (prevention of pregnancy).
Efektivitas Enhancer Natrium Lauril Sulfat Dalam Patch Topikal Antiinflamasi Ekstrak Etanol Kencur (Kaemferia Galanga L.) Terhadap Jumlah Neutrofil dan Makrofag Pada Mencit Fatmawati, Desy; Dermayati, Cyntia Zain; Hamid, Iwan Sahrial; Hendriati, Lucia
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1970.423 KB) | DOI: 10.35617/jfi.v8i2.517

Abstract

Ethanol extract Kencur (Kaempferia galanga L.) has been proven to have antiinflammatory effect as well as to decrease the side effect of NSAIDs drug use, to develop the formulation of ethanol extract of kencur, then made in the dosage form of topical patch. Topical patch preparations are expected to avoid effects on the gastrointestinal tract, first- pass metabolism, and facilitate the use of the patient thereby increasing patient compliance. In the patch formulation, the most important things to note is the penetration enhancer/ enhancer, and enhancer used in this study is sodium lauryl sulphate. This study aims to determine the effectiveness of sodium lauryl sulphate in the preparation of a topical patch of kencur extract as anti inflammatory on the number of neutrophils in the blood. The research method uses canrrageenan as an inflammation inductor and neutrophil count observation was conducted using blood smears, then was observed on the first, third and seventh. Group of treatment which was given sodium diclofenac gel as positive control, group of treatment which was without enhancer as the 1st group, groups of treatment which were givenenhancer 1%, 3%, and 5% as the 2nd, 3rd and 4th group. The result was analyzed by one way ANOVA, followed by Post Hoc Duncan. The experimental results prove that there was a significant difference between the number of neutrophils and macrophages in the negative control group who were not given enhancer and the treatment group were given enhancer sodium lauryl sulphate values ( p < 0.05 ). As well as the group treated with the addition of enhancer sodium lauryl sulfate showed a greater amount of decline compared to the treatment group that contains only ethanol extract kencur.
PROBLEM PEMILIHAN OBAT PADA PASIEN RAWAT INAP GERIATRI DI RSUP DR. SARDJITO YOGYAKARTA Rahmawati, Fita; Ellykusuma, Nany Yusuf; Pramantara, I Dewa Putu; Sulaiman, Syed Azhar Syed
Jurnal Farmasi Indonesia Vol 4, No 1 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i1.5

Abstract

Old age is associated with chronic diseases and disabilities, which in turn require multiple medications. This often complicate diagnosed and appropriate drug therapy. The aim of the study was to determine types and number of inappropriate drug in geriatric patients in Bougenville Ward Dr. Sardjito Hospital Yogyakarta. Research type is descriptive. Data taken prospectively during two period, January to February 2006 and Agust to October 2006. The study was conducted in 100 geriatric patients hospitalized with inclusion criteria 65 years old and above and admission into Bougainville ward (interne department) RSUP Dr. Sardjito Hospital, Yogyakarta. Data collecting was conducted through medical record then adjustment of inappropriate drug of choice was identified by pharmacist-physician discussion. Evaluation of the data was carried out descriptively. The result of the study showed that inappropriate drug of choice occurred in 48 cases. This problem include more effective drug available 12 cases, contraindication present 15 cases, dosage form inappropriate 2 cases, condition refractory to drug 1 case, drug not indicated (unsafe) for condition 9 cases, patient received unnecessary multiple drug combination 9 cases. The finding of our study support pharmacist in collaboration between physician-pharmacist-nurse can effectively reduce incidence of Drug Related Problems in geriatric patient. ABSTRAK Penelitian ini bertujuan untuk mengetahui jumlah dan persentase Drug-Related Problems (DRPs) yang terjadi pada pasien geriatri di Bangsal Bougenville IRNA I RSUP Dr. Sardjito Yogyakarta. Penelitian bersifat deskriptif, pengambilan data dilakukan secara prospektif pada 100 pasien dengan kriteria pasien berumur lebih dari 60 tahun dan menjalani rawat inap di bangsal Bougenville IRNA I bagian Penyakit Dalam RSUP Dr. Sardjito. Data diambil pada 2 periode waktu yaitu bulan Januari â?? Februari 2006 dan bulan Agustus-Oktober 2006. Identifikasi Drug Related Problem (DRP) terkait dengan pemilihan obat yang tidak tepat dilakukan melalui diskusi dengan klinisi. Analisis data selanjutnya dilakukan secara deskriptif. Hasil penelitian menunjukkan bahwa problem pemilihan obat yang tidak tepat terjadi sejumlah 48 kasus. Problem ini meliputi obat yang diterima pasien bukan merupakan obat yang paling tepat 12 kasus, pasien menerima kombinasi obat yang tidak diperlukan sebanyak 9 kasus, obat dikontraindikasikan pemakaiannya untuk pasien sejumlah 15 kasus, obat tidak aman bagi kondisi pasien 9 kasus, bentuk sediaan tidak tepat 2 kasus, obat yang digunakan sudah merupakan obat yang paling tepat namun pada kasus tersebut tidak efektif sejumlah 1 kasus. Untuk mengurangi kejadian Drug-Related Problems (DRPs) pada pasien geriatri diperlukan peningkatan peran aktif farmasis serta kerja sama diantara tenaga medis dalam memberikan pelayanan kesehatan.
ISOLASI SENYAWA ANTIOKSIDAN DARI KELOPAK BUNGA NUSA INDAH (Mussaeda frondosa L.) Putra, Deddi P.; Fatra, H. Al; Bakhtiar, A.
Jurnal Farmasi Indonesia Vol 5, No 1 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i1.37

Abstract

An antioxidant flavonol glycoside isoquercitrin (0.01% w/w) from white petals of Mussaenda frondosa L flowers has been isolated in form of amorf yelowish powder, m.p. 288-230 oC. The structure was established from data of chromatography, UV-Vis spectra with shift reagents, infrared as well as the analysis of spectral data of  1H and 13C NMR. Antioxidant activity was performed by inhibition of radical scavenger of 2,2-difenil-1-pikrilhidrazil (DPPH) 50mM and the compound showed a high persentage inhibition of 93.97% compared to quersetin (92.92%). The compound was first reported from white petal of Mussaenda frondosa L.   ABSTRAK Antioksidan isokuersitrin (0,01% b/b) telah diisolasi dari kelopak putih bunga Nusaindah (Mussaenda frondosa L.), berupa amorf berwarna kuning dengan jarak leleh 228-230°C. Struktur senyawa ini ditetapkan berdasarkan (pola) kromatografi, spektrofotometer ultraviolet dengan berbagai pereaksi geser, spektrum inframerah serta analisis spektrum RMI (1H dan 13C). Pemeriksaan aktivitas antioksidan dilakukan dengan metode DPPH (radikal 2,2-difenil-1-pikrilhidrazil) 50mM dan senyawa (1) memiliki persentase inhibisi sebesar 93,97% sebanding dengan kuersetin (92,29%). Senyawa ini baru pertama dilaporkan dari kelopak putih bunga Mussaenda frondosa L
PENGARUH PRAPERLAKUAN BROKOLI (Brassica oleracea L. var. botrytis L.) TERHADAP FARMAKOKINETIKA RIFAMPISIN PADA TIKUS Wahyono, Djoko; Hakim, Arief Rahman
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.69

Abstract

The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats. The study was conducted using female Sprague Dawley rats which were divided  into 3 groups (6 rats for each group). The groups were given a single oral rifampicin 50,4 mg/kg BW as a control group and were confered multiple doses oral (once daily for seven days) (P-I) and single dose oral oral (P-II) broccoli 23,43 g/kg BW before treatment with rifampicin. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged rifampicin in blood. From the concentration of rifampicin vs time data  was determined rifampicin pharmacokinetics parameters i.e. Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2 elimination, ClT and K. The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23,43 mg/kg bw 1 hours prior to single oral administration of the drug did not change significantly (P>0,10). Prefeeding the animals with broccoli 23,43 g/kg bw once daily for 7 consecutive days has increased the total clearance of rifampicin 46,90% (P<0,10). The increase in the total clearance rifampicin due to the compound has decreased Cmaks 36,54% (P<0,10). ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pemberian praperlakuan brokoli (Brassica oleracea L. var. botrytis L.) terhadap farmakokinetika rifampisin pada tikus. Penelitian menggunakan tikus putih betina galur Sprague Dawley yang dibagi menjadi 3 kelompok masing-masing terdiri dari 6 ekor hewan. Kelompok I (kontrol) diberikan  rifampisin secara oral dosis 50,4 mg/kg BB,   kelompok II dan III (perlakuan) diberikan brokoli secara oral dosis 23,43 g/kg BB sekali sehari selama 7 hari (P-I) dan 1 jam sebelum (P-II) diberikan rifampisin dengan dosis yang sama seperti kelompok I. Setelah seluruh hewan mendapatkan perlakuan, pada jam-jam ke- 0,25; 0,5; 1; 1,5; 2;  3; 4; 6; 8; 10; 12, dan 24  diambil cuplikan darah (0,2 ml) dari vena lateralis ekor, guna penetapan kadar rifampisin utuh secara HPLC. Kadar rifampisin utuh dalam darah dihitung berdasarkan kurva baku. Harga-harga parameter farmakokinetika rifampisin (Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2, ClT dan K) dihitung berdasarkan data kadar rifampisin utuh dalam darah terhadap waktu. Hasil penelitian menunjukkan praperlakuan brokoli satu jam sebelum pemberian rifampisin tidak mempengaruhi farmakokinetika rifampisin (P>0,10), namun pemberian brokoli sekali sehari selama 7 hari sebelum pemberian rifampisin mampu meningkatkan ClT rifampisin sebesar 46,90% (P<0,10). Akibat kenaikan ClT rifampisin tersebut, harga Cmaks mengalami penurunan sebesar 36,54% (P<0,10).

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