Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Pemanfaatan Kitosan Tersambung Silang dengan Tripolifosfat sebagai Eksipien Gel Ikan Haruan (Channa Striatus) ]]>
<![CDATA[DINA RAHMAWANTY]]>;
<![CDATA[EFFIONORA ANWAR]]>;
<![CDATA[ANTON BAHTIAR]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Meat of snakehead fish (Channa striatus) has been reported can be used for wound healing because contains proteins, essential amino acids, lipid and fatty acids that inuenced wound healing process. The present study was performed in order to formulate gels contain meat powders of snakehead fish for wound healing. The formulas were used 1 g (formula 1) and 2 g (formula 2) meat powder of snakehead fish as an active ingredient. Meat powder of snakehead fish have been made nanosuspension use ionic gelation method with chitosan and sodium tripolyphosphate and formulated to gel form using HPMC as gelling agent. Suspenses have been physicochemical charactheried. The results showed that suspenses (formula 1 and formula 2) have particle sie in range of 41.665.5 nm and 41.2.1 nm respectively polidispersity inde of 0.512 and 0.456 respectively eta potential ()2.15 m and ()2.35 m respectively both of formulas have spherical particles.]]>
<![CDATA[Preparasi dan Karakterisasi Sediaan Solid Lipid Nanoparticle (SLN) Gliklazid ]]>
<![CDATA[ANISA AMALIA]]>;
<![CDATA[MAHDI JUFRI]]>;
<![CDATA[EFFIONORA ANWAR]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Solid lipid nanoparticle (SLN) has been proposed as colloidal carriers using solid lipid as matrix material. In this study, gliclazide-loaded solid lipid nanoparticle has been prepared with high shear homogenization and freeze drying method using stearic acid as lipid material, Tween 80 and PEG 400 as surfactant, ethanol as`co-solvent and lactose as cryoprotectant. Characterization was performed on SLN dosage from before and after freeze drying, which includes the analysis of particle size, zeta potential value, morphology analysis and entrapment efficiency of gliclazide. Results indicated gliclazidecan be formulated in SLN dosage form using high shear homogenization and freeze drying method. The morphology study revealed that the prepared SLN were irregular in shape with mean particle size of 878.0 ± 246.3 nm and 745.8 ± 204.0 nm. Zeta potensial values of gliclazide-loaded SLN were found –]]>
<![CDATA[Pengembangan Instrumen Pengukuran Kepuasan Pasien atas Layanan Pharmaceutical Care ]]>
<![CDATA[TUNGGUL ADI PURWONUGROHO]]>;
<![CDATA[VITIS VINI FERA RATNA UTAMI]]>;
<![CDATA[NURYANTI NURYANTI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Development and validation of the instrument to assess patient satisfaction to pharmaceutical care is important to be conducted. It will provide a reliable tool so that research to measure patient satisfaction regarding to pharmaceutical care could be further developed. First, content of the questionnaire was developed based on the literature review and focus group discussion of the panel. Then, the draft was tested to 5 respondents as a readability measurement. After received input from readability test’s respondents and made some changes, panel re-tested the questionnaire as content validity analysis. Finally, the questionnaire was distributed to other 30 respondents to get data for factor analysis, construct validity test and reliability test. Thirteen items was found as important factors that inuence patient satisfaction to pharmaceutical care based on literature review and focus group discussion activity. The questionnaire was further tested on 30 respondents. In the factor analysis assessment, categorization of items could not be made. Validation test using Pearson correlation and reliability test using Cronbach’s Alpha toward each item on the questionnaire showed that all items were valid and reliable, except one item in the “hope” section. Further study with greater number of respondents is required to re-validate this questionnaire.]]>
<![CDATA[Studi Interaksi Obat dan Reaksi Obat Merugikan pada Pasien HIV/AIDS dengan Koinfeksi Tuberkulosis di RSUP Dr. Hasan Sadikin Bandung ]]>
<![CDATA[ALEXANDRA VANIA ANDI]]>;
<![CDATA[LIA AMALIA]]>;
<![CDATA[RUDI WISAKSANA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[HIV/AIDS and tuberculosis require combination therapy that can lead to drug interactions and unwanted drug effects or adverse drug reactions (ADRs). This study was aimed to determine the potential drug interactions, estimate the occured ADRs and provide treatment recommendations for HIV/AIDS patients with tuberculosis. This research was a descriptive study which was conducted retrospectively in forty eight HIV/AIDS patients with tuberculosis receiving treatments in the Teratai clinic, Dr. Hasan Sadikin Bandung Hospital in 2013. From these forty eight patients, there were 109 incidences of potential drug interactions with major significance, 299 incidence of with moderate significance and 58 with minor significance. Estimated ADRs with the greatets number found in this study was 8 incidences of gastrointestinal disorders, 5 incidences of drug eruption, 5 drug-induced liver injury (DILI) incidences and 4 peripheral neuropathy incidences. Patients receiving category 1 tuberculosis therapy was recommended to use tenofovir, lamivudine, and efavirenz as antiretroviral therapy, whereas patients receiving category 2 tuberculosis therapy was recommended to use zidovudine, lamivudine, and efavirenz.]]>
<![CDATA[Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata ]]>
<![CDATA[NUGRAHANINGSIH NUGRAHANINGSIH]]>;
<![CDATA[SARJADI SARJADI]]>;
<![CDATA[EDI DHARMANA]]>;
<![CDATA[HERTANTO WAHYU SUBAGIO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.]]>
<![CDATA[Kejadian Efek Samping Kinin pada Pasien Malaria di RSUD Bontang, Kalimantan Timur ]]>
<![CDATA[NITA RISTIAWATI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Quinine intravenous for severe malaria and complications, is recommended until the patient is able to use the oral formulation. The purpose of this study was to monitor the side effects that arise during the administration of quinine in malaria patients in Bontang Public Hospital and evaluate the use of other drugs that may increase the incidence of quinine side effects. This study was conducted by using descriptive study design. Monitoring of side effects is based on qualitative data, through clinical observation before and after the patients received the drug. The events of side effects were evaluated from the data collectedby usingNaranjo algorithm to determine possible (score 1-4), probable (score 5-8) and certainty (definite) (score 9). From the study, it is found that 32 patients (88.89 %) experienced quinine side effects, 2 patients (5.55 %) did not experience significant side effects. 7 patients (19.44 %) were using cimetidin, 6 patients (16.67 %) had more than 2 side effects. Possible influence of cimetidine on the clearance of quinine that cause the increase of quinine levels in the blood may increase the risk of the events of quinine side effects.]]>
<![CDATA[Pengembangan Pewarna Rambut dari Ekstrak Kental Gambir (Uncaria gambir Roxb.) dalam Sediaan Setengah Padat ]]>
<![CDATA[LATIRAH LATIRAH]]>;
<![CDATA[TETI INDRAWATI]]>;
<![CDATA[ANNY VICTOR PURBA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Gambier (Uncaria gambir Roxb.) is one of the alternatives used as a natural colouring agent in foods and drinks. The aim of this research was to develop extract gambier as a hair dye. Gambier extract was obtained by macerated with water in base condition (pH 8-10). The resulting extract was evaluated for hair adhesion, organoleptic, physical, chemical and irritation test to rabbit’s skin. Viscous gambier extract has 0HUE value of 338.73 ± 0.116 (purple), can be processed into permanent hair colour cream with 0HUE value of 42.167 ± 0.231 (red), pH 8, ammoniac odor, produce red yellowish hair with 0HUE value of 53.43 ± 0.060, fulfil requitment for microbiology, not iritant to rabbit's skin has density of 0.903 0.006 g/L and viscosity of 13,100 ± 0.000 cP.]]>
<![CDATA[Optimasi Formula Emulgel Serbuk Kasar Papain ]]>
<![CDATA[MOCH FUTUCHUL ARIFIN]]>;
<![CDATA[SYARMALINA SYARMALINA]]>;
<![CDATA[DIANA SYARMALINA]]>;
<![CDATA[SHAFA NABILAH]]>;
<![CDATA[DIDA MAULIDA HASANAH]]>;
<![CDATA[HIFZIEL AZHAR]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Crude powder of papain is very irritative and unstable, thus it should be formulated in emulgel using factorial design 2. The purpose of the study was to assess the effect of gelling agent (2.5% HPMC, 1 % Carbomer 940 ), oil phase ( liquid paraffin 5% to 7.5 % ), emulsifier ( 1.5% -2% Tween 80 - Span 80) and determine the optimum formula. Viscosity, ease of spread, proteolytic activity and antimicrobial activity of papain emulgel were used as the parameters in formula optimization. Each parameter had a contour plot. With the use of superimposed countor plot, the shaded area could be determined as the optimum formula. The results of the factor effect analysis and its interactions were that gelling agent gave significant effect (p<0.05) and dominant in increasing the viscosity of emulgel and the activity of papain proteolytic enzyme. However, it decreased the diameter of the dispersing area and the inhibition zone diameter. The increase in the concentration liquid paraffin concentration had a dominant and significant effect towards the improvement of the emulgel’s dispersive power and the proteolytic activity of papain. The increase in the combination of Tween 80-Span 80 emulgator had a dominant and significant effect towards the improvement of viscosity and the decrease in the dispersive power, the proteolytic activity, and the inhibition zone diameter. From the superimposed contour plots analysis and response optimizer, the optimum formula was achieved by 2.5% of HMPC gelling agent, 5.6% of liquid paraffin, and 2.4% of emulsifier combination.]]>
<![CDATA[Efek Antioksidan Larutan Kosolven Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) pada Tikus dengan Parameter MDA dan SOD ]]>
<![CDATA[ROS SUMARNY]]>;
<![CDATA[LILIEK NURHIDAYATI]]>;
<![CDATA[SITI SOFIAH]]>;
<![CDATA[YATI SUMIYATI]]>;
<![CDATA[FRANSISKA DIANA SANTI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Mangosteen (Garcinia mangostana L.) rinds extract in capsule form has been marketed. a-mangostin, the active compound of G. mangostana had been known has low solubility in water. This study was aimed to measure and compare antioxidant effect of a-mangostin as cosolvent solution to extracts suspentions. 25 rats were divided into 5 groups: negative (I) and positive (II) control, cosolvent solution (III), extract (IV) and extract® (V). Treatment were given for 14 days, free radicals were induced by CCl . MDA were analyzed using thiobarbituric acid method while SOD by using adenochrome assay. Results showed MDA level were: 1.0±0.19; 0.3±0.05; 0.4±0.04; 0.6±0.04 and 0.5±0.00 nmol/mL, whereas SOD activity were: 17±0.0; 123±25.3; 107±19.0; 73±18.9 and 97±27.0 U/mL for group I, II, III, IV and V, respectively. Kruskal Wallis test showed a significant difference in MDA between group III with IV and V (p>0.05), showing cosolvent has higher ability to decrease MDA than the extracts suspension. There were significant differences of SOD between group III and IV (p>0.05), meaning cosolvent has higher ability to increase SOD activity compare to the extracts. Research showed cosolvent has a higher antioxidant effect with potential to inhibit MDA formation by 70% and increase SOD activity by 623%.]]>
<![CDATA[Profil Pengobatan Pasien Rawat Jalan Diabetes Melitus Tipe 2 setelah Pelaksanaan JKN ]]>
<![CDATA[MITA RESTINIA]]>;
<![CDATA[YUSI ANGGRIANI]]>;
<![CDATA[TRI KUSUMAENI]]>;
<![CDATA[ARIES MERYTA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[In 2014, health insurance entirely colected together into Badan Penyelenggara Jaminan Sosial (BPJS) became Jaminan Kesehatan Nasional (JKN). But there is different payment method that is ASKES used Fee for Services (FFS) method and BPJS use INA-CBGs method. Diabetes mellitus is a chronic disease that patients with that diagnosed should use drug continuously. Therefore, research with conducted by time series longitudinal retrospective method that aimed to observe impact of JKN about drug treatment profile among outpatients of type 2 DM in X Hospital Jakarta. Total of samples collected were 84 patients, 31 (36.90%) of male and 53 (63.10%) of female. Most patients (29.76%) were 66-70 years old. There were 38 patients with 10 times of visite, 27 patients with 11 times of visite, 19 patients with 12 times of visit. Based on drug treatment profile, after JKN has launched, decreasing of total of drug use, number of visit increased to 42 visits, kinds of drug appropriate with DPHO decreased until 79%, kinds of drug appropriate with national formularium rised 97%, generic drugs also increased 54% and non generic drug decreased 47%. Based on descriptive analysis, when JKN has launched, there were impact toward drug treatment profile.]]>
