Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Evaluasi Drug Related Problems (DRPs) Antibiotik pada Pasien Sepsis di Rumah Sakit di Yogyakarta ]]>
<![CDATA[SAMUEL BUDI]]>;
<![CDATA[ZULLIES IKAWATI]]>;
<![CDATA[IWAN DWIPRAHASTO]]>;
<![CDATA[TITIK NURYASTUTI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Sepsis is a manifestation of the most severe acute infections that can lead to the various organ failure generally ends with death in 30-50% of cases. The number of sepsis deaths in developed countries can be reduced to 11-15%, but in developing countries it was reported above 45%. Proper and adequate use of empirical antibiotics may decrease the risk of death in sepsis and may at least shorten patient duration of care in the hospital. Aim to this study was determine the pattern of antibiotic use, the incidence of Drug Related Problems (DRPs) and clinical outcomes in septic patients in hospital X at Yogyakarta. An observational study was carried out during the period of January-December 2015 in hospital X at Yogyakarta. Data were collected retrospectively among patients with sepsis, age > 15 years old, hospitalized during the the study period. From 632 cases, 162 patients were diagnosed as sepsis and met the inclusion criteria of the study. The antibiotics used were cephalosporin (42.58%), quinolone (17.46%), carbapenem (10.77%), aminoglycoside (9.33%), imidazole (8.85%) and macrolide (4.88%). Poor clinical outcomes associated with DRPs (64.29%) were greater than those that showed good clinical outcomes (35.71%). The incidence of DRPs in sepsis treatment is still high (60.49%), and is generally associated with antibiotic needs, the inappropriate selection of antibiotics, inadequate dosage and the presence of antibiotic interactions.]]>
<![CDATA[Evaluasi Penerapan CDOB sebagai Sistem Penjaminan Mutu pada Sejumlah PBF di Surabaya ]]>
<![CDATA[VANNINA AGUSTINI]]>;
<![CDATA[WAHYU UTAMI]]>;
<![CDATA[WAHONO SUMARYONO]]>;
<![CDATA[UMI ATHIYAH]]>;
<![CDATA[ABDUL RAHEM]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Good Pharmaceutical Distribution Practice is called as CDOB in Indonesia is a guidelines to ensure pharmaceutical product quality throughout the distribution chain..This guideline consist of nine aspects, and pharmaceutical wholesalers (PBF) are required to implement the principle in the guideline as part of compliance to the pharmaceutical wholesaler regulation. The purpose of this research is to assess the extent of the implementation of Good Pharmaceutical Distribution Practices in the pharmaceutical daily operation.This research is descriptive with random sampling technique to determine which pharmaceutical wholesalers to be selected. The samples were 41 pharmaceutical wholesalers in Surabaya and they were given questionnaire they need to answer.. The data were collected in the period of August until September 2015, where the CDOB certifi cation was not mandatory yet. According to data collected, results show that 40 out of 41 (97.56%) PBF do not possessed CDOB certifi cate. From 41 PBFs, 18 (43.90%) PBF has met ≥80% CDOB, 16 (39.02%) PBF has met ≥65 - <80% CDOB, 6 (14.63%) PBF met ≥ 50 - <65% CDOB and 1 (2.44%) PBF met <50% CDOB. There was 1 (2.44%) PBF never conduct a study of the quality management, 4 (9.76%) offi cial pharmacist of respective PBF had never attended CDOB’s training and 5 (12.20%) PBF all their personnel have not been trained CDOB, 5 (12.20%) PBF never check the registration number, there are 2 (4.88%) PBF rarely keep the appropriate medication storage temperature indicated on the drug packaging.Overall, it may be said that not all the PBF in Surabaya implemented 9 aspects of CDOB. This could aff ect directly or indirectly to the quality of pharmaceutical products they distributed. CDOB certifi cation however, just became mandatory in November 2017.]]>
<![CDATA[Antihiperglikemik Kombinasi Minyak Biji Mahoni (Swietenia mahogani (L.) Jacq-Glibenklamid pada Tikus Diinduksi Aloksan ]]>
<![CDATA[DIONYSIUS ANDANG ARIF WIBAWA]]>;
<![CDATA[KETUT WIRIANA]]>;
<![CDATA[LUCIA VITA INANDHA DEWI]]>;
<![CDATA[RATNA AGUNG SAMSUMAHARTO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Diabetes mellitus (DM) is a chronic disorder metabolism of glucose in the body. Mahogany seeds (Swietenia mahagoni (L.) Jacq.) reportedly contains fl avonoids, alkaloids and saponins which can be used as therapy of diabetes mellitus. This study aimed to determine the eff ects of antihyperglycemic combination of mahogany seed oil-glibenclamide in male rats hyperglycemiced by alloxan induction. The mahogany seed oil liquefaction processed by using hydrolic pressed instrument 100 psi pressure. This study using Wistar strain male rats aged 2-3 months as many as 35 heads which were divided into 7 groups: group I (normal control) with distilled water added, while the II-VII group with alloxan induced intraperitoneal 140 mg/kg body weight two times. Group II as a negative control was added 0.5% CMC, group III was added glibenclamide 0.09 mg/200 g BB, IV groups oiled mahogany seeds 2 mL/200 g BW, group V, VI, and VII were added a combination of mahogany seed oil glibenclamide with each ratio (75%: 25%, 50%: 50%, 75%: 25%). The distribution of the test preparation 1 times a day for 12 days and blood glucose measurement performed on days 3, 6, 9, and 12. Data has been analyzed by oneway ANOVA (signifi cant p <0.05). The results obtained the combination of mahogany seed oil-glibenclamide provides eff ect to reduction in blood glucose levels induced male rats alloxan, the combination group mahoni-glibenclamide seed oil have equal activity in lowering blood glucose levels with a single chemical drug glibenclamide. Mahogany seed oil is potentially antidiabetic.]]>
<![CDATA[Uji Efikasi Ekstrak Metanol Daun Torbangun (Plectranthus amboinicus) pada Sel Epitel Kelenjar Susu Manusia MCF-12A ]]>
<![CDATA[FITRY TAFZI]]>;
<![CDATA[NURI ANDARWULAN2]]>;
<![CDATA[PUSPO EDI GIRIWONOB]]>;
<![CDATA[FITRIYA NUR ANISA DEWID]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Torbangun (Plectranthus amboinicus) is an herbaceous plant that grows in the tropical region. Torbangun can increase breast milk and has antioxidant activity. The objective of this research was to evaluate the antioxidant and cytotoxic activities of methanol extract of torbangun leaves and to identify diff erentially expressed lactation genes upon incubation of MCF-12A human cell epithelial mammary gland with methanolic extract of torbangun leaves. The results showed that the methanolic extract of torbangun leaves had a scavenging activity of DPPH radical with EC50 value of 14.14 μg/ mL. At lower concentration of methanol extracts of torbangun leaves showed no potent cytotoxic eff ect on MCF-12A with IC50 value of 155.24 μg/mL. The methanolic extract of torbangun leaves increased genes expression of prolactin receptor and glucocorticoid receptor in human mammary gland epithelial cells MCF-12A.]]>
<![CDATA[Studi Genotipe Sitokrom P450 2A6 Alel CYP2A6*4 dan CYP2A6*9 pada Subyek Uji Perokok Suku Jawa Indonesia ]]>
<![CDATA[CHRISTINE PATRAMURTI]]>;
<![CDATA[FENTY FENTY]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[CYP2A6 belongs to the CYP2 family of P450 cytochromes were highly polimorphy. CYP2A6*1 (wild type) was an active allele, CYP2A6*9 was agen decreased allele and the CYP2A6*4 was an inactive allele. By using the polymerase chain reaction technique (PCR), the CYP2A6 polymorphism was studied among Javanese Indonesian smokers. In the process of genotyping the CYP2A6*9 allele, some subjects who had been genotyped as CYP2A6*1/*4 in our previous studies were regenotyped as CYP2A6*9 in this study. The primer forward 2A6*9S and the primer reverse 2A6*9AS-wild type were used in these study. The Promega Go Taq Green Master Mix reagent were used to amplifl y the allele CYP2A6*1 in the positions at -395 to -28 of the CYP2A6 gene. The sample studied consisted of 20 smokers with Cigarrete per-Day (CPD) <10 and 13 smoker with CPD 11-20 from Javanese Indonesian population. In theses research, the subjects had been genotyped as CYP2A6*1/*4 in our previous studies. The allele frequencies of CYP2A6*1, CYP2A6*4, and CYP2A6*9 were 48.5%, 48.5%, and 3%, respectively. When these allele were considered simultaneously, among the subject, 63.9% were genotyped for CYP2A6*1/*4 and 6.1% were genotyped for CYP2A6*1/*4/*9. Based on the data collected, it could be concluded that the polymorphism of CYP2A6 among Javanese population sample study was not aff ected on smoking behavior.]]>
<![CDATA[Isolasi dan Identifi kasi Senyawa Kimia Zat Anti Kanker dari Daun Kopasanda (Chromolaena odorata (L.)) ]]>
<![CDATA[MUHAMMAD FITRAH]]>;
<![CDATA[HENDIG WINARNO]]>;
<![CDATA[PARTOMUAN SIMANJUNTAK]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Isolation and identifi cation of chemical compound as anticancer from the leaves of Kopasanda (Chromolaena odorata L.) had been done. Extraction was conducted successfully with n-hexane, ethylacetate and ethanol by maceration, and by refl ux for water solvent. Fractionation of ethylacetate extract by column chromatography (SiO2). n-hexane-ethylacetate = 10:1 ~ 1:1; ethylacetate). n-hexaneethylacetate = 5:1) gave one pure isolated fraction fr. 5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. Chemical structure determination was done based on spectral data interpretation of Infra Red, 1D NMR (1H, 13C) and 2D NMR (H-H COSY, HMQC and HMBC) and mass spectra (LC-MS). Pure isolated fraction fr. 5-3 was deducted as methyl ether naragenine.]]>
<![CDATA[Validasi Kuesioner Baru Menilai Pengetahuan dan Persepsi tentang Kombinasi antara Pengobatan Herbal dan Konvensional ]]>
<![CDATA[I. N. FARIDAH]]>;
<![CDATA[M.N. C. PUTRI]]>;
<![CDATA[D. A. PERWITASARI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Indonesia is a country which has great potential of herbal medicine, although combination between herbal and conventional medicine can be benefi cial or harmful. Knowledge and perceptions about that combination are needed to achieve the best treatment eff ect. To validate a new instrument assessing knowledge and perceptions of patients about combination between herbal and conventional medicine. This study used cross sectional study which was conducted in some of pharmacy in Yogyakarta. Inclusion criterias of the subject were people who visited to the pharmacy with ages above 18 years old and below 65 years old, also had used the combination of herbal and conventional medicine for minimal a month to achieve the same goal of treatment. Items of the questionnaire were developedby existing literatures and added some new items. The content validity had been conducted by some experts. Analysis statistic with bivariate correlations was used to determine the validity and reliability of the questionnaire. Subjects who met the inclusion criteria were 30 people, which are consisted of 15 ofhealthy people and the rest are people who use the combination. In the domain of knowledge, there are 16 valid questions over 19 questions. Reliability had been calculated by 16 questions and it was reliable (cronbach alpha 0.863). In the perception domain, there were 8 valid questions. The reliability showed that the questions were reliable (cronbach alpha 0.862). There are 3 invalid questions because all of the answer is similar. Our study provides that this new questionnaire was valid and reliable to a ssessknowledge and perception of the patient who use combination of herbal and conventional medicine.]]>
<![CDATA[Fraksinasi Ekstrak Butanolik Kaldu Fermentasi Isolat Kapang Tanah Banjarmasin Biomcc-F.T.3762 Berbasis Uji Aktivitas Penghambatan Dihidroorotat Dehidrogenase Plasmodium falciparum ]]>
<![CDATA[AMILA PRAMISANDI]]>;
<![CDATA[HARMITA HARMITA]]>;
<![CDATA[ANIS HERLIYATI MAHSUNAH]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Butanolic extract of soil fungus BioMCC-F.T.3762 fermentation broth exhibited inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a fl avin dependent mitochondrial electron transport chain, an essential enzyme in de novo pyrimidine biosynthesis pathway of the parasite. The crude butanolic extract exhibited PfDHODH inhibition of 97% at a concentration of 413 μg/mL, and showed no inhibitory activity against its human homolog. Bioassayguided fractionation was performed on butanolic extract of microbial fermentation broth to isolate the active compounds. The active fraction was isolated using liquid–liquid partition, silica gel column chromatography, octadecylsilane (ODS) column chromatography and was purifi ed by preparative high performance liquid chromatography (HPLC). Major peak of active fractions, FS10-2-12 and FS10-2- 13, were detected by PDA HPLC, which showed a retention time of 12.6 minute and 13.9 minute at 254 nm, respectively. The active fractions exhibited 75% and 40% inhibitory activity against PfDHODH, respectively, at a concentration of 100 μg/mL. In comparison, atpenin A5, a known potent mitochondrial complex II inhibitor exhibited 75% inhibitory activity againts PfDHODH at 366 μg/mL.]]>
<![CDATA[Efektifi tas Ekstrak Kulit Manggis (Garcinia Mangostana) terhadap Jumlah Sel NK dan Kadar Ifn-γ pada Penderita HIV di RSUD Cirebon ]]>
<![CDATA[MARIA DYAH KURNIASARI]]>;
<![CDATA[EDI DHARMANA]]>;
<![CDATA[MUHAMAD HUSEIN GASSEM]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Mangosteen peel contains xanthone as antioxidant, useful as prooxidant balancer. The activity of xathone can be found from the number of NK cells that will increase the production of IFN-γ cytokine. The human experimental research has been done by Randomized Control Group Pretest-Post Test Design, 20 patients sample for each group. Mann Whitney test was used to determine the diff erences between the group 1 & group 2. The Spearman’s Rho Test was used to determine the correlation between the NK cells number and IFN-γ level. There are no signifi cant diff erences between NK cell number (p:0.911) and IFN-γ level (p:0.588) in the pre and post test examination after have been given mangosteen peel extract. There are no signifi cant correlations between NK cell number and IFN-γ level in each group (p: 0.074). There are no eff ects of giving mangosteen peel extract on the number of NK cell and IFN-γ level to HIV patients.]]>
<![CDATA[Dampak Positif Fraksi Etil Asetat dari Kalanchoe pinnata terhadap Antibodi Anti-Smith dan Sel T Reg pada Mencit Lupus ]]>
<![CDATA[NIKEN INDRIYANTI]]>;
<![CDATA[JUNAIDI KHOTIB]]>;
<![CDATA[JOEWONO SOEROSO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Kalanchoe pinnata (Lmk) Pers is a medicinal plant that has many activities, such as antioxidant, anti-infl ammation and immunosuppressant activities. Based on our previous study, aqueous extract of this plant leaves has a repairing eff ect on lupus nephritis model. The expected active compounds are flavonoids. Those compounds are separated in the ethyl acetate fraction. Therefore, this study observed the activity of the ethyl acetate fraction of Kalanchoe pinnata (Lmk) Pers on reducing the level of Anti- Smith autoantibody and the regulation function of CD4+CD25+ T reg in lupus mice. The experimental groups were a negative control group that received placebo, ethyl acetate fraction of Kalanchoe pinnata (Lmk) Pers (EF-KP) group and a positive control group that received cyclophosphamide. The anti-Sm level was measured by using indirect ELISA. The spleen cells were prepared for CD4+CD25+ T reg assay using fl ow cytometry. The result of this experiment was a reduction of anti-Sm antibody level. The decrease was suffi cient to stabilize lupus condition. The fl ow cytometry assay results showed the increase in the relative percentage of CD4+CD25+ T reg. This function can inhibit the reactivity of autoantigens, so it prevents tissue and organ damage from lupus. However, further research is needed to observe the complete mechanism.]]>
