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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 721 Documents

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Formulasi Sediaan Krim Tabir Surya dari Ekstrak Etanol Buah Bisbul (Diospyros blancoi) Harry Noviardi; Devi Ratnasari; Muhammad Fermadianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Bisbul fruit is one of the tropical plants that grows in Indonesia. Phytochemical contents of bisbul fruit are alkaloids, tannins, flavonoids and phenolic compounds. Flavonoids and phenolic compounds are potentially as antioxidants. Antioxidants could inhibit skin cell damage due to oxidation process. This study aimed to make the optimum sunscreen cream, based on quality, stability and activity as a sunscreen from bisbul fruit (Diospyros blancoi). The sample used in this research was bisbul, which made into extract. The extraction was done by a maceration method using 95% ethanol solvent. The results showed that extract yield obtained was 12%. Furthermore, made into a sunscreen cream preparation with concentrations of 10, 20, and 40%. The cream had been made, then was evaluated the quality organoleptic test, pH, adhesiveness, dispersive power, viscosity, stability, and the Sun Protection Factor (SPF) value. The results showed that of bisbul extract could be made into a sunscreen cream. The SPF value obtained from the extract concentration of 10, 20, and 40% consecutively were 9.25; 10.02; and 13.00. Furthermore, it could be concluded that the formula with a concentration of 40% was the best quality of the cream and the highest SPF value of 13.00 with maximum protection.

Kadar Makronutrien Dan Nilai Indeks Glikemik Tepung Umbi Suweg (Amorphophallus campanulatus) Dengan Dan Tanpa Difermentasi Dian Ratih Laksmitawati; Umi Marwati; Vergie Indriani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Low-glycemic indexed foods are increasingly in demand. The glycemic index value is influenced by macronutrient composition. Fermentation can change macronutrient levels of foods. This study aims to analize the effect of lactic acid bacteria fermentation on macronutrient content (protein, fat, carbohydrate) and glycemic index of suweg (Amorphophallus campanulatus) tuber flour. Tuber were thinly sliced, fermented with 10% lactic acid bacteria T1-2 isolated from previous studies, then incubated at room temperature for 4 days. The fermented tuber was then made into flour. The fermented suweg flour was tested to determine the glycemic index using experimental mice. Macronutrient levels of carbohydrates, fats and proteins are chemically determined. The results showed that during the lactate acid bacteria fermentation process 0-4 days there was an increase of lactat acid bacteria viability from day 0 to day 2 (3,64x108- 20,38x108 cells / ml) and decreased after day 2 (14,63x108- 7,91x108 cells / ml), the total acid count increased (0,2066% -1,2599%) as the pH decreased (5,43-4,37). The determination respectively result of protein, fat and carbohydrate contents of fermented suweg fluor was 7,41%, 0,46% and 0,38% and 6,05%, 0,38% , 82,15% in non fermented suweg fluor. The glycemic index value of fermented suweg flour was 64,6 and 69,4 in non fermented fluor. Based on statistical test, macronutrient content (fat, carbohydrate, protein) and glycemic index showed no significant difference between fermented and non fermented suweg fluor (P> 0,05). Fermentation of the lactic acid bacteria on suweg tuber for four days had no effect on the glycemic index and carbohydrate, fat and protein levels on the tubers.

EnglishPenyembuhan Luka Diabetes Krim Biosurfaktan Dialkil Alginat pada Ekspresi TNF-α TGF-β, Reepitelisasi, dan Kolagenisasi Cut Raihanah; Nurul Mahyani; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diabetic wound healing is delayed by many factors, including high TNF-α expression and low TGF-β expression which can affect the formation of new epithelial tissue and collagen as the main goal of the wound healing process. One of the diabetic wound healing agent is biosurfactant dialkyl alginate where so far its use in cream form for diabetic wound has never been reported. This study aimed to determine TNF-α, TGF-β, reepithelization and the collagenization of biosurfactant dialkyl alginate cream in diabetic biopsy wounds in STZ-induced rat. Biosurfactant dialkyl alginate was made in cream form and applied to biopsy wounds on the backs of rat twice a day for 9 days. Observation of TNF-α and TGF-β expression were performed by immunohistochemical staining, while epithelial and collagen with staining HE and Mallory. The results showed that the biosurfactant dialkyl alginate cream had an activity to decrease TNF-α expression, increase TGF-β expression and reepithelization but did not have any significant activity on collagenization. These results suggest that the biosurfactant dialkyl alginate cream can accelerate the healing of diabetic wound.

Pengaruh Pembentukan Dispersi Padat Meloksikam - PVP K-25 terhadap Penetrasi Perkutan dari Sediaan Gel Sukmadjaya Asyarie; Sasanti Tarini D; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1114.156 KB)

Most drugs are weak acids or bases and have a low water solubility. Ionized molecules are generally in small amounts absorbed by biological membranes. One possibility of drug modification for transport through biological membranes is by solid disperse system which enhances drug solubility. The solubility of drugs in such a system increases due to particle size reduction and transformation of its crystalline form. In this study, the dispersion system was used to increase the solubility of meloxicam which can influence the percutaneous permeation. Solid dispersion was prepared by modified solvent method using various ratios of PVP K-25 and was also able to lower the meloxicam melting point. Solid dispersion of meloxicam-PVP-K-25 (1:5) was characterized by infrared absorption spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, and thin layer chromatography. Percutaneous penetration was studied by using a flow-through diffusion cell system, and besides that showed a lower diffusion rate of solid dispersion of meloxicam-PVP-K-25 compared to meloxicam.

Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Instalasi Rawat Jalan RSUD dr. Soegiri Lamongan Periode Tahun 2017 Dian Sa'idah; Hajar Sugihantoro; Abdul Hakim; Siti Maimunah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Hypertension is a non-communicable disease characterized by increased blood pressure that reaches > 140/90 mmHg. The incidence of hypertension and its complications continues to increase every year so the potential for irrational use of drugs is also increasing. The purpose of this study was to determine the rationality of the use of antihypertensive drugs at the outpatient installation of Hospital Dr. Soegiri Lamongan in the 2017 period, which reviews the exact indication, the right patient, the right drug, and the right dosage. This study is an observational study conducted by descriptive method and uses retrospective data, namely medical record sheets of hypertensive patients in 2017. The sampling method used was proportional stratified random sampling. The study population was 451 medical records of hypertensive patients, the number of samples used was 82 medical records where there were 269 prescription sheets in it. The data obtained are then compared using the 2013 American Society of Hypertension (ASH) literature and 2017 Hypertension Clinical Guidelines. The results showed that the rationality of the use of antihypertensive drugs in Dr. Soegiri Lamongan Hospital in 2017 period is 100% accurate on indications, 91,82 % right on patients, 88,85% right on drugs, and 98,14% right on dosages.

Evaluasi Efek Samping OBat Kemoterapi terhadap Quality of Life (QOL) Pasien Kanker Payudara di Rumah Sakit X Jakarta Sondang Khairani; Sesilia A Keban; Meyke Afrianty
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Breast cancer is the number one cancer type discovered at women in the world. Most causes are genetic factors and hormonal factors. One cancer treatments with chemotherapy. Chemotherapy drugs active in cells dividing and reproducing, but cells normally to be affected by chemotherapy and side effects from chemotherapy drugs affect quality of life. The aim of the study to evaluate side effects of chemotherapy drugs on the quality of life of breast cancer patients. Sampling technique observational prospective breast cancer patients with completed the chemotherapy cycle from September 2017 to April 2018 with descriptive analysis and statistics by looking correlation between drug side effects and Quality of Life (QoL). Results of the study were side effects of fatigue 100%, nausea 67,5%, vomiting 60%, no appetite 63,75%, fever 42,5%, joint pain 43,75%, diarrhea 16,25%, difficulty swallowing 16,25%, allergies 5%, itching 1,25%, mouth sores 3,75%, swollen right hand 1,25%, constipation 3,75%. QoL results are physical 6,2%; psychology 5,3%; social 4,9%; spiritual 6,8%. Results of Sperman test showed no correlation between the side effects of chemotherapy and QoL P> 0,05. This study shows that there is no relationship between the side effects drug chemotherapy and QoL in breast cancer patients.

Potensi Pengembangan Industri dan Bioekonomi Berbasis Makanan Fermentasi Tradisional Suyanto Pawiroharsono
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1251.258 KB)

Consumption of traditionally-fermented foods is around 25% of the total human food consumption. Indonesia has several important traditionally-fermented foods such as tempe (fermented soybean), tape (fermented cassava or glutinous rice), etc. Those foods are in general produced in smallscale industries or in home industries, which appear somewhat dirty, unhygienic and not standardized concerning its processing and the end product. The fermentation process benefits the improvement of its value: to preserve, to increase the nutrition value, flavor and taste as well as to produce a new product. Microorganisms play an important part in the fermentation process. The microorganisms involved in the traditionally-fermented food are usually a multiculture with a predominant strain. The microorganisms perform metabolic reactions and yield profit such as: (i) save to be consumed, (ii) easy to digest, and (iii) improving its nutritional and nutraceutical value, which are all advantageous for health. In addition, several traditionally-fermented foods also contain active substances potentially used for health, for preventing as well as for healing some diseases. The development of advanced biotechnology is to be expected in promoting the traditionally fermented food in favour of the food industry.

Uji Sitotoksik Ekstrak Buah Phaleria macrocarpa terhadap Sel Kanker Lestari A 549 dan THP-1 Pertamawati Kartakusumah; Susi Kusumaningrum; Hendig Winarno
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (801.364 KB)

Fruits of Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) has been used to cure various health problems, including empirical treatment for cancer. The therapeutic effect of natural material is related to the chemical compound contains. In fruits of Phaleria macrocarpa, various chemicals are present such as alcaloid, flavonoid saponin, fenol and tannin, which showed anticancer activity, as well as unknown compounds which ones presumably supportive for cancer treatment. An in vitro experiment is therefore set up with the objective of examining the effect of fruit extract on male human lung carcinoma epithelial cells (A-549 cell line) and human peripheral blood leukemia acute cells (THP-1 cell line). Various concentrations: 5, 10, 25, 50 and 100 ppm of fruit extract were evaluated. Observations were made 72 hour after incubating A-549 cells and THP-1 cells in each treatments. The results showed that fruit might inhibit the growth of A-549 cells and THP-1 cells. Inhibitory concentration (LC) of fruit extract after 72 hours of incubation is 9,43 ppm for A-549 cells and 5,36 ppm for THP-1 cells. Inhibitory potential effect of these fruits in THP-1 cells are better than in A-549 cells. The effect might be associated to the active compounds contained in these material.

Hubungan antara Karakteristik Pasien dan Terapi terhadap Nilai Retensi di RSJ Menur Surabaya Arifani Siswi Diasari; Antonius Adji Prayitno Setiadi; Lila Nurmayanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Methadone maintenance therapy program (MMTP) is the government's efforts to reduce drug abuse in Indonesia.The MMTP success parameters can be seen from the retention rate which is the length of time patients undergo methadone maintenance therapy after receiving stabilization therapy (administration of methadone for 6 weeks or 42 days). This study aimed to determine the relationshipof the patientscharacteristics and therapy to the retention rate in Menur Psychiatric Hospital Surabaya. This cross-sectional study was conducted retrospectively by reviewed the patient’s medical record dan involved 41 subjects who were selected by consecutive sampling. Patient characteristics and therapy was analyzed descriptively and the variables relationship with retention rate was analyzed by using Spearman’s correlation test.The results showed the retention rate at 6 months (4.9%), 9 months (12.2%), 12 months (19.5%), 24 months (26.8%), 36 months (26.8%) , 48 months (4.9%) and 60 months (4.9%). According to Spearman's correlation test, the smallest maintenance dose shows a significant correlation to the retention rate (p = 0.036 with sufficient correlation r = -0.382). Therefore, the selection of the smallest dose in patients undergoing MMTP needs a particular concern to increase the successfulness of this program, which is indicated by the retention rate in this study.Methadone maintenance therapy program (MMTP) is the government's efforts to reduce drug abuse in Indonesia.The MMTP success parameters can be seen from the retention rate which is the length of time patients undergo methadone maintenance therapy after receiving stabilization therapy (administration of methadone for 6 weeks or 42 days). This study aimed to determine the relationshipof the patientscharacteristics and therapy to the retention rate in Menur Psychiatric Hospital Surabaya. This cross-sectional study was conducted retrospectively by reviewed the patient’s medical record dan involved 41 subjects who were selected by consecutive sampling. Patient characteristics and therapy was analyzed descriptively and the variables relationship with retention rate was analyzed by using Spearman’s correlation test.The results showed the retention rate at 6 months (4.9%), 9 months (12.2%), 12 months (19.5%), 24 months (26.8%), 36 months (26.8%) , 48 months (4.9%) and 60 months (4.9%). According to Spearman's correlation test, the smallest maintenance dose shows a significant correlation to the retention rate (p = 0.036 with sufficient correlation r = -0.382). Therefore, the selection of the smallest dose in patients undergoing MMTP needs a particular concern to increase the successfulness of this program, which is indicated by the retention rate in this study.

Efek Ekstrak Petroleum Eter Daun Ara (Ficus Racemosa Linn.) pada Indeks Fagositosis Mencit (Mus musculus) Candra Dwipayana Hamdin; Andriliana Trihastuty; Siti Rahmatul Aini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Terpenoid compound from ara’s leaf is known to have immunosuppressant activity by inhibit blood cells proliferation. Immunosuppressant is a group of drugs that can suppress excessive immune responses. The aim of this research was investigated the immunosuppressant effect of petroleum ether from ara’s leaf (Ficus racemosa Linn.) on mice (Mus musculus). The immunosuppressant activity was conducted by carbon clearance method to investigate the ability of phagocytosis with carbon as an antigen that is injected intravenously, followed by determining organ index. All data was analyzed by SPSS. The result showed that at dose of 560 mg/kgbw and 1120 mg/kgbw, extract found to have immunostimulant activity with phagocytic index values respectively of 1.5 and 1.1, while the dose of 1680 mg/kgbw was immunosuppressant with phagocytic index 0.7. The lymphoid organ index showed a significantly difference between petroleum ether from ara leaf extract by dose 1680 mg/kgbw with negative control (p<0.05). Based on the results of the non-specific immune response, it can be concluded that the petroleum ether ara’s leaf extract by dose 1680 mg/kgbw has immunosuppressant activity.

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Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

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Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA