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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 721 Documents

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Analisis Perencanaan dan Pengendalian Obat di Rumah Sakit Pluit Tahun 2015 Endang Setiawati; Anny Victor Purba; Wahyudi Uun Hidayat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Drug planning at Pluit Hospital is carried out using a consumption method that is based on previous use. The purpose of this study was to determine the investment value and use of drug supplies based on a combination of consumption methods with ABC, VEN and Reorder Point (ROP) analysis. This research is a qualitative and quantitative descriptive study with retrospective data collection during the period May-October 2016 at Pluit Hospital. ABC analysis results based on the investment value of the total group A drug items have a percentage of 69.90%; group B 20.07% and group C 10.03%. ABC analysis results based on the use of group A 69.95%; group B 20.04% and group C 10.01%. VEN analysis results for group V 3.24% absorbed investment of 5.15%; group E 60.10% absorbed investment 76.56% and group N 36.66% absorbed investment 18.29%. Analysis of drug planning based on ABC and VEN methods has high, medium and low investment values, usage values and NIK. While the analysis of drug control based on the method of Lead Time, Safety stock and Reorder Point guarantees the availability of drugs on an ongoing basis.

Isolasi, Karakterisasi dan Uji Aktivitas Biologi Asam Kojat dari Fermentasi Cair Aspergillus Flavus LS03 Hani Mulyani; Rizna T D; Megawati Megawati; Sofa Fajriah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Aspergillus flavus LS03 is a type of fungus isolated from rhizosphere soil in West Lombok, which showed potential as an α-glucosidase inhibitor and free radical scavenger in the early stages of screening activity. This study aimed to identify and characterize secondary metabolite as antidiabetic and antioxidants from A. flavus LS03 fungus grown on liquid medium of potato broth (PDB). The testing of antidiabetic activity is based on the inhibition of the α-glucosidase enzyme while the antioxidant is based on the ability to reduce DPPH free radicals. The result of separation and purification was obtained by active isolate (1) which was identified as 5-hydroxy-2- (hydroxymethyl) -1.4-piran (kojic acid) based on spectroscopic data. Kojic acid (1) shows strong potential as an α-glucosidase enzyme inhibitor and free radical DPPH with IC50 values of 35.34 and 149.9 μg / mL, respectively.

Formulasi Nanoemulsi Ekstrak Etanol Buah Okra (Abelmoschus esculentus (L.) Moench.) dan Uji Aktifitas Antikolesterol secara In-vitro Ratna Djamil; Sarah Zaidan; Vera Butar Butar; Diah Kartika Pratami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Okra fruit has a flavonoid, phytosterol and pectin content, which is potential as an anticholesterol agent. The pharmacological activity of ethanol extract 70 % of okra fruit (EEOF) can be improved by forming nanoemulsion. This study aimed to prepare an ethanol extract 70 % and nanoemulsion of okra fruit and to prove the cholesterol inhibition in vitro EEOF is smaller than the nanoemulsion of EEOF. The okra fruit was extracted by kinetic maceration, the EEOF was analyzed by a phytochemical screening test and cholesterol inhibition assay in vitro using Liebermann-Burchard reagent. The anticholesterol activity was expressed as IC50 values. Nanoemulsion of EEOF prepared by spontaneous emulsification method using capmul, propylenglycol, glycerin (1 : 2.5 : 2 mL). The result of phytochemical screening of okra fruit simplicia and EEOF were contained flavonoid, steroid, triterpenoid, saponin, and coumarin. The resulting nanoemulsion has a 134.7 nm in diameter with a potential zeta value of -26.72 mV. EEOF has IC50 of 764.11 µg/mL and nanoemulsion of EEOF have IC50 of 712.50 µg/mL. Nanoemulsion can improve anticholesterol IC50 value because it was penetrated the gap between cells so that the delivery and bioavailability were higher.

Formulasi Gel Transfersom Limbah Kulit Bawang Merah (Allium cepa. L) menggunakan Perbandingan Fosfolipid dan Surfaktan Winda Permata Sari; Soniya Tamara; Sherli Permatasari; Septia Andini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Red onion tunic waste contains quercetin which has anti-inflammatory activity. The formulation of anti-inflammatory preparations with the transdermal route is a solution towards the effect of gastrointestinal in the oral route. Transfersome is a nano vesicle particle that can increase the penetration of transdermal formulation. This study aims to characterize red onion tunic waste transfersome based on the ratio of phospholipids and surfactants used. The formulation of the best transfersome will be made into gel based formulation and the particle will be evaluated. Transfersome is made in 3 formulas namely Formula 1 (F1) with a ratio of phospolipids:surfactant (90:10), F2 (85:15), and F3 (70:30). This characterization included particle size distribution, potential zeta, entraptment efficiency, deformability index, and vesicle morphology. The best transfersome formulas are then formulated into gel preparations. The results showed that the best transfersome formula was F1 (90:10), with an average particle size of 357.9 ± 6.3 nm, zeta potential of -24.9 ± 0.9 and the entraptment efficiency results reached 77.964%. The morphology of the vesicles produced is spherical according to the expected vesicle criteria, but in gel-based formulation, the particle size not distributed homogenously.

Efektivitas Edukasi Media Booklet Pasien Diabetes Mellitus Tipe 2 Kualitas Hidup Rawat Jalan di RS Anwar Medika Khurin In Wahyuni; Antonius Adji Prayitno Setiadi; Yosi Irawati Wibowo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

DM management is expected to improve the quality of life of patients because the quality of life is the ﬁ nal result of each medical intervention; therefore, it becomes a standard of every succesful therapy. One of the improvements in quality of life can be done through education. In providing education, booklet method can be an eﬀective way to deliver information about the activities problem. This study used one-group pre-test post-test design. This study aims to determine the quality of life before and after giving education to outpatients in Anwar Medika Hospital from November 2017 to January 2018 with sample of 109 patients. The measurement of quality of life improvement was measured by the Diabetes Quality of Life (DQOL) score which has 4 domains: satisfaction domain, the impact of DM concerns due to DM and physical, psychological and social concerns. Quantitative analysis carried out by the Wilcoxon signed rank test and showed that there are diﬀerences in quality of life with signiﬁcance of 0.000 (p <0.005) from each domain. Therefore, it can be concluded that, education could impact an important role on improving quality of life.

Uji Aktivitas Antihialuronidase In-Vitro dan Karakteristik Fisik Nanostructured Lipid Carrier Ekstrak Rimpang Langkuas laki-laki (Alpinia zerumbet) Siti Umroh Noor; Dian Ratih Laksmitawati; Wahono Sumaryono
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The rhizome of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) contains phenolic compounds, has antihyaluronidase activity which can reduce wrinkles on the skin. This study aims to determine the physical characteristics and antihyaluronidase activity of the nanostructured lipid carrier (NLC) of the Alpinia zerumbet rhizome extract in-vitro. Alpinia zerumbet rhizome powder (4/18) was extracted by kinetic maceration method using 70% ethanol solvent, concentrated with a rotary vacuum evaporator at 100 mm Hg at a temperature of ± 50oC. The resulting extract was prepared into NLC nanoparticles using polyethyleneglycol 8-beeswax, isopropyl myristate and acrylyl glucoside with the high speed homogenization-ultrasonication method. The resulting NLC extracts were characterized by nanoparticle size and morphology, polydispersity index and zeta potential and antihyaluronidase activity test was determined using the Sigma Aldrich and Tu & Tawata methods with slight modifications. The results of the NLC characterization of Alpinia zerumbet rhizome extract were 171.3 nm; 0.37; -26.8 mV; and spherical shape. The results of the antihyaluronidase activity of Alpinia zerumbet rhizome extract loaded NLC was 552.75 µg/mL. It was concluded that the Alpinia zerumbet rhizome extract loaded NLC can be formulated into topical preparations which have the potential to be antihyaluronidase with the ability to reduce wrinkles on the skin.

Aktivitas Daya Hambat Ekstrak Etanol Biji Pinang (Areca catechu L.) terhadap Isolat Bakteri Gigi Meiriza Djohari; Armon Fernando; Annisa Safitri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Areca nut is traditionally used by the community to strengthen teeth. Areca nuts contain alkaloid, flavonoid, and terpenoid as antibacterials. This study aims to determine the types of dental bacteria resulting from isolates and determine the effect of the administration of ethanol extract of areca nut (Areca catechu L.) on the results of isolates of dental bacteria. Antibacterial activity testing using disc diffusion method with the concentration of areca nut ethanol extract 10%, 20% and 30%. The results showed that bacteria of the tooth are Lactobacillus casei, Branhamella catarrhalis, Streptococcus sp. Ethanol extract of areca nut (Areca catechu L.) is better to inhibit the growth of Lactobacillus casei compared to Branhamella catarrhalis and Streptococcus sp in the medium to weak category. Two Way ANOVA test results on inhibitory zone diameter stated that there were differences between the concentration groups of 10%, 20%, 30%, positive control and negative controls and there were differences in the inhibitory activity of Lactobacillus casei compared to Branhamella catarrhalis and Streptococcus sp but there were no significant differences on the inhibitory activity of Branhamella catarrhalis with Streptococcus sp.

Potensi Minyak Atsiri Temu Kunci (Kaempferia pandurata) dan Komponennya sebagai Pelangsing Aromaterapi Irma Hermawati Suparto; Rahmi Nur Wahidah; Irmanida Batubara
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Temu kunci (Kaempferia pandurata) is one of the Indonesian aromatic plants containing essential oils. The objective of this study was to evaluate the potential compound in temu kunci essential oils that has activities as slimming aromatherapy. Essential oil was obtained from the rhizome by distillation then further fractionated using column chromatography and obtained 7 fractions. Based on the gas chromatography mass spectrometer, the main component of the essential oil of temu kunci was o-cymene, while the main component in fraction 1 was limonene. Fraction 1, camphor and the essential oils were tested in vivo as slimming aromatherapy using adult male Sprague Dawley rats given for 5 weeks. Animals received inhalation of camphor and essential oils showed a higher tendency to increase body weight compared to animals given fraction 1. Animals treated with fraction 1 showed the lowest body weight gain response (47%) eventhough not significant, however it gave the lowest total consumption per weekly (P<0.05). Therefore, based on these results, fraction 1 that has limonene is potential as slimming aromatherapy agent.

Profil Lipid dan Gambaran Histopatologi Aorta Tikus Hiperlipidemia dengan Pemberian EKSTRAK Kopi Hijau Fransiska Maria Christianty; Diana Holidah; Fifteen Aprila Fajrin; Monica Cinuradha Aura Salsabina; Andrean Roni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The high prevalence and risk of death from cardiovascular disease has led to the development of alternative treatments derived from nature. Green coffee has not undergone a roasting process. The product is claimed as a weight loser, even though the cardiovascular effects are still controversial. This study aim was to determine the impact of green coffee bean extract on rat lipid profiles and aortic histopathology. Green coffee bean extract made by a re-maceration method using 96% ethanol. Rats were induced with high-fat diet then treated with green coffee bean extract at a dose of 200; 400; and 800 mg/kg BB. Rats were sacrificed, blood was taken for lipid profile measurements and observations were made on histopathological preparations of rat aorta. The results showed that administration of green coffee bean extract (especially doses of 200 mg/kg BW) for 14 days in hyperlipidemic mice could significantly improve lipid profiles, except HDL levels. Microscopic observations showed that green coffee bean extract could enhance the rat aorta histopathology even though it did not match normal conditions. We can conclude that green coffee bean extract has potential effects to be developed as an alternative to traditional medicine that has antihyperlipidemic effects and cardiovascular protective effects.

Pengaruh Pemberian Aspartam secara Oral terhadap Kadar AST dan ALT Serum serta Gambaran Histopatologi Hati Tikus Putih Ros Sumarny; Sondang Khairani; Mohamad Rega Satria Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Aspartame is low calorie sweetener metabolized into aspartic acid, phenylalanine and methanol, methanol cause damage to the liver. The purpose this study to determine the effect rats of oral aspartame administration for 90 days on biochemical parameters AST, ALT and liver histopathology. Rats were divided randomly into four groups: normal control, dose groups 126, 252, 504 mg/kgBW. Blood samples were taken on the 0th, 30th, 60th and 90th days to measure AST, ALT levels and 90th day to see liver histopathology. AST and ALT measurements using UV-VIS spectrophotometry with a wavelength of 340 nm. The levels of AST and ALT on the 90th day in the normal group 41,55 and 48,40 UI/L. Dose groups 126, 252, and 504 mg / kgBW were low doses 54,62 and 57,72 UI/L, 66,88 and 70,47 UI/L, 77,50 and 80,03 UI/L. Rats histopathology liver of aspartame showed hemorrhage. Concluded aspartame can increase of AST and ALT levels in rats blood serum and liver damage.

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Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

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Contact Name
Syafira Dwi Cahyani

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adminjifi@univpancasila.ac.id

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+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA