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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 721 Documents

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Aktivitas Antioksidan Senyawa yang berasal dari Kayu Artocarpus heterophyllus ENOS TANGKE ARUNG; KUNIYOSHI SHIMIZU
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.381 KB)

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus bybiologically activity-guided fractionation, namely antioxidant. The isolated compounds are cudraflavoneC, kuwanon C, norartocarpin, albanin A and artocarpanone have more hydroxyl groups seem to bespecifically to scavenge H2O2. These experimental results demonstrated that each scavenging compounddifferent in its scavenge capacity toward different form of radicals.

Pengaruh Ekstrak Lengkuas Putih [Alpinia galanga (L.) Willd] terhadap Infeksi Trichophyton mentagrophytes pada Kelinci DJAENUDIN GHOLIB; DARMONO DARMONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1233.304 KB)

Lengkuas putih [Alpinia galanga (L.) Willd] has long been known to be used in treatment of dermatophytosis, a skin disease caused by dermatophytes fungi such as Trichophyton mentagrophytes. The fungi infects hairs, skins, and nails that contain keratin. The study was conducted in order to measure the effect of ethanol extract of Alpinia galanga in inhibiting Trichophyton mentagrohytes colonies both through in vitro test and in vivo test using infected rabbits . The results showed that minimal inhibition concentration (MIC) of Ahoinia galanga extract Was 1.5%. The extract was administered in cream preparation on in vivo test with minimal concentration (1.5%). Three group of rabbits were treated with the extract cream preparation (Group I), 2% with ketokonazol cream (Group II, positive control), and With none (Group III, negative control), respectively. The results showed that the infected rabbits treated with either cream containing the extract or ketokonazol were better recovered from infection than the rabbits in negative control group.

Efek Antidiare Ekstrak Air Bunga Nagasari (Mesua Ferrea L.) Terhadap Mencit BALB/c yang Diinduksi Minyak Jarak Putu Monik Ananta Puspitarini; Iman Surya Pratama; Bambang Fajar Suryadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Nagasari (Mesua ferrea L.) has a empirically repute for management of diarrhea in West Nusa Tenggara Province. However, the safety and efficacy of the nagasari flowers extract have not been scientifically validated in animal model. This study wasaimed to investigate the antidiarrheal effect of water extract of the nagasari flowers in BALB/c mice. The antidiarrhea activity of nagasari flowerswas investigated using castor oil-induced diarrhea increase in diarrhea index in mice.In castor oil-induced diarrhea test, mice received various consentrations of nagasari flowers extract (0,4% w/v; 0,8% w/v; and 1,6% w/v), where as negative controls received CMC-Na 1% and positive controls received loperamide 0,7 mg/kgBW orally once daily for 1 day and the mice droppings were observed. The phytochemical screening of nagasari flowers contain flavonoid, saponin, and phenolic. Water extract of nagasari flowers at concentration 1,6% showed significant inhibitory activity against castor oil-induced diarrhea when compared with positive controls (diarrhea index 0,083 ; p>0,05). Therefore, this study provides a scientific support for the acclaimed traditional use water extract of Mesua ferrea L. for the treatment of diarrheal diseases.

Pembuatan dan Pengujian Kondisioner Rambut Menggunakan Lendir dari Daun Kembang Sepatu (Hibiscus rosa-sinensis L.) Hamidah Supriati; Irham Pratama Ridwan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Many ornamental plant growing in tropical and subtropical regions one is Hibiscus which is a native plant from East Asia. Conditioner is one of semi solid preparation used to hair after using shampoo. The porpose of the research is getting formulation hair conditioner from Hibiscus with various concentration. This research is a descriptive analytic in the laboratory. Conditioner making with mix oil phase and melted water. The indrediens to be use are dimethicone, sethyl alcohol, stearic acid, TEA, glycerin, methyl paraben, propyl paraben and aquadest. Physical stability tests carried out were organoleptic test, homogeneity test, pH test and cream type test with various concentrations of hibiscus leaf mucus which were 15%, 20%, 25% and 30%, and as a comparison were the formulations of conditioner preparations without using hibiscus mucus . The results showed that the manufacture of conditioner with variations in the concentration of mucilage of hibiscus leaves (Hibiscus rosa-sinensis L.) and physical stability testing on formula 4 shows stable and softer textured results. The conclusion obtained is that formulas 1, 2, 3 and 4 have met the requirements of semi-solid preparations.

Analisis Kebutuhan Pasien pada Pelayanan Kefarmasian di Klinik Rawat Jalan RSUD dr. Soebandi Jember: Studi Kasus Layanan Resep Zora Olivia; Umi Athijah; Wahyu Utami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The aim of this research was to know the drug related need in the pharmacy service atpharmacy special prescription service. Descriptive study was done to out patient who fulfi ll prescriptionin the pharmacy Dr Soebandi Jember Hospital. A sample of this population is 557 patients taken withsampling techniques with stratifi ed random sampling. Retrieval of data in this study using a questionnaireinstrument. From the data needs of the patient at the pharmacy pharmacy services in the majority ofpatients explain need to therapy appropriate treatment indication for 85.6 %, at eff ective 84.9 %, atsafely 77.4 % and can be used according to the rules of use of 94.4 %. Based on these data it can beconcluded that the needs of patients at the pharmacy services are appropriate indications, eff ective,safe and can be used according to the rules of use. The requirement can be achieved due to appropriatepharmacy services running and providing pharmaceutical care is a pharmacist. Reimbursements arereimbursed by the insurance company should not be given to Pharmacist Pharmacy for pharmaceuticalcare can not walk if no pharmacist.

Efek Antidiare Infusa Daun Senggani (Melastoma malabathricum L.) Pada Mencit Jantan Galur Swiss Webster Yang Di Induksi Oleum ricini Nova Suliska; Thito Dwi E; Herlinda Herlinda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diarrhea is a disorder of defecation more than 3 times a day with the consistency of liquid stool, blood and/or mucus. The plants that is used by the community for diarrhea is senggani (Melastoma malabathricum L.). This study aims to determine the antidiarrheal effects and dose of senggani leaves infusion in mice induced by Oleum ricini. Mice were grouped into 5 groups: the positive control group (diarrhea induction), the comparison group (loperamide), and senggani leaves infusion test group with a dose of 26 mg/kg bw, 52 mg/kg bw, and 104 mg/kg bw. Mice induced diarrhea with Oleum ricini, 30 minutes later the mice were given the samples, except the positive control group. The faecal frequency, weight, and consistency were measured every 30 minutes for 4 hours. Senggani leaves infusion group 52 mg/kg bw showed the frequency and faecal weight were significantly different compared to the positive control group (P <0.5) at 240 minutes observation. The faecal consistency of senggani leaves infusion groups 52 mg/kg bw tends to be normal at 240 minutes observation. Senggani leaves infusion 52 mg/kg bw showed the best antidiarrheal effect compared to senggani leaf infusion 26 mg/kg bw and 104 mg/kg bw in Oleum ricini-induced mice.

Karakterisasi Nanopartikel dan Uji Antiagregasi Platelet Secara In-Vitro terhadap Ekstrak Rumput Laut Coklat (Sargassum polycystum) Hasil Hidrolisis Enzim Sellulase Kartiningsih Kartiningsih; Syamsudin Abdillah; Partomuan Simanjuntak; Cyntia Cyntia; Haryo Haryo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Brown seaweed contains fucoidan, a large molecular weight sulfate polysaccharide (about 100,000 Da) which has platelet antiagregation activity. This activity is achieved if the fucoidan has a small molecular weight (3900-7600 Da) so this activity can increase by hydrolized with sellulase Enzym. The purpose of this study was to obtain extract nanoparticles that meet physical quality requirements and have a higher platelet antiagregation activity than brown seaweed extract both before and after hydrolysis. Extraction was using kinetic maseration method using 80% ethanol after that using 2% calcium chloride solution. The results were dried and hydrolyzed with cellulase enzyme and nanoparticles were made by ionic gelation method. Nanoparticle characterization results in particle size of 552.8, polydispersity index of 0.569, potential zeta of +53.5 mV, and spherical shape. In-vitro testing results for platelet antiagregation activity showed the percentage of platelet aggregation inhibition of brown seaweed extract with a concentration 500µg / mL is 22.19% and extracts after hydrolysis was 57.94% and nanoparticles extract after hydrolysis was 72.93%. Extract nanoparticles meet physical quality requirements and extracted nanoparticles after hydrolysis have the highest platelet antiagregation activity compared to brown seaweed extract both before and after hydrolysis.

Aktivitas Antibakteri Fraksi Allium ascalonicum Linn A562275sal Lembah Palu terhadap Shigella dysenteriae Akhmad Khumaidi; Kumalahayati Maulina; Arsa Wahyu Nugrahani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Shallot (Allium ascalonicum Linn.) is one of the typical plants of Central Sulawesi which is used as traditional medicine such as to treat infectious diseases. This study aims to determine the fractions that have high activity from bulbs and leaves in inhibiting the growth of Shigella dysenteriae bacteria and determining the organic compounds that have antibacterial activities. Extraction was carried out by maceration method using ethanol 96% for both samples. Liquid-liquid fractionation was used as a fractionation method using hexane, ethyl acetate and water solvents, sequenly. The antibacterial activity test used the diffusion method with the pile technique and TLC-bioautography. The results showed that ethyl acetate fraction gave the highest activity of bulbs samples, while in leaves samples ethyl acetate fraction and hexane fraction were able to provide good inhibitory activity. The organic compounds were identified by thin layer chromatography method. Flavonoids compounds have identified for bulbs samples (Rf 0.18). In the leaves samples, steroids compounds were identified in the ethyl acetate fraction (Rf 0.62) and terpenoid compounds (Rf 0.48) in the hexane fraction. Based on the result, the shallot is potentially be developed as an antibacterial material.

Selektivitas Pemisahan Isoniazid dan Asetilisoniazid dalam Plasma Manusia In-vitro secara Kromatografi Cair Kinerja Tinggi Novi Yantih; Yahdiana Harahap; Wahono Sumaryono; Rianto Setiabudy; Lestari Rahayu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Bioanalysis method is needed to pharmacokinetic study of INH as antituberculosis. The main problem is INH structure is similar to that of acetyl isoniazid (AcINH) as its metabolite. Therefore, a selective separation method is needed to separate the INH from its metabolite and matrix. The aim of this study was to test the selectivity of separation method of INH and AcINH in human plasma in-vitro by high performance liquid chromatography (HPLC). The HPLC system used a reversed phase with UV detector and hexane sulphonate as an ion counter. The optimum conditions was obtained by using C18 as stationary phase, hexane sulphonate (pH 2.47)-methanol (65:35) as mobile phase, with flow rate of 1mL/min, and UV detector at wavelength of 265nm. The selectivity of method separation was indicated by a resolution value of ≥ 1.5. The tailing factor for INH and AcINH were 1.297, dan 1.912, respectively. The k values ware less than 10 and N values were greater than 5000 indicate good separation efficiency. The developing of HPLC was a selective for separating of INH and AcINH in human plasma in-vitro.

Antiinflammatory Activity Patch Ethanol Extract Of Leaf Katuk (Sauropus Androgynus L. Merr) Rise Desnita; Sri Luliana; Desy Siska Anastasia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The leaf katuk (Sauropus androgynus L. Merr) extract at a dose of 400 mg / kg BW had antiinflammatory activity in rat by induction of carrageenan. Patch are adhesive plasters containing medicinal substances placed on the skin to delivery active substances. Patch can offer practicality, comfort and accuracy of dosage in the application of leaf S. androgynus extract.This research was a laboratory experimental research by making patch of leaf S. androgynus extract and inflammation effect used rats as its animal test. Inflammatory healing activity was seen from the percentage reduction in inflammation in rats after patch application. Patch of leaf S. androgynus extract dose 400 mg / kg BW has percentage of inflammatory inhibition ranged between 66,67-100%. Statistical test results using one-way anova patch leaf S. androgynus extract showed good effectiveness in curing inflammation. Effectiveness between leaf S. androgynus extract patch and diclofenac sodium patch relatively the same in curing inflammation.

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Home Page

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Contact Name Syafira Dwi Cahyani

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Phone +6287780957284

Journal Mail Official syafira.ffup@univpancasila.ac.id

Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

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Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA