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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Isolasi bakteri Escherichia coli pada lawar merah babi di kota Denpasar Dennis Yulianto; I Dewa Made Sukrama; Made Agus Hendrayana
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: An alarming incidence rate of food-borne diseases in Indonesia become more worrible, especially the one which is caused by Escherichia coli. Based on Food and Drug Supervisory Agency or Badan Pengawas Obat dan Makanan (BPOM) in Indonesia, there are 18.144 people who got infected by food-borne illnesses in 2011. These facts are quite alarming for the people who live in Bali and they are more likely to consume lawar merah babi.Â Lawar merah babi is a traditional Balinese food made from the mix of vegetable, meat, and some other ingredients as well as it is usually mixed by hand which make it susceptible to be contaminated by bacteria such as Escherichia coli. Aim: The study aims to investigate the E. coli contamination within lawar merah in Denpasar. Method: This descriptive cross-sectional study was conducted using 12 samples of lawar merah babi which were sold in 12 different places all across the Denpasar City. These samples were taken to Microbiology Laboratorium at Medical Faculty, Udayana University. There are three variants of dilution for each sample which are 10-1, 10-2, and 10-3. Each sample was cultured using eosin methylene blue agar as the media. Some of the sample without clear representation in the media will go through further identification. The results of Escherichia coli colonization were counted by the total plating count method to produce them in CFU/g for each of the samples.Result: Some of the samples have been contaminated by Escherichia coli (67%) approximately 17x104 CFU/g contamination average level.Conclusion: The samples exceed the contamination limit which is permitted by the BPOM recommendation, where the maximum Escherichia coli contamination level should not exceed over than 3 CFU/g.

Microbiota-based therapies for chronic kidney disease Dessy Natasha Ade Putri; Chika Christianne Moreen Nababan
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Increasing prevalence of chronic kidney disease (CKD) worldwide has been concerned as a global public health issue because of the burden of adverse outcomes, including mortality. Gut microbiota can be used as a potential therapeutic target to slow the progression of CKD.Aim: This literature review aims to provide an in-depth review about the potency of microbiota-based therapy for CKD.Method: from 58 journals reviewed, 51 were found suitable as references for this paper. The keywords used are â€œgut microbiota,â€ â€œchronic kidney diseaseâ€, â€œprebioticâ€, â€œprobioticâ€ and â€œfecal microbiota transplantationâ€ on selected search engines.Result: In general, it has shown that microbiota-based therapies do have potential therapeutic effect as it can improve inflammatory response, uremic toxin, insulin resistance and cardiovascular risk.Conclusion: Prebiotic, probiotic, fecal microbiota transplantation and novel therapies have shown beneficial effects in treating patients with CKD.

Karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017 Rose Widanti Sugiyanto; Ni Ketut Sri Diniari; Ni Ketut Putri Ariani
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Bipolar disorder is a brain disorder that changes the mood, though, energy and behavior. These abnormalities are implicated by manic, hypomanic, depression and mixed episodes. The incidence of bipolar disorder is not too high, ranging from 2% -4%. However, the incidence of bipolar disorder is more prolonged and more increase.Aim: This study aims to determine the characteristics of bipolar disorder treated in RSUP Sanglah Denpasar in the period April 2016 - March 2017.Method: This study is a descriptive retrospective design which is set at the General Hospital (RSUP) Sanglah Denpasar. Data obtained in the form of secondary data of patient's medical record on period April 2016 - March 2017. Data were analyzed by using SPSS program.Result and Conclusion: Of the 15 patients, the average age of the patient is 31-40 years (46.7%) with the first onset suffered on average 31-40 years old (40%), the most female (66.7% ), senior high school education (86.6%), unmarried marital status (53.3%), private employment (66.7%), bipolar type affective disorder bipolar episode now manic with psychotic symptoms (60%), none family history (80%), stressor of work problems (66.7%) with comorbid psychiatry (6.7%) and some with non-psychiatric comorbid (6.7%), substance abuse (26.7%), and most pharmacological therapy with anticonvulsant antipsychotic combination (20%) and non-pharmacological one by suggestive communication (40%) as well. Gangguan bipolar adalah kelainan otak yang ditandai dengan perubahan mood, pemikiran, energi dan tingkah laku. Kelainan ini ditandai dengan episode manik, hipomanik, depresi dan campuran. Dapat dikatakan insiden gangguan bipolar tidak tinggi, berkisar 2%-4%. Namun, angka kejadian gangguan bipolar terus meningkat dari tahun ke tahun.Tujuan: Untuk mengetahui karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017.Metode: Penelitian ini berupa desain deskritif restrospektif yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April 2016 – Maret 2017. Data dianalisis dengan menggunakan program SPSS.Hasil dan Simpulan: Dari 15 pasien, rata-rata berusia 31- 40 tahun (46,7%) dengan onset pertama kali menenderita rata-rata berusia 31-40 tahun (40%), jenis kelamin terbanyak adalah perempuan (66,7%), pendidikan terakhir SMA (86,6%), status pernikahan belum menikah (53,3%), pekerjaan swasta (66,7%), tipe bipolar gangguan afektif bipolar episode kini manik dengan gejala psikotik (60%), tidak ada riwayat keluarga (80%), stressor masalah pekerjaan (66,7%) dengan komorbid psikiatri (6,7%) lalu sebagian dengan komorbid non psikiatri (6,7), penyalahgunaan zat (26,7%), dan terapi farmakologi terbanyak dengan kombinasi antipsikotik antikonvulsan (20%) serta terapi non farmakologi dengan pemberian komunikasi informasi edukasi (40%).

Karakteristik anemia pada lansia di RSUP Sanglah Denpasar pada bulan Januari-Juni 2017 Alvi Laili Zahra; Ida Bagus Putu Putrawan; Tjokorda Gde Dharmayuda
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Anemia is a symptom depending on the decrease of hemoglobin levels, the number of erythrocytes, and the volume of erythrocytes. The symptoms of anemia commonly occur in the elderly. In general, the common causes that often complained in the elderly are less efficient in absorbing some of the nutrients, decreased appetite due to illness, difficulty swallowing due to reducing of saliva, slow feeding, reduced teeth, and nausea. Anemia in the elderly should not be considered as an unavoidable consequence of aging. Treatment of this problem should start as early as possible.Aim: This study aims to determine the characteristics of anemia in the elderly in RSUP Sanglah from January to June 2017.Method: This research is a descriptive cross sectional study conducted at RSUP Sanglah Denpasar. Data obtained in the form of secondary data patient record period JanuaryÂ - June 2017. Data were analyzed using Microsoft Excel 2010.Result: Of the 102 patients, the average age was 69.3 Â± 7.1 years with the highest proportion of patients aged 60-70 years old is 56 people (54.9%). The proportion of male is 71 people (69,6%). Of the total samples, there were 75 patients anemia patientsÂ (73.5%) and 27 patients without anemia (26.5%). The highest proportion of anemia depend on their stages are 51 patients of mild anemia (68%). 47 patients (62.7%) were normochromic and normocitary anemia. The highest proportion is anemia with kidney disease (38,7%).

Karakteristik Pasien Melanoma Maligna di Subbagian Bedah Onkologi RSUP Sanglah Tahun 2015-2016 Gusti Ngurah Agung Adi Paramartha; I Wayan Niryana; Putu Anda Tusta Adiputra
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Background: Malignant melanoma (MM) is one of the skin malignancies derived from melanocyte cells. It is the most common cause of death, about 75% of all cases of skin cancer. Skin cancer is ranked fourth among the ten most common tumors in Bali.Aim: To know the characteristics of malignant melanoma patients in the sub-section of surgical oncology Sanglah Hospital Year 2015-2016.Method: This study is cross-sectional descriptive research conducted at Sanglah General Hospital in Denpasar. The data obtained in the form of secondary data, patient medical records, as of 2015 till 2016. Data were analyzed using the SPSS program.Result and Conclusion: The results showed that of 11 patients, incidence with the highest proportion of patients with age range 45-59 years number of 4 people (36.3%). The most top gender was women of 6 (54.5%). The highest subtype of Nodular Melanoma (NM) was 7 (63.6%).

Karakteristik pasien dengan infeksi Burkholderia cepacia di RSUP Sanglah pada tahun 2014-2016 Dea Antariksa; Ni Nyoman Sri Budayanti; Ni Nengah Dwi Fatmawati
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Burkholderia cepacia complex (Bcc) is a group of 17 species that are genetically and phenotypically similiar. Bcc is an opportunistic pathogen in which it will cause an infection in a person who has had a previous severe lung infection or a person with a weak immune system. Objective: This study aims to determine the characteristics of Burkholderia cepacia compleks patients at RSUP Sanglah Denpasar period 2014-2016 Sanglah Hospital. Methods: This was an observational descriptive study with a cross-sectional study design and a retrospective approach. The subjects were 29 patients diagnosed with Burkholderia Cepacia bacteria and performed bacterial culture at Sanglah Hospital on January 1, 2014 s.d. December 31, 2016. The research data is secondary data obtained from the book Microbiology section Sanglah Hospital. Results: The results showed that patients with isolated Burkholderia cepacia who were admitted to Sanglah Hospital consisted mostly of 37.9% old age categories (> 50 years) and adults (18-50 years); 65.5% male sex and 34.5% female gender; 62.1% were admitted to the ICU; 24.1% were diagnosed with sepsis;

Tingkat pengetahuan dokter umum mengenai bukti medis kekerasan seksual di RSUD se-Provinsi BALI tahun 2017 I Gusti Ayu Agung Dwijayanti; Dudut Rustyadi; Kunthi Yulianti
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Sexual violence is a frequent criminal offense. Targets that become victims of the crimes can be women even today many occur in children. Medical evidence is the key to the proof of a case of sexual violence that is usually made by a forensic specialist. A general practitioner is expected to be able to examine the medical evidence of sexual violence considering the number of forensic specialists who are not comparable with the geographical area of Indonesia.Aim: The study aims to know the level of knowledge and relation between the variable of age, practice experience, and level of education related to the knowledge level of general practitioners about medical evidence of sexual violence.Method: This study is descriptive cross-sectional research located at Emergency Department all over General Hospital in Bali Province. The subject is general physician â‰¤60 years old. Data obtained use questionnaire containing a set of questions.Result: The results showed the general practitioner knowledge level about medical evidence of sexual violence was good. Of the 110 samples, 87.3% had a good level of knowledge, 11.8% was sufficient, and 0.9% had less knowledge level. One variable influenced the general physician's knowledge level was practical experience (p = 0.039). Moreover, the age (p = 0.908) did not have a significant relationship to the general practitioner knowledge level about medical evidence of sexual violence.Conclusion: It is essential that practical experience for a doctor's knowledge level about medical evidence of sexual violence is critically important.

Proporsi depresi pada penderita diabetes melitus tipe 2 di RSUP Sanglah Denpasar Gede Aditya Ersa Krisnawan; Putu Aryani; Komang Ayu Kartika Sari
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Introduction: Over 285 millions of people in 2010 in the world live with diabetes mellitus type 2 (DMT2). In Indonesia based on Riskesdas 2013, 2.45 millions of people live with DMT2 or around 1.5% of Indonesiaâ€™s total population. One of the disease causded by DMT2 is depression. 30% people with DMT2 has also experience depression. Depression in Indonesia based on Riskesdas 2013 has 19 millions of people suffering from it or 11.6% of Indonesiaâ€™s total population.Method: This research was a descriptive study with cross-sectional approach. The subjects was 51 patients diagnosed with diabetes melitus type 2 and did the follow-up in Diabetic Centre of RSUP Sanglah from October-November 2017.Data for this research was acquired Â from interview using Zung Self Depression Scale (ZSDS).Result: The results showed 78.9% sample which experience depression higher in women (80.0%), the unemployeed subject (88.6%), medium educational degree (86.2%), duration of illness >5 years (87.5%), the usage of insulin (81.0%), and patient with complication history (78.8%).Conclusion: Higher depression was found in patients with DMT2 with female gender, not working, disease duration> 5 years, history of insulin use, and had a history of complications. The proportion of depression in DMT2 patient was high, thus further research on relation between depression and DMT2 is necessary to conduct

Prevalence of anemia on chronic kidney disease and its influenced factors in Sanglah General Hospital 2015-2017, Bali Rubahshini Gunaseelan; I Wayan Surudarma; Desak Made Wihandani; I Wayan Gede Sutadarma
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Anemia is the most common disease among chronic kidney disease (CKD) patients. Its prevalence increased gradually as kidney function decreased. Globally, it affects 1.62 billion people, which corresponds to 24.8% of the population.Aim: To determine the prevalence of anemia on CKD and its influenced factors at Sanglah Hospital, Bali.Method: This was a descriptive design study conducted in Sanglah General Hospital, Denpasar, Bali from 2015 until 2017. Medical records of the patients became the secondary data for this research.Result: From 2015 to 2017, there were 384 cases of CKD and 95 were anemic in the hospital. The prevalence of this case was 24.7 %. The age group of 51 - 60 years had the highest case. The males majorly dominated anemia on CKD. Anemia in stage V of CKD patients was the highest, and it increased more significant as the stages worsen, and diabetes was the leading underlying disease among anemia in CKD patients followed by CVD and glomerulonephritis. The hemoglobin level mean and glomerular filtration rate was lower than the normal one.

Faktor determinan kematian ibu di RSUP Sanglah Denpasar tahun 2016 Rela Hamdanillah; Anom Suardika; Made Darmayasa; Ida Bagus Gde Fajar Manuaba
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Maternal mortality is the death of women during pregnancy or within 42 days of delivery, whether associated with pregnancy or complications exacerbated by pregnancy and not related to incidental causes. Maternal mortality is a critical indicator in assessing the level of wellbeing and public health status. The risk of maternal death is divided into three such as remote determinants, intermediate determinants, and acute clinical determinants.Aim: This study aims to determine the determinant factors as a role player in maternal mortality at Sanglah Hospital Denpasar in 2016.Method: This research is cross-sectional descriptive research conducted at RSUP Sanglah Denpasar. The sample of the study was all mothers died at Sanglah Hospital during the year 2016. The data obtained in the form of patient medical record data. Data were analyzed by descriptive methods.Result and Conclusion: The maternal mortality caused by the remoted determinant factors which were the highest in the maternal group with 9-12 years of education (77.3%) and the working mother group (54.5%). On the intermediate determinant, the highest is at age 20-35 years (81.8%), with parity 2-3 (63.6%), 2-10 year of gestational distance (54.5%), the most top obstetric factors are preeclampsia/eclampsia (27.2%), but the nonobstetric cause is the leading cause of maternal mortality. Kematian ibu adalah kematian wanita selama masa kehamilan atau dalam kurun waktu 42 hari setelah melahirkan, baik yang berhubungan dengan kehamilan maupun komplikasi yang diperburuk oleh masa kehamilan, serta tidak berhubungan dengan penyebab incidental. Angka kematian ibu merupakan indikator penting dalam menilai tingkat kesejahteraan dan status kesehatan masyarakat. Faktor yang berkontribusi terhadap kematian ibu secara garis besar dapat kelompokkan menjadi penyebab obstetrik dan penyebab non obstetrik. Menurut McCarthy dan Maine, risiko kematian ibu dibagi menjadi 3 yaitu, determinan jauh, determinan antara dan determinan dekat.Tujuan: Untuk mengetahui faktor-faktor determinan yang berperan dalam kematian ibu di RSUP Sanglah Denpasar tahun 2016.Metode: Penelitian ini merupakan penelitian deskriptif cross-sectional yang dilakukan di RSUP Sanglah Denpasar. Sampel penelitian adalah semua ibu meninggal di RSUP Sanglah selama tahun 2016. Data yang diperoleh berupa data rekam medis pasien, kemudian dianalisis secara deskriptif.Hasil dan Kesimpulan: Kematian ibu yang disebabkan karena faktor determinan yang tertinggi yaitu pada kelompok ibu dengan pendidikan 9-12 tahun (36,4%) dan kelompok ibu yang bekerja (54,5%). Pada faktor determinan antara yang tertinggi yaitu pada usia 20-35 tahun (81,8%), dengan paritas 2-3 (63,6%), jarak kehamilan 2-10 tahun (54,5%), faktor penyebab obstetrik yang tertinggi adalah preeklampsia/eklampsia (27,2%), namun secara garis besar penyebab non obstetrik merupakan penyebab utama kematian ibu.

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