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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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Analisis faktor risiko infeksi malaria sesudah bencana gempa bumi di Kabupaten Lombok Barat, Indonesia Michelle Amazing Grace Rampengan; Ni Made Utami Dwipayanti; Putu Cintya Denny Yuliyatni
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.084 KB) | DOI: 10.15562/ism.v11i1.660

Abstract

Background: Malaria is an infectious disease that often arises in post-disaster situations such as earthquakes. The earthquake that occurred in Lombok caused damage to people's homes and forced them to live in emergency tents. This condition increases the risk of malaria transmission so that malaria outbreak occurs. This study aims to determine the risk factors for malaria infection after the earthquake disaster in West Lombok Regency.Methods: A case-control study was conducted among 168 respondents located in four Public Health Services working areas in West Lombok. Cases were positive malaria sufferers based on microscopic examination results and were recorded in the health centre register in the September-November 2018 period. In addition, the controls were people who did not suffer from malaria based on microscopic examination results and lived in the study area. Case samples were selected by systematic random sampling from the register of health centres and control samples were selected by convenient sampling from communities living in one hamlet with cases. The bivariate analysis uses Chi-Square and Fisher-Exact test, while multivariate analysis uses logistic regression in SPSS version 20 for Windows.Results: The results showed that the proportion of male and female did not differ between groups of cases and controls (50.0%; p = 1.00). Most of the case groups were > 34 years old (51.8%) while controls were ≤ 34 years old (55.4%). There were no differences in proportions at the level of education, occupation, type of residence, length of refuge, and location of refuge in the two groups (p> 0.05). The results of multivariate analysis showed that the risk factors for malaria infection after the earthquake disaster in the district of West Lombok were primarily due to the presence of gardens in refugee camps (AOR = 11,899; 95% CI: 2,369-59,774).Conclusion: The existence of gardens in refugee camps is the most influential risk factor for malaria infection after the earthquake disaster in West Lombok Regency. Latar Belakang: Malaria adalah penyakit menular yang sering muncul pada situasi sesudah bencana seperti gempa bumi. Gempa bumi yang terjadi di Lombok ini mengakibatkan kerusakan pada rumah-rumah warga dan mengharuskan mereka tinggal di tenda-tenda darurat. Kondisi ini meningkatkan risiko penularan malaria sehingga terjadi Kejadian Luar Biasa (KLB) malaria. Penelitian ini bertujuan untuk mengetahui faktor risiko infeksi malaria sesudah bencana gempa bumi di Kabupaten Lombok Barat.Metode: Penelitian kasus-kontrol (case-control) dan berlokasi di empat wilayah kerja puskesmas di Kabupaten Lombok Barat sebanyak 168 responden dilakukan pada penelitian ini. Kasus adalah penderita malaria positif berdasarkan hasil pemeriksaan mikroskopis dan tercatat dalam buku register puskesmas pada periode September-November 2018. Sedangkan kontrol adalah orang yang tidak menderita malaria berdasarkan hasil pemeriksaan mikroskopis dan tinggal di wilayah tempat penelitian. Sampel kasus dipilih secara systematic random sampling dari buku register puskesmas dan sampel kontrol dipilih secara convenient sampling dari masyarakat yang tinggal satu dusun dengan kasus. Analisis bivariat menggunakan chi square dan fisher sedangkan analisis multivariat menggunakan regresi logistik pada SPSS versi 20 untuk Windows.Hasil: Hasil penelitian menunjukkan bahwa proporsi jenis kelamin laki-laki dan perempuan tidak berbeda antar kelompok kasus dan kontrol (50,0%; p=1,00). Sebagian besar kelompok kasus berusia > 34 tahun (51,8%) sedangkan kontrol berusia ≤ 34 tahun (55,4%). Tidak terdapat perbedaan proporsi pada tingkat pendidikan, pekerjaan, jenis tempat tinggal, lama mengungsi, dan lokasi mengungsi pada kedua kelompok (p>0,05). Hasil analisis multivariat menunjukkan bahwa faktor risiko infeksi malaria sesudah bencana gempa bumi di kabupaten Lombok Barat adalah sebagian besar oleh keberadaan kebun di lokasi pengungsian (AOR=11,899; 95%IK: 2,369-59,774).Simpulan: Keberadaan kebun di lokasi pengungsian merupakan faktor risiko yang paling berpengaruh terhadap infeksi malaria sesudah bencana gempa bumi di Kabupaten Lombok barat.
Profil hasil pemeriksaan CT-Scan pada pasien tumor paru di Bagian Radiologi RSUD Dr. Zainoel Abidin periode Juli 2018-Oktober 2018 Indrita Iqbalawaty; Nurul Machillah; Farjriah Farjriah; Asnawi Abdullah; Muhammad Yani; Teuku Muhammad Ilzana; Cut Rizka Rahmi; Teuku Muhammad Khaled
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.366 KB) | DOI: 10.15562/ism.v10i3.661

Abstract

Latar Belakang: Tumor paru masih menjadi penyebab utama keganasan di dunia. Tumor paru merupakan pertumbuhan abnormal benjolan pada jaringan paru yang dapat bersifat jinak ataupun ganas. CT scan merupakan salah satu modalitas yang digunakan untuk mengevaluasi dan mendiagnosis kecurigaan tumor paru. Penelitian ini bertujuan untuk mendapatkan gambaran profil hasil pemeriksaan CT scan pasien tumor paru.Metode: Jenis penelitian yang digunakan adalah studi deskriptif retrospektif. Pengambilan sampel dilakukan di Bagian Radiologi RSUD Dr. Zainoel Abidin periode Juli 2018 – Oktober 2018. Data diperoleh dari hasil ekspertisi CT scan toraks dan kuisioner karakteristik responden. Didapatkan 66 kasus tumor paru yang memenuhi kriteria inklusi.Hasil: Berdasarkan diagnosis radiologis, ditemukan 66 kasus tumor paru, dimana sebagian besar pasien berjenis kelamin laki-laki (63,6%); dengan kelompok usia terbanyak pada usia 60-69 tahun (37,9%); merokok aktif meningkatkan faktor risiko pada tumor paru; pasien memiliki gejala klinis awal terbanyak nyeri dada dan sudah dalam stadium lanjut; lokasi tumor terbanyak adalah paru kanan; dan tulang merupakan lokasi metastasis terbanyak ditemukan pada kasus tumor paru penelitian ini.Simpulan: Penelitian ini diharapkan dapat memberikan umpan balik positif bagi manajemen tumor paru dan dapat digunakan sebagai dasar acuan untuk penelitian selanjutnya. Background: Lung tumor is still being the most common tumors in the world. Lung tumor is defined as the abnormal growth of lumps in lung tissue that might be benign or malignant. CT scan is one of the most appropriate modality to diagnose the supposition of lung tumors and evaluating the tumor itself. The purpose of this study is to identify the CT scan images of patients with a lung tumor.Method: The study was conducted by a retrospective descriptive design. In this study, sampling was performed at Radiology Department, Zinoel Abidin General Hospital, from July 2018 to October 2018. Data were obtained from the thorax CT scan examination request forms and questionnaire of respondent characteristics. There were 66 cases of lung tumors that met the inclusion criteria.Results: There were 66 cases (53.2%) of lung tumors based on the radiological diagnosis. Most of the cases were males (63.6%); the largest age group consisted of patients aged 60-69 (37.9%); active smoking was the most important risk factor of lung tumor; patients mostly came with chest pain as an early symptom and at the final stage of lung tumor; the most common site of lung tumor was right lung; bone was the most common site of metastatic site.Conclusion: This study can provide positive feedbacks in the whole management of lung tumor, and can be used as a basis for further research.
Gambaran kepatuhan terapi antiretroviral pada lelaki-seks-lelaki di Klinik Bali Medika Phebe Indriani; Putu Cintya Denny Yuliyatni; Luh Seri Ani; I Wayan Weta
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.011 KB) | DOI: 10.15562/ism.v11i2.664

Abstract

Background: HIV prevalence in Indonesia and Bali is quite large. The main factor in achieving success in the treatment of HIV / AIDS virus infections is compliance.Aim: This study aims to determine the adherence of ARV therapy to MSM based on the characteristics and clinical stage in one of the CST clinics, the Bali Medika clinic. This descriptive study with cross sectional design used simple random sampling from the register of HIV patients at the Bali Medika Clinic so as to get 90 MSM (male-sex-male) patients. Data sources were taken from medical records regarding the characteristics, clinical stage, and treatment compliance of the study subjects. The data obtained were analyzed and displayed in the form of frequency tables and cross tables.Results: The majority of MSM sufferers with HIV are less than 31 years old; single (95.6%); low education (52.2%); have a job (94.4%); are in clinical stage I (77.8%); do not have coinfection (86.7%); use FDC drugs (92.2%); and suffered side effects from dizziness (90.0%). Most (66.7%) adhere to the Bali Medika Clinic.Conclusion: MSM at the Bali Medika Clinic tend to have high compliance in carrying out ARV therapy. Latar Belakang: Prevalensi HIV di Indonesia dan Bali cukup besar. Faktor utama dalam mencapai keberhasilan pengobatan infeksi virus HIV/AIDS adalah kepatuhan.Tujuan: Penelitian ini bertujuan untuk mengetahui kepatuhan terapi ARV pada LSL (lelaki-seks-lekali) berdasarkan karakteristik dan stadium klinis di salah satu klinik CST, yaitu klinik Bali Medika.Metode: Desain penelitian dengan rancangan potong lintang ini menggunakan simple random sampling dari daftar register pasien HIV di Klinik Bali Medika sehingga mendapatkan 90 pasien LSL. Sumber data diambil dari rekam medis mengenai karakteristik, stadium klinis, dan kepatuhan terapi dari subjek penelitian. Data yang diperoleh dianalisis dan ditampilkan dalam bentuk tabel frekuensi dan tabel silang.Hasil: Sebagian besar LSL penderita HIV berusia kurang dari sama dengan 31  tahun; belum menikah (95,6%); berpendidikan rendah  (52,2%); memiliki pekerjaan (94,4%); berada dalam stadium klinis I (77,8%); tidak memiliki koinfeksi (86,7%); menggunakan jenis obat FDC (92,2%); dan menderita efek samping pusing (90,0%). Sebagian besar (66,7%) patuh berkunjung ke Klinik Bali Medika.Simpulan: LSL di Klinik Bali Medika cenderung memiliki kepatuhan yang tinggi dalam menjalankan terapi ARV.
Efek pemberian ekstrak etanol bawang putih (Allium sativum) sebagai hepatoprotektor pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi parasetamol dosis hepatotoksik Made Subhawa Harsa
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.702 KB) | DOI: 10.15562/ism.v11i1.666

Abstract

Garlic (Allium sativum) is a plant that known to have various properties that can be used in treatment as a hepatoprotective agent. This study aim was to determine the effect of garlic ethanol extract (Allium sativum) in Wistar strain white male rats (Rattus norvegicus) which was induced by paracetamol in hepatotoxic dose. This research is an experimental study with randomized the post-test only control group design with sample consisted of twenty-four Wistar strain white male rats (Rattus norvegicus). The sample were divided into four groups: control groups, group P1 (given garlic ethanol extract 10 mg/kg), group P2 (ethanol extract of garlic was given 20 mg/kg) and group P3 (given the ethanol extract garlic 30 mg/kg). This study for seventeen days. The entire samples were terminated in order to draw blood to examine SGPT and SGOT. The data of SGPT and SGOT examined by One Way ANOVA. Result showed that there was significant difference in SGPT and SGOT values between groups after given ethanol extract of garlic (Allium sativum) (α <0.05). From the analysis we can concluded that garlic ethanol extract (Allium sativum) can be used as a hepatoprotective agent in Wistar strain white male rats (Rattus norvegicus)  induced by paracetamol in hepatotoxic dose.
Prevalensi sarkopenia dan frailty di desa Pedawe, Mangupura, Serai dan Songan I Gusti Agung Wilaja Putra; I Gusti Putu Suka Aryana; I Nyoman Astika; RA Tuty Kuswardhani; Ida Bagus Putrawan; Ketut Rai Purnami
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1160.459 KB) | DOI: 10.15562/ism.v11i2.667

Abstract

Background: Frailty is characterized by a decrease in multi-organ physiological functions. Sarcopenia and frailty have a significant impact on individuals and society so it is necessary to know the prevalence in the community. This study aimed to determine the prevalence of sarcopenia and frailty in rural areasMethod: The was a cross-sectional study in the elderly population in the villages of Pedawa, Mangupura, Serai and Songan. Measurement of muscle mass using bioelectrical impedance analysis (BIA) and categorized based on the recommendation of the Asian Working Group for Sarcopenia (AWGS). Frailty is established through a screening questionnaire based on the Cardiovascular Health Study. The study was chosen by simple random sampling and population register data.Results: The study involved 235 elderly people with 117 people in Pedawe village, 71 people in Mangupura village, 34 people in Serai village and 13 people in Songan village with a composition of 35.5% men and 64.5% women. In this study sarcopenia in women was 51% and men 49%, while frailty was experienced in 58.9% women and 41.02% men. The mean age is 67.7 years. The prevalence of total sarcopenia is 59% with the lowest percentage ranging from the villages of Mangupura (30%), Songan (53.8%), Pedawe (70.9%), and Serai (79.4%). The overall frailty prevalence in the four villages is 17% with the percentage starting from the lowest being Mangupura (1.4%), Serai (5.9%), Songan (22.2%) and Pedawe (29.1%).Conclusions: The prevalence of sarcopenia and frailty is most common among elderly women. The highest prevalence of sarcopenia was found in Serai village and frailty prevalence was highest in Pedawe village. Latar Belakang: Frailty ditandai dengan adanya penurunan fungsi fisiologis multi organ. Sarkopenia dan frailty memberikan dampak yang bermakna bagi individu dan bagi masyarakat sehingga perlu untuk mengetahui prevalensinya di masyarakat. Penelitian ini bertujuan untuk mengetahui prevalensi sarkopenia dan frailty di daerah pedesaanMetode: Penelitian menggunakan studi potong lintang pada populasi lansia di desa Pedawa, Mangupura, Serai dan Songan. Pengukuran massa otot menggunakan bioelectrical impedance analysis (BIA) dan dikategorikan berdasarkan rekomendasi Asian Working Group for Sarcopenia (AWGS). Frailty ditegakkan melalui kuesioner skrining berdasarkan Cardiovascular Health Study. Penelitian dipilih dengan cara simple random sampling dan data register penduduk.Hasil: Penelitian melibatkan 235 orang lanjut usia dengan jumlah 117 orang di desa Pedawe, 71 orang di desa Mangupura, 34 orang di desa Serai dan 13 orang di desa Songan dengan komposisi 35,5% laki-laki dan 64,5% perempuan. Pada penelitian ini sarkopenia pada perempuan adalah 51% dan laki-laki 49%, sedangkan frailty dialami 58,9% perempuan dan 41,02% laki-laki. Rerata usia adalah 67,7 tahun. Prevalensi sarkopenia total adalah 59% dengan persentase masing-masing mulai dari yang terendah adalah desa Mangupura (30%), Songan (53,8%), Pedawe (70,9%), dan Serai (79,4%).  Prevalensi frailty keseluruhan di empat desa adalah 17% dengan persentase masing-masing  mulai dari yang terendah adalah desa Mangupura (1,4%), Serai (5,9%), Songan (22,2%) dan Pedawe (29,1%).Kesimpulan: Prevalensi sarkopenia dan frailty paling banyak ditemukan pada lansia perempuan. Prevalensi sarkopenia paling tinggi didapatkan di desa Serai dan prevalensi frailty didapatkan paling tinggi di desa Pedawe.
The determinant factors for Quality of Life (QOL) among children with Acute Lymphoblastic Leukemia (ALL) after induction phase at Sanglah General Hospital, Bali, Indonesia Made Suadnyani Pasek; Ketut Ariawati; Bagus Ngurah Putu Arhana; I Gusti Lanang Sidiartha; I Gusti Ngurah Sanjaya Putra; I Gusti Ngurah Made Suwarba
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.044 KB) | DOI: 10.15562/ism.v11i2.668

Abstract

Background: The Quality of Life (QOL) of patients with acute lymphoblastic leukemia (ALL) is important to be examined. Some determinant factors of the QOL for ALL patients are age, gender, ethnicity, nutritional status, level of income of parents, educational level of parents, and risk groups. This study aims to determine the quality of life score among children with ALL after the induction phase of chemotherapy and to determine determinant factors that are associated with the quality of life of children with ALL.Methods: An observational analytic study using a cross-sectional approach has been conducted among 38 ALL patients to assess the QOL after the induction phase chemotherapy at Sanglah General Hospital. The independent sample T test evaluated comparative values between independent factors. Multivariate analysis was assessed by the General Linear Model ANCOVA. Data were analyzed using SPSS version 20 for Windows.Results: Most of the respondents were age > 5 years old (55.3%), followed by the male (55.3%), well-nourished of nutritional status (55.3%), low parents’ educational status (55.3%), a high income of parents (52.6%), standard risk of stratification (52.6%), and non-Balinese ethnicity (55.3%). The mean score of QOL was 79.37±21.64. The results showed that male gender (95% CI: 2.35-16.04; p=0.010), high income of parents (95% CI: 3.17-22.05; p=0.010), standard risk factors (95% CI: 1.48-16.36; p = 0.020) were significantly related to the QOL of children with ALL.Conclusion: High-income parents, standard risk stratification, and male gender are determinant factors for higher QOL scores of children with ALL after the chemotherapy induction phase.
Retinoblastoma unilateral: sebuah laporan kasus pada pelayanan kesehatan sekunder dengan fasilitas terbatas Junetta Airene Priskila Taba; Cliff Ernst
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.097 KB) | DOI: 10.15562/ism.v11i2.669

Abstract

Background: Retinoblastoma is a primary malignant intraocular neoplasm derived from retinoblast beyond retinal development.Purpose: To report a case of Unilateral Retinoblastoma in secondary health care with limited facilities.Case report: We present a case of a 34-months old girl with unilateral retinoblastoma that transfer to the hospital with proptosis of the right eye, severe pain and drastic weight loss. Orbital exenteration was the treatment of choice due to poor prognosis of visual function and due to lack of facilities for further ancillary studies. After family members consented to right eye exenteration, then the ophthalmologist did the surgery. Later on, about one month post exenteration, histopatological report confirmed the diagnosis of retinoblastoma. Based on the need for chemotherapy, patient was referred to a more complete health care facilities.Conclusion: Retinoblastoma should be considered as an intraocular tumors especially in children until proven otherwise. Specifically in areas with limited facilities, it is very important to be able to detect early signs of retinoblastoma and avoid the development of disease to worse stage (extraocular retinoblastoma). Latar Belakang: Retinoblastoma merupakan neoplasma intraokular maligna primer yang berasal dari sel retina imatur (retinoblas) dalam perkembangan retina.Tujuan: Untuk melaporkan kasus Retinoblastoma Unilateral dalam perawatan kesehatan sekunder dengan fasilitas terbatas.Laporan kasus: Kami menghadirkan kasus seorang gadis berusia 34 bulan dengan retinoblastoma unilateral yang diperiksakan ke rumah sakit dengan proptosis mata kanan, nyeri parah, dan penurunan berat badan yang drastis. Orbital exenteration adalah pengobatan pilihan karena prognosis buruk dari fungsi visual dan karena kurangnya fasilitas untuk studi tambahan lebih lanjut. Setelah anggota keluarga menyetujui pembedahan mata kanan, maka dokter mata melakukan operasi. Kemudian, sekitar satu bulan pasca eksenterasi, laporan histopatologis mengkonfirmasi diagnosis retinoblastoma. Berdasarkan kebutuhan untuk kemoterapi, pasien dirujuk ke fasilitas perawatan kesehatan yang lebih lengkap.Kesimpulan: Retinoblastoma harus dianggap sebagai tumor intraokular terutama pada anak-anak sampai terbukti sebaliknya. Khususnya di daerah dengan fasilitas terbatas, sangat penting untuk dapat mendeteksi tanda-tanda awal retinoblastoma dan menghindari perkembangan penyakit ke tahap yang lebih buruk (retinoblastoma ekstraokular).
Uji antihiperglikemia ekstrak etanol daun sembung (Blumea balsamifera L.) terhadap tikus wistar jantan (Rattus norvegicus) Sri Wahjuni; Nur Hafsia; Ni Wayan Bogoriani
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (786.521 KB) | DOI: 10.15562/ism.v11i2.670

Abstract

Background: Sembung leaves (Blumea balsamifera L.) leaves are proven to contain flavonoid compositions that contain antihyperglycemic properties. This study aimed to evaluate effect of sembung leaves ethanol extract towards serum blood glucose of hyperglicemia wistar rats.Method: This study includes the maintenance of test animals, fractionation and purification using TLC, column chromatography, and LCMS, free radical scavenging activity of 1.1-diphenyl-2-picrillhidrazil (DPPH) as well as experimental methods with pre-post test control group design. Twenty male Wistar rats (Rattus norvegicus) were divided into five groups, the negative control group (aquades), the positive control (glibenclamide 0.18 mg/day/200gbw) and the test group with varying doses of 50 mg/kgbw, 100 mg/kgbw, and 150 mg/kgbw for 14 days and carried out measurement of blood sugar levels in rats. Rats collected data were analyzed using the One Way ANOVA test and continued with the LSD test.Results: Result of LCMS management is flavonoid composition consisting of syringetin with mz=347. In the free radical scavenging activity of DPPH ethylacetate fraction of Sembembal leaf extract IC50 value is 0.5369 μg/ml or 536.9 ppm. Data on rat blood regression levels were analyzed using the One Way ANOVA test and continued with the LSD test each showing a value of p=0.000. This value indicates a significant difference between each group (p<0.05).Conclusion: Ethanol fraction of sembung leaves can reduce protein levels in male wistar hyperglycemia rats. The secondary metabolism of syringetin contained in sembung leaves which contains antioxidants. Latar belakang: Blumea balsamifera (daun sembung) terbukti memiliki senyawa flavonoid dengan khasiat antihiperglikemik. Penelitian ini guna mengkaji efek pemberian ekstrak etanol daun sembung terhadap penurunan kadar glukosa darah pada tikus wistar jantan yang hiperglikemia.Metode: Penelitian ini meliputi pemeliharaan hewan uji, fraksinasi, dan pemurnian menggunakan metode KLT, kromatografi kolom, dan LCMS, uji aktivitas pengikatan radikal bebas 1,1-diphenyl-2-picrylhydrazyl (DPPH) serta metode eksperimental dengan pre-post test control group design. Dua puluh ekor tikus wistar jantan (Rattus norvegicus) dibagi menjadi lima kelompok, kelompok kontrol negatif (aquades), kontrol positif (glibenclamide 0,18 mg/hari/200gBB)  dan kelompok uji dengan variasi dosis fraksi etilasetat ekstrak etanol daun sembung 50 mg/kgbb, 100 mg/kgbb dan 150 mg/kgbb selama 14 hari dan dilakukan pengukuran kadar gula darah pada tikus. Data kadar glukosa tikus dianalisis dengan menggunakan uji One Way ANOVA dan dilanjutkan dengan uji LSD. Pada penelitian ini didapatkan hasil dari fragementasi LCMS adalah senyawa flavonoid yang berupa syringetin dengan mz=347.Hasil: Pada evaluasi aktivitas pengikatan radikal bebas DPPH fraksi etilasetat ekstrak etanol daun sembung memiliki nilai IC50 adalah 0,5369 µg/ml atau 536,9 ppm. Data kadar glukosa darah tikus yang dianalisis dengan menggunakan uji One Way ANOVA dan dilanjutkan dengan uji LSD masing-masing menunjukkan nilai p=0,000. Nilai ini memperlihatkan perbedaan signifikan antar tiap kelompok intervensi (p<0,05).Simpulan:  Fraksi ekstak etanol daun sembung dapat menurunkan kadar glukosa darah pada tikus wistar jantan yang hiperglikemia. Penurunan glukosa darah ini diduga berasal dari metabolit sekunder syringetin yang terkandung dalam daun sembung yang berperan sebagai antioksidan.
Pemberian ekstrak kulit buah anggur (Vitis vinifera L.) mampu menurunkan kadar malondialdehid (MDA) plasma pada tikus dengan diet tinggi kolesterol Etik Nurhidayati; Ni Made Linawati; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.354 KB) | DOI: 10.15562/ism.v11i2.671

Abstract

Introduction: High cholesterol levels will cause disease, one of which is cardiovascular disorders or diseases. Based on WHO data in 2012 there were 17.5 million deaths in the world due to cardiovascular disease. Coronary heart occupies the highest position at 42% where one of the most common risk factors is dyslipidemia. This research aimed to evaluate the effect of grape skin extract on plasma MDA level.Methods: This study is an experimental study with a post-test only control group research design. Thirty male Wistar rats aged 2-3 months with a body weight of around 200 grams and healthy, classified into 4 treatment groups and a control group with a high cholesterol diet and administration of different dosages of grape skin extract, dose of 100 mg/175 gbw (gram body weight), 250 mg/175 gbw, and 500 mg/175 gbw. All blood samples were taken on day 30 and an MDA test was performed. Kruskal Wallis test was performed to analyze the correlation.Results: The test results obtained with p<0.05 in the group of rats given grape skin extract at a dose of 100 mg/175 gbw, 250 mg/175 gbw, and 500 mg/175 gbw, thus showing significantly lower MDA levels compared with control group.Conclusion: Administration of grape skin extract to rats given a high cholesterol diet may reduce plasma MDA levels. Latar belakang: Kolesterol yang tinggi di dalam darah akan mengakibatkan berbagai masalah kesehatan, salah satunya adalah gangguan atau penyakit kardiovaskular. Data tahun 2012 terdapat 17,5 juta kematian di dunia karena masalah kardiovaskular. Jantung koroner menduduki posisi tertinggi yaitu 42% dimana salah satu faktor risiko terseringnya adalah dislipidemia. Mengetahui dampak pemberian kulit buah anggur terhadap MDA plasma tikus adalah sasaran penelitian ini.Metode: Sebuah penelitian eksperimental menggunakan metode post-test only diterapkan pada penelitian ini. Tiga puluh tikus wistar jantan, umur 2-3 bulan, berat rerata 200 gram, dan sehat, dikelompokkan ke dalam 1 kelompok kontrol serta 4 kelompok perlakuan dengan diet tinggi kolesterol dan pemberian dosis ekstrak kulit anggur yang berbeda-beda, yaitu dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb. Pada akhir penelitian, yaitu hari ke- 30, semua sampel diambil darahnya kemudian dilakukan uji MDA.Hasil: Uji penelitian dengan Kruskal Wallis memperoleh hasil p=0,035 (p<0,05) pada kelompok tikus yang diberikan ekstrak kulit anggur dengan dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb, sehingga menunjukkan kadar MDA lebih rendah signifikan dibanding dengan kontrol.Simpulan: Pemberian ekstrak kulit buah anggur memiliki dampak penurunan MDA plasma pada tikus dengan diet tinggi kolesterol.
Hubungan tingkat pengetahuan ibu tentang pencegahan diare dengan kejadian diare pada balita di Desa Pemecutan Kelod, Denpasar, Bali I Made Adi Narendranatha Komara; I Putu Oka Kresna Jayadi; Ni Luh Putu Ari Jayanti; Putu Triyasa; Arya Krisna Manggala; Putu Sutisna
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.17 KB) | DOI: 10.15562/ism.v11i3.672

Abstract

Background: In Indonesia, 100,000 infants died caused by diarrhea annually. In 2014, diarrhea sufferers were found mostly in Community Health Center II West Denpasar. In 2015, primarily located in Desa Pemecutan Kelod, which is in the working area of Community Health Center II West Denpasar. The occurrence of diarrhea in children cannot be separated from the role of their mothers. This study aims to determine the relationship of mothers’ knowledge level on prevention of diarrhea with the occurrence of diarrhea in under-five children in Desa Pemecutan Kelod.Methods: A cross sectional analytic design was conducted among 90 samples. The variables studied were mothers’ knowledge as an independent variable and diarrhea in under-five children as a dependent variable. The instrument used in this study was a questionnaire that has been examined for validity. Data were analyzed using SPSS version 17 for Windows.Results: The results showed that most respondents had good knowledge of 63.3%, around 38.6% of the under-five children suffered diarrhea. Mothers with sufficient knowledge (21.1%), approximately 42.1% of the under-five children suffered diarrhea, and mothers with inadequate knowledge (15.6%), around 78.6% of the under-five children suffered diarrhea. There was a significant relationship between mothers’ knowledge level in preventing diarrhea and diarrhea in under-five children (p=0.025).Conclusion: Based on the study results, particularly regarding the fact there was still a low level of mothers’ knowledge, it is recommended the health center staff give proper health education on the prevention of diarrhea. Latar Belakang: Setiap tahun di Indonesia 100.000 balita meninggal karena diare. Pada tahun 2014 di temukan penderita diare di Provinsi Bali terbanyak di Wilayah Kerja Puskesmas II Denpasar Barat, sedangkan pada tahun 2015 terbanyak di Desa Pemecutan Kelod yang merupakan wilayah kerja Puskesmas II Denpasar Barat. Tingginya angka kejadian diare pada anak tidak lepas dari pengetahuan ibu. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan ibu tentang pencegahan diare dengan kejadian diare pada balita di Desa Pemecutan Kelod. Metode: Penelitian ini menggunakan desain penelitian analytic cross sectional dengan 90 sampel yang dipilih secara random sampling. Variabel yang diteliti adalah pengetahuan ibu sebagai variabel bebas dan kejadian diare pada balita sebagai variabel tergantung. Instrumen yang digunakan pada penelitian ini adalah kuesioner yang telah diuji validitas. Data dianalisis dengan SPSS version 17 for Windows.Hasil: Hasil penelitian menunjukkan sebagian besar (63,3%) ibu memiliki pengetahuan baik, dan sebanyak 38,6% balitanya mengalami diare. Pada 21.1% ibu dengan pengetahuan cukup, sebanyak 42,1% balitanya mengalami diare, dan pada 15,6% ibu yang memiliki pengetahuan kurang sebanyak 78,6% balitanya mengalami diare. Terdapat hubungan yang bermakna antara tingkat pengetahuan ibu tentang pencegahan diare dengan kejadian diare pada balita (p=0,025).KesimpulanBerdasarkan hasil penelitian ini, terutama dengan kenyataan masih ada pengetahuan ibu yang kurang, disarankan agar petugas kesehatan memberikan penyuluhan tentang pencegahan diare.

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