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INDONESIA
YARSI Medical Journal
Published by Universitas Yarsi
ISSN : 08541159     EISSN : 24609382     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 232 Documents
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FUNGAL PERITONITIS PADA PASIEN DENGAN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS Adilistya, Tika; Timan, Ina Susianti
Jurnal Kedokteran YARSI Vol 24, No 2 (2016): MEI - AGUSTUS 2016
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v24i2.261

Abstract

Fungal peritonitis hanya terjadi pada 3-6% kasus dialysis-related peritonitis namun angka mortalitasnya sangat tinggi. Gambaran klinis tidak spesifik sehingga sulit dibedakan dengan peritonitis bacterial. Analisis dan biakan cairan dialisat berperan penting sebagai pedoman terapi antimikroba.Laki-laki berusia 22 tahun menjalani CAPD selama 10 tahun, datang ke RS dengan nyeri perut berat pada saat inflow dan outflow cairan. Pada pemeriksaan analisis cairan didapatkan makroskopis kuning keruh, hitung leukosit 2.580 sel/µL dengan PMN sebanyak 90%, dan kadar protein total 1.0mg/dL. Pada pemeriksaan biakan ditemukan Candida Tropicalis.Pemeriksaan analisis cairan dialisat peritoneal belum lazim dilakukan dan sampai saat ini belum terdapat nilai rujukan. Pada pasien ini dijumpai cairan keruh, jumlah leukosit lebih dari 100 sel/µL dengan dominasi PMN, serta biakan positif, sehingga memenuhi kriteria diagnosis fungal peritonitis menurut International Society of Peritoneal Dialysis tahun 2009. Pada pasien ini dijumpai kadar protein total 1,0g/dL. Dalam keadaan normal, caira dialisat tidak mengandung protein. Adanya peritonitis menyebabkan pembukaan pori besar pada membrane peritoneum sehingga terjadi kobocoran makromolekul.Analisis caira dialisat penting dilakukan pada kecurigaan infeksi. Diagnosis fungal peritonitis dapat ditegakkan melalui pemeriksaan analisis cairan serta dipastikan melalui pemeriksaan biakan.
AKTIVITAS ANTIOKSIDAN DAN EFEK SITOTOKSIK EKSTRAK KOLA (COLA NITIDA) PADA KULTER SEL KANKER HATI (HEPG-2) Endrini, Susi; Marsiati, Himmi; J, Suherman; O, Fauziah; R, Asmah
Jurnal Kedokteran YARSI Vol 17, No 1 (2009): JANUARI - APRIL 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.103 KB) | DOI: 10.33476/jky.v17i1.195

Abstract

Liver cancer is one among cancers with increasing incidence in the world. Cola fruit (Cola nitida) is a fruit that is rich in properties and has been known since the Dutch colonial era. This fruit contains ingredients such as those contained in tea and chocolate such as methylxanthine and its derivatives. This study aims to determine the content of antioxidants and cytotoxic effects of cola fruit extracts obtained from Indonesia and Malaysia on liver cancer cell lines. Antioxidant content of fruit extracts of cola was assessed using DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) and cytotoxic effects were studied using MTT (3 - (4,5-Dimethylthiazol-2-Yl)diphenyltetrazolium bromide -2.5) on human liver cancer cell lines (HepG2). The results showed that cola fruit from Malaysia contained high antioxidant with the IC50 value of 37.2 ?g/mL whereas IC50 of value of its Indonesia?s cola fruit was 66.0 ug / mL. The similar results have been shown in the cytotoxic test using HepG-2 liver cancer cell lines. Malaysia?s cola fruit extract has a smaller IC50 value of 6.5 ?g / mL while the fruit extract of Indonesia?s cola showed IC50 value of 39.5 ?g / mL. These values indicates that the fruit extract of cola is a potential anticancer activities especially on liver cancer. Further studies are required to clarify this hypothesis.
ANTIOKSIDATIF ESTROGEN DALAM MENGHAMBAT ADVANCED OXIDATION PROTEIN PRODUCT AKIBAT REAKSI GLIKOSILASI Adenan, Adenan; Suhartono, Eko; Setiawan, Bambang
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.708 KB) | DOI: 10.33476/jky.v15i1.1004

Abstract

Ethinyl estradiol is an estrogen derivative used as contraceptive or hormone replacement therapy to maintain woman?s sexual function. The aim of this study was to examine ethinyl estradiol antioxidative activity and its potency to inhibit protein oxidation by glycocylation reaction. This study was an in vitro assay and its antioxidative activity by H2O2 scavenging, ?OH scavenging, metal chelating were measured. Activity as inhibitor of Advanced Oxidation Protein Products (AOPP) was carried out by using glycocylation reaction. Three groups (n=6), i.e P0 control (3 ml of serum), P1 (3 ml of serum + glucose 500 mM), and P2 (3 ml of serum + glucose 500 mM + ethinyl estradiol 0,15gr/100mL) were used in this study. The result of this study showed that H2O2 scavenging, ?OH scavenging, metal chelating were 48,889%, 15,139%, 11,538% respectively. For AOPP inhibition, P0 and P1 was different significantly (p 0,05), P0 and P2 was not different significantly (p 0,05), and P1 and P2 was different significantly (p 0,05). It was suggested that antioxidative mechanism from ethinyl estradiol could inhibit AOPP formation generated by glycocylation reaction.
STUDI LEPTOSPIRA SP PADA BEBERAPA DAERAH RAWAN BANJIR DI JAKARTA Widiyanti, S.Si, M.Si, PhD, Dian; Irmawati Purbo Astuti, Ike
Jurnal Kedokteran YARSI Vol 24, No 2 (2016): MEI - AGUSTUS 2016
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v24i2.121

Abstract

Leptospirosis termasuk re-emerging disease dan sering menjadi wabah setelah bencana banjir. Penyakit ini disebabkan oleh bakteri Leptospira patogen yang ditansmisikan secara langsung lewat hewan terinfeksi atau tidak langsung melalui lingkungan yang terkontaminasi urin hewan tersebut. Studi mengenai Leptospira yang ada di lingkungan perairan daerah rawan banjir dilakukan untuk mengetahui penyebaran Leptospira, terutama strain patogen, sehingga dapat dilakukan antisipasi pencegahan. Sampel dikumpulkan dan diukur pHnya dari 20 penampungan air, seperti waduk, danau, sungai, selokan air, di daerah rawan banjir di Jakarta, dan dikultur pada medium Korthof modifikasi mengandung 5-fluorouracil. Pengamatan hasil kultur dilakukan dengan mikroskop lapang gelap selama satu bulan. Diferensiasi Leptospira dilakukan dengan deteksi gen flaB. Hasil menunjukkan bahwa 75% dari sampel yang diperoleh, positif Leptospira. Ph sampel air sebesar 6,6?7,9 masih sesuai untuk pertumbuhan Leptospira. Analisis dengan gen flaB menunjukkan bahwa Leptospira yang diisolasi termasuk jenis saprofit. 
PERLUKAH MENGHITUNG UKURAN SAMPEL? Murti, Bhisma
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.055 KB) | DOI: 10.33476/jky.v15i1.1009

Abstract

Sample size is an issue worth-considering but not the most essential thing to fulfil for a good research. A much more crucial cause of concern to any research is the validity of inference a research is drawing, i.e. the extent to which the research is able to control systematic error that stems from bias and confounding. Sample size refers to random error; it does not address nor correct systematic error. The larger sample size, the less random error, the more precise estimates a research can yield about difference/ association/ effect of a variable(s). Most of the assignment of values in any sample size formula is arbitrary. As such, the product of estimating sample size, regardless of the formula being used,  cannot be viewed as an absolute end; the actual sample size can be larger or smaller than the estimated one. Beyond statistical aspect, several other important factors should be considered when estimating sample size, such as ethics, cost, and the amount oftime available for conducting the research.
EFEK EKSTRAK ETANOL AKAR ANTING- ANTING (ACALYPHA INDICA) TERHADAP LIBIDO MENCIT Yasmin, Cut; Eriani, Kartini; Sari, Widya
Jurnal Kedokteran YARSI Vol 21, No 1 (2013): JANUARI - APRIL 2013
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.239 KB) | DOI: 10.33476/jky.v21i1.17

Abstract

Penelitian ini bertujuan mengevaluasi efek pemberian ekstrak etanol akar anting-anting (Acalypha indica) terhadap libido mencit. Penelitian ini meng-gunakan Rancangan Acak Lengkap, terdiri atas empat perlakuan dengan lima ulangan. Perlakuan terdiri atas pemberian ekstrak etanol akar anting-anting dengan dosis: 0, 150, 300, dan 600 mg/kg bb yang diberikan sekali sehari selama 7 hari. Parameter libido yang diamati adalah mounting latency, intromission latency, dan jumlah orgasme. Data hasil penelitian dianalisis dengan analisis varian dan dilanjutkan dengan uji Jarak Berganda Duncan. Hasil penelitian menunjukkan ekstrak etanol akar anting-anting berpengaruh nyata dalam penyingkatan bermulanya mounting dan intromission, serta meningkatkan jumlah orgasme. Pemberian ekstrak etanol akar anting-anting dengan dosis 300 dan 600 mg/kg bb merupakan dosis yang dapat meningkatkan libido.This research was aimed to evaluate the effect of anting-anting (Acalypha indica) root ethanol extract on sexual arousal of mice. The experimental method with completely randomized design was applied, that consisted of four treatments and five repetition. The treatments were 0, 150, 300, dan 600 mg/kg bw anting-anting root ethanol extract given once a day for 7 days. Observed parameter were mounting latency, intromission latency, and the number of orgasm. The data was analyzed by analysis of variance and continued by Duncan?s multiple range test. The result showed that anting-anting root ethanol extract was significantly difference to shorten the starting of mounting, intromission, and increasing the number of orgasm. The application of anting-anting ethanol extract with dose of 300 and 600 mg/kg bw was able to increase sexual arousal.
GAMBARAN TINGKAT RISIKO DAN FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN RISIKO DIABETES MELLITUS TIPE 2 DI BUARAN, SERPONG Fadhilah, Maritha
Jurnal Kedokteran YARSI Vol 24, No 3 (2016): SEPTEMBER - DESEMBER 2016
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v24i3.295

Abstract

Diabetes Mellitus (DM) adalah penyakit dengan morbiditas dan mortalitas yang tinggi. Pencegahan berkembangnya DM akan memberikan manfaat yang signifikan. Tujuan penelitian ini untuk mengetahui gambaran tingkat risiko dan faktor-faktor yang berhubungan dengan risiko Diabetes Mellitus Tipe 2 (DMT2) pada masyarakat binaan KPKM Buaran. Penelitian ini menggunakan desain cross sectional dan dilaksanakan dari Maret-Juni 2015 di Buaran, Serpong.  Sebanyak 126 responden dengan usia lebih dari 30 tahun terpilih menggunakan two stage cluster sampling, kemudian diwawancara dan diperiksa dengan menggunakan kuesioner yang diadaptasi dari Finnish Diabetes Risk Score (FINDRISC). Hasil penelitian didapatkan sebanyak 33,3% berisiko tinggi, 58,7% berisiko sedang, dan 7,9% berisiko rendah untuk menderita DMT2 dalam 10 tahun. Berdasarkan analisis bivariat menggunakan uji chi square didapatkan hubungan yang bermakna antara tingkat risiko DMT2 dengan jenis kelamin (p = 0,03), usia (p = 0,03), indeks massa tubuh (p 0,001), lingkar perut (p 0,001), riwayat tekanan darah tinggi (p 0,001), riwayat gula darah tinggi (p 0,001), dan riwayat keluarga DM (p 0,001). 
SIKAP DAN AKTIVITAS BIDAN DI DESA MEMBINA DUKUN BAYI DALAM MENOLONG PERSALINAN DAN MERAWAT BAYI Mulyono N, Mulyono N; Sudibyo S, Sudibyo S; Qomariah, Qomariah; Riyasa, I Ketut; Riyanto M, Riyanto M
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.703 KB) | DOI: 10.33476/jky.v13i1.1049

Abstract

One of the main task and function midwife is to guide the health cadre and Traditional Birth Attendance (TBA). A Study  of House Hold Health Survey (SKRT) in 1995 found  that 48,4% childbirth is helped by TBA, 38,6% by midwife, 4,2% by doctor, 3,8% by nurse, and the rest by others or without help. Most of cases of tetanus neonatorum in Indramayu till 1998 occurred at the childbirth process helped by TBA. It was not known how midwives trained and supervised the TBA in helping childbirth and caring the babies. The desaign of the research was a cross-sectional one with the purpose to know the activities of midwives. Research locations were at several Puskesmas in Indramayu District. Result of the study were among others: midwives were not so busy in conduc-ting the main task, because most of them (70%) helped only one child birh of a mother per month and the number of BTA to be trained were only about 3 people. So they should have much time to coduct training more intensively to TBA. The training method used were most ?ceramah?and practical skill (59,6%). The language used was active native language. Whereas the majority of the training subjects (77%) were about caring navel string, understanding the complication of chilbirth (52%), and helping childbirth rightly (44%). The majority of equipment used for training were scissor (68%), and brush (58,4%).
HUBUNGAN REAKTIFITAS UJI TUSUK DENGAN KADAR IMUNOGLOBULIN (IG) E DALAM SERUM PENDERITA DERMATITIS ATOPIK Kariosentono, Harijono
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.498 KB) | DOI: 10.33476/jky.v13i1.1054

Abstract

Skin prick test is an in vivo examination performed on the allergy suspected patients to one or more common allergens including atopic dermatitis. Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease commonly associated with an increase of IgE and a family history of atopic disease. The aim of the study was to learn the correlation between the rates of skin prick test response and the level of IgE in the serum of atopic dermatitis patients. The post test only design was control group design was, 18 AD patients and 12 individuals as the control group. The result indicated that a significant difference was observed between the reactivity of the skin prick test and the level of either IgE total or IgE specific. In conclusion a positive correlation was shown between the skin prick test and the level of IgE on AD patients employed involving.
DETEKSI MUTASI LANGKA, DELESI 619 BP, PADA GEN BETA-GLOBIN DARI ETNIS MELAYU MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS YARSI Kenconoviyati, Kenconoviyati; Prayuni, Kinasih; Susilowati, RW; Yuliwulandari, Rika; Salam M. Sofro, Abdul
Jurnal Kedokteran YARSI Vol 23, No 2 (2015): MEI - AGUSTUS 2015
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.228 KB) | DOI: 10.33476/jky.v23i2.98

Abstract

Beta-thalassemia merupakan gangguan hematologis autosomal yang secara genetis mengakibatkan berkurangnya sintesis beta-globin di hemoglobin. Beta-talasemia sebagian besar disebabkan oleh mutasi titik, insersi atau delesi dalam gen beta-globin yang terletak pada lengan pendek kromosom 11. Organisasi Kesehatan Dunia (WHO) memperkirakan terdapat sekitar 1,5% dari populasi global (80-90 juta orang) adalah pembawa ?-thalassemia. Tidak ada studi komprehensif untuk mendeteksi pembawa beta-thalassemia di Indonesia, terutama untuk mutasi delesi 619 bp, yang mencakup ekson 3 dan memiliki prevalensi yang tinggi. Kami menggunakan metode gap-PCR yang di-kombinasikan dengan metode elektroforesis gel untuk memper-kirakan adanya mutasi delesi 619 bp pada 48 siswa Fakultas Kedokteran Universitas YARSI dengan etnis Melayu. Analisis Blast hasil sekuensing dari ketiga sampel menunjukkan bahwa terdapat similaritas 98% antara hasil amplifikasi dengan ke daerah gen beta-globin pada kromosom 11 (No. Aksesi U01317.1). Berdasarkan hasil visualisasi elektroforesis gel, semua produk PCR dari 48 sampel, menunjukkan bahwa semua sampel tidak membawa mutasi delesi 619 bp yang ditunjukkan dengan ukuran produk PCR yang sama dari semua sampel, yaitu berukuran 1.457 bp dan 2.291 bp dari PCR I dan 1.212 bp dari PCR II.Beta-thalassaemia is an autosomal haematological disorder resulting in a genetically deficient synthesis of the ?-globin chain in haemoglobin. It is mostly caused by point mutations, a small deletions or insertions within the beta-globin gene which is located as a cluster on the short arm of chromosome 11. The World Health Organization has estimated that about 1.5% of the global population (80 to 90 million people) were carriers of ?-thalassemia. There are no comprehensive study to detect carrier of ?-thalassemia in Indonesia especially for 619 bp deletion mutation, which encompasses exon 3, that has greater prevalence. We used gap-PCR combined with gel electrophoresis methods to roughly screen the presence of major indel mutation in 48 Medical Faculty, Universitas YARSI students with Malay ethnic. To validate whether the PCR product obtained is the beta-globin gene, a direct sequencing of 3 PCR products were performed. The Blast analysis of the sequence was also done using NCBI database. The result showed that the PCR products obtained in this study showed 98% identity to human beta-globin gene region on chromosome 11 (No. Acc. U01317.1). In the electrophoresis of all PCR products of 48 samples, the result showed that all the samples did not carry any major indel mutation showing by the presence of similar length of PCR products in gel electrophoresis, which has 1.457 bp and 2.291 bp product from PCR I and 1.212 bp product from PCR II. 

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