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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 196 Documents
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Aktivitas Penyembuhan Luka Sayatan Sediaan Salep Ekstrak Etanol Daun Patiwala (Lantana camara L.) Nuralifah Nuralifah; Nur illiyyin Akib; Rifa’atul Mahmudah; Fery Indradewi Armadany; Parawansah Parawansah; Indah Amalia Lestari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16522

Abstract

Patiwala (Lantana camara L.) contains flavonoid compounds, tannins, and saponins which are efficacious as a wound healer. Research on activities test of the incision wound healing ointment preparations from patiwala leaf ethanol extract (Lantana camara L.) aims to know the wound healing activity of ointment slices of ethanol extract of patiwala leaves in male white rabbits, as well as knowing the potential irritation of ointment preparations from ethanol extract of patiwala leaves in humans. Phytochemical screening was done by the color testing reaction method. The ointment formulation was carried out by the smelting method using vaseline album and cera alba base with a concentration of 4% extract. The incision wound healing activity test was performed with the Morton method using a rabbit test animal. The irritation test was carried out using the patch test method on 12 panelists. Phytochemical screening results prove that the patiwala leaves contain flavonoid compounds, tannins, and saponins which are efficacious as wound healers. The best activity test results on wound healing in rabbits are incision ointment of patiwala ethanol extract at 4% concentration with 100% healing time for 10,3 days. The results of the irritation test showed that the ointment extract of patiwala leaves proved to be non-irritating so it was safe to use. It was concluded that the ethanol extract of 4% patiwala leaves had activity as a wound healing wound.
Analisis Hubungan Tingkat Pengetahuan terhadap Perilaku Swamedikasi Batuk selama Masa Pandemi Covid-19 Lusi Ariska Triani; Hariyanto IH; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15669

Abstract

The Covid-19 pandemic gave an impact on the limitation of health services in health facilities, causing people to choose self-medication as their treatment method. The purpose of this study is to determine the level of knowledge and self-medication behavior of cough symptoms in Rasau Jaya District and the correlation between those two variables during the Covid-19 pandemic. Cross-sectional design with purposive sampling technique was used as a research method for 75 respondents and questionnaires were used as a measuring tool. Data processing was carried out using SPSS statistical tests. We found that none of the respondents had low knowledge levels with 71 respondents (94,7%) having a good level of knowledge and 4 respondents (5,3%) having sufficient levels. This result are in line with self-medication behavior showed that 73 respondents (97,3%) have a good level of behavior at doing self-medication of cough and 2 respondents (2,7%) have deficient levels. The majority people in Rasau Jaya District have a good level of knowledge and self-medication behavior and we found that there is a correlation between those two variables.
Pengaruh Kelengkapan Resep Terhadap Prescribing Error Obat Golongan Benzodiazepin di Tiga Apotek Kota Bandung Nuke Fendiana; Meta Kartika Untari; Ika Purwidyaningrum
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15784

Abstract

Reviewing prescriptions, especially psychotropic drugs, is one part of clinical pharmacy services carried out by pharmacists to analyze drug-related problems and avoid medication errors, especially at the prescribing stage. The purpose of this study was to determine the suitability of prescribing services for benzodiazepine drugs with the Regulation of the Minister of Health of the Republic of Indonesia and to find the effect of administrative, pharmaceutical and clinical completeness on the incidence of prescribing errors in prescribing benzodiazepine drugs in three pharmacies in Bandung City in 2021. This research method is a descriptive research conducted retrospectively where the data were prescriptions for January 2021-December 2021 at three Bandung City Pharmacies. The analysis was carried out by grouping each data variable from administrative, pharmaceutical and clinical aspects which were then processed using Microsoft Excel and SPSS programs. The results showed that the completeness of prescription psychotropic benzodiazepines still did not meet the requirements of the Regulation of the Minister of Health of the Republic of Indonesia No. 73 of 2016 where the total incidence of prescribing errors in the prescription section was 11.66%, subscription was 16.58% and pro was 100. %, there is a significant relationship with a correlation coefficient value of 0.269 which means that there is a sufficient influence between doctor qualifications and the incidence of prescribing errors and there is a relationship between the completeness of administrative, pharmaceutical and clinical prescriptions with the incidence of prescribing errors which is significant with a probability value of 0.000 and a correlation coefficient value of 0.749 which means strong influence. Based on the data above, it can be concluded that the completeness of prescriptions in the Administrative, Pharmaceutical and Clinical categories is still not complete in accordance with the Regulation of the Minister of Health No. 73 of 2016.
Studi Rasionalitas Pemakaian Obat Antihipertensi Pada Kasus Pasien Rawat Jalan Teti Sutriati Tuloli; Endah Nurrohwinta Djuwarno; Faramita Hiola; Fika Nuzul Ramadhani; Divia Handayani Mudjidu
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16018

Abstract

Hypertension is a disease that happens when the systolic and diastolic blood pressure is higher than 140/90 mmHg. This study aimed to identify the use of an anti-hypertension drug on outpatients at Kota Timur Community Health Center in Gorontalo, with medical records of hypertension patients from January to June 2021 as the data source. Employing the univariate analysis method, this study obtained patients' data to be recapitulated into the primary table to be descriptively analyzed. The findings in gender frequency revealed that 36 male respondents attained 53.3% of percentage and 81 female respondents attained 46.6% of percentage, while the respondent age frequency that is mostly 46-65 years old numbered 83 patients (71%), 26-45 years old numbered 22 patients (18.80%), and 65 years old numbered 12 patients (10.25%). Based on drug use from January to June 2021, the most consumed drug is Amlodipine, with 70 consumption (60%). Further, based on diseases in other categories from January to June 2021, the highest diagnosis on hypertension patients is 71 times of hypertension (60%), while the systolic and diastolic pressure category from January to June 2021 revealed that the highest blood pressure of the stage 1hypertension patients is 63 times (54%).
Isolasi dan Karakterisasi Jamur Endofit Lamun (Thalassia hemprichii) Dari Kawasan Teluk Tomini Mahdalena Sy. Pakaya; Wiwit Zuriati Uno; Dizky Ramadani Putri Papeo; Dewi Rahmawaty Moo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15852

Abstract

Endophytic fungi live in their host tissues. Endophytic fungi can produce compounds similar to their hosts as well. In this case, the use of endophytic fungi can reduce the exploitation of seagrass (Thalassia hemprichii) populations in Tomini Bay. This study aims to isolate and determine the characteristics of the endophytic fungus of seagrass (Thalassia hemprichii) from the Tomini Bay area. The test method used is the isolation and characterization macroscopically and microscopically. The results of the isolation obtained two isolates of endophytic fungi coded J1 and J2 with different characteristics. The isolate code J1 had microscopic characteristics of a yeast-like shape, while the isolate code J2 had the characteristic of non-septate hyphae.
Evaluasi Penyaluran Vaksin Sesuai Standar CDOB (Cara Distribusi Obat yang Baik) Kintan Fahra Ningrum; Iswandi Iswandi; Meta Kartika Untari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15644

Abstract

Vaccines are biological products made using germs and then weekened. According to existing studies, 75% of vaccines in Indonesia are exposed to freezing temperatures during the distribution process, as a result, vaccines cannot be used anymore. The City Health Office has responsibility for the distribution of vaccines, especially in health centers, which must be evenly distributed and given regularly at the right time. The purpose of this study is the distribution of cold chain vaccines from the City Health Office to Salatiga Health Centers using the 2020 CDOB regulatory guidelines. This study uses an observational method that has a descriptive nature and evaluation using data collection techniques by interviewing with pharmacists or vaccine managers. The data will be based on the analysis of the result of data collection using an interview sheet, and the results will be stated with a percentation. The results of the study indicate that the distribution guidelines for the rantai dingin vaccine distribution system from the Health Office to the Salatiga City Health Center using the 2020 CDOB have a good category with a percentage of 72,72% and 84,21%. Then, there was a discrepancy in the distribution carried out by the Health Service to the Salatiga City Health Center but no deviation occurred, the vaccine distributed was not damaged or expired. Factors that may occur due to discrepancies are the lack of Human Resources (HR) for vaccine managers and vaccine warehouses that have not been maximized.
Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Uji Aktivitas Antidiabetes Ekstrak Etil Asetat Daun Lamun (Enhalus acoroides) Pada Mencit (Mus musculus) Hamsidar Hasan; A.Mu'thi Andy Suryadi; Zulfianto Djufri
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15379

Abstract

Diabetes mellitus is a severe condition, chronic in nature, that occurs when there is an increase in blood glucose levels (GDS) 200 mg/dL or hyperglycemic conditions. Some plants are reported to have anti-diabetic effects. One of the examples is seagrass (Enhalus acoroides), which has α-glucosidase enzyme inhibitory effects in vitro. The community often uses it as traditional medicine. This present work explores the anti-diabetic activity of ethyl acetate extract of seagrass (Enhalus acoroides) leaves against male mice (Mus musculus) charged with 90% sucrose solution. It employed the oral sucrose tolerance test (OSTT) methodology. Activity tests on mice were carried out in five treatment groups, namely: group I or a negative control (Na-CMC 1% w/v); group II or a positive control (acarbose); group III (ethyl acetate extract dose 50 mg/kg BW); group IV ( ethyl acetate extract at a dose of 150 mg/kg BW), and; group V (ethyl acetate extract at a dose of 250 mg/kg BW). All data were analyzed by using a one-way ANOVA statistical test. The results show that the ethyl acetate extract of seagrass leaves can inhibit the absorption of sucrose, in which the most significant total inhibition occurred at a dose of 250 mg/kg BW, i.e., 68 mg/dL. A substantial inhibition was also found at a dose of 150 mg/kg BW, which was 82 mg/dL and at a dose of 50 mg/dL or 103 mg/dL. In conclusion, the ethyl acetate extract of seagrass leaves has anti-diabetic activity.
Identify the Rhodamin B on lipsticks in the market Using Thin Layer Chromatography (TLC) Method Nurul Fajriani; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15392

Abstract

Rhodamine B is a synthetic dye used as a dye for paper and textiles. This dyeis prohibited from being used in cosmetics including lipstick because it can cause skin irritation, irritation to the digestive tract, poisoning, and can cause cancer. The research aims to identify Rhodamine B contained in lipstick circulating in the market area of Pontianak City. Sampling was carried out using purposive sampling technique, obtained 7 samples of lipstick circulating in the market area of Pontianak City. The analysis of Rhodamine B in this lipstick was carried out by Thin Layer Chromatography method using silica gel plate GF 254 and the mobile phase is a mixture of n-butanol, ethyl acetate, and ammonia in a ratio (10:4:5). The results of this study obtained 2 positive samples containing Rhodamine B, namely samples A and E. The Rf values in the samples were 0.75 and 0.675, which were close to the Rf value for the comparison of Rhodamine B, which was 0.7375. The identification results showed that from 7 lipstick samples there were 2 samples positive for Rhodamine B dye. 
Characterization of The Process of Making Golden Sea Cucumber (Stichopus hermanii) Simplicia Sumaryani Sumaryani; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15730

Abstract

haracterization is the first step to ensuring uniformity of drug quality. Golden sea cucumber (Stichopus hermanii) is one of the natural ingredients that has efficacy as a wound-healing drug. This study aims to determine the characterization of the process of making golden sea cucumber Simplicia originating from Pelapis Island, Kayong Utara Regency, as raw materials for wound healing drug preparations. Simplicia was characterized biologically including morphology and habitat, physically including organoleptic, moisture content, ash content, and acid insoluble ash content, and chemically including phytochemical screening and protein content. Simplicia making process consists of sample collecting, wet sorting, washing, boiling, smoking, first drying, chopping, and second drying, dry sorting, packaging, and storage.% yield obtained is 8,43%. The results of the characterization were that fresh golden sea cucumbers had a yellow body, long of 31 cm, bodyweight of 1.3 kg, body thickness of 5 cm, and live in rock and coral areas with a sea depth of about 10-15 meters. Simplicia are brownish yellow, the distinctive smell of sea cucumbers, salty taste, and thin slices. The water content, ash content, acid insoluble ash content, and protein of Simplicia were 9.8%, 13.77%, 0.20%, and 36.1%, respectively. The outcome of phytochemical screening showed that Simplicia qualitatively contained alkaloids, saponins, and triterpenoids.

Page 13 of 20 | Total Record : 196

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