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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Impact of Donation Frequency on Iron Stores and Hemoglobin Levels in Regular Blood Donors Lili Novri Yanti; Rofinda, Zelly Dia; Syofiati; Rikarni; Husni; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1282

Background: Regular blood donation, while crucial for healthcare systems, can lead to iron deficiency and anemia in donors. This study investigated the impact of donation frequency on iron stores and hemoglobin levels in regular blood donors. Methods: A cross-sectional study was conducted on 82 regular blood donors at the blood transfusion unit of Dr. M. Djamil General Hospital from February to April 2024. Participants underwent pre-transfusion screening, including a questionnaire on donation frequency and iron supplement use. Blood samples were collected during donation, and serum ferritin, hemoglobin, and erythrocyte indices (MCV, MCH, MCHC) were measured if the C-reactive protein (CRP) test was negative. Data were analyzed using the Kruskal-Wallis test. Results: The mean age of the donors was 31 years, with the majority being female (56.1%). The most common donation frequency was 6-10 times (34.15%). None of the donors reported using iron supplements. Serum ferritin levels showed significant differences among female donors based on donation frequency (p=0.004) but not among male donors (p=0.114). Hemoglobin levels also differed significantly among female donors (p=0.002), but not among male donors (p=0.213). Significant differences were observed in MCV and MCH values in both male and female donors (p<0.001 and p=0.001, respectively), but not in MCHC values (p=0.135). Conclusion: Donation frequency significantly impacts iron stores and hemoglobin levels in female blood donors but not in male donors. Regular monitoring of iron stores, particularly in female donors, is crucial to prevent iron deficiency and anemia.

Impact of Tocolytic Therapy on Cardiovascular Outcomes in Preterm Labor: A Systematic Review and Meta-Analysis Ni Putu Ika Regiana Maharani; I Gede Agus Rio Saputra; Anak Agung Ngurah Gede Anggra Pramana; I Putu Gede Budiana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1283

Background: Preterm labor is a significant cause of neonatal morbidity and mortality, and tocolytic therapy is often used to delay delivery and improve neonatal outcomes. However, tocolytic drugs can have adverse cardiovascular effects, including an increased risk of atrial fibrillation (AF). This meta-analysis aims to evaluate the impact of tocolytic therapy on cardiovascular outcomes in preterm labor, focusing on the risk of AF. Methods: A systematic literature review was conducted following PRISMA guidelines. Relevant studies published between 2013 and 2024 were identified through PubMed, Scopus, ScienceDirect, and Cochrane Library. Studies evaluating the cardiovascular effects of tocolytic therapy in preterm labor were included. The primary outcome was the incidence of AF. Secondary outcomes included other cardiovascular adverse events. Results: Ten studies met the inclusion criteria, comprising 550 pregnant women receiving tocolytic therapy. Tocolytic therapy was associated with a significantly increased risk of AF compared to no tocolytic therapy (mean difference 0.2, 95% CI 0.10-0.30). Nifedipine and ritodrine had a higher risk of AF compared to atosiban. The risk of AF was also higher in patients with pre-existing cardiovascular diseases. Conclusion: Tocolytic therapy, particularly with nifedipine and ritodrine, increases the risk of AF in preterm labor. Atosiban appears to be a safer option for patients with cardiovascular risk factors. Careful consideration of the potential cardiovascular risks and benefits is crucial when making tocolytic therapy decisions.

Successful Management of Acute Respiratory Failure Following Drowning in a Child: A Case Report Diki Septian; Anggun Pulihana Wilujeng
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1284

Background: Drowning is a significant global public health issue, leading to a substantial number of deaths annually, particularly among children. Acute respiratory failure (ARF) is a common and life-threatening complication of drowning, necessitating prompt and effective management. This case report describes the successful management of ARF in a 6-year-old child following a drowning incident. Case presentation: A 6-year-old male child was brought to the emergency department (ED) after being rescued from a river. He was unconscious, cyanotic, and in respiratory distress. Initial assessment revealed a Glasgow Coma Scale (GCS) score of 9, oxygen saturation of 45% on room air, and crackles on lung auscultation. He was immediately intubated and placed on mechanical ventilation. A chest X-ray showed evidence of pneumonia and pulmonary edema. Arterial blood gas analysis confirmed acute hypoxemic respiratory failure. The patient was transferred to the intensive care unit (ICU) and managed with mechanical ventilation, antibiotics, and corticosteroids. He demonstrated gradual improvement in respiratory status and neurological function, leading to successful extubation and eventual discharge with a full recovery. Conclusion: This case highlights the critical role of prompt recognition and aggressive management of ARF in drowning victims. Early intubation and mechanical ventilation, along with supportive care, can lead to successful outcomes even in severe cases. This report emphasizes the importance of raising awareness about drowning prevention and the need for readily available emergency medical services to improve outcomes in such incidents.

Clinical Characteristics and Management of Steroid-Induced Glaucoma Pattih Primasakti; Lucyana; Fitratul Ilahi; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1285

Background: Steroid-induced glaucoma (SIG) is a secondary glaucoma characterized by elevated intraocular pressure (IOP) due to steroid use. This study aimed to analyze the clinical characteristics and management of SIG patients at Dr. M. Djamil General Hospital Padang, Indonesia, from January 2019 to August 2023. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with SIG. Data collected included age, gender, steroid type, route of administration, duration of use, IOP at diagnosis, underlying diseases, glaucoma stage, and treatment. Results: Seventeen patients were diagnosed with SIG. The majority were female (70.58%) and aged 4-39 years (58.83%). The most common underlying diseases were systemic lupus erythematosus (SLE) and allergic conjunctivitis (47%). Oral steroid administration was most frequent (76.4%), with a usage duration of 2-12 months in most cases (70.6%). IOP at diagnosis ranged from 22 to 31 mmHg in most patients (82.3% right eye, 64.7% left eye). Most patients presented with mild glaucoma (70.5%). Topical anti-glaucoma medications were the primary treatment (76.4%), with trabeculectomy performed in some cases (23.6%). Conclusion: SIG is a preventable condition. Early detection and appropriate management are crucial to prevent vision loss. The clinical characteristics identified in this study contribute to a better understanding of SIG in our population. Further research on the interplay of risk factors, genetics, and histopathology is needed to enhance our comprehension of SIG.

Dietary BCAAs (Branched Chain Amino Acids) and Cognitive Function: Implications for Nutritional Interventions in Elderly Populations Willya Eka Putri; Nur Indrawaty Lipoeto; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1286

Background: The aging process is often accompanied by a decline in cognitive function, impacting memory, attention, and decision-making. Malnutrition, including protein deficiency, is recognized as a contributing factor to cognitive decline in elderly populations. Branched-chain amino acids (BCAAs), essential amino acids obtained solely from dietary sources, play a pivotal role in various physiological processes, including neurotransmitter synthesis and protein synthesis in the brain. This study aims to investigate the relationship between serum BCAA levels and cognitive function in elderly individuals. Methods: A cross-sectional study was conducted on 25 elderly subjects (age > 60 years) in Padang, Indonesia. Serum BCAA levels were measured using High-Performance Liquid Chromatography (HPLC), and cognitive function was assessed using the Montreal Cognitive Assessment - Indonesian version (MoCA-Ina). Statistical analysis was performed to determine the correlation between BCAA levels and MoCA-Ina scores. Results: The mean serum levels of total BCAAs, leucine, isoleucine, and valine in the elderly subjects were 0.40 ± 0.15 mM, 0.09 ± 0.06 mM, 0.05 ± 0.02 mM, and 0.26 ± 0.10 mM, respectively. The median MoCA-Ina score was 23 (range: 8-27), indicating a significant proportion of participants with cognitive impairment. Statistical analysis revealed no significant correlation between total BCAA levels and MoCA-Ina scores (r = 0.071, p = 0.735). However, a moderate positive correlation was observed between isoleucine levels and MoCA-Ina scores (r = 0.344, p = 0.092), although not statistically significant. Conclusion: This study suggests that serum BCAA levels, particularly isoleucine, may have implications for cognitive function in elderly populations. Further research with a larger sample size and longitudinal design is warranted to elucidate the complex relationship between dietary BCAAs, serum BCAA levels, and cognitive health in aging individuals.

Unfractionated Heparin versus Low Molecular Weight Heparin for Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients: A Meta-analysis Rendi Dwi Prasetyo; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1287

Background: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in acutely ill medical patients. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are effective for VTE prophylaxis, but their relative efficacy and safety remain unclear. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing UFH and LMWH for VTE prophylaxis in acutely ill medical patients. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 2013 to 2024. The primary outcome was the incidence of VTE. Secondary outcomes included major bleeding and mortality. Results: Seven RCTs with a total of 5,412 patients were included. LMWH was associated with a significantly lower risk of VTE compared to UFH (relative risk [RR] 0.68; 95% confidence interval [CI] 0.52-0.88; p = 0.004). There was no significant difference in major bleeding (RR 0.91; 95% CI 0.65-1.27; p = 0.58) or mortality (RR 0.93; 95% CI 0.78-1.11; p = 0.43) between the two groups. Conclusion: LMWH is more effective than UFH for VTE prophylaxis in acutely ill medical patients without increasing the risk of major bleeding or mortality. LMWH should be considered the preferred agent for VTE prophylaxis in this population.

The Clinical Significance of DAT Positivity: A Comparative Analysis of IgG, C3d, and IgG/C3d-Positive Patients Khaulah Karimah; Zelly Dia Rofinda; Husni; Rikarni; Deswita Sari; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1288

Background: The direct antiglobulin test (DAT) is a crucial diagnostic tool in immunohematology, used to detect the presence of antibodies and/or complement components on the surface of red blood cells. DAT positivity is frequently associated with autoimmune hemolytic anemia (AIHA) and other immune-mediated hemolytic conditions. This study aimed to investigate the clinical significance of DAT positivity by comparing the characteristics of patients with IgG, C3d, and IgG/C3d-positive results. Methods: A retrospective study was conducted on 55 patients with DAT-positive results, identified from the Blood Transfusion Unit of Dr. M. Djamil General Hospital Padang between June 2023 and August 2023. DAT-positive samples were further analyzed using monospecific anti-human globulin (AHG) reagents to determine the presence of IgG, C3d, or both on the red blood cells. Patient demographics, clinical diagnoses, blood groups, transfusion history, and hematological parameters were collected and analyzed. Results: Out of the 55 DAT-positive patients, 51 (92.7%) were positive for IgG alone, 3 (5.5%) were positive for both IgG and C3d, and only 1 (1.8%) was positive for C3d alone. The majority of patients were adults (>18 years old) and female. A history of blood transfusion (>3 times) was common, particularly in the IgG-positive group. Hematological parameters indicative of hemolysis (hemoglobin ≤9 g/dL, reticulocyte count >2%, and total bilirubin >2 mg/dL) were observed in a significant proportion of patients, especially those with IgG and/or C3d positivity. Conclusion: IgG positivity was the most common finding in DAT-positive patients, highlighting the prevalence of warm AIHA. The presence of C3d, alone or with IgG, suggests the involvement of complement activation and may indicate a different underlying pathology. This study emphasizes the importance of using monospecific AHG reagents to characterize DAT-positive results, as this information can aid in the diagnosis, management, and prediction of clinical outcomes.

Immunophenotyping vs. Bone Marrow Aspiration in Pediatric Acute Leukemia: A Comparative Analysis Satria Utomo; Yulia, Dwi; Elfira Yusri; Rismawati Yaswir; Husni; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1289

Background: Acute leukemia is a significant global health concern, with increasing prevalence worldwide and in Indonesia. Accurate diagnosis and classification of acute leukemia subtypes, primarily acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), are crucial for effective treatment. Immunophenotyping and bone marrow aspiration (BMA) are commonly used diagnostic methods, each with its strengths and limitations. This study aimed to analyze the concordance between immunophenotyping and BMA in diagnosing and classifying acute leukemia in children. Methods: A retrospective cross-sectional study was conducted on 46 children diagnosed with acute leukemia at Dr. M. Djamil General Hospital Padang from January 2022 to July 2023. Data were collected from medical records, including patient demographics, immunophenotyping results, and BMA findings. Concordance between the two diagnostic methods was analyzed using Fisher's exact test. Results: The study population consisted of 30 (65.2%) males and 16 (34.8%) females, with a median age of 4 years. Immunophenotyping identified 24 (52.2%) cases as ALL and 22 (47.8%) as AML. BMA classified 26 (56.5%) cases as ALL and 20 (43.5%) as AML. There was a high concordance between the two methods, with only 2 (4.3%) cases showing discordant results. These two cases were classified as AML by immunophenotyping but as ALL by BMA. Conclusion: Immunophenotyping and BMA demonstrate a high level of concordance in diagnosing and classifying acute leukemia in children. The few discordant cases highlight the importance of considering both methods, especially in challenging cases, to ensure accurate diagnosis and appropriate treatment.

Pre- and Perioperative Optimization of a Geriatric Patient on Antithrombotic Therapy Undergoing Dermatologic Electrosurgery: A Case Report Laila Kurnia Fitri; Subagio
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1291

Background: Electrosurgery is a common and effective technique for removing skin lesions and achieving hemostasis in dermatologic surgery. However, managing patients on antithrombotic therapy, especially geriatric patients with comorbidities, presents a significant challenge. This case report highlights the importance of meticulous pre- and perioperative optimization in such patients to ensure safe and successful outcomes. Case presentation: A 69-year-old male patient with a history of congestive heart failure (CHF), Non-ST elevation myocardial infarction (NSTEMI), type 2 diabetes mellitus, and hypertension presented with a nevus exhibiting cornu cutaneous. The patient had been on long-term aspirin therapy. The case discusses the complexities involved in deciding whether to discontinue aspirin, weighing the risks of bleeding against the potential for thrombotic events. After a three-week delay and consultation with an internist to address elevated coagulation parameters, the electrocauterization excision was performed successfully. Conclusion: This case underscores the critical role of multidisciplinary collaboration and evidence-based decision-making in the perioperative management of geriatric patients on antithrombotic therapy undergoing dermatologic procedures. It emphasizes the need for individualized risk assessment and optimization strategies to balance the competing risks of bleeding and thrombosis.

Serum Nerve Growth Factor as a Biomarker for Chemotherapy-Induced Peripheral Neuropathy: A Cross-Sectional Study Rifki Irsyad; Restu Susanti; Fanny Adhy Putri; Yuliarni Syafrita; Syarif Indra; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1292

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment. Nerve growth factor (NGF) plays a crucial role in neuronal health and has been implicated in CIPN development. This study investigated the relationship between serum NGF levels and CIPN in cancer patients undergoing chemotherapy. Methods: A cross-sectional study was conducted on 60 cancer patients receiving chemotherapy at Dr. M. Djamil General Hospital Padang, Indonesia, from June to October 2024. Serum NGF levels were measured, and CIPN was assessed using the Toronto Clinical Scoring System (TCSS). The relationship between NGF and CIPN was analyzed using the Mann-Whitney test. Results: The median serum NGF level was significantly lower in patients with CIPN (n=43) compared to those without CIPN (n=17) (103.26 pg/ml vs. 148.91 pg/ml, p=0.029). No significant association was found between chemotherapy regimens and CIPN or NGF levels. Conclusion: Lower serum NGF levels are associated with CIPN in cancer patients undergoing chemotherapy. NGF may serve as a potential biomarker for CIPN, aiding in early detection and management. Further research is needed to explore the clinical utility of NGF as a predictive and monitoring tool for CIPN.

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Rachmat Hidayat

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Kab. ogan ilir,

Sumatera selatan

INDONESIA