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INDONESIA
Medical and Health Science Journal
Published by Universitas Nahdlatul Ulama Surabaya
ISSN : 25497588     EISSN : 25497596     DOI : https://doi.org/10.33086/mhsj
Core Subject : Health, Social,
Health Professions Social Sciences
Medical and Health Science (MHSJ) published peer-reviewed original articles research, case report or article review. This journal is published twice (February and August) by Faculty of Medicine Universitas Nahdlatul Ulama Surabaya.
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Articles 192 Documents
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THE EFFECT OF CITICOLIN IN MOTORIC IMPROVEMENT OF ACUTE ISCHEMIC STROKE PATIENTS IN SITI KHODIJAH SEPANJANG HOSPITAL Dza’wan Maula Iwanatud Diana; Laily Irfana; Yelvi Levani; Uning Marlina
Jurnal Ilmu Kesehatan dan Kesehatan Vol 4 No 2 (2020): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v4i2.1579

Abstract

Background: According to WHO, stroke is the leading cause of morbidity and the second cause of death with a mortality rate of around 5.54 million. Stroke, based on its etiology, consists of ischemic and hemorrhagic. Ischemic stroke is caused by a blockage in the blood-brain, whereas hemorrhagic stroke occurs due to the rupture of brain blood vessels. Based on the pathophysiology of ischemic stroke, its therapy consists of thrombolytic in thrombus for brain reperfusion and anticoagulants or antiplatelet in strokes due to embolization because it is grown in a collateral-containing lavatory and neuroprotectant assistance to trace cytotoxic nerves. Neuroprotectants that are often used are piracetam and citicoline. Citicoline improves neuronal cell membranes by increasing synthesis of the main component of cell membranes, phosphatidylcholine, then repaired neuronal cell membranes. Objective: To find out motor improvement in stroke patients at Siti Khodijah Sepanjang Hospital by giving 500mg of citicoline per day orally for 5 days. Methods: A case-control observational analytic study using medical record data. Consists of a group with standard therapy, antiplatelets, and another group with 500mg/day antiplatelet and citicoline therapy for 5 days. Patients were examined for MRC motor on the first day and the fifth day. Results: The statistical test used the Chi-Square test  and wilcoxon test with a significance value of 0.00 and 0,01 (<0.05). Conclusion: obtained significant motor improvement in stroke patients 500mg/day for 5 days at Siti Khodijah Sepanjang Hospital.   Latar belakang: Menurut WHO stroke menjadi penyebab utama morbiditas dan sebab kematian nomor dua dengan angka kematian sekitar 5,54 juta. Stroke berdasarkan etiologinya diklasifikasikan menjadi stroke iskemik dan stroke hemoragik. Stroke iskemik merupakan stroke yang diakibatkan oleh adanya sumbatan pada pembuluh darah di otak sedangkan stroke hemoragik akibat adanya pecahnya pebuluh darah otak. Berdasarkan patofisiologinya terapi stroke iskemik terdiri dari trombolitik pada iskemik akibat trombus untuk reperfusi otak dan antikoagulan atau antiplatelet pada stroke akibat emboli sebagai pencegahan terbentuknya trombus pada pembuluh darah kolateral serta pemberian neuroprotektan untuk menghambat penyebaran kerusakan neuroglia pada penumbra akibat proses sitotoksik. Neuroprotektan yang sering digunakan adalah pirasetam dan citicolin. citicolin berfungsi memperbaiki membran sel neuron dengan meningkatkan sintesis komponen utama membran sel yaitu phosphatidylcholine sehingga terjadi peningkatan perbaikan membran sel neuron. Tujuan: Untuk mengetahui perbaikan motorik pada pasien stroke iskemik akut di RS Siti Khodijah Sepanjang. Metode: Jenis penelitian analitik observasional case-control bersifat retrospektif menggunakan data rekam medis. Terdiri dari kelompok dengan terapi standar yaitu antiplatelet dan kelompok lain dengan terapi antiplatelet dan citicolin 500mg/hari selama 5 hari. Pasien dilakukan pemeriksan motorik MRC di hari pertama dan hari kelima. Hasil: Uji statistik menggunakan uji Chi-Square dan uji wilcoxon dengan nilai signifikansi masing-masing 0,00 dan 0,01 (<0,05). Kesimpulan: didapatkan perbaikan motorik yang signifikan pada pasien stroke iskemik akut dengan pemberian citicoline 500mg/hari selama 5 hari di Rumah Sakit Siti Khodijah Sepanjang.
META-ANALYSIS : COMPARISON OF NEOVAGINA SUCCESS RATE WITH VECCHIETTI'S LAPAROSCOPIC METHOD AND DAVYDOV'S LAPAROSCOPIC METHOD IN MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME (MRKH) PATIENTS Yanuar Prionggo; Eighty Mardiyan Kurniawati
Jurnal Ilmu Kesehatan dan Kesehatan Vol 4 No 2 (2020): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v4i2.1641

Abstract

Background: Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is caused by an embryological growth disorder of the mullerian duct. Laparoscopic Vecchietti and Davydov are laparoscopic surgery techniques that are often used for neovaginal surgery Objective: This paper aims to compare the success rate of neovagina with the Vecchietti laparoscopic method and Davydov's laparoscopic method in patients with Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) Methods: A systematic data search was performed on a medical database (PUBMED, MEDLINE, Cochrane Database, Google Scholar). Inclusion criteria: (1) randomized randomized study of the Vecchietti Laparoscopic Method with Davydov’s Laparoscopy, (2) all inclusive papers can be accessed completely, and (3) the data obtained can be accurately analyzed Data acquisition and analysis: We searched for a random blind study (RCT) with the following keywords: (1) Vecchietti Laparoscopy [title] AND (2) Davydov’s Laparoscopy [title] AND Mayer-Rokitansky-Kuster-Hauser syndrome [title] Results: Three RCTs comparing neovaginal success with the Vecchietti laparoscopic method and Davydov's laparoscopic method a total of 122 patients were analyzed. Average vaginal length (mean difference [MD] -0.70, and 95% [CI] -0.99 to -0.41 (P <0.00001), Average number of Female Sexual Function Index scores (mean difference [MD] -1.34, and 95% [CI] -1.71 through -0.96. (P <0.00001) Conclusion: This meta-analysis concludes that Davydov’s Laparoscopic Method is better in terms of postoperative vaginal length and the Female Sexual Function Index Score
THE EFFECTIVENESS OF PRASTERONE VS PLACEBO THERAPY AS THE VULVOVAGINAL ATROPHY TREATMENT IN MENOPAUSAL WOMEN: META-ANALYSIS STUDY Zettira Maulida Prasha; Hari Paraton
Jurnal Ilmu Kesehatan dan Kesehatan Vol 4 No 2 (2020): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v4i2.1656

Abstract

Background : Vulvovaginal atrophy is a condition that often occurs in menopausal women due to Estrogen decreased. Prasterone (DHEA) is a steroid hormone that can be converted into Estrogen in the target tissue. Objective : This paper aims to evaluate the effectiveness of administering Prasterone as Vulvovaginal Atrophy therapy in menopausal women. Methods : A systematic data search was performed on a medical database (PUBMED, Google scholar, Cochrane). Inclusion criteria: (1) randomized study of Prasterone as Vulvovaginal Atrophy therapy in postmenopausal women, (2) all-inclusive papers can be accessed completely, and (3) the data obtained can be accurately analysed. Results: Three RCTs with a total of 696 patients were analysed. The average number of Superficial Cells (mean difference [MD] 7.63, and 95% [CI] 7.57 to 7.70 (P <0.00001). The average number of Parabasal Cells (mean difference [MD] -29.84, and 95% [CI] -30.25 to -29.44 (P <0.00001). The average number of vaginal pH (mean difference [MD] -0.69, and 95% [CI] -0.70 to -0.68 (P <0.00001). The average number of Dyspareunia (mean difference [MD] -0.38, and 95% [CI] -0.39 to -0.37 (P <0.00001). All diamonds do not intersect the vertical line, and have p <0.05, it proves that there are significant differences between the two groups. All non-hysterectomized women have an atrophic or inactive endometrium. Side effects that are often complained of is headache and application site discharge. Conclusion This meta-analysis concludes that Prasterone therapy has a significant therapeutic effect for Vulvovaginal Atrophy in menopausal women
COMPARISON THE SUCCESS RATE OF VESICOVAGINAL FISTULA REPAIR SURGICAL WITH TRANSVAGINAL AND TRANSABDOMINAL PROCEDURE : META ANALYSIS Norma Pattinama; Gatut Hardianto
Jurnal Ilmu Kesehatan dan Kesehatan Vol 4 No 2 (2020): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v4i2.1663

Abstract

Objective: This paper aims to evaluate the success rate of vesicovaginal fistula (VVF) repair surgery by transvaginal (TVAG) and transabdominal (TPA) procedure. Method: Literatures were searched on the online database, PUBMED and Google Scholar. All of the studies should be belonging on to inclusion criteria. The literatures had qualitative analyze by the authors and bias criteria based on Review Manager 5.3 application. It also had quantitative analyzed by the same application. Results: The literatures have 191 patients (transvaginal-n=107; transabdominal-n=84). The data was homogen (Chi2<df; P>0,05). The forest plot showed that TPA has a higher success rate than TVAG, still not statistically significant (test overall effect P>0,05; 95%CI was 0,59 to 5,30). Conclusion: Transabdominal procedure has a higher success rate.
PREVALENCE OF CHRONIC KIDNEY DISEASE AMONG COMMUNITY REMOTE AREAS IN SABAH: POPULATION-BASED STUDY Nor Ain Mior Nizam; Malehah Mohd Noh; Shamsul Bahari Shamsuddin
Jurnal Ilmu Kesehatan dan Kesehatan Vol 4 No 2 (2020): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v4i2.1669

Abstract

In this population-based study, we determined the prevalence of chronic kidney disease of community in remote areas of Ranau, Sabah to have accurate information for health-care planning. It also investigated the association of risk factors with the prevalence of CKD. A sample of 270 individuals, compared to the study of the National Health and Morbidity Survey 2011, of the adult population (over 18 years old) undertaken in West Malaysia. We measured the estimated glomerular filtration rate (eGFR) using this CKD-EPI equation. The total prevalence of chronic kidney disease in this group was 53%. An estimated 3.3% had stage 1 chronic kidney disease (eGFR >90 ml/min per 1.73m2), 32.6% had stage 2 (eGFR 60–89 ml/min per 1.73m2), 4.1% had stage 3 (eGFR 30–59 ml/min per 1.73m2), 7% had stage 4 (eGFR 15–29 ml/min per 1.73m2), and 6% had stage 5 chronic kidney disease (eGFR <15 ml/min per 1.73m2). Only 4% of respondents with chronic kidney disease were aware of their diagnosis. The significant risk factors included family history of kidney disease, alcohol consumption, smoking status, hypertension, diabetes mellitus, and dyslipidemia. Thus, chronic kidney disease in East Malaysia is common and warrants early detection, and treatment to potentially improve outcomes can be implemented.
The Effect of Caulerpa Cylindracea Extract on Histopathology Depiction of Male Rattus Norvegicus Gaster Mucosa Induced by Indomethacin FITRI HANDAJANI; Adya Hidayatullah; Nita Pranitasari
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1671

Abstract

ABSTRACT Background: A lot of food can repair gastric mucosal damage. For example, sea grapes or the Caulerpa cylindracea with its flavonoid content. Anti-inflammatory and anti-ulcer effect can reduce gastric lesions due to ulcerogenic agents. Indomethacin is used to induce gastric ulcers in experimental animals. Based on this background, this study was conducted to analyze the effect of Caulerpa cylindracea extract, on the histopathological picture of gastric mucosal damage of Rattus norvegicus male rats.   Method: 32 male Rattus norvegicus rats were divided into 4 groups, (1) Group K(-), the untreated group, (2) Group K(+) induced by indomethacin 30mg/kgBB per head (3) Group P1 induced by indomethacin 30 mg/kgBB and Caulerpa cylindracea extract 1gr/100grBB per head, (4) Group P2, induced by indometacin 30mg/kgBB and 2gr/100grBB of Caulerpa cylindracea extract per head.   Result: There was a significant difference (p = 0.001) between the degree of gastric mucosal damage in group K(+) given only indomethacin and group P1 given Indomethacin and 1gr/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.001) between group K(+) and group P2 that given Indomethacin and 2g/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.004) between group P1 and group P2. Data revealed on group K(-) without any treatment did not obtain significant results (p = 0.060) with group P2.    Conclusion: Giving Caulerpa cylindracea extract with 1 gr/100grBB dose and 2gr/100grBB dose can repair mucosal damage in Rattus norvegicus male rats induced by indomethacin.   
The Labor-Induced Pregnancy Cases In Dr Soetomo General Hospital: A Descriptive Study Alfin Firasy
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1673

Abstract

Background: Labor induction is a procedure to stimulate uterine contractions during pregnancy before labor begins on its own to achieve a vaginal birth with medical or mechanical intervention to start the labor. This procedure aims to stimulate more extensive contraction in the uterus. The labor induction can reduce the caesarean rate. Prostaglandin E2 (PGE2) and misoprostol are the commonest medicine used to ripen the cervix in the Dr. Soetomo Hospital. Objective: Our study aim to evaluate the success rate of induction of labor patient. Methods: This study was a descriptive study using the medical record in 2018 in the Dr. Soetomo General Hospital, Surabaya. A total of 183 patient’s medical record data who underwent induced labor were used in this study. Inclusion criteria were the women with indication to deliver and have no cephalo-pelvic disproportion. Women with contraindication labor induction were excluded. Data was described using table and narrative approach. Results: The most range of gestational age was 21-36 weeks (53.01%) followed by 37-42 weeks (42.07%). There were 68 patients (37,1%) primigravida and 115 patients (62,8%) were multipara. The major induced labor was conducted with misoprostol (78.6%), and the most pelvic scores were 2 (58.46%) before underwent induced labor. Vertex delivery was the preferred mode of delivery after the induction of labor with 89 patients (48,62%). The labor induction failure followed with the caesarean operation were 27 patients (14,7%) and one patient (0,54%) with hysterotomy, most of them caused by failure to progress and fetal distress. There were 78 babies (43%) with the weight over 2500 g, 28 babies (31%) were over 2000 g, and the other was below 2000 g. A total of 84.71% with labor induction can be delivered vaginally, and It is a good number to reduce the rate of caesarean operations. Conclusion: This study concludes that misoprostol uses for the induction of labor than the other. Delivery abdominal is less percentage than the additional delivery finds that as a failure of induction of labor. The Labor induction success to delivered vaginally can reduce the rate of caesarean operation.
The Effect of Tomate Juice On Trigliserida Levels Of Male White Rats Induced by Alloxan FITRI HANDAJANI; Ibrahim Shihatta
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1740

Abstract

Background: Tomato juice is believed to affect triglyceride levels in the blood because it contains lycopene. This study aims to determine the effect of tomato juice (Solanum lycopersicum) on blood triglyceride levels in the wistar strain of male Rattus norvegicus induced by alloxan. Methods: 24 were divided into 3 groups, (1) Group K (-) experimental animals without treatment, (2) Group K (+) experimental animals induced by alloxan 150 mg / kgBB, (3) Treatment group K (P) animals tried alloxan induced 150 mg / kg and got 1.75 ml / head of tomato juice. Results: There was a significant difference in mean triglyceride levels between groups K (-) and group K (+). This indicates that the induction of alloxan increases blood triglyceride levels. There were significant differences in the mean triglyceride levels between the K (+) and K (P) groups because tomato juice contained lycopene which could reduce triglyceride synthesis. Conclusions: Tomato juice (solanum lycopersicum) reduced wistar strain male Rattus novergicus triglyceride levels induced by alloxan.  
A Systematic Review: Comparison of triple drug therapy versus double drug therapy for Lymphatic Filariasis I Gusti Agung Ari Kusuma Yana
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1878

Abstract

Background: Lymphatic filariasis is a parasitic infection caused by nematodes such as filaria Wuchereria bancrofti, Brugia malayi, and Brugia timori. These parasites can be transmitted through mosquito bites such as several species of mosquitoes, particularly Anopheles, Aedes, Culex, and Mansonia with geographical variations in the dominant vector identity. The main strategy used consists of community-wide mass drug administration (MDA) for the entire population at risk to stop disease transmission and prevent infectious morbidity. WHO recommends the use of annual medication in combination with the triple drug ivermectin therapy. Objective: To compare DEC and albendazole (IDA) versus the two drugs albendazole and diethycarbamazine or albendazole and ivermectin therapy. Methods: The literature search was carried out independently by the researcher using the Sciencedirect, Pubmed, and Cochrane online databases without limiting the type of study or the year of publication. The keywords used in this study were combined with the Boolean operator, namely "AND" namely ((((Lymphatic filariasis) AND (albendazole)) AND (diethylcarbamazine)) AND (ivermectin)) AND (compare). Results: Where triple drug therapy was significantly better in reducing and clearing microfilariae and worm nests in patients with lymphatic filariasis compared to two drug therapy alone. However, side effects occur more frequently in the combination of three therapies. The average side effects were low, such as headaches, joint pain, fatigue, and nausea. Conclusion: although it has relatively low side effects that occur in three drug combinations rather than two drug combination therapy, triple therapy combination therapy is more effective than two drug therapy in treating lymphatic filariasis disease.
Pre Clinic Grade and Clinic Periods Effect on Progress Test of UNISMA Medical Profession Students Ariani Ratri Dewi
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 1 (2021): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i1.1880

Abstract

Introduction: Pre clinic grade point is often seen as predictor of good performance in professional education whose short term goal is to pass national examination which command progress test to evaluate the preparation. Purpose: To know the effect of pre clinic grade point and clinical study periods in progress test result of medical profession students. Methods: 135 students of medical profession programme completed computer based progress test of 200 national standardized questions in 200 minutes using siPENA software. Progress test result then analysed based on how long they have been studied and their pre clinic grade point using ANOVA – Tukey HSD and Pearson correlation in SPSS for Windows ver 19 Results: Although students with pre clinic grade 2,50-2,74 have lower progress test result, but it’s not statistically significant (p>0,05). The same happen in clinic study periods with the longer the students in their clinical rotation, the better their result (p>0,05). The trends which showing better result in higher pre clinic grade point and time they spend in clinical rotation agrees with previous studies. Conclusion: Pre clinic grade point and clinic study periods has little to no effect on progress test result of medical profession students in UNISMA.

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