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CERATA Jurnal Ilmu Farmasi
Published by STIKES Muhammadiyah Klaten
ISSN : 20891458     EISSN : 26851229     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology
CERATA Jurnal Ilmu Farmasi is a collection of publication journals, covering a lot of common problems or issues related to the Pharmaceutical sciences, including Pharmacetics, Biopharmacy, Drug Delivery Systems, Pharmaceutical Physics, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Biotechnology and Microbiology, Pharmacology and Toxicology, Pharmacokinetics, Clinical and Community Pharmacy, Pharmaceutical Regulation and Marketing, Herbal Medicine
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Articles 117 Documents
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Formulasi dan Uji Aktivitas Perlindungan Tabir Surya Emulgel Ekstrak Etanol Kulit Bawang Merah (Allium cepa L.) secara In Vitro dan In Vivo Vivin Nopiyanti; Lisa Wulandari; Suhartinah
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Sunscreen is a preparation used on the surface of the skin that works to absorb, scatter, or reflect ultraviolet light. Skin of red onion (Allium cepa L.) is one of the natural ingredients that can be used as sunscreen, especially the. Skin of red onion contains flavonoid and tannin compounds that have the potential as sunscreen. This study aims to find out the ethanol extract skin of red onion in the form of emulgel preparations that have good physical quality and stability, SPF value and sunscreen protection activities. Ethanol extract skin of red onion is obtained by maceration using 50% ethanol solvents. Emulgel ethanol extract skin of red onion is made in 4 formulas with variations in extract concentrations of 0,05% ; 0,1% and 0,2%. Emulgel preparations are carried out physical quality test, stability, determination of SPF value (Sun Protection Factor) in vitro using UV-Vis spectrophotometry. The SPF value is calculated by the Mansyur equation. The in vivo test used a male rabbit (New Zealand) were irradiated with a UV B exoterra lamp for 24 hours to see the resulting effects of erythema. The results showed that the onion peel ethanol extract emulgel had good quality and stability. Sunscreen protection tests in vitro and in vivo showed that the sunscreen protection activity met the requirements for the effectiveness of sunscreen with an SPF value of emulgel with a concentration of 0,05% ; 0,1% and 0,2% of 9,59 classified as protection extra, 21,14 and 35,85 were classified as ultra protected and the erythema score after 24 hours of UV exposure was 0.
Uji Aktivitas Antibakteri Obat Kumur Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Muhammad Nurul Fadel; Endang Setyowati; Yulis Trinovitawati; Wahid Sabaan
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Dental caries is a disease of the oral cavity caused by Streptococcus mutans bacteria. The mouthwash used continuously will cause side effects. So it is necessary to develop mouthwash preparations from natural ingredients, one of the plants is wuluh starfruit leaves (Averrhoa bilimbi L.) which contain flavonoids, tannins and saponins as antibacterial agents. The aim of this study was to determine the activity of the formulas for the mouthwash of wuluh starfruit leaves extract (Averrhoa bilimbi L.) which can affect the bacteria Streptococcus mutans. Research using the disc diffusion method, mouthwash made in 3 formulas, namely FI, FII, FIII with concentrations of 10%, 15% and 20%, which were placed on TSA media that had been overgrown with Streptococcus mutans bacteria incubated and the diameter of the inhibition zone (zone). clear). The results of the research on formula I (10%) on the first day get an average of 4.3 mm and day 14 get an average of 4 mm, this includes the classification of weak inhibition zones (less than 5 mm), formula II (15% ) get an average of 6.3 mm and day 14 get an average of 6 mm including the classification of moderate inhibition zone (5mm-10mm), formula III (20%) gets an average of 9.5mm and day 14 gets an average an average of 9.2 mm including the moderate inhibition zone classification (5mm-10mm), while the positive control (Povidone Iodine 1%) got an average of 13.8 mm and the 14th day got an average of 13.5 mm including the strong inhibition zone classification (more than 10mm) and negative control haven't drag zone. Based on the results of the data above, the formula of wuluh starfruit leaves mouthwash (Averrhoa bilimbi L.) can inhibit Streptococcus mutans bacteria.
Uji Aktivitas Anti Inflamasi Ekstrak n-Heksan, Etil Asetat dan Etanol Daun Kecombrang (Etlingera Elatior) Pada Tikus Putih Jantan Galur Wistar (Rattus Norvegiucus) Dea Alfanda; Slamet; Sigit Prasojo
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Kecombrang (Etlingera elatior) is one of the Indonesian herbal plants, frequently used by our society as anti-inflammation. This medicine has a function to reduce infection. This study aims to examine the activity of ani-inflammation from the extract of n-hexan, ethyl acetate, and ethanol of kecombrang (Etlingera elatior) leaves. It useá experimental as a method by using inflammation inhibition test on the tested white male mouse of galur wisiar as sampie. This sample is divided into 6 groups and each was given at a dose at 50 mg/kgweight, 100 mg/KGBW, 150 mg/KGBW, and 200 mg/K.gBW. Besides, for the positive control group, Diclofenac sodium was used at a dose of 4.5 mg / KGBW, which was previously induced by edema with 1% Karangenan. Edema measurenients were carried out every 10 minutes after being induced by carrageenan using a pletismometer. The data result of anti-inflammation activity from each extract has been exainined the differences between test groups with the ANOVA statistical test The result of Tukey statistical test stated ethanol extract of kecombrang leaves at a dose of 200 mg/KGBW has a good anti-inflammation activity, achieving a value of 0.972, 0.994, and 1,000. It means there is no different anong extract of n-hexan, ethyl acetate, and ethanol.
Penetapan Kadar Kafein Pada Teh Kering Kemasan Produksi Industri Teh di Pekalongan Rina Widhyani; Khusna Santika Rahmasari; Wirasti; Rini Kristiyanti; Slamet
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Caffeine is one of the main alkaloid compounds in tea. The maximum limit of caffeine compounds in beverage food products based on SNI 01-7152-2006 is 50 mg / serving. Pekalongan has a packaged dry tea industry with a variety of brands, so caffeine content testing is required. This study aims to determine the differences in caffeine content in packaged dry tea produced by the tea industry in Pekalongan which is analyzed and to determine the caffeine content of all brands of tea samples that meet the maximum caffeine content requirements. The method used is the reverse phase High Performance Liquid Chromatography (HPLC) method with octadecyl silica C18 as stationary phase, methanol for HPLC mobile phase with a flow rate of 1 mL / minute and a wavelength of 274 nm. The results showed that there were differences in caffeine content in packaged dry tea produced by the tea industry in Pekalongan. The level of caffeine is 1.753 mg / g (T1), 4,870 mg / g (T2), 5,157 mg / g (T3), 2,394 mg / g (T4), 3,601 mg / g (T5), 3,275 mg / g (T6), 3,900 mg / g (T7), 3,725 mg / g (T8), 7,048 mg / g (T9) and 5,348 mg / g (T10). The ten brands of tea samples in a dose of 5 grams per serving have a caffeine content that meets the maximum limit requirements according to SNI 01-7152-2006, namely 50mg / serving with the highest caffeine content in sample T9. The ten brands of tea samples are safe for consumption
Optimisasi Tween 80 dan Span 80 Sebagai Emulgator dalam Formula Krim Tabir Surya Kombinasi Ekstrak Etanol Daun Alpukat (Persea americana M.) dan Nanopartikel Seng Oksida Dengan Metode Simplex Lattice Design Erindyah Retno Wikantyasning; Nabilla Indianie
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Avocado leaves contain flavonoid which act as antioxidant whereas nanoparticles of zinc oxide can protect the skin against a wide spectrum of UV. The purpose of this study was to determine the effect of variation of Tween 80 and span 80 as emulsifier and determine the optimum formula of sunscreen scream containing ethanol extract of avocado leaves and zinc oxide nanoparticles. Avocado leaves were extracted by maceration method using ethanol. Nano zinc oxide is obtained by the High Energy Ball Milling technique and characterized using Particle Size Analyzer. Determination of the optimal cream formula with variations in the concentration of Tween 80 and Span 80 is done by Simplex Lattice Design (SLD) method. The maceration resulted ethanolic extract of avocado leaves with a yield of 34.4%. The synthesised zinc oxide nanoparticles obtained showed 179.47±5.98 nm in diameter. The results showed that increasing concentrations of Tween 80 and decreasing concentration of Span 80 increased spreadability but decreased the viscosity and adhesiveness of creams. The SPF evaluation of creams showed a medium protection category (SPF>15). The optimum formula was obtained with the ratio of Tween 80 and Span 80 was 7,8 and 3,2%, respectively, with the desirability value of 0.863.
Identifikasi Golongan Senyawa Flavonoid Ekstrak Etanol Daun Anting-Anting (Acalypha indica L.) Rahmi Nurhaini; Muchson Arrosyid; Titik Susanti
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Anting-anting leaf is one type of plant that has medicinal properties and has not been widely used by the community. Previous research stated that the ethanol extract of Anting-anting has secondary metabolite compounds such as saponins, flavonoids, alkaloids, tannins. Flavonoids are a source of antioxidants that can inhibit premature aging caused by free radicals produced by pollution. Flavonoids can be used to avoid deadly diseases including heart disease and cancer. The purpose of this study was to determine the class of flavonoid compounds present in anting-anting leaf (Acalypha indica L.). The method used in this study was a color reaction, the material used was anting-anting leaf (Acalypa indica L.), CH3COONa. , FeCl3, Na2CO3, NaOH 0.1 N, CH3COOPb, H2¬SO4. The results of this study indicate that the Anting-anting extract (Acalypa Indica L.) positively contains flavonoids of the anthocyanidin group, using Na2CO3 reagent, the color formed is green, and positive contains flavonol and flavone groups using H2SO4 and NaOH reagents, the color formed is yellow.
Standarisasi Parameter Spesifik Dan Non Spesifik Ekstrak Etil Asetat Daun Beluntas (Pluchea indica L.) Sholikhah Deti Andasari; Choiril Hana Mustofa; Eka Oktavia Arabela
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Traditionally, the leaves of Beluntas (Pluchea indica L.) are used as medicine to eliminate body odor, as a fever reducer (antipyretic), increase appetite (stomakik), laxative sweat (diaphoretic), pain, diarrhea and vaginal discharge. The need to determine the quality standard of the extract from a review of specific and non-specific parameters of the ethyl acetate extract of the leaves of beluntas (Pluchea indica L). The extract was made by maceration method using ethyl acetate and the quality standard was determined by determining specific parameters including extract identity, extract organoleptic and soluble compounds in ethyl solvent and phytochemical screening. Non-specific parameters which include drying shrinkage, specific gravity and moisture content. The results of the observation of specific parameters obtained the identity of the thick extract, blackish green color, characteristic aromatic odor and bitter taste. The content of the soluble compound in ethanol is 22.201%±2.163. The content of water-soluble compounds was 24.578% ± 2.326. Identification of the chemical content of the extract was positive for flavonoid compounds, tannins and saponins, and negative for alkaloid compounds. Moisture content 15,878±2,087. Drying shrinkage 20.895% ± 3.674. Specific gravity 0.668 g/mL ± 0.355.
Pengaruh Suhu terhadap Stabilitas Larutan Vitamin C (Acidum ascorbicum) dengan Metode Titrasi Iodometri Putu Vellina Damayanti; I Gusti Ngurah Jemmy Anton Prasetia
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
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The stability of pharmaceutical preparations is a very important criterion for a good production result where the stability of the drug can be influenced by external factors such as temperature. The sample used was a vitamin C solution with another name Acidum Ascorbicum (ascorbic acid) with a molecular formula of C6H8O6 and a molecular weight of 176.13 g / mol where the solution was tested for stability using the Iodometric titration method. Based on the calculation results, the vitamin C levels obtained in sample I (without heating) were 0.16644% w/v, in sample II (heating for 30 minutes) was 0.06376% w/v, in sample III (heating for 60 minutes) which is 0.15675% w/v, in sample IV (heating for 90 minutes) is 0.15288% w/v, and in sample V (heating for 120 minutes) is 0.16063% w/v. Thus, an increase in temperature can accelerate the occurrence of reactions that can disturb a substance's stability. Vitamin C The longer the heating time, the more vitamin C is oxidized, so that the remaining vitamin C levels will decrease due to the decomposition process.
Pengaruh Purifikasi Terhadap Kandungan Zat Aktif Dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
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Purifikasi ekstrak etanol 50% daun kelor (Moringa oleifera L.) dilakukan untuk meningkatkan kandungan zat aktif flavanoid, β-karoten, saponin dan tanin yang memiliki aktivitas sebagai antioksidan. Tujuan penelitian ini adalah mengetahui jenis pelarut yang paling optimal antara etil asetat dan n-heksan dalam fraksinasi ekstrak etanol 50% daun kelor. Penelitian dimulai ekstraksi etanol 50% daun kelor dengan maserasi dan dilanjutkan evaporator kemudian waterbath sampai diperoleh ekstrak kental. Ekstrak kental yang diperoleh dari ekstraksi selanjutnya dilakukan purifikasi. Fraksinasi dengan melarutkan ekstrak kental etanol 50% daun kelor (E1) dan aquades pada suhu 70ºC kemudian ditambahkan etil asetat pada corong pisah hingga di peroleh fraksi etil asetat (E2), ekstrak kental etanol 50% daun kelor (E1) ditambahkan n-heksan pada corong pisah hingga terjadi pemisahan fase sehingga diperoleh fraksi n-heksana (E3). Ekstrak dan fraksi dievaluasi parameter meliputi kadar air ekstrak dengan gravimetri, kadar β-karoten dengan HPLC dan aktivitas antioksidan dengan DPPH. Data dianalisis statistik dengan taraf kepercayaam 95%. Hasil Penelitian menunjukkan bahwa kadar air ekstrak etanol 50% daun kelor adalah 4,16 dengan CV 4,62%. Kadar β-karoten paling optimal pada fraksi n-heksana (E3) kemudian etil asetat (E2) dan etanol 50% (E1) yaitu 1.48 ± 0.01%, 1.19 ± 005% dan 0.73 ± 0.01%. Sedangkan aktivitas antioksidan (IC50) paling optimal pada fraksi n-heksana (E3) kemudian etanol 50% (E1) dan etil asetat (E2) yaitu 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml dan 58.79 ± 0.10ug/ml. Nilai aktivitas antioksian menunjukkan pada fraksi n-heksana dan ekstrak etanol 50% termasuk dalam kategori sangat kuat sedangkan fraksi etil asetat termasuk dalam kategori kuat sehingga berpotensi sebagai antioksidan.
Pemeriksaan Kualitas Air Minum Secara Mikrobiologis di Daerah Bukit Jimbaran Arie Pradina Putri I Putu Mas
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
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The main problem faced in drinking water consumtion is contamination both chemically and biologically. The increasing population in the Bukit Jimbaran area makes demand for drinking water increased. This study was aims to examine the quality of drinking water microbiologically in Bukit Jimbaran area. Research had been carried out in the Laboratory of Microbiology and Virology, Faculty of Mathematics and Natural Science, Udayana University by taking samples from 3 drilled wells and 3 refill drinking water depots randomly. This research was experimental used Most Probable Number (MPN) test for the microbiological of the water that consist of presumptive test using Lactose Broth (LB), confirmative test using Brilliant Green Lactose Broth (BGLB), and complete test using endo jelly media. The result of presumptive test showed two samples of drilled well drinking water and three samples of refill drinking water were positive for Coliform. The result of confirmative test and complete test showed that three refill drinking water samples were positive for Coliform faecal bacteria and E. coli, which showed that the samples were not suitable for consumption

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