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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 140 Documents

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Effect of Physical Training Towards Body Balance in Overweight Condition Purwo Sri Rejeki; Anita Faradilla Rahim; Rizki Eka Prasetya
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

An overweight individual has morphological changes in the muscle resulting functional impairment and can cause reduction in body balance system. Balance is an ability to maintain both static and dynamic equilibrium on various positions. An overweight person will experience a decrease in abdominal muscle strength and center of gravity shift. Physical training has positive effects to increase body balance. Stretching exercise maintains and increases the elasticity of muscle, tendon, fascia, ligament and joint motion and improve balance. Resistance exercise increases muscle performance which has benefit effect on balance system dynamically. The proprioceptive, an important part of balance maintenance to feel joint position or body when moving, can be improved by training that performed using balance board. Mechanoreceptor that is stimulated and the adaptation of the body's balance control that is influenced by balance board training results a good proprioceptive.

Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2 Thamrin, Husin; Sutjahjo, Ari; Pranoto, Agung; Soelistijo, Soebagijo Adi
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031 Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.

THE USE OF KINSHIP ANALYSIS ON PATERNITY TESTING THROUGH CODIS STR LOCI ‘CSF1PO' AND ‘THO1' Putri, Dwi Fitrianti Arieza; Yudianto, Ahmad
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Paternity tests compare a child's DNA pattern with the possible father to examine the DNA heritage in ensuring kinship. If there is no information from the father and mother or the child that can be used as a comparison in the forensic DNA examination process (paternity test), there must be a comparison from a close relative as an alternative to obtain the forensic DNA examination. This experiment's purpose is to analyze the use of kinship analysis in forensic identification especially in a paternity test. Methods: This is a descriptive experiment using a cross-sectional design through locus analysis of DNA forensic examination in paternity test using the kinship analysis through STR CODIS loci: CSF1PO and THO1. The variables of this experiment were ‘locus' as the independent variable and ‘allele number' as the dependent variable. This experiment conducted a paternity tests to 8 samples in which the subjects were siblings; the test was administered on the CSF1PO and TH01 loci. Results: This experiment displayed similar allele numbers on the same locus, both in 50% and 100% allele numbers; the research showed similarity in allele numbers of both siblings of which ¼ were inherited from the parents (for 50% allele number similarity), and ½ were inherited from the parents (for 100% allele number similarity). Conclusion: This proves that a paternity test using siblings as the closest kin (kinship analysis) can be used as an alternative if no comparison is obtained from both the parents.

‘Wanting' and ‘Liking' Brain Mechanisms in Coaching: A qEEG Study using the CARE Coaching Model Puspa, Lyra; Ibrahim, Nurhadi; Brown, Paul T.
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Coaching has become increasingly popular for leadership development and behavioral change in organizations. Recent studies suggest that motivation is essential in enhancing the effectiveness of workplace coaching. A number of studies revealed that delta and beta-gamma oscillations are associated with the human motivational process through ‘wanting' and ‘liking' mechanisms. However, the brain mechanisms of motivation in coaching have not been studied. This preliminary study is the first attempt to explore the ‘wanting' and ‘liking' mechanism of coaching, by investigating the activity of the delta and beta oscillations during a face-to-face coaching session through quantitative electroencephalogram (qEEG).Methods: Six male, right-handed, middle managers of an organization (mean age = 31.6) were recruited voluntarily as participants. A multichannel EEG (19 electrodes, 10/20 System) was used to record brain activity in both the resting state and the continuous 45-minute coaching session whilst using the CARE Model. The artifact-free EEG data were then quantified using wavelet analysis to obtain induced band power. Results: Significant increase was shown in delta and beta-gamma activities throughout the coaching session. Increased delta absolute power was found in the frontal, parietal, and occipital regions, whilst increased beta-gamma activity was significantly detected in the frontal, posterior temporal, and occipital regions. Conclusion: This preliminary result suggests that coaching, with regard to the CARE Model, induces both ‘wanting' and ‘liking' mechanisms simultaneously. Thus, the present findings provide the first preliminary neuroscientific underpinnings of the role of motivation in enhancing the effectiveness of workplace coaching through induced ‘wanting' and ‘liking' mental processes.

Profile of Acute Pharyngitis at Dr. Soetomo General Hospital Pediatric Outpatients Clinic in 2013 Amanda Trilana; Dwi Susanti; Satrio Boediman
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Acute Pharyngitis remains a common health problem in the world, especially in developing countries andmostly infects children. Around 6,2 to 9,7 million children worldwide went to clinics and emergency department with pharyngitis. This study aims to find the characteristic of acute pharyngitis in childen at Dr. Soetomo Hospital Surabaya.Methods: This study was a cross sectional, using medical records of acute pharyngitis patients in pediatric outpatient clinic. Data collected based on age, sex, chief complaint, additional complaints and clinical signs.Results: Total samples were 92 patients with sex proportion of 48 males (52,2%) and 44 females (47,8%). Based on age, mostly at 0 – 3 years old (68,4%). The most common chief complains were fever, followed by cough and sore throat for 55,4%, 28,2% and 16,4% respectively. Based on additional complain, 56,5% still has good appetite. Based on clinical signs, hyperemic pharyngeal was 91,3% and lymph nodes enlargement was 8,7%.Conclusion: Acute pharyngitis mostly infected toddler characterized with fever, and hyperemic pharyngeal as a clinical sign.

Anti-eczema Mechanism of Action of Nigella sativa for Atopic Dermatitis: Computer-aided Prediction and Pathway Analysis Based on Protein-chemical Interaction Networks Widyaswari, Meidyta Sinantryana; Noventi, Iis; Supriyana, Herdiantri
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.

Back Matter Volume 1 No. 2, 2018 Back Matter
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v1i2.20371

Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models Vania Azalia Gunawan; Harlina Soetjipto; Arifa Mustika
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19129

Introduction: Diabetes mellitus is a degenerative disease characterized by chronic hyperglycemia conditions in the body. Various complications of diabetes mellitus are caused by oxidative stress condition. Petiveria alliacea (P. alliacea) is a potential plant and easy to grow in hot regions. Leaf extracts of P. alliacea contain flavonoids and tannins which work as antidiabetic and antioxidant. In addition, other compounds found in P. alliacea leaf extracts like linoleic acid and allantoin show an increase in insulin secretion. Therefore, this study aimed to determine the antidiabetic activity of ethanolic extract of P. alliacea. Methods: We investigated the hypoglycemic and antioxidant effect of P. alliacea on STZ-induced diabetic rats. Rats were randomly divided into six groups named normal control, diabetes control, metformin (150 mg/kg/d), low dose of P. alliacea (90 mg/kg/d), intermediate dose (180 mg/kg/d), and high dose (360 mg/kg/d). Rats were orally given the treatment daily in the morning for fourteen days. At the end of the study, blood glucose level was measured and rats were sacrificed to measure blood malondialdehyde level.malondialdehydeResults: P. alliacea extract dose of 90 mg/kg and 360 mg/kg, and also metformin significantly decrease blood glucose levels. P. alliacea extract dose of 360 mg/kg was able to lower blood malondialdehyde level significantly which were not obtained on metformin. Conclusion: This finding suggests that ethanolic extract of P. alliacea possess antidiabetic effect at least on rats.

Front Matter Volume 3 No.1, 2020 Front Matter
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.20376

Challenging Therapy In Pregnant Woman With Systemic Lupus Erythematosus (SLE) and Chronic Hepatitis B Choirina Windradi; Awalia Awalia
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19198

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that attacks various body systems, especially in women of reproductive age. Therefore, patients who are planning a pregnancy or are pregnant need to assess the risk and predicts of disease activity during pregnancy. The most common complications of SLE in pregnancy are SLE disease activity, preterm delivery, preeclampsia and preganancy loss. Here, we report a pregnant SLE patient with co-infection hepatitis B. As the consequence of treated with immunosuppressant agent, both disease progression and immunosupressant agent can lead to severe infection. Furthermore, perinatal transmission is the most common form of transmission of hepatitis B. Finally, proper management could save mother and newborn.

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Muhammad Miftahussurur

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Kota surabaya,

Jawa timur

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Muhammad Miftahussurur

Contact Email bhsj@journal.unair.ac.id

Phone -

Journal Mail Official bhsj@journal.unair.ac.id

Editorial Address -

Location Kota surabaya, Jawa timur INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
-

Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA