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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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KAJIAN KELUARGA tHALAssEMIA b-HEMOGLOBIN E Nurul A; Adi K Aman; Ratna A G
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.911

Abstract

HbE-b thalassemia is an inherited hemoglobin disorder of gene combination b thalassemia and HbE. It is caused by thalassemia and hemoglobinopathy gene,which acting as the allele in the same locus of chromosome. The clinical presentation is more severe than HbEhomozygote and almost similar to b thalassemia major. This disease is found predominantly in South East Asia, including Indonesia.The family study is very needed in order to genetic screening to prevent hemoglobinopathy and thalassemia homozygote. The objective ofthis study is to know the pedigree from the daughter who suffer from HbE- b thalassemia which is taken care in the children ward at H.Adam Malik Top Refferal Hospital, Medan. The family study was also done to both father and mother, one sister and to both grandparent.An examination was carried ,which include physical examination, complete cell blood count, peripheral blood morphology, hemoglobinanalysis with Hb-electroforese pH 8.5 agarose medium and read with densitometri, and osmotic fragility examination. From the familystudy was found that her father suffer from HbE heterozygote while the mother suffer from b thalassemia trait and sister got HbE- bthalassemia. The father and mother have no relative acceptance and there is no any blood linkage. Her grandparent could not performthe blood sample because they were have already passed away .
KLONING DAN OVEREKSPRESI PROTEIN P24-GAG HIV (Cloning and Overexpression P24-Gag of HIV) Efrida Efrida; Andani Eka Putra
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1218

Abstract

HIV diagnosis is confirmed by viral culture, but this process takes a long time. Another method used to detect HIV-specific antigensor antibodies is by immunoassay. Generally, antigen-antibody based methods are used as a screening test. Based on the stability ofthe sequences found in the first (1) study year, the researchers designed this study for the production of p24 recombinant protein.These proteins will be developed as diagnostic markers based on sero-immunology technique. The aim of this study was to know theconstruction and over expression of protein p24gag from local isolates and analysis of the diagnostic potential of doing design specificprimers against p24gag protein, cloning and over expression of the gene, as well as to obtain a p24 protein that has been purified.This research results will be applied later to develop a method based on local isolates of HIV diagnosis. This research was a descriptivestudy, conducted over seven (7) months in the Biomedical Laboratory of the Faculty of Medicine, Andalas University and Departmentof Clinical Pathology, Dr. M. Djamil Hospital, Padang. This study was carried out by using samples of local isolates originating fromthe first year of research. Stages of the research were: 1) the design of primers for cloning, amplification and sequencing, 2) cloninginto pDEST and pENT, 3) transformation of the target gene, 4) detection of fragment insertions, 5) protein expression and proteinanalysis by SDS-PAGE, immunoblotting and 6) purification. The conclusions of this study were: the design of specific primers againstp24gag protein used fragments attb1, attb2, Shine Delgano and Kozac effective for protein expression. The results showed that thepresence of protein 24kDa expression was identical to HIV p24gag protein. Further research needs to be conducted to identify potentialimmunological target protein.
APO B/APO A-I RATIO IN PATIENTS WITH STENOSIS CORONARY HEART DISEASE GREATER OR LESS THAN 70% Dedi Ansyari; Tapisari Tambunan; Harris Hasan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1198

Abstract

Penyakit kardiovaskular adalah salah satu penyebab terbesar kematian di dunia, termasuk di Indonesia. Salah satunya adalahpenyakit jantung koroner yang disebabkan adanya aterosklerosis. Perlu adanya petanda pengganti proses aterosklerosis sebagai faktorkebahayaan dan sebagai peramal aterosklerosis dan PJK. Apo B dan rasio Apo B/Apo A-I dianggap sebagai petanda yang terbaik. Tujuanpenelitian untuk mengetahui rasio Apo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70% dan lebih kecil 70%.Metode penelitian dengan potong lintang di 69 pasien PJK, yaitu 46 pasien PJK dengan stenosis lebih besar atau sama dengan 70% dan23 pasien PJK dengan stenosis lebih kecil 70% di Departemen Kardiologi FK. USU/RSUP H. Adam Malik Medan bekerja sama denganDepartemen Patologi Klinik FK. USU/RSUP. H Adam Malik Medan masa waktu Juli 2015 sampai dengan November 2015. Hasil telitiandidapatkan kadar Apo B di pasien PJK dengan stenosis lebih besar atau sama dengan 70% adalah 115,63±30,96 dan pasien PJK denganstenosis lebih kecil 70% adalah 96,43±25,62 dengan nilai p=0,013. Kadar Apo A-I di pasien PJK dengan stenosis lebih besar atau samadengan 70% adalah 148,30±26,80 dan pasien PJK dengan stenosis lebih kecil 70% adalah 173,74±32,33 dengan nilai p=0,001. RasioApo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70% adalah 0,79±0,20, rasio Apo B/Apo A-I di pasienPJK dengan stenosis lebih kecil 70% adalah 0,55±0,14 dengan nilai p=0,0001. Dari hasil telitian dapat disimpulkan, bahwa terdapatperbedaan bermakna kadar Apo B, Apo A-I serta rasio Apo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70%dan pasien PJK dengan stenosis lebih kecil 70%.
AKTIVITAS SGOT, SGPT DI PENDERITA LUKA BAKAR SEDANG DAN BERAT Sri Nurul Hidayah; Mutmainnah .; H. Ibrahim Abd. Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.942

Abstract

Burn injury is a kind of trauma with the high mortality and morbidity rate that needs special treatment since the very first phaseup to the end. this study targeted medium to severe burns, limited to liver complications. the objective of this study is to calculate andobserve the difference Sgot, SgPt activities in medium and severe burns. the Methods of this study was Cross Sectional, we conductedon 42 subjects with medium to severe burns, Hospitalised during the period of June 2005 to May 2007 at DR.Wahidin Sudirohusodohospital of Makassar. the data were calculated and statistically analysed using the SPSS V.11.5. We obtained of 12 (28.6%) mediumburn injuries and 30 (71.4%) severe burn injuries. In medium burn subjects the got showed normal activities in 6 subjects (50%) andhigh activities in 6 subjects (50%), the gPt showed normal activities in 8 subjects (66,7%) and high activities in 4 subjects (33.3%).In severe burn subjects the got showed normal activities in 6 subjects (20%) and high activities in 24 subjects (80%), the gPt showednormal activities in 13 subjects (43.3%) and high activities in 17 subjects (56.7%). there was no significant difference in the increasingactivities of Sgot and SgPt in either medium or severe burns, where p > 0.05. Increased activities of SgPt and Sgot was higher insevere burns than in medium ones. It was also obtained that increasing Sgot activities was found more often than SgPt in patientswith either medium or severe burns.
LEUKEMIA SEL PLASMA Wiwin H; DB. Hadiwidjaja
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.874

Abstract

A woman 40 years old, with pathologic fractures confirmed by radiological examination. She has a history of chronic bone painin her leg and pelvis. Laboratory examination reveals classical data of multiple myeloma, but with increased plasma cell leukemia inperipheral blood. It is necessary to differenciate plasma cell leukemia with multiple myeloma especially in high degree proliferatingterminal stage. Recommendation for a new method ie flowcytometry immunophenotyping has been proposed for hemato-oncology.
ANALYSIS OF BLOOD UREA NITROGEN/CREATININ RATIO TO PREDICT THE GASTROINTESTINAL BLEEDING TRACT SITE Arfandhy Sanda; Mutmainnah Mutmainnah; Ibrahim Abdul Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1162

Abstract

Perdarahan saluran cerna merupakan keluhan pasien yang sering dijumpai dalam keseharian dan untuk penatalaksaannyadilakukan dengan menentukan lokasi perdarahan dan gejalanya. Berdasarkan lokasi perdarahan saluran cerna dibagi menjadi duayaitu perdarahan saluran cerna atas (SCBA) dan perdarahan saluran cerna bawah (SCBB), sedangkan gejala perdarahan dibagi menjadi3 yaitu hematemesis (muntah darah segar), melena (feses kehitaman) dan hematokezia (perdarahan lewat anus berwarna merah terang).Data penggunaan rasio BUN/kreatinin untuk menentukan lokasi perdarahan saluran cerna di Indonesia masih kurang sehingga penelititertarik untuk meneliti analisis rasio BUN/kreatinin untuk meramalkan lokasi perdarahan pada saluran cerna dengan tujuan untukdiagnosis dan penatalaksanaan yang lebih cepat. Penelitian ini dilakukan untuk meramalkan letak perdarahan saluran cerna yaituSCBA atau SCBB pada pasien rawat inap di RSUP Wahidin Sudirohusodo masa waktu Januari-Desember 2014. Penelitian dilakukansecara potong silang dengan menggunakan uji t-tidak berpasangan untuk menentukan kenasaban rasio BUN/Kreatinin dengan lokasiperdarahan saluran cerna. Selama masa waktu Januari-Desember 2014 diperoleh data sebanyak 144 pasien perdarahan saluran cernadengan perdarahan SCBA sebanyak 64 pasien (44%), serta perdarahan SCBB 80 pasien (56%). Pada perdarahan SCBA, nilai rerataBUN 33,2 mg/dL, nilai rerata kreatinin 1,06 mg/dL, dan rerata rasio BUN/Kreatinin 32. Terdapat kenasaban yang bermakna antaralokasi perdarahan saluran cerna dan nilai rasio BUN/kreatinin (t=6,394; p=0,001). Pasien dengan perdarahan saluran cerna bagianatas memiliki rasio BUN/kreatinin lebih tinggi dibandingkan dengan pasien dengan perdarahan saluran cerna bagian bawah.
PERBEDAAN BERMAKNA KADAR SERUM AMILOID A ANTARA STENOSIS KORONER DIBANDINGKAN BUKAN STENOSIS KORONER (Significantly Higher Level of Serum Amyloid A Among Coronary Stenosis Compared to NonStenosis) I Nyoman G Sudana; Setyawati Setyawati; Usi Sukorini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1273

Abstract

Coronary stenosis is one of the major causes of death from heart disease. The gold standard of coronary stenosis diagnosis isestablished with angiography, however it is invasively, complicated and expensive. Serum Amyloid A (SAA) is an acute phase proteinthat appears as chronic and acute inflammatory agent that is specific to the process of stenosis development. Serum Amyloidal A testmethod is noninvasive, relatively easy and affordable. The aim of this study was to know the differences of Serum Amyloid A levelsin patients with nonstenosis and coronary stenosis in Dr. Sardjito General Hospital Yogyakarta by determination. The study is a casecontrol study. The samples were selected consecutively with typical chest pain, were divided into two (2) groups of nonstenosis andstenosis by coronary angiography test. The principal of the Serum Amyloid A test is ELISA method. Nonstenosis and coronary stenosisgroups were analyzed by mean of Serum Amyloid A level based on the angiography test. The data were analyzed with Independentt-test, odds ratio with a significancy of p <0.05 and confidence interval 95%. The samples of this study consisted of 60 patients, dividedinto nonstenosis and coronary stenosis. The analysis of Independent t tests showed significant differences between the subject SAA levelsof nonstenosis and stenosis (4.35 ug/mL vs 21.75 mg/mL, p=0.001, with an odds ratio 9.84 (CI 95% 2.38 to 40.73). Based on thisstudy, it can be conclued that the results indicate significantly higher level of Amyloid A Serum among the coronary stenosis comparedto the nonstenosis.
PRIMARY MYELOFIBROSIS Muhammad Irhamsyah; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1518

Abstract

 A 55-year-old male was admitted to hospital with chief complaint of abdominal distention since one year before admission, and it became more prominent than before. The physical examination showed splenomegaly with schuffner line S5, and it was confirmed with ultrasonography. The routine blood test showed a hemoglobin level of 9.2 g/L, leukocyte count of 14.690/µL and thrombocyte count of 115 x 103/µL. From the peripheral blood smear results, the suspected diagnosis of chronic myeloid leukemia with differential diagnosis of a leukemoid reaction was made. However, bone marrow aspiration revealed hypoplastic marrow of primary myelofibrosis. The patients with primary myelofibrosis need early diagnosis and treatment to manage the symptoms of splenomegaly, stop fibrosis process and extramedullary hematopoiesis. Early treatment, in this case, can decrease poor prognosis and mortality rate.
EKSPRESI KORESEPTOR HUMAN IMMUNODEFICIENCY VIRUS CCR5 DAN CXCR4 PADA SUBSET SEL LIMFOSIT T SERTA MONOSIT Agnes Rengga Indrati; Hinta Meijerink; Herry Garna; Bachti Alisjahbana; Ida Parwati; Reinout van Crevel; Andre van der Venn
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1012

Abstract

Chemokine receptors CCR5 and CXCR4 which lied on lymphocyte cell surface play important role in HIV infection and pathogenesis.The expression of these chemokine receptors will affect progressively the disease. The objectives of the study are to find the distributionof lymphocyte T cell subset and monocyte among the peripheral blood mononuclear cells and to know the determination of CCR5 andCXCR4 co receptors expression on T lymphocyte cells subset and monocyte. This study is a preliminary study to explore the distributionof co receptors CCR5 and CXCR4 expression in healthy people. The sample taken is peripheral blood mononuclear cells (PBMC) fromhealthy subjects. The identification of T lymphocyte cells subsets and monocyte, and the expression of CCR5 and CXCR4 co receptorswere determined using flowcytometry. The memory T cell (CD4+CD45RO) is found to be the largest proportion among T lymphocyte cell(66.2%), whereas the other T lymphocyte cell subset, regulatory T cell, which identified by CD25+ high expression was found between2.0-5.3% from the whole T lymphocyte cell. The proportion of CXCR4 co receptors was found higher compare to CCR5 co receptorson all T lymphocyte subsets and monocyte. Only small proportion of monocyte expresses both co receptors (2.85%), but most of the Tlymphocyte cell expressed both CCR5 and CXCR4. The expression of the CXCR4 on regulatory T cell (18.18%) is the lowest compared toother cells, but the fluorescence intensity of both co receptors was very high (CCR5 53.53 and CXCR4 49.33). The different distributionof CCR5 and CXCR4 co receptors among T lymphocyte cell subsets and monocyte will influence the vulnerability and the pathogenicityof HIV infection.
CHRONIC MYELOID LEUKEMIA IN PREGNANCY Rosa Dwi Wahyuni; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1338

Abstract

Chronic Myeloid Leukemia (CML) is one of leukemias characterized by abnormal growth of myeloid cells in bone marrow. The Philadelphia chromosome is diagnostic parameter for CML. This chromosome is t(9;22) (q32;q21), a translocation chromosome 9 and 22 relocates a portion of proto-oncogene c-ABL from chromosome 9 to BCR on chromosome 22. Chronic myeloid leukemia consisting of three phases; Chronic, Accelerating and the Blast crisis phase. The clinicaling symptoms of CML are hypercatabolism, splenomegaly, anemia, bruising and sign of Gout. Chronic myeloid leukemia in pregnancy shows a better prognosis than acute leukemia in pregnancy. Chronic myeloid leukemia has the risk of leukocytosis which can lead to uteroplacental insufficiency giving rise to various consequences: fetal growth retardation and perinatal mortality. Moreover, the therapy of CML should be carefully administered considering the fetal effects.  Both sexes have the same risk, mostly in the range of 40 to 60 years old. In this case report, a 38-year-old pregnant female (G1P0A0) with 37 weeks of gestational age was diagnosed as CML on August 2013 and was treated with 500 mg of Cytodrox/Hydroxyurea twice to three times a day until January 2014. Laboratory evaluation on November 10th, 2014, showed leucocytes 449500/µL, erythrocytes 2.58.106/µL, hemoglobin 8.0 g/dL, thrombocytes 437,000/µL and hematocrit 23%. The peripheral blood smear showed normocytic normochromic erythrocytes, anisocytosis, ovalocytes, significantly increased leucocyte count, predominance polymorphonuclear series, all maturation series of myelocytes, 7% myeloblast, normal thrombocyte count and morphology. Based on these evaluations, the patient was diagnosed as CML. The evaluation of Neutrophil Alkaline Phosphatase (NAP) scored 1.

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