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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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PENGGUNAAN ANTIBIOTIKA BAGI PENDERITA BALITA PNEUMONIA DAP. Rasmika Dewi; Dewa Ayu Swastini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1037

Abstract

Pneumonia is a major cause of morbidity and mortality of children under 5 years old (toddlers). The number of antibiotics use as a therapeutic treatment of pneumonia has caused bacterial resistance, medicinal side effect, and increasing medication cost. Thisresearch was carried out intended to know the relationship between antibiotic regimens used for pneumonia therapy and the outcome ofparameters, such as body temperature and respiratory rate (RR), as well as the length of stay. This study is carried out in a retrospectivedescriptive design, using pneumonia patient’s medical record (children under 5 years old), during the period from the 1December 2008. It was shown in this study that the dose of antibiotics given to pneumonia children under 5 years old are in single,combination, and transition form. The single antibiotics most widely used is Cefotaxime (87.5%), and the combination is Ampicillin–Chloramphenicol (94.4%) while transitional is Ampicillin –Chloramphenicol to Cephalosporin group (58.3%). The use of antibiotics forpneumonia among children under five patients either single, combination, and transition was successful in obtaining therapy outcome,including decreasing body temperature from > 38° C to normal body temperature, is 36° C–38° C and decreasing RR value with theaverage length of stay for five (5) days. st January – 31st
NILAI RUJUKAN SOLUBLE TRANSFERRIN RECEPTOR (sTfR) {(Soluble Transferrin Receptor Refence Value (sTfR)} Anggraini Iriani; Endah Purnamasari; Riadi Wirawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1268

Abstract

Iron in plasma is carried by transferrin delivered to cells through the interaction with a specific membrane receptor, namelytransferrin receptor. The soluble transferrin receptor (sTfR) is a transferrin receptor monomer which lost its first 100 amino acids, andcirculates in the form of transferrin and its receptor complex. Erythroblasts and reticulocytes are the main source of serum TfR Theconcentration of sTfR in serum is useful to diagnose iron deficiency, especially for patient with chronic disease. A new parameter sTfRis reported to be a surrogate marker of bone marrow iron store. The sTfR concentration can describe the functional iron status whileferritin reflects the iron storage status. The aim of this study was to know a reference interval of sTfR in normal adults by provision.Subjects were 157 healthy adults from clinical medical check up who had met the inclusion criteria and were willing to participate asresearch subjects. Soluble Transferrin Receptor (sTfR) examination was performed using reagents from Roche. The statistical calculationswere performed by SPSS 22. The results showed that there was no significant difference between sTfR levels in men and women as wellas in the age group ≤40 years and >40 years. The STfR reference value in this study was calculated based on 95% CI (X±2SD), is0.197–0.598 mg/dL. It can be concluded that the sTfR reference value is 0.197–0.598 mg/dL.
THE RELATIONSHIP BETWEEN NITRIC OXIDE AND GLYCEMIC CONTROL IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS IN THE ADAM MALIK HOSPITAL MEDAN Yessy Suziarty; Ratna Akbari Ganie; Santi Syafril
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1513

Abstract

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. Hyperglycemia and other metabolic changes can cause Nitric Oxide (NO) production disturbance. This study investigated the difference in the levels of NO and its’relationship with HbA1c in controlled and uncontrolled diabetes mellitus type 2 patients in the Adam Malik Hospital. This study was a cross-sectional study, conducted in Outpatient Clinic and Inpatient Ward of Internal Medicine Section of Endocrinology in the Adam Malik Hospital on June through October 2016, involving 70 patients type 2 Diabetes Mellitus (DM) consisting of 35 controlled type 2 diabetes patients and 35 uncontrolled type 2 diabetes patients that fulfill this study’s criteria. Nitric Oxide examination conducted by using Chemwell analyzer with the principle of double-antibody sandwich using Enzyme-Linked Immunosorbent Assay (ELISA). There was no significant relationship between HbA1c and Nitric Oxide in patients with controlled (r = 0.264) (p = 0.125) and uncontrolled (r = 0.194) (p = 0.265) type 2 diabetes mellitus. But there was a significant relationship between HbA1c and NO in patients with type 2 DM (r = 0,636) (p = 0.0001). In this study, there was no significant association between HbA1c and Nitric Oxide levels in patients with controlled and uncontrolled type 2 diabetes mellitus. There is a statistically significant relationship between HbA1C and NO in patients with type 2 diabetes.
DIAGNOSIS FILARIASIS BERDASAR HAPUSAN DARAH TEPI H. I. Malewa; Prihatini .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.951

Abstract

Filariasis is a disease group affecting humans and animals caused by nematode parasites of the order Filariidae, commonly calledfilariae. Filarial parasites may be classified according to the habitat of the adult worms in the vertebral host. the lymphatic groupincludes Wucheria bancrofti, Brugia malayi and Brugia timori. the cutaneous group includes Loa-loa, onchocerca volvulus, andMansonella streptocerca. the body cavity group includes Mansonella perstans and Mansonella ozzardi. these parasites are transmittedto humans through the bite of an infected mosquito. Clinical findings vary from asymptomatic until severe, depending on geography,parasite species, immune response and intensity of the infection A 19-years-old Javanese woman, presented with oedema on right legs.She has been suffering from oedema on right leg since she was 7-years-old. Physical examination showed elephantiasis on the right leg.Early, the patient had swelling in right inguinal area spreading into her right leg. the oedema was persistent and become larger untilnow. there was no fever and pain. She had history living in South Borneo when she was 1 until 4 years old. She did not receive anymedication before. Laboratory examination showed no abnormality both of complete blood count and clinical chemistry. From thin bloodsmear examination many forms of microfilariae were found. the data showed manifestation of filariasis in the blood.
RAGAMAN GENETIK GEN POLIMERASE VIRUS HEPATITIS B PADA PASIEN HEPATITIS B KRONIK DENGAN PENGOBATAN TELBIVUDIN Gondo Mastutik; Juniastuti Juniastuti; Ali Rohman; Mochamad Amin; Poernomo Boedi Setiawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1097

Abstract

Infection caused by hepatitis B virus (HBV) is still a major global health problem and can cause liver cirrhosis and hepatocellularcarcinoma as well. Telbivudine is one among the drugs used to treat the disease routinely. However, using this drug in a long term therapymight cause mutations in HBV polymerase gene that decreases the effectiveness of the therapy. Here with the researchers report the geneticvariations of the gene isolated from telbivudine-which is used treated chronic hepatitis B patients in Surabaya, Indonesia. The blood serawere collected at Dr. Soetomo hospital from 10 telbivudine-treated and 10 untreated chronic hepatitis B patients. The DNA viral wasisolated and purified from each serum. Sequence polymerase gene at nucleotides 455 to 796 was amplified by PCR, and then analyzedbio informatically to determine their mutation profile. This study revealed a point mutation in HBV25 sample at nucleotide A1525G thatgives rise to I509V modification. Such mutation is also observed in a sequence that is available in Gen Bank with an accession numberAY641562. Additionally, the researchers found point mutations A1554G, T1593C, and C1629T in HBV25 sample and a point mutationA1554G in HBV20 sample. However, these mutations are silent. To conclude, the mutation in HBV polymerase gene among telbivudinetreatedchronic hepatitis B patients in Surabaya is known as A1525G.
GEJALA RUBELA BAWAAN (KONGENITAL) BERDASARKAN PEMERIKSAAN SEROLOGIS DAN RNA VIRUS Kadek Kadek; S. Darmadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 2 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i2.885

Abstract

Rubella infection with occurs during pregnancy, especially during the first trimester often caused by Congenital Rubella Syndrome(CRS). CRS can resulting abortions, miscarriages, stillbirth, and severe birth defects. The baby diagnosed with CRS when characterizedby signs or symptoms from the following two categories A (Cataracts/congenital glaucoma, congenital heart disease (most commonlypatent ductus arteriosus or peripheral pulmonary artery stenosis), loss of hearing, pigmentary retinopathy) or one categorie A andone catagorie B (Purpura, splenomegaly, jaundice, microencephaly, mental retardation, meningoencephalitis, radiolucent bone disease.Laboratory confirmation can be obtained by any of the following: virus isolation, serologi test (pasif hemaglutination, latex agglutinationtest, hemaglutination inhibisi, Flouresence immunoassay, Enzyme immunoassay), RNA test.
IDENTIFIKASI BAKTERI AEROB GRAM NEGATIF DAN GRAM POSITIF MENGGUNAKAN METODE KONVENSIONAL DAN OTOMATIK Patricia M. Tauran; Irda Handayani; Nurhayana Sennang
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1065

Abstract

Choosing the method of bacteria identification is crucial to obtain accurate and quick results. This study will analyze the identificationresults of Gram negative and Gram positive from aerobic bacteria by examination using conventional and automatic methods at Dr.Wahidin Sudirohusodo Hospital Laboratory. A total of 85 samples consisting of 66 Gram negative bacteria and 19 Gram positive bacteriawere identified using conventional and automated methods. In this study, there was some correspondent identification result betweenthe conventional as well as the automated methods, namely 31.5% for Gram negative bacteria and 30.8% for Gram positive bacteria.However, the non-correspondent identification result between conventional and automated methods was found greater, namely, 68.5%for Gram negative bacteria and 69.2% for Gram positive bacteria. The non-correspondent identification result was due to the developmentof bacterial taxonomy and the differences of numbers and types of the biochemical tests between conventional and automatic methods.Bacteria identification using automated method is more accurate and faster than the conventional method, so it is recommended usingthis particularly for the laboratory and educational referral center.
MOLECULAR PATHOLOGY OF CEREBROVASCULAR ATHEROSCLEROSIS Marsetio Donosepoetro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.835

Abstract

Cerebrovascular disease are the third most common cause of death in Western countries. The most frequent manifestation of disease is a sudden episode of neurological deficit termed stroke which is the result of cerebral haemorrhage or cerebral infaction in the mayority of cases. Stroke secondary to atherosclerosis is most common in people over 50 years old.The incidence of stroke rises dramatically with ages, with the risk doubling with each decade after 35 years old. About 5 % of people over 65 years old have at least one stroke. Atherosclerosis is condition where fatty acid deposits occur in the inner lining of arteries and the forming of atherosclerotic plaque,a mass consisting of fatty deposit, and blood platelets.The plaque may obstruct or my trigger clot,a trombus,at that location causing cerebral trombosis.It is called ischemmic stroke. The basis of the response to injury hypothesis introduced by Russel Ross is that the earliest cellular events that occur during atherosclerosis is a specialized type of chronic inflammatory response to cell injury. What may begin as a protective inflammatory reponse can become excessive and deleterious to the cell of the artery wall. The adhesion of leucocytes on endothelial cells and their trans –endothelial migration into intima are mediated by adhesion molecules on the endothelial cell membrane that mainly belong to two protein families:the selectin and the addhesion molecules.
PENETAPAN TARIF PEMERIKSAAN LABORATORIUM PATOLOGI KLINIK BERDASARKAN METODA JAROS ML Maria I; Diah P; Tahono .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1030

Abstract

A hospital as an institution of public health assistance expected to extend comprehensive service and complex appropriate around public demand, capable of sophisticated laboratory examination with achievable cost. To be successful in the financial management of thelaboratory, we must be able to identify and categorize costs, understand the relationship between revenue and reimbursement, becomefamiliar with the budget process and use financial ratios and information to make sound decisions. Cost per test laboratory examinationsare needed to determine the real costs, cost information, and to appraise examination efficiency and budget. Laboratory costing per testbased on Jaros ML method demonstrates various ways to determine the cost of a test and how to establish its charge. The greater thedemand laboratory tests per month, the lower the cost per reportable result (CPRR) and the greater the efficiency of laboratory test.
T-CD4+ DAN PROFIL LIPID DI HIV (T-CD4+ and Lipid Profile in HIV) Yulia Hayatul Aini; Coriejati Rita; Agnes Rengga Indrati; Rudi Wisaksana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1259

Abstract

Human Immunodeficiency Virus (HIV) infection patients are often reported to be associated with changes of lipid metabolism.A previous study suspected that there was a correlation between low CD4+ T-lymphocyte counts with the lipid profile in HIV-infectedpatients. The objective of this study was to know the assessment of the lipid profile (total cholesterol, HDL, LDL and triglyceride) inpatients with HIV infection and their correlation with CD4+ T-Lymphocyte count. This study was conducted at the Hasan Sadikin Hospital,Bandung using retrospective data, and analysis method as the study design. The study was performed on 402 HIV-infected patients.A significant difference was found in all lipid parameters between patients with and without ART (p<0.05). Weak correlations werefound between CD4+ T-Lymphocyte with total cholesterol and HDL levels (r<0.04), and a very weak correlation as well with the LDLlevel (r<0.2). There was no correlation with the triglyceride levels (p=0.751). The lipid profile showed a weak correlation with CD4+T-Lymphocyte, therefore, it can not be used as a parameter to know the severity of disease relating to the HIV infection. However, it canbe useful for monitoring the metabolic effect of the given therapy, because there was a significant difference between those patients withand without ART.

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