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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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ESTIMATED BLOOD LOSS IN OPEN HEART SURGERY (Taksiran Kehilangan Darah di Bedah Jantung Terbuka) Riesti Ekasanti; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1232

Abstract

Taksiran kehilangan darah merupakan perkiraan kehilangan darah di setiap tindakan pembedahan. Permintaan darah untukpersiapan pembedahan elektif sering tidak sesuai dengan jumlah darah yang ditransfusikan selama tindakan tersebut karena belum adapanduan mengenai jumlah permintaan darah untuk tata langkah bedah. Penelitian ini bertujuan untuk mengetahui taksiran kehilangandarah pada pembedahan jantung terbuka dan kesesuaian dengan permintaan darah dalam kegiatan tersebut. Penelitian dilakukan secaraobservasional retrospektif seraya mengambil data rekam medis di Instalasi Rekam Medik RSUP dr. Wahidin Sudirohusodo Makassarantara bulan Januari 2009−Desember 2012. Sebanyak 32 pasien yang menjalani bedah jantung terbuka didapatkan dengan presentasilaki-laki sebanyak 22 pasien (68,75%) dan perempuan sebanyak 10 orang (31,25%). Jumlah taksiran kehilangan darah bedah jantungterbuka rerata 2,80 kantong darah lengkap (980 mL) dan permintaan darah untuk kegiatan tersebut rerata sebanyak 4,00 kantong(1400 mL). Antara jumlah permintaan darah persiapan bedah dan taksiran kehilangan darah (p=0,149) terdapat ketidaksesuaian.Taksiran kehilangan darah di bedah jantung terbuka di RSUP dr. Wahidin Sudirohusodo Makassar di RSUP dr. Wahidin SudirohusodoMakassar adalah 2,80 kantong darah lengkap (980 mL), yang tidak sesuai dengan jumlah permintaan darah persiapan bedah.
POLA KETAHANAN (RESISTEN) DAN KEPEKAAN (SENSITIVITAS) KUMAN TERHADAP ANTIMIKROBA Y F Tallulembang; Nurhayana Sennang; Benny Rusli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.958

Abstract

In the developing countries including Indonesia, there still have problems with infectious diseases. Generally the hospitalized patientsin the Surgery section through have antimicrobial therapy. The treatment is intended to prevent nosocomial infection that usually foundin overnight treatment patients at the department of surgery. This study is carried out to know the pattern of micro-organism’s resistanceand sensitivity against various antimicrobial at department of surgery, Dr. Wahidin Sudirohusodo Hospital Makassar, January–June2008. A descriptive study of retrospectively collective data was carried out on 160 specimens by sensitivity test at the department ofsurgery, Dr. Wahidin Sudirohusodo Makassar Hospital, started from January up to June 2008. The five common bacterial found in thisstudy where Staphylococcus epidermidis, Klebsiella pneumonia, Enterobacter agglomerans, Staphylococcus saprophytic and Escherichiacoli. The sensitive antimicrobial drugs found where Vancomicin, Sulbactam/Cepoperazone, Cefepim, Gentamicin, Ceftazidim, Novobiocin,followed by the resistance antimicrobial were Methicillin, Tetracycline, Cefuroxim, Erythromycin, and Doxyciclin. The most bacterial typefound was Klebsiella pneumoniae, the most sensitive antimicrobial was Vancomicin and the most resistances were Methicillin.
POLA KUMAN BERDASARKAN SPESIMEN DAN SENSITIVITAS TERHADAP ANTIMIKROBA Rostina Rostina; B Rusli; M Arief; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.890

Abstract

High prevalence of infectious diseases in Indonesia lead to the use of uncontrollable anti microbial treatment with less concern todrug resistance, marked with fewer requests for sensitivity testing. This leads to irrational anti microbial treatment and increasing drugresistance. With unsupported condition for using a sensitivity test prior to anti microbial treatment, a common guide for choosing ananti microbial agent for infection of specific organ system is needed. A descriptive study of retrospectively collected data of sensitivity testresults was done on 841 spesimens from sources of infected organs in Wahidin Sudirohusodo Hospital of Makassar during 2005–2006periods. Objectives of this study are to know the microbial pattern of specific organ infection (represented by microbes of the specimens),antimicrobial sensitivity pattern of the microorganisms, and whether there is shifting of the pattern within a 1 year period. Shiftingof microbial patterns during 2005–2006 period was found. Klebsiella aeroginosa, Enterobacter agglomerans, Alkaligenes faecalis andEscherichia coli were the most frequent micro organisms found from spesimens examined. Most of antimicrobial drugs commonlyused were found effective to most of micro organisms, while amikacin, cefepime, gentamycin, sulbactam, tobramycin, vancomycin andmeropene were still sensitive enough to the majority of the infectious agents.
LIPID PROFILE ANALYSIS ON REGULAR AND NON-REGULAR BLOOD DONORS (Analisis Profil Lipid di Pendonor Darah Reguler dan Non-Reguler) Waode Rusdiah; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1180

Abstract

Profil lipid merupakan petunjuk untuk menilai faktor kebahayaan penyakit jantung koroner, terutama jika terdapat bukti adanyaperoksidase lipid. Beberapa laporan telah mengaitkan donor darah secara regular dengan menurunnya tolok ukur profil lipid. Donordarah secara regular akan menurunkan kadar zat besi dan pada gilirannya akan menurunkan peroksidase lipid. Penelitian ini bertujuanmengetahui kadar profil lipid di pendonor darah regular dan non-regular, menggunakan pendekatan secara potong lintang denganmengambil sampel darah di UTD Transfusi Darah Dinas Kesehatan Propinsi Sulawesi Selatan. Diperoleh sebanyak 60 sampel darah yangberasal dari donor regular 30 orang (50,0%) dan non-reguler 30 orang (50,0%). Rentang umur 18–40 tahun 27 orang (45,0%) dan41-60 tahun 33 orang (55,0%). Di telitian ini kelompok pendonor darah regular rerata memiliki kolesterol total 157,93 mg/dL dan LDL95,33 mg/dL yang lebih rendah dibandingkan dengan kelompok non-regular dan menunjukkan perbedaan bermakna secara statistik(ρ=0,001). Kadar HDL secara bermakna lebih tinggi (ρ=0,015) di kelompok non-regular 43,20 mg/dL dibandingkan dengan kelompokregular 35,50 mg/dL. Kadar Trigliserida (ρ=0,673) menunjukkan tidak terdapat perbedaan bermakna antara kelompok regular dannon-regular. Donor secara teratur dapat memberikan perlindungan terhadap penyakit kardiovaskular seperti yang tercermin dari nilairerata kolesterol total dan kadar LDL yang secara bermakna lebih rendah di pendonor darah regular daripada non-reguler.
HASIL TES LAJU ENDAP DARAH CARA MANUAL DAN AUTOMATIK N. Ibrahim; Suci Aprianti; M. Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.840

Abstract

Erythrocyte sedimentation rate (ESR) is a non specific test that describes changes in protein plasma and is useful to determine inflammatory case. ESR is determined by using manual and automatic. In big cities, automatic method is more popular now days, but in periphery area, manual method is still the choice. To find out correlation between the results of manual and automatic tests. Cross sectional study was carried out among 200 patients at dr. Wahidin Sudirohusodo Public Hospital of Makassar from September to October 2005. The data were analyzed using R-Square (R2) and regression test using SPSS 11.5. There is significant correlation (P<0.05) among vertical manual, oblique manual and automatic methods. R2 of automatic and vertical methods are 0.95 (the first one hour) and 0.94 (the second one hour), as well as the R2 of oblique and vertical methods are 0.62 (the first one hour) and 0.87 (the second one hour) respectively. There is correlation among the results of the three methods. To convert the result of automatic to vertical, an equation of vertical score = 4.32 + 1.00 (automatic score) can be used. Meanwhile, conversion of oblique score to vertical score is vertical score = 7.58 + 0.99 (oblique score).
DIFFERENCES OF LYMPHOCYTE PROLIFERATION INDEX AFTER CULTURE FILTRATE PROTEIN 10 STIMULATION IN PATIENTS WITH ACTIVE AND LATENT TUBERCULOSIS AND HEALTHY INDIVIDUALS Binar R. Utami; Betty Agustina T; Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1144

Abstract

Angka kejadian tuberkulosis di dunia semakin meningkat, akibat rendahnya ketepatgunaan vaksin BCG untuk pencegahan infeksi TB.Saat ini telah dikembangkan vaksin DNA dari protein M.tuberculosis yaitu Culture filtrate protein-10 (CFP-10) yang dapat merangsangrespons imun seluler. Tujuan penelitian ini adalah mengetahui salah satu kemampuan antigenik antigen CFP-10 pasca stimulasi CFP-10 di pasien TB aktif, TB laten dan orang sehat. Penelitian bersifat eksperimen semu (quasi experimental). Sampel penelitian adalahPeripheral blood mononuclear cell (PBMC) dari 10 pasien TB paru aktif baru, 10 TB laten RS Khusus Paru Surabaya dan 10 orangsehat. Perlakuan kultur PBMC tanpa stimulasi (pembanding), dengan Mitogen (PHA) sebagai pembanding positif dan dengan stimulasiantigen CFP-10 diinkubasi pada CO2 5% selama 5 hari. Uji proliferasi limfosit dilakukan dengan menambahkan MTT. Indeks proliferasilimfosit adalah rasio antara absorban pembanding dan absorban dengan stimulasi pada λ 560 nm. Terdapat perbedaan bermakna indeksuji proliferasi limfosit pascastimulasi CFP-10 antara pasien TB paru aktif dan orang sehat (p=0,019) dan di pasien TB aktif, TB latendan orang sehat (p=0,0356). Antigen CFP 10 mampu merangsang respons imun protektif pada pasien TB aktif, TB laten dan orangsehat. Aktivitas imunogenik antigen CFP-10 dapat dipengaruhi oleh status imun seseorang dan kemampuan antigen CFP menginduksirespons imun protektif.
ANALYSIS OF LACTIC AND HEMATOCRIT LEVELS OF BLOOD STORAGE IN DR. WAHIDIN SUDIROHUSODO GENERAL HOSPITAL BLOOD BANK Rysna Wahyu; Asvin Nurulita; Rachmawati Muhidin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1450

Abstract

The components of Packed Red Cells (PRC) are transfused to patients in order to repair oxygen transportation to tissues. The blood is stored at 2-6oC to delay red blood cells metabolism during storage. Red blood cells undergo structural and functional changes biochemically which affect their viability and function. This is a prospective cohort study with time series design. Samples were taken from fresh blood PRC which were moved to transfer bag for approximately 20 mL, then stored in the refrigerator. Lactic acid and hematocrit levels were assessed with spectrophotometry and flow cytometry methods on day 1, day 4, and day 8 of storage in the Dr. Wahidin Sudirohusodo General Hospital Blood Bank. Statistical tests used were Friedman and Wilcoxon. Statistical results are significant if p < 0.05. Total samples were 15 fresh blood PRC. Friedman statistical test showed a significant difference in lactic level (p < 0.001) and hematocrit level (p=0.012) on day 1, day 4, and day 8 of storage. Wilcoxon test showed significantly higher lactic level between day 4 and day 1 (p < 0.01); day 8 and day 1 (p < 0.01); day 4 and day 1 of storage (p < 0.01). Hematocrit level between day 4 and day 1 (p < 0.05); day 8 and day 1 (p < 0.05) were significantly higher; day 8 and day 4 of storage (p > 0.05) showed insignificant difference. Results showed that lactic and hematocrit levels of PRC stored blood were increased according to storage duration. Packed red cells blood is recommended to be given in < 6 days for lower acidosis risk. Further studies are also recommended with a shorter interval of assessment and a bigger sample size.
DIAGNOSIS TUBERKULOSIS PARU MENURUT KEKERAPAN PEMERIKSAAN DAHAK Larissa Larissa; Ida Parwati; A K Sugianli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1096

Abstract

Nowadays in Indonesia, three times (first spot-second in the morning-third spot) microscope sputum examination to find acid fastbacilli is used to diagnose pulmonary tuberculosis (TB). WHO policy (2007) recommends a reduction of sputum smears from three upto two times. The International Standards for Tuberculosis (2009) stated that the suspected pulmonary TB patients should have at leasttwo sputum specimens for microscopic examination with one early morning sputum. The aim of this study is to know whether pulmonaryTB can be confirmed only by two sputum specimen in the investigation. The subjects consist of patients who were examined three timesof their sputum at the Microbiology Laboratory of Clinical Pathology Department, at Hasan Sadikin Hospital from 2011–2012 (2 yearsperiod). This study used analytical retrospective method, with investigation agreement between the two first sputum (one of the specimenwas the morning sputum) with the third sputum using kappa coefficient and McNemar test. During the study between 2011–2012, therewere examined 3744 TB suspected patients. There is an excellent agreement (k=0.835) between the two times examination of the firstsputum and the third one. The positive possibility of the third sputum when the first two specimens were negative is only 1.7% (p=0.000).Based on this study there is an excellent agreement between the two times sputum examination with the third one. That means twosputum specimen can be used for the confirmation of pulmonary TB.
FUSI GEN BREAKPOINT CLUSTER REGION ABELSON KINASE (BCRABL) DAN UJI HEMATOLOGIS RUTIN Delita Prihatni; Ida Parwati; Rahmat Sumantri; Rully MA. Roesli; Nurizzatun Nafsi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.440

Abstract

Chronic myeloid leukemia (CML) is a type of Chronic myeloproliferative disorders in pluripotencial stem cell haematopoiesis cell disease caused by somatic mutation chromosomal translocation of the Abelson (ABL) and Breakpoint Cluster Region (BCR) genes on chromosomes 9 and 22. The Breakpoint Cluster Region Abelson Kinase (BCR-ABL) gene encodes different fusion transcripts of messenger Ribo Nucleic acid (m RNA)/type of fusion gene that vary in size depending on the breakpoint in the BCR gene. The majority of CMLcases have been shown to have either b3a2 or b2a2 fusion gene. This research is a preliminary study designed to know how to identify a quantification BCR-ABL gene and expression fusion of gene and its relation to routine haematological parameters. The researchers analyzed 12 adults who were positive using a quantification ratio BCR-ABL and Glucose-6-Phosphate Dehydrogenase (G6PDH) as a house keeping gene by real-time quantitative polymerase chain reaction (RQ PCR) of chronic phase of CML patients, qualitative of translocation of BCR-ABL gene by gel agarose and routine haematological tests by a haematologic analyzer. The average quantification ratio of BCRABL gene and G6PDH was 0.0881, 50% patients had b3a2 fusion gene, 41.6% had b2a2 dan 0.4% had e1a1. Fusion gene b3a2 showed a quantification ratio, haemoglobin level and leukocyte count higher compared to b2a2 fusion gene.
RERATA VOLUME TROMBOSIT DI DIABETES MELITUS (Mean Platelet Volume in Diabetes Mellitus) Maria Enrica; Nina Tristina; Anna Tjandrawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1254

Abstract

Diabetes Mellitus (DM) is a state of chronically hyperglycemia, which is caused by impaired insulin secretion and function. Thealteration in coagulation system in DM patients served as the basic etiology of macro and micro vascular complication. Platelets are oneof the factors that have a role in the coagulation system and undergo pathological changes in DM patients. Mean Platelet Volume (MPV)is an indicator of platelet function and activation. Larger platelets have more dense and more reactive pro coagulant granules. The aimof this study was to know whether there were differences in MPV between DM patients compared to medical check-up participants atthe Dr. Hasan Sadikin Hospital, Bandung.. The research used analytical descriptive, retrospective data. The inclusion criteria of thisresearch was DM patients and medical check up participants whose serum fasting glucose and two (2) hours post prandial serum glucosewere within the normal range. The data were taken from medical records of DM patients and medical check up participants. The datawere further analyzed with SPSS ver. 15 program using unpaired T-test. In this study, no significant difference between DM patientsand medical check up participants (p>0.05) was found. It can be concluded that Mean Platelet Volume if used as single, can not predictvascular complication in DM patients.

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