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Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia

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Published by Pengurus Besar Ikatan Dokter Indonesia

ISSN : 20891067 EISSN : 26543796 DOI : http://dx.doi.org/10.47830

Core Subject : Health, Science, Education,

Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

Journal Of The Indonesian Medical Association (JInMA) / Majalah Kedokteran Indonesia (MKI) adalah Jurnal yang berada di bawah naungan Pengurus Besar Ikatan Dokter Indonesia (PB IDI) dan sebagai Kanal InformasiIlmiah di Kalangan Dokter Umum dan Dokter Spesialis serta Profesi Terkait.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 435 Documents

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Peran Pemeriksaan Mutasi Gen Dead-Box Helicase 41 (DDX41) pada Sindroma Mielodisplasia Hipoplastik Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton; Imannuel, Erica Valencia; Supriadi, Vegy; Lukito, Diane; Raharjo, Yohanes Timothy; Devi, Wivina Riza; Bintoro, Siprianus Ugroseno Yudho
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1847

Introduction: DDX41 gene mutations can occur in hematopoietic malignancies, especially acute myeloid leukemia (AML) and myelodysplastic syndrome. The average incidence of myelodysplastic syndrome (MDS) in the general population is 4.5 out of 100,000 people per year. Myelodysplastic syndrome (MDS) can occur with different genetic mutations and will provide different prognoses and therapy results. Hypoplastic myelodysplastic syndrome (MDS) is often found in 10-15% of MDS patients. There have been no case reports or research studies in Indonesia that have reported a case of hypoplastic myelodysplastic syndrome associated with a mutation in the Dead Box Helicase 41 (DDX41) gene.Case Report: A 66-year-old man presented with complaints of weakness. The patient had a history of myelodysplastic syndrome diagnosed two years earlier. Bone marrow aspiration revealed cellularity with decreased granulopoiesis and thrombopoiesis, and myeloblasts accounted for 2.0%. Genetic testing using a Next Generation Sequencing (NGS) panel identified DDX41 p.(Pro258Leu) at 47.9%, DDX41 p.(Arg525His) at 1.7%, and ASXL1 p.(Gln977Ter) at 1.6%. The patient was treated with a combination therapy of venetoclax and azacitidine. Follow-up bone marrow aspiration showed improved cellularity, increased erythropoiesis activity, and a reduction in the number of dysplastic cells. Case Discussion: Mutations in the DDX41 gene can mostly be found in cases of hypoplastic myelodysplastic syndrome, while in normocellular or hypercellular myelodysplastic syndrome, genetic mutations such as SF3B1, TET2, STAG2, ASXL1, and BCOR are mostly found. The DDX41 gene is related to cellular molecules and innate immunity. The DDX41 gene mutation is a determining factor in the administration of chemotherapy. The DDX41 gene mutation is a determining factor in the selection of chemotherapy drugs.Conclusion: DDX41 genetic testing with NGS method is essential for determining the prognosis and appropriate therapy in the management of hypoplastic myelodysplastic syndrome cases.

Hubungan Pengetahuan Dengan Sikap Pada Calon Jemaah Haji dan Umrah Lansia Terhadap Pencegahan Dehidrasi Amalia, Firda; Savitri, Pritha Maya; Agustini, Diana; Kristanti, Melly
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1859

Introduction: Hajj and Umrah are Islamic pilgrimages performed in Saudi Arabia, often taking place during the summer season when temperatures may exceed 40°C. Such extreme conditions increase the risk of dehydration, especially among the elderly. Dehydration in older adults can lead to severe complications, even death. Preventive measures can be achieved through adequate knowledge and positive attitudes toward fluid intake.Methods: This was an observational analytic study with a cross-sectional design. Respondents were selected using purposive sampling, consisting of 50 elderly Hajj and Umrah pilgrims. The study was conducted from February to December 2023 at the NRA Hajj and Umrah Bureau, South Jakarta. Data were analyzed using the chi-square test to assess the relationship between knowledge and attitudes toward dehydration prevention.Results: The majority of respondents had good knowledge (62%) and moderate attitudes (56%), with most being female aged 60–65 years. Bivariate analysis showed a significant relationship between knowledge and attitudes of elderly Hajj and Umrah pilgrims toward dehydration prevention (p = 0.035).Conclusion: There is a significant relationship between knowledge and attitudes of elderly Hajj and Umrah pilgrims toward dehydration prevention.

Pengaruh Penyakit Komorbit dengan Keberhasilan Terapi Tuberkulosis Resisten Obat pada pasien DR-TB di Rumah Sakit Dr Soebandi Tahun 2018-2022 Hafa, Muhammad Rafi’uddin; Mufida, Diana Chusna; Wisudanti, Desie Dwi; Raharjo, Angga Mardro
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1956

Introduction: Drug-resistant tuberculosis (DR-TB) is a major health concern in Indonesia, where treatment success rates remain low. Comorbidities such as diabetes mellitus (DM) and human immunodeficiency virus (HIV) may worsen patient outcomes by complicating disease management and increasing the risk of treatment failure. This study aimed to assess the impact of comorbidities on treatment success among DR-TB patients at dr. Soebandi Hospital Jember.Method: An analytic observational study was conducted on 228 DR-TB patients at RS dr. Soebandi in 2018-2022 who had completed treatment, selected using total sampling. Data were analysed using bivariate analysis to examine associations between comorbidities and treatment outcomes.Results: The overall treatment success rate was 36.8%. Comorbidities were present in 37.3% of patients and were associated with a significantly lower success rate compared to those without comorbidities (21.2% vs. 46.2%; p=0.000; OR=3.19). DM (p=0.018; OR=2.17) and HIV (p=0.026; OR=9.31) each significantly reduced treatment success. A combination of DM and hypertension also showed a significant association (p=0.041; OR=9.44).Conclusion: Hypertension alone, chronic kidney disease, and chronic hepatitis were not statistically related to treatment success. Comorbidities, particularly DM, HIV, and the combination of DM with hypertension, significantly affect DR-TB treatment success. Addressing these conditions could improve patient outcomes and enhance treatment programs.

Peran Kelenjar Hipofisis dan Pengaruh Neuroendokrin terhadap Perilaku Manusia: Telaah Literatur Sistematik Maskan, Siti Nur Asiyah; Najihan, Imroatun; Devinadia, Khanifa Aulia Ayu; Raynugroho, Mohammad; Najmi, Naila Syifaun; Rinjani, Nella Andin; Juliantika, Putri; Shafa, Rifdha Nur; Rahmadhani, Risma Dwi; Saraswanto, Febryan Tri Pamungkas
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1965

Human behavior is shaped by the complex interaction between the nervous and endocrine systems. The pituitary gland, as a major component of the endocrine system, plays a crucial role in regulating both physiological and psychological functions through the secretion of various hormones. This study aims to systematically review the role of the pituitary gland and the influence of the neuroendocrine system on human behavior. The research employed a Systematic Literature Review (SLR) method, analyzing eight selected scientific articles published between 2021 and 2025. Articles were sourced from Google Scholar, ScienceDirect, and ResearchGate using relevant keywords, and filtered following PRISMA guidelines. The review revealed that pituitary-secreted hormones such as ACTH, GH, prolactin, LH, FSH, and oxytocin have significant impacts on stress regulation, emotions, social bonding, and cognitive functions. The hypothalamic–pituitary–adrenal (HPA) axis plays a central role in the stress response and is strongly linked to psychological symptoms including anxiety and depression. Additionally, non-pharmacological interventions such as music therapy have been shown to stabilize neuroendocrine activity and effectively reduce anxiety. The pituitary gland functions as a hormonal control center that influences various aspects of human behavior. This review underscores the importance of neuroendocrine understanding within psychological contexts and supports the development of physiological-based interventions for mental well-being.

Denervasi Ginjal: Suatu Terapi Tambahan Hipertensi Resisten Laksono, Sidhi
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1972

Hypertension is one of the major risk factors for cardiovascular disease worldwide. Evidence has demonstrated that effective blood pressure control can reduce cardiovascular morbidity and mortality while slowing the progression toward end-stage renal disease. However, blood pressure control rates in the global population remain far from optimal despite the availability of various lifestyle-based and pharmacological treatment options. Recent data indicate that among approximately 120 million adults with hypertension in the United States, only about 23% have successfully achieved the target blood pressure of kess then 130/80 mmHg, whereas nearly 45% continue to have blood pressure levels ≥140/90 mmHg.

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Ferius Soewito

Contact Email -

Phone +6221-31937910

Journal Mail Official jinma_mki@idionline.org

Editorial Address Jl. Dr. G. S. S. Y Ratulangie No. 29, Menteng, Jakarta Pusat 10350

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Ferius Soewito

Contact Email
-

Phone
+6221-31937910

Journal Mail Official
jinma_mki@idionline.org

Editorial Address
Jl. Dr. G. S. S. Y Ratulangie No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA