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Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara
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International Journal of Nasopharyngeal Carcinoma
Published by Universitas Sumatera Utara
ISSN : 26569027     EISSN : 26569035     DOI : https://doi.org/10.32734/ijnpc
Core Subject : Health,
Health Professions Medicine & Pharmacology
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 94 Documents
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NASOPHARYNGEAL CARCINOMA CHARACTERISTIC AT ARIFIN ACHMAD HOSPITAL IN JANUARY-OCTOBER 2018 Harianto
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2041

Abstract

Introduction: Nasopharyngeal carcinoma is the most head and neck malignancy worldwide that is capable of performing distant metastasis and potentially to relapse. Indonesia prevalence of cancer estimate 1.4% or approximately 347.792 population and the highest found in D.I Yogyakarta, whereas Riau province counted 0.7% or around 4.301 population. This concludes the nasopharyngeal carcinoma stand as the 4th of the most malignancy in Indonesia after the mamae carcinoma, cervix carcinoma, and skin tumor. Objective: The purpose of this study is to asses the characteristic of NPC patient in Arifin Achmad Hospital Riau Province involving the incidence, gender, age, histopathology classification, distribution by the period and the therapy. Material and method: Retrospective cross-sectional approach with the descriptive presentation to assess the entire population of nasopharyngeal carcinoma based on gender, age, histopathology classification and treatment in January to October 2018. The data obtained from several data provide unit and process into a frequent and distribution table. Result: The number of the cases obtained include the new case and old case was 137 cases sequently 62 new cases and 75 old cases. Men were most affected and the commonest occurring in range 40-60 years. All the most histopathology classification was the undifferentiated nasopharyngeal carcinoma. Most of the patient treated with chemotherapy. Conclusion: NPC was the highest incidence of the head and neck malignancy commonly in men. All the most occurred in early elderly and the highest histopathology type was undifferentiated nasopharyngeal carcinoma (WHO Type III). Chemotherapy was the choice to treat the patient.
ADVANCED NASOPHARYNGEAL CARCINOMA WITH NASAL POLYP: A MISDIAGNOSED CASE Oke Kadarullah
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2042

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) commonly misdiagnosed in early stage, because of it’s multiple nonspesific sign and symptoms also because of the difficult anatomic site. Especially if there is a comorbid in the area around the nasopharynx, most likely will end up with missdiagnosis. So the mortality rate are still high due to advanced stage incidence. Case report: Reported a 58 years male with history of recurrent nasal bleeding since 6 months ago accompanied by hearing problem and also ear fullnes since 11 months ago. There also a severe headache since 4 months ago and a left neck mass arised within 2 months approximately 6 cm in dimension. In nasopharyngocopy found a gelatinous mass at right nasal cavity and nasopharyngeal mass extend to both nasal cavity. The biopsy results are polip nasi Hellquist Type I and Nonkeratinizing Carcinoma Undifferentiated type. CT showed the nasopharyngeal mass has extend intracranially. Patient’s management were planned to polypectomy and chemoiiradiation. Despite of the tumor was radiosensitive, the prognosis and the survival rate are low because the patient came at stage IV. Conclusion: Educating the society, health workers and hospital staff is a critical step for controlling NPC at early stage
ACTIVITY OF SUPEROXIDE DISMUTASE ENZYME IN EARLY AND ADVANCED STAGES OF NASOPHARYNGEAL CARCINOMA Gunterus Evans; Abdul Kadir; Riskiana Djamin; Abdul Qadar Punagi; Sutji P. Rahardjo; Mochammad Hatta
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2055

Abstract

Introduction:Nasopharyngeal cancer (NPC) ranks - fourth among all cancers in Indonesia. Objective:This study aimed to determine the levels of SOD in patients with NPC. Material and methods : This was a cross sectional study of analytic observational, using consecutive sampling, with 45 patients with NPC and 15 controls. Results: Average of SOD enzyme levels were higher in the NPC patient group (± 1877.87224 1137.119495) compared with the control group (± 441.42120 320.355669) (p <0.05). SOD enzyme levels were higher in advanced stage ± 2060.67363 1179.147923 compared with early stage ± 1338.86685 680.958439 (p <0.05). Conclusion: The level of SOD enzyme in patients with nasopharyngeal cancer is higher than in the control group, and the level is higher in the advanced stage group than in the early stage group.
ROLE OF DIETARY INTAKE AS RISK FACTOR FOR NASOPHARYNGEAL CARCINOMA IN MUHAMMADIYAH HOSPITAL PALEMBANG JUNE 2017-SEPTEMBER 2018 Norman Imansyah Rizal; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2056

Abstract

Introduction Nasopharyngeal Carcinoma (NPC) are the most common malignancy of Ear, Nose, Throat, Head and Neck in Indonesia. Until now Epstein Barr virus as factor causing NPC, but nonviral cause like dietary intake and food can also cause an increase in the prevalence of NPC. Objective To evaluate the role of dietary intake as a risk factor in NPC patients in the department ORLHNS Muhammadiyah Hospital Palembang. Material and method Using medical record data in Muhammadiyah Hospital Palembang from June 2017 until September 2018, this is a descriptive crossectional study. The primary outcomes were patient medical history about their dietary intake, as well as examination for NPC like physical examination, CT Scan, and biopsy result. Result A total of 17 cases of NPC, 64.70% (11 patients) were man and 35.3% (6 patients) were women. From medical history we get dietary factor that as risk factor to cause NPC were salted fish 11 patient (64.7%), 4 salted meat (23.5%) and 2 alcohol consumption (5.9%). Conclusion Dietary intake or food are a non-viral factors that correlate in increasing the risk of NPC. The highest dietary factors are salted fish (64.7%).
CONTRIBUTION OF CANCER STEM CELLS TO THE METASTATIC MECHANISM IN POSITIVE LMP I WHO TYPE III NASOPHARYNGEAL CANCER PATIENT BEFORE AND AFTER NEOADJUVANT CHEMOTHERAPY Pudji Rahaju; Anis Eko Kristiawan; Endang Retnoningsih
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2057

Abstract

Introduction Nasopharyngeal cancer is the most common malignant tumour of the head and neck that caused high mortality. Most of patients came for treatment in late stage with enlargement of the neck lymphnode. Cancer stem cells are characteristic of stemness such as self-renewal and survival that caused tumour metastasis and recurrence. CD44, SOX2 and CCR7 are marker for NPC stem cells. Method Nine new patients NPC, WHO type III, positive LMP1 were examined for volume of the neck lymphnode, CD44, SOX2 and CCR7 expression before and after treatment chemotherapy cisplatin based. Staging determined by AJCC/UICC 2010. Result The results of this study showed that all subjects have increased SOX2 and CCR7 expression after treatment with statistically negative correlation. CD44 did not altered before and after treatment and cannot be evaluate. Correlation between alteration of the increase SOX2 and CCR7 expression and reduction of the volume have shown statistically positive correlation. Conclusion Neoadjuvant Chemotherapy Cisplatin based eliminated progenitor cells but did not for cancer stem cells in NPC. This result indicates that NPC with higher cancer stem cells must be more attention forward potential resistance and recurrence of the tumour. Although the have received all Stanford treatment
CHARACTERISTICS AND RISK FACTORS OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA IN WEST NUSA TENGGARA HOSPITAL Mochammad Alfian Sulaksana; Hamsu Kadriyan
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2058

Abstract

Introduction Nasopharyngeal carcinoma (NPC) is the most common cancer in the head and neck. NPC is a malignancy of squamous cell on nasopharyngeal epithelial with the most common predilection site in rosenmuller fossa. Theetiology of this disease are multifactorial. A low oral hygiene on naso-oro-hypopharyngeal/laryngeal wall, Epstein Barr Virus (EBV) infection, smoking, alcohol consumption, genetic/hereditary factors, exposure to radiation, nutritional, deficiencies or decreased imune system are recognized as a risk factors. The study aim is to find out a characteristic of patients with nasopharyngeal carcinoma and their risk factors in the west Nusa Tenggara Hospital in September-October 2018. Methods The study design was descriptive–cross sectional. The research subjects were NPC patients who came to the West Nusa Tenggara Hospital ENT-HNS Clinic, in the period September-October 2018. Results There were 37 patients enroled to this study. According to this study, the most patients found in age group 46 to 55 years (35.1%), predominantly men (67.6%) with the men and women ratio 2.5: 1. Based on patients origin, they come from all districts in west Nusa Tenggara province, with the most districts found in West Lombok (29.7%). The most risk factors were food factors (food preservative 19.9%, food flavoring 19.9%, salted fish 15.6% carcinogenic (grilled food) 6.5%), and environmental factors (cigarettes 11.3%, smoke 4.8 % and 4.8% dust). Conculsion There were several risk factors found in this study, however, the most risk factor was food factors (61.9%) followed by environmental factors (20.9%).
CHARACTERISTICS OF NASOPHARYNGEAL CARSINOMA IN CHILDREN AND ADOLESCENTS IN DR. ZAINOEL ABIDIN GENERAL HOSPITAL BANDA ACEH Lily Setiani; Fadhlia; Benny Kurnia; Yerni Karnita
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2062

Abstract

Introduction: Nasopharyngeal Carcinoma (NPC) is a malignant tumor arising from epithelial cells that cover the nasopharynx. NPC is a rare malignancy in children. The incidence of NPC varies by age, geographical and ethnic factors which indicate both genetic and environmental factors contribute to the tumor growth. NPC in children has several features different from adults. Objective: To assess characteristics of nasopharyngeal carcinoma in children and adolescents in dr. Zainoel Abidin general hospital Banda Aceh from 2014-2019. Methods: The study was conducted in dr. Zainoel Abidin general hospital Banda Aceh. This study is a descriptive with cross sectional retrospective design. The data collected from medical records of patients diagnosed with nasopharyngeal carcinoma from January 2014-September 2019. The variable including regional distribution, gender, age (between 0-25 years), histopathologic types, stage and chemotherapy regimen used. The sampling was done by total sampling method. Results: The result showed that there was 17 patients of nasopharyngeal carcinoma in children and adolescents with the highest case came from Bireuen and North Aceh district 3 (17.7%) patients, respectively. South Aceh and West Aceh distric 2 (11.8%) patients, respectively. Nasopharyngeal carcinoma mostly infected 9 (53%) male patients than 8 (47%) female with a sex ratio of 1.1 : 1. The age most affected is at the end of childhood between 17-25 years had 9 (53%) patients and between 12-16 years had 8 (47%) patients with the average age range was 17.2 years (range 13-22 years). Most of histopathologic types had found in the type of undifferentiated carcinoma (WHO type III) as many as 7 (41.1%) patients with stage IV being the most frequent 9 (53%) patients. The most widely used chemotherapy regimen is a combination of Cisplatin and Docetaxel with 10 (62.5%) patients. Conclusion: Nasopharyngeal carcinoma in children generally occur at the end of childhood with the most common type of undifferentiated carcinoma (WHO type III) and stage IV which associated with advanced locoregional disease and higher rates of distant metastasis.
THE ROLE OF CYP2E1 POLYMORPHISM IN THE ACTIVATION OF PROCARCINOGEN METABOLISM OF NASOPHARYNGEAL CARCINOMA Farhat Farhat; Elvita Rahmi Daulay; Jessy Chrestella
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2063

Abstract

Intoduction: Cytochrome P450 2E1 (CYP2E1) is the enzyme as a part of CYP 450 enzyme families. It acts in phase I metabolism which result in the formation of electrophilic molecule and elevation of reactive oxygen species (ROS). Review: The last is responsible in development of cancer by damaging the protein and DNA, leading to mutation and increase cell proliferation. Nitrosamine as the most carcinogen for nasopharyngeal carcinoma (NPC) is the substrate of this enzyme. This chemical is contained in the salted fish, tobacco smoke, beer, and preserved food such as meat product. Nitrosamine needs CYP2E1 to activate the pro-carcinogen in order to act is carcinogenic effect. Polymorphism of CYP2E1 is associated with higher transcriptional activity and enzyme activity. Conclussion: It means the ability of this enzyme to activate pro-carcinogen of nitrosamine will increase, leading to higher chance to develop cancer, including NPC.
RISK FACTOR OF NASOPHARYNGEAL CARCINOMA DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG R. Ayu Hardianti; Yussy Afriani Dewi; Rina Desdwi Utami
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2065

Abstract

Introduction Nasopharyngeal carcinoma (NPC) is malignancy of squamous cells on nasopharyngeal epithelial layer and the most common otorhinolaryngology malignancy found in Indonesia. Etiology of NPC is multifactorial including, food, environment, genetics, and Epstein-Barr virus infection. The study aimed to determine the highest risk factors on the incidence of nasopharyngeal carcinoma in Otorhinolaringology-Head and Neck Surgery Department dr. Hasan Sadikin General Hospital Bandung. Method The study design was descriptive retrospective from medical record of NPC patients at Otorhinolaringology-Head and Neck Surgery Department, dr. Hasan Sadikin General Hospital Bandung in 2010-2015. Result There were 462 nasopharyngeal carcinoma patients in this research (265 men and 161 women) with three most common risk factors history of smoking (50.7%), mosquito coils use (43.2%), and consumption of salty fish (39.7%). Conclusion Smoking, mosquito coils, and consumption of salty fish affect the incidence of nasopharyngeal carcinoma.
COMPARISON OF CYTHOCROME P450 FAMILY 2 SUBFAMILY A POLYPEPTYDE 6 (CYP2A6) GENE POLYMORPHISM PROPORTION ON EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE I Gde Ardika Nuaba; Komang Andi Dwi Saputra; I Ketut Suanda; I Gusti Ayu Trisna Dewi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2066

Abstract

Introduction Nasopharyngeal carcinoma (NPC) is a malignancy derived from epithelial cells lining the nasopharynx. The etiology of nasopharyngeal carcinoma is multifactorial. One of the risk factors is CYP2A6 gene polymorphism which causes nitrosamines are not metabolized, leading to DNA change that could trigger cancer. Objectives The purpose of this study is to know the association of CYP2A6 gene polymorphism and clinical stage of undifferentiated type of NPC Material and Method This is a cross sectional analytic study. The sample in this study were 80 nasopharyngeal carcinoma patients whose treated in ENT-HN department of Sanglah General Hospital between 2017 - 2018. The collected data consist of subject’s characteristic and CYP2A6 gene polymorphisms identified by the PCR-RFLP technique. Results The probability of CYP2A6 gene polymorphism in the undifferentiated type of NPC in the Balinese tribe is 3.125 times greater in advanced stage than early stage. Based on multivariate analysis, there was a statistically significant association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese with p value = 0,0048 (p < 0,05). Conclusion There is association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese tribe.

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