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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 469 Documents
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Relationship of Determinant Factors to Severity Level of Caesarean Section Based on the INA-CBGs System at Dr. M. Djamil Padang Fauzi Ahmad Hasibuan; Aladin, Aladin; Yetti, Husna
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.23-29.2025

Abstract

Abstract Introduction: Cesarean deliveries are increasing worldwide and now account for one fifth (21%) of all deliveries. This has exceeded the standard for caesarean section operations by WHO by around 5-15%. In Indonesia cesarean delivery rate was 17.6% percent with the highest proportion in DKI Jakarta (31.1%), the lowest in Papua (3.3%). West Sumatra is ranked second highest with a caesarean section rate of 23.8%. Objective: To determine the relationship between age, education, employment, nutritional status, number of ANCs, underlying diseases, and the severity of caesarean section. Method: This research is an observational analytical design with a croseksio area approach. It aims to relate the relationship between age, education, employment, nutritional status, number of ANCs, and underlying diseases, and the severity of caesarean section. Results: This study had 400 research subjects who underwent caesarean section operations, with 16 research subjects experiencing caesarean sections with severe severity, 276 research subjects experiencing moderate severity, and 108 research subjects experiencing mild severity. Using the Chi-Square correlation test, there was significant relationship between a history of ANC and the history of underlying disease on the severity of caesarean section. There was no significant relationship between age, education, employment, or nutritional status on the severity of caesarean section. Conclusion: There was significant relationship between history of ANC and history of underlying disease on the severity of caesarean section. Keywords: Determinant Factors, Cesarean section, Level severity, INA-CBGs  
Gut Microbiota Profile in Endometriosis Patients at Dr. M. Djamil Padang, West Sumatra, Indonesia Haviz Yuad; Utama, Bobby Indra; Lipoeto, Nur Indrawaty; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.134-145.2025

Abstract

Objective: Endometriosis (EMS) is a chronic gynecological condition affecting up to 10% of women worldwide. The pathogenesis associated with hormonal imbalance, immune dysregulation, and changes in the gut microbiota. Gut microbiota dysbiosis may drive chronic inflammation that contributes to the progression of EMS. This study hypothesizes that certain gut microbiota profiles are associated with these factors in EMS patients, potentially developing non-invasive diagnostics and more targeted therapies. Methods: This is an observational analytical study with a case-control design conducted at Dr. M. Djamil Padang General Hospital in May 2024 with a sample size of 44 people. Case samples were women aged 18–40 years who were diagnosed with endometriosis based on the inclusion criteria, while the control group were women of reproductive age without a diagnosis of endometriosis. Data testing used the Next Generation Sequencing method, microbiome analysis test, and SPSS test. Results: The majority of EMS patients were aged 30-37 years, married, and had Nullipara obstetric status. In addition, the gut microbiota was dominated by the phyla Bacteroidetes and Firmicutes. Conclusion: There is a relationship between gut microbiota dysbiosis and the incidence of endometriosis, namely an increase in Bacteroidetes and a decrease in Firmicutes Keywords: endometriosis, dysbiosis, bacteroides, firmicutes, gut microbiota
Relationship of BMI and Parity with High Grade Serous Ovarian Cancer at RSUP Dr. M. Djamil Padang Murizal, Thanya Amoret Alya; Syamel Muhammad; Eka Nofita; Henny Mulyani; Selfi Renita Rusjdi; Fathiyyatul Khaira
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.259-266.2025

Abstract

Introduction : Ovarian cancer is the 8th most common cancer in women. High grade serous carcinoma (HGSC) is a subtype of ovarian cancer with the highest case and death rate compared to other types. Therefore, a preventive approach is needed by reviewing the underlying risk factors of this cancer. Body mass index (BMI) and parity are modifiable risk factors for ovarian cancer. This study aims to determine the relationship BMI and parity on high grade serous subtype ovarian cancer at RSUP Dr. M. Djamil Padang. Method: observational analytic study with a cross sectional approach. This research was conducted at RSUP Dr. M. Djamil Padang using medical record data of epithelial ovarian cancer patients at RSUP Dr. M. Djamil Padang from 2021 to 2022 with a sample of 129 patients. The data analysis method used in this research is the Chi-square test. Result : Epithelial ovarian cancer patients are most found at >50 years old (55%), menopausal woman (65.9%), non obese (77.5%) and  parous women (76%). Conclusion : There was no relationship between body mass index and parity with the incidence of ovarian cancer, subtype high grade serous, at RSUP Dr. M. Djamil Padang.
Factors Related to Primary Dysmenorrhoea in Students at The Faculty of Medicine of Andalas University in 2023 Dzaky, Aditya Luthfian; Karmia, Hudila Rifa; Abdiana, Abdiana
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.267-278.2025

Abstract

Introduction: Dysmenorrhoea or menstrual pain is a commonly reported reproductive health issue, particularly affecting those aged 18-25 years. It can significantly disrupt daily activities and reduce productivity. The high prevalence of dysmenorrhoea is attributed to multiple factors, which are multifactorial in nature. The research aims to identify the factors related to incidence of primary dysmenorrhoea among in students of the Bachelor of Medical Education Study Program at the Faculty of Medicine, Andalas University 2023. Method: A cross-sectional study was conducted in October 2023 using a Google form to collect primary data. The sample consisted of 212 female students from the batch of 2020-2022, selected using a simple random sampling technique. Univariate and bivariate analyses were used to analyse the data, with the chi-square test employed in bivariate analysis. Results: The results of the study of the relationship between age of menarche, family history of sleep quality, and duration of menstrual bleeding, the incidence of primary dysmenorrhoea obtained p values of p = 0.538, p = 0.059, p = 0.004, and p = 1.000. Conclusion: There is a significant relationship between sleep quality and the incidence of primary dysmenorrhoea. However, there is no significant relationship between menarche age, family history, and duration of menstrual bleeding with the incidence of primary dysmenorrhoea in students of the Bachelor of Medical Education Study Program at the Faculty of Medicine, Andalas University 2023.It is important for all women of childbearing age to be aware of the risk factors that cause dysmenorrhoea and the measures taken to alleviate menstrual pain.
A Rare Case of Female Urethral Diverticulum Muhammad Iqbal; Yulia Margaretta Sari; Bobby Indra Utama
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.305-317.2025

Abstract

Background: DU is a varied and challenging case of pelvic surgery because the diagnosis is difficult to make. Symptoms that appear in women vary, ranging from incidental findings, lumps or swelling, and pain in the vagina, as well as discharge from the urethra with a periurethral mass. Objective: In this report, we report a case of DU in a 32-year-old woman who complained of a painful lump in her genitals. This patient underwent transvaginal urethral diverticulectomy and successfully resolved the symptoms of urethral diverticulum he experienced. Methods: Management of urethral diverticulum in this report, namely by history taking, physical examination, supporting examination consisting of transvaginal and transperineal ultrasound, as well as cystourethroscopy before excision and reconstruction of the urethral diverticulectomy is carried out on this patient. Results: This patient had a successful transvaginal urethral diverticulectomy, with no early post-surgical complications found. Conclusion: Reducing the rate of problems following surgery is possible by adhering to the excision and reconstruction principles of urethral diverticulectomy.
A Mother Who Experienced TRALI After a Caesarian Section on the Indication of Severe Pre-eclampsia with a Macrosomic Fetus Lestari, Puti Fajri; Satria, Pom Harry
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.298-304.2025

Abstract

Introduction: Transfusion-Related Acute Lung Injury (TRALI) is a severe, often fatal, complication of blood transfusion. Obstetric patients with severe pre-eclampsia are uniquely susceptible due to a "two-hit" mechanism, where the underlying inflammatory condition primes the lungs for injury from a subsequent blood transfusion. This report presents a case of post-transfusion respiratory distress in such a high-risk patient, highlighting the diagnostic challenges. Case Report: A mother with severe pre-eclampsia underwent a caesarean section for a macrosomic fetus, complicated by postpartum hemorrhage. She was transfused with two units of Packed Red Cells (PRC). Approximately 12 hours after the transfusion was completed, she developed acute-onset, progressive shortness of breath, requiring management in the High Care Unit. Discussion: In this complex postpartum case, the central challenge is diagnosing acute respiratory distress following Caesarean delivery, severe pre-eclampsia, and a blood transfusion. Given the patient’s heightened vulnerability due to pre-eclampsia and surgery, the transfusion may have triggered acute lung injury via the "two-hit" model. TRALI diagnosis relies on clinical suspicion and requires immediate cessation of transfusion, respiratory support, and careful hemodynamic management. Conclusion: This case underscores the importance of recognizing TRALI as a potential cause of respiratory distress in obstetric patients with pre-eclampsia, emphasizing the need for prompt diagnosis and supportive care.
Neoplasia Trofoblastik Gestational Pasca-Mola pada Wanita Usia 25 Tahun Satria Kusuma, Nur Huda; Wildan Aulia Firdaus
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.288-297.2025

Abstract

Introduction: Hydatidiform mole is the most common gestational trophoblastic disease in regions such as Asia, Africa, and Latin America, with a lower incidence in European countries. In Indonesia, the incidence ranges from 1 in 100 to 141 pregnancies, particularly affecting women under 20 and over 45 years old, often in those with low socio-economic status and nutritional deficiencies (such as protein, folic acid, and carotene). Case Presentation: A 25-year-old female presented to Malang City General Hospital with complaints of recurring brownish-black foamy vaginal discharge, nausea-vomiting for two months. She had regular menstrual cycles and no contraception use. On examination, the uterine fundal height was one finger above the symphysis pubis with no fetal heart sounds or uterine contractions. Vaginal examination revealed a closed cervix and foamy black blood. Ultrasound showed a retroverted uterus, a 6.4 mm gestational sac without a fetal pole, 37.0×31.6mm residual tissue, a honeycomb pattern, and no myometrial invasion. Blunt curettage removed 30 grams of bubble-like tissue. Histopathology confirmed a complete hydatidiform mole. β-hCG levels and uterine size continued rising post-curettage. Discussion: A significant number of low-risk PGTN patients with a FIGO score of 0-6 show a complete response to first-line methotrexate/folinic acid therapy. However, those with a score of 6 or β-hCG levels >100,000 IU/l have a higher resistance rate. Despite this, the survival rate remains very high. Conclusion: PGTN is a malignant uterine tumor linked to molar pregnancies. Single-agent chemotherapy remains the standard treatment and has a generally favorable prognosis.
Pelvic Floor Distress Inventory – 20 As Quality of Life Score Predictor in Patient Using Pessary Arwan, Berriandi; Andi Rinaldi; R.M. Sonny Sasotya; M. Rizkar Arev Sukarsa; Eppy Darmadi Achmad
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.190-196.2025

Abstract

Introduction: Pelvic organ prolapse is one of women’s health major concern associated with decreased quality of life that may cause a disruption in the bladder, gastrointestinal and sexual dysfunction. Women’s Health Initiative (WHI) stated 41% of women aged 50-79 years pelvic organ prolapse symptoms and surgeries performed rate increased from 1.5 to 4.9 cases per 1,000 women per year. Objective: To determine changes in quality of life based on Indonesian version of Pelvic Floor Distress Inventory – 20 questionnaire in patients with pelvic organ prolapse. Methods: Prospective cohort study carried out in Hasan Sadikin Hospital, Bandung City, Indonesia during the period Januari 2022 – March 2023. The quality of life was followed up three months after hospital discharge. We used the Indonesian version of Pelvic Floor Distress Inventory – 20 (PFDI-20). Results: In this study, 20 subjects were involved. The result showed that significant reduction in the quality of life score in patients after the treatment of pelvic organ prolapse with conservative treatment such as pessary insertion based on scale Indonesia version of PFDI – 20 questionnaire, with the highest a preoperative PFDI-20 score of 275 and after therapy score reduction until 50. Conclusions: There is a reduction in quality of life scores in patients with pelvic organ prolapse underwent surgery. Further research should be conducted in large number to assess the quality of life of patients with pelvic floor dysfunction in Indonesia using these questionnaire.
Female Sexual Function Index As Sexual Disfunction Predictor On Women Using A Pessary Setyawan Nurtanio; Andi Rinaldi; R.M. Sonny Sasotya; M. Rizkar Arev Sukarsa; Eppy Darmadi Achmad
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.197-204.2025

Abstract

Introduction: Pelvic organ prolapse (POP) is the abnormal descent of pelvic organs that can cause various symptoms, including sexual dysfunction, especially in menopausal women. With increasing life expectancy, the prevalence of POP-related female sexual dysfunction is also rising. Sexual discomfort can result from vaginal wall thinning, stiffness, fatigue, and inability to achieve orgasm, affecting overall well-being and quality of life. Objective: This study aimed to evaluate the improvement in female sexual function using the Indonesian version of the Female Sexual Function Index (FSFI) one week after pessary insertion in both sexually active (SA) and non-sexually active (NSA) women with POP. Methods: A descriptive before-and-after study was conducted on 20 women aged 50–65 years with POP grades II–IV at Al-Ihsan Hospital, Bandung, between November 2023 and January 2024. All subjects received ring pessary treatment. The FSFI questionnaire was administered before and one week after pessary insertion to assess sexual function. Results: Among 20 participants (mean age: 57 years), 16 (80%) reported sexual dysfunction before pessary insertion. After one week, 14 women (70%) were categorized as not having sexual dysfunction, while 6 (30%) remained in the dysfunction group. Of the 16 women initially affected, 11 (68%) experienced improved sexual function. The ring pessary proved effective without negatively affecting sexual activity. Conclusions: Pessary use in women with POP can improve sexual function without adverse effects on sexual intercourse. However, limitations include the small sample size, short follow-up, and use of only one pessary type. Additionally, multiple unmeasured factors, such as biological, cultural, and social factors, can influence outcomes.
Prophylactic Misoprostol-Oxytocin Combination in Preventing Postpartum Hemorrhage : A Meta-Analysis Rohman, Gilang Rizqy Perdana Aries; Diana, Lani; Sujiati, Tatik
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.167-177.2025

Abstract

Background: Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality worldwide. Active management of the third stage of labor, including prophylactic uterotonics, is essential in reducing PPH incidence. Oxytocin is the first-line agent; however, misoprostol has been considered as an adjunct due to its stability, accessibility, and effectiveness. This meta-analysis evaluates the efficacy of the misoprostol-oxytocin combination compared to oxytocin alone in preventing PPH. Methods: A systematic literature search was conducted following PRISMA guidelines using PubMed, ScienceDirect, and Cochrane Library up to November 28, 2024. Randomized controlled trials (RCTs) comparing the misoprostol-oxytocin combination versus oxytocin alone for PPH prevention were included. Statistical analysis was performed using Review Manager 5.4, with mean difference (MD) and relative risk (RR) as effect measures. Heterogeneity was assessed using the I² statistic. Results: A total of seven RCTs met the inclusion criteria. The misoprostol-oxytocin combination significantly reduced the risk of PPH compared to oxytocin alone (RR 0.71; 95% CI 0.55–0.91; p=0.007; I²=54%). Blood loss was significantly lower in the combination group (MD -33.77 mL; 95% CI -62.27 to -5.26; p=0.02; I²=80%). Hemoglobin drop was also reduced (MD -0.75 g/dL; 95% CI -1.48 to -0.01; p=0.02; I²=84%). However, the combination therapy was associated with a higher incidence of pyrexia. Conclusion:The combination of misoprostol and oxytocin is more effective than oxytocin alone in reducing postpartum blood loss and hemoglobin drop. Despite increased pyrexia rates, its benefits in preventing PPH may outweigh the risks, particularly in high-risk populations. Further large-scale studies are needed to refine dosing strategies and assess long-term outcomes.

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