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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 215 Documents
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FORMULASI SEDIAAN SPRAY GEL EKSTRAK DAUN BANDOTAN (Ageratum conyzoides.L) SEBAGAI ANTINYAMUK Mangalik, Anastasia Reni; Helmidanora, Rusdiati; Sa'adah, Hayatus
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.364

Abstract

There are many types of mosquitoes that cause disease in humans, one of which is the Anopheles mosquito that spreads malaria. Bandotan plants are used to treat colic, flu, fever, antidiarrheal, diarrhoea. The purpose of this study was to determine the concentration of bandotan (Ageratum conyzoides.L) leaf extract that provides the best physical properties and anti-mosquito activity in spray gel preparations. The research method conducted was experimental. The object studied was the formulation of bandotan leaf preparation as an antinyamite. The research stages include plant determination, sample collection, simplisia preparation, extraction using maceration method with 70% ethanol solvent, identification of secondary metabolite compounds, preparation of spray gel formula, and preparation evaluation. Bandotan leaf extract was formulated into anti-mosquito spray gel preparations with concentration variants of 10%, 15%, 20%, and using positive control of X brand anti-mosquito spray as a comparison. The preparation testing included organoleptic test, homogeneity test, pH test, viscosity test, and mosquito repellency test. The results of data collection were analysed statistically. A good preparation formula is found in the negative control formula because it has a stable consistency and pH. The results showed that the ethanol extract of bandotan leaves was not significantly different from the organoleptic test, homogeneity test, viscosity test, and pH test. The greatest mosquito repellency was at a concentration of 20% which was 66.33%, at concentrations of 10% and 15% had an average anti-mosquito activity of 22.83% and 57.83% respectively for the positive control with brand X of 99.30%.
IDENTIFIKASI JENIS SAPONIN DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL KULIT BATANG SEKILANG (Embelia borneensis Scheff.) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 9027 DAN Streptococcus mutans ATCC 25175 Hayon, Maria F.K.; Supriningrum, Risa; Fatimah, Nurul
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.368

Abstract

Sekilang stem bark (Embelia borneensis Scheff.) contains secondary metabolites, such as alkaloids, flavonoids, tannins, and saponins. Saponin compounds are divided into two types, namely steroids and triterpenoids which have the ability as antibacterial, antifungal, antidiabetic and expectorant. The purpose of this study was to determine the type of saponin and to determine the antibacterial activity of the methanolic extract of sekilang bark against Streptococcus mutans and Pseudomonas aeruginosa bacteria. The research stages included plant determination, sample collection, simplicia making, extract preparation by maceration method using methanol, phytochemical screening, identification of saponins and antibacterial activity test of methanol extract of sekilang stem bark by disc diffusion method against Streptococcus mutans and Pseudomonas aeruginosa bacteria with a concentration of 15% , 20%, 25%, 30%, and 35%. The results showed that the methanol extract of sekilang stem bark contained triterpenoid saponins and had antibacterial activity against Streptococcus mutans bacteria at concentrations of 15%, 20%, 25%, 30%, and 35% with an inhibition zone formed of 7.65 mm, 7.89 mm, 7.67 mm, 7.98 mm, and 7.13 mm the criteria for antibacterial strength were categorized as moderate. The methanolic extract of the bark of sekilang did not show antibacterial activity against Pseudomonas aeruginosa bacteria, because there was no inhibition zone formed around the paper disc. The positive control used was amoxicillin 0.1% and the negative control used 1% DMSO.
POTENSI ANTIBAKTERI EKSTRAK ETANOL DAUN SELUTUI PUKA (Tabernaemontana macrocarpa Jack.) TERHADAP BAKTERI Streptococcus mutans DAN Porphyromonas gingivalis Sabatini, Sheila Dwi; Handayani, Fitri; Sundu, Reksi
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.372

Abstract

The Dayak people in West Kutai, East Kalimantan use selutui puka leaves for the treatment of toothache and canker sores. Bacteria that often cause infections in the oral cavity are Streptococcus mutans and Porphyromonas gingivalis. The aim of this study was to determine the activity of the ethanol extract of selutui puka leaves as an antibacterial against Streptococcus mutans and Porphyromonas gingivalis. The research phase involved collecting samples, plant determination, preparing simplicia, preparing extracts and testing antibacterial activity using the paper disc diffusion method with extract concentrations of 15%, 30% and 45%, DMSO negative control 1%, positive control Ciprofloxacin 0.1%. The results showed that the average diameter of the inhibition zone for Streptococcus mutans at an extract concentration of 15% was 17.70 mm (strong), 30% was 19.43 mm (strong), and 45% was 23.60 mm (very strong). ) and against Porphyromonas gingivalis bacteria at an extract concentration of 15% of 17.43 mm (strong), 30% of 23.33 mm (very strong), and 45% of 26.03 mm (very strong).
ANALISIS RESEP TIDAK TERLAYANI PASIEN RAWAT JALAN DI INSTALASI FARMASI RSU X JAKARTA Agustina, Ika; Tuahuns, Farida; Charles, Charles; Adina, Arfie Nur
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.374

Abstract

Pharmacy service is inseparable from health service system of a hospital. The service of pharmacy unit shall be a priority because an effective and efficient service will affect in the fulfillment of prescriptions. Furthermore, the management on the pharmaceutical stock will influence the revenue of the hospital (part of revenue center). The purpose of this research is to find out the percentage of unfilled prescriptions of outpatients from many different units, its reasons, and Therapeutic Class of unserved drug items. The research applies descriptive method using prospective data i.e. 25,259 R/ sheets of prescriptions obtained by total sampling technique. The research was conducted in three months from February to April 2021. The result of the research shows that there are unfilled 467 R/ prescriptions due to several factors, such as the drugs are not listed in the formularies, the drugs are out of stock, and the prescribed or patient-requested drugs are not covered by the insurance. Internal medicine unit has the most unfilled prescriptions (160 out of 467). The main reason is the drugs are out of stock (133 out of 467). Medicines for Gastritic, Respiratory, Heart Diseases and Allergicare the top lists in the Therapeutic Class, which is in accordance with data showing that Intenal Medicine, Emergency Department dan General Practisioners, Pulmonary, Dermatology and Venereology, and Obstetrics and Gynecology are the top 5 polyclinics with the number of unserved prescriptions due to out of stock.
UJI ANTIOKSIDAN EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) LERENG GUNUNG ARGOPURA KABUPATEN JEMBER PADA BERBAGAI KONDISI PENYANGRAIAN Pebriarti, Iski Weni; Diana, Agustin Nourma
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.381

Abstract

Coffee (Coffea arabica L.) is a plant which has been cultivated in Indonesia and it is one of natural source of antioxidants. The main bioactive component which contain antioxidant properties is chlorogenic acid. The roasting process can cause chlorogenic acid in coffee beans to decrease as the temperature increases and the length of roasting, so the way coffee is served as a source of antioxidants which may need to be considered. The purpose of this study was to determine the group of compounds and antioxidant activity contained in Arabica coffee beans obtained from the slopes of Mount Argopura at various conditions of roasting. The samples of Arabica coffee beans each done roasting in advance at a temperature of 160°C - 180°C; 190°C - 210°C; and 220°C - 240°C before it is milled. The used of extraction method is maceration using 80% ethanol solvent. Antioxidant activity testing was done by DPPH method. Antioxidant activity is expressed based on the IC50 value (Inhibitor Concentration 50%). The highest value of antioxidant activity was obtained from Arabica coffee beans roasted at a moderate temperature with a value of IC50 26.41 ± 0.182 ppm. The result of the T-test obtained a sig value < 0.05 which indicates a difference in the antioxidant activity produced by the extract of Arabica coffee beans at various conditions of roasting.
POLA PENGGUNAAN DAN ANALISIS EFEKTIVITAS BIAYA OBAT ANTINYERI PADA PASIEN DIABETIK NEUROPATI DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG Sari, Tri Purma; Perwitasari, Dyah Aryani; Supadmi, Woro
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.390

Abstract

Diabetic neuropathy is gathering symptom clinic which influence system nerves, well single or combination and could happen in a manner suddenly, no detected, with symptom clinic and no specific signs but dangerous. Incidence diabetic neuropathy happen between 60% to 70% on type I and type II DM patients. Methods of data collection carried out prospectively. Data were obtained from outpatient data with a diagnosis of diabetic neuropathy who met the inclusion criteria and received analgetics from September to December 2020. Then a cost-effectiveness analysis was performed by calculating the ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio) values. The results showed that the most commonly used analgetics was gabapentin at 65.96%, either alone or in combination with an effectiveness percentage of 83.87%. The use of analgetics with the lowest cost is a single Paracetamol of IDR 73,770. The lowest ACER values were shown in the use of the single analgetics Paracetamol and the combination of Amitriptyline-Paracetamol, namely 737.70 and 805.30.
ANALISA PERESEPAN DAN INTERAKSI KOMBINASI DUA MACAM ANTIBIOTIK INTRAVENA DI RUMAH SAKIT X TANGERANG SELATAN Chusun, Chusun; Retno, Fitriani; Yosep, Fauzi
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.391

Abstract

One of the mainstay drugs to treat infections is antimicrobials, including antibacterials/antibiotics, antifungals, antivirals and antiprotozoa. Antibiotics are drugs used in infections caused by bacteria. Antibiotics that are not used wisely can lead to resistance problems. Therefore, the use of antibiotics must follow a rational strategy of prescribing antibiotics. Irrational prescribing will increase the occurrence of drug side effects, drug interactions, medical costs and result in decreased patient compliance in taking drugs.       The purpose of this study was to determine the pattern of prescribing combinations of intravenous antibiotics in one prescription sheet and their interactions. This research is a type of quantitative research, with descriptive methods and using retrospective data. The population in this study were all prescription sheets of inpatients who had been served at the X  Hospital Pharmacy Installation for the period January 1 to March 31, 2021. The samples were all prescription sheets containing a combination of 2 (two) intravenous antibiotics (injection or infusion), all of which totaling 170 sheets.      The results showed that there were more male patients than female patients, namely 52.3% with the largest age range between 46-55 years (29.41%). Of the 15 combinations of 2 (two) intravenous antibiotics, there were 6 combinations that had moderate pharmacodynamic interactions. Moderate interactions are clinically significant, usually avoided in combination or used only in special circumstances and with close monitoring of health workers. Of the 170 prescription sheets, 135 sheets (79.4%) were prescribed by internal medicine specialists. All intravenous antibiotics prescribed according to the X  Hospital Formulary and the National Formulary.
PEMANFAATAN LIMBAH KULIT BAWANG PUTIH (Allium sativum L.) SEBAGAI BAHAN AKTIF PEMBUATAN SABUN CAIR S, Panji Ratih; R, Sih Wahyu; Fitriyany, Erna; I, Cikra; Calya, Finna; Sari, Septiana
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.392

Abstract

Utilization of household waste in Indonesia is still very rarely done, one of which is the use of garlic skin waste. From research by Allemann & Baumann in 2008, garlic skin is rich in antioxidant compounds so it can protect skin cells from free radical damage if used as a skincare product, one of which is liquid bath soap for the body. This research aims to formulate garlic skin extract as liquid soap. The concentration used is 10%. The liquid soap formulation used was 17 g of SLS, 3 g of NaCl, 9 g of Cocamidopropyl Betaine, 9 g  of Glycerin, Fragrances, and Dyes to taste. Garlic skin extract liquid soap is evaluated for its physical quality consisting of organoleptic test results in the form of liquid, gum-scented and red-colored, pH test of 8.2, height test and foam stability of 79 mm, moisture content test of 51.12%, specific gravity test of 1.012 g/ml, and irritation test declared non-irritating. The results showed that garlic skin extract liquid soap with a concentration of 10 % had a physical quality that complied with their requirements. This research concludes that garlic skin extracts liquid soap meets the requirements of the physical quality test and safe for the skin because it does not cause irritation to the skin when used.
FORMULASI LIP BALM EKSTRAK LIDAH BUAYA (ALOE VERA) DAN BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI PELEMBAB BIBIR Tampubolon, Antetti
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.394

Abstract

Lip balm is a cosmetic preparation with main components such as waxes, fats and oils. The purpose of this study was to determine whether Aloe vera and red dragon fruit extracts could be formulated as moisturizers and natural dyes in lip balm preparations. The study was carried out experimentally, including the formulation of preparations with concentrations of Aloe Vera extract 3%, 6%, 10%, and Red Dragon Fruit extract 3%, 5%, 7%. Examination of the physical quality of the preparation, namely homogeneity test, stability during 28 days of storage at room temperature, melting point, pH, and preference test. The results showed that (F1) with a concentration of 3% aloe vera and 3% red dragon fruit met the requirements for homogeneity, melting point, pH, and stability tests, on (F2) with a concentration of 6% aloe vera and 5% red dragon fruit does not meet the requirements of the pH test, but meets the requirements of the homogeneity test, melting point test, and stability test. Whereas for (F3) with a concentration of 10% aloe vera and 7% red dragon fruit did not meet the homogeneity and pH test requirements, but met the melting point and stability test requirements. It can be concluded that Aloe Vera Extract and Red Dragon Fruit can be formulated into lip balm dosage forms. Differences in concentration variations can affect the moisture on the skin and the color of the preparation.
GAMBARAN EFEKTIFITAS PENERAPAN 5 STANDAR OPERASIONAL PROSEDUR (SOP) PELANGGAN DI PBF BINA PRIMA SEJATI JAKARTA BARAT Brahmono, Angga; Saragi, Sahat; Andayani, Nurita
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.396

Abstract

The CDOB guidelines state that in implementing CDOB, one must have an SOP. SOP formulation as a benchmark in assessing the effectiveness and efficiency of agency performance in implementing its work program. The principle of preparing SOPs must also be oriented to the parties served so that they can provide satisfaction to users. It is important for PBF to pay attention to the quality of services provided to pharmacies because it can lead to satisfaction and a positive attitude from customers. The purpose of this study was to determine the effectiveness of implementing 5 customer SOPs at PBF Bina Prima Sejati. The method used in this research is descriptive method with observation. The results of the study showed that the results of the SOP for distributing drugs to new pharmacies were 93.65% carried out by officers; SOP for handling customer complaints has only been implemented 43.81%; SOP for handling counterfeit and suspected counterfeit drugs has only been implemented 80.47%; The SOP for handling new returned drugs was 98.64% carried out by officers and the SOP for handling new recalled drugs was 89.68% carried out by officers. Overall 5 SOPs related to new customers 81.25% are carried out by officers. If it is seen that the effective implementation of the SOP must be 100%, then the implementation of the 5 customer SOPs is not effectively carried out by officers.

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