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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL dan FRAKSI DAUN SEMBUNG (Blumea balsamifera L.) TERHADAP BAKTERI Staphylococcus epidermidis Sa'adah, Hayatus; Pristanti, Ragilia; Warnida, Husnul
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.440

Abstract

Sembung Leaves (Blumea balsamifera L.) is a plant with many properties, one of which is antibacterial. Sembung leaves have several chemical compounds such as tannins, saponins, and flavonoids which function as antibacterials. This study aims to determine the diameter of inhibition zone, the value of Minimum Inhibition Concentration (MIC) dan the value of Minimum Bactericidal Concentration (MBC) of ethanol extract, n-hexane fraction, ethyl acetat fraction and water fraction of sembung leaves (Blumea balsamifera L.) against the staphylococcus epidermidis bacteria. Antibacterial testing by using disc diffusion dan solid dilution methods. Ethanol extract and fractions of sembung leaf (Blumea balsamifera L.) that has been obtained are diluted with a concentration of 10%, 25%, and 50%. The positive control as clindamycin 1% and DMSO as the negative control. The results showed that ethanol extract of sembung leaves (Blumea balsamifera L.) can inhibit the growth of Staphylococcus epidermidis bacteria at a concentration of 10% which is 8,1 mm, concentration of 25% which is 9,13 mm, concentration of 50% which is 10,1 mm. The n-hexane fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10 % which is 6,1 mm, concentration of 25% which is 7,11 mm, concentrarion of 50% which is 7,21 mm. The ethyl acetate fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10% which is 9,1 mm, concentration of 25% which is 11,16 mm, concentration of 50% which is 12,26 mm. The water fraction there is no inhibition zone diameter. The MIC of ethanol extract of sembung leaves is 10%, n-hexane fraction is 25% and ethyl acetate fraction is 10%. The MBC of ethanol extract was at a concentration of 25%, n-hexane fraction at a concentration of 50% and ethyl acetate fraction at a concentration of 10%.
FORMULASI SEDIAAN GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) SEBAGAI TERAPI LUKA SAYAT PADA KELINCI NEW ZEALAND WHITE Raharjo, Danang; Ika Dwi Ningrum; Listyani, Tiara Ajeng
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.443

Abstract

Breadfruit leaf (Artocarpus altilis) is a type of plant that has a single to oval leaf from the Moraceae family. There are secondary metabolites in breadfruit leaves (Artocarpus altilis), namely flavonoids, tannins, and saponins which are efficacious as a treatment for the wound healing process. This study aims to determine whether breadfruit leaf extract (Artocarpus altilis) can be formulated into a gel preparation and to determine the maximum concentration of breadfruit leaf extract (Artocarpus altilis) in wound healing. This study was an experimental study to determine the maximum concentration in healing cuts with varying concentrations of 6.25%, 12.5%, and 25% tested on 5 male rabbits with 3 treatment groups. Wound healing data were analyzed using One Way ANOVA (Analysis of Varian) and the physical evaluation of the gel preparation was analyzed descriptively. The results showed that breadfruit leaf extract (Artocarpus altilis) could be formulated into gel preparations and fulfilled the physical evaluation test for gel preparations. Statistical test results had a significant effect on wound healing in rabbits p=0.001 (p<0.05) and the maximum concentration in wound healing was a concentration of 25% with a healing time of 11 days.        
UJI FISIK DAN UJI HEDONIK SEDIAAN LIP CREAM EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) Amanda, Larissa; Pratiwi, Pramita Yuli; Pradana, Riska Chandra
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.446

Abstract

Red Betel leaf (Piper crocatum Ruiz & Pav) has many benefits, one of the examples for antioxidant. Red Betel has not been widely used as a cosmetic preparation. This study was to know the result of physical test a lip cream with red betel leaf extract (Piper crocatum Ruiz & Pav) which has good physic and was liked by panelist. The use of red betel leaf extract in formula 1 was 0,9%, formula 2 was 1,2%, and formula 3 was 1,5% extract. Lip cream preparation tests produced from physical tests included organoleptic test, homogeneity, spreadability, adhesiveness, pH test, and hedonic test. The result of lip cream formulation indicated a homogeneous preparation, easy to spread with 5.2-5.4 cm, had a good adhesion with 10-20 second and owned pH of more than 4. The three formulas were by the standard requirement. In the hedonic test of texture, the most liked was formula 2 (83%), formula 3 was the most liked because of color (88%), and the aroma in formulas 1, 2, and 3 have the same aroma was liked by panelist (83%) The conclusion of the study was the result of a physical test of quality showed that each formulation accordance with a good lip cream standard.  
UJI EFEK ANTIBAKTERI KOMBINASI DAUN GEDI DAN DAUN KUMIS KUCING TERHADAP Staphyloccocus aureus Karnelasatri, Karnelasatri; Trisina, Jessica; Sekeon, Yehuda Yeziel Theofilus; Febriani, Fany
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.458

Abstract

            Gedi (Abelmoschus manihot (L.) Medik) and Java tea leaves (Orthosiphon aristatus (Blume) Miq.) are known to have antibacterial activity. The combination of these two plants in inhibiting Staphylococcus aureus bacteria needs to be known to determine whether there is a synergistic effect from the combination. The synergistic effects can be demonstrated by the presence of greater antibacterial activity in the combination of both plants compared to single plant extracts. The extraction of both leaves was carried out with 96% ethanol and the maceration method. Antibacterial assay utilized the disc diffusion method with an extract concentration of 10,000 ppm and an extract ratio between two extracts was 100:0, 75:25, 50:50, 25:75, and 0:100. The positive control used was gentamicin, while the negative control used was dimethyl sulfoxide (DMSO). The resulting inhibition zones of extract combinations were 8.21 mm, 9.49 mm, 7.86 mm, 8.03 mm, and 8.74 mm, respectively. The results of data analysis using One Way ANOVA showed a sig p> 0.05, which indicated that there was no significant difference between extract comparisons, both single and combined. Based on the inhibitory zones was obtained and the statistical analysis, the combination of 10.000 ppm 96% ethanol extract of Gedi and Java tea leaves had an antibacterial activity in the weak category and did not have a synergistic effect in inhibiting the growth of Staphylococcus aureus.
FERMENTASI BIJI BUAH NANGKA (Artocarpus heterophyllus Lam.) MENGHASILKAN ETANOL OLEH Saccharomyces cerevisiae DENGAN ANALISA KROMATOGRAFI GAS (GC) Fitriani, Ana; Kartika, Rudi; Akkas, Erwin
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/df0qqc47

Abstract

Research of bioethanol production from jackfruit seeds through fermentation using saccharomyces cerevisiae with the addition of tofu waste as nutrition source of microorganism. the aims of this research to determine the concentration of bioethanol that has been produced with the variation of concentration of tofu waste nutrients and variation of fermentation time. the hydrolysis process through enzymatic uses alfa-amylase on liquefaction process and glucoamylase on saccharification process. the fermentation process used Saccharomyces cerevisiae and tofu waste as a source of nutrition. variation of fermentation time 6, 8 and 10 days and variation of tofu waste nutrients concentration 0,75%; 1,5% and 2,25% (w/v). Ethanol content was obtained by gas chromatography analysis, the result showed the highest concentration of bioethanol obtained at the addition of tofu waste nutrients was 1,5% (w/v) and fermentation time for 10 days with bioethanol concentration obtained at 65,72%.
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER WAJAH GEL PEEL-OFF EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) Aditama, Agnis Pondineka Ria; Kusumaningtyas, Rili; Karimah, Widya Nuratika; Paramita, Denok Risky Ayu; Rashati, Dewi; Muslikh, Faisal Akhmal
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.467

Abstract

            Red dragon fruit (Hylocereus polyrhizus) has many benefits. The fruit peel is rich in antioxidants which have the potential to improve the health and beauty of facial skin. Traditional use requires a long preparation time and formulation is needed to make preparations with more effective, practical and long-lasting storage. The facial mask formulation is a peel-off gel preparation that can moisturize the skin and increase the effect of the active ingredients. Quality assurance, namely safety, quality and benefits, is very necessary, which can be done by testing the physical stability of the preparation. The aim of this research is to obtain a formula made from the active ingredient Hylocereus polyrhizus fruit peel extract in the form of a peel-off gel facial mask and the best physical stability. HPMC was used as a carrier base by varying the concentration, namely 2%; 3% and 5%. Evaluation of the physical stability of the preparation was carried out, namely homogeneity, organoleptic, spreadability, viscosity, pH and dry time tests of 14 and 28 days. Storage is carried out at warm (30-40°C), room (15-30°C), and cold (2-8°C) temperatures. The best formula is 3% HPMC concentration with the best physical stability. Variations in storage temperature have an effect on physical organoleptics (color), viscosity and dispersion, but have no effect on physical homogeneity, drying time and pH. Cold temperatures (2-8°C) show the best stability because they can maintain physical stability.
GAMBARAN FUNGSI GINJAL PASIEN DIABETES MELITUS TIPE II DI PUSKESMAS TLOGOSARI KULON KOTA SEMARANG Rukminingsih, Fef; Julianti, Carla
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.476

Abstract

Type II Diabetes Mellitus (DMTII) patients who are not treated properly can experience decreased renal function. The use of oral hypoglycemic drugs (OHG) can cause a decrease in renal function. Glomerular Filtration Rate (GFR) can describe a decrease in renal function. The aim of this study was to determine the description of renal function in DMTII patients at the Tlogosari Kulon Health Center, Semarang City. This research is a descriptive observational study. The sampling technique used was purposive sampling. Data was obtained from medical records of DMTII patients for the period September–December 2022. The inclusion criteria were patients with DMTII who received OHG therapy for at least one year, aged ≥45 years, had the most recent serum creatinine examination, with or without comorbidities. If the patient's data is incomplete or the patient has a history of renal problems, they will be excluded. Based on the research results, it was discovered that there were 55 DMTII patients, consisting of 39 patients (70.90%) women and 16 patients (29.10%) men. A total of 29 patients were aged between 60-69 years (52.73%). A total of 39 patients had comorbidities such as hypertension and/or dyslipidemia. A total of 76.36% received OHG combination therapy. Forty percent of patients experienced a decrease in GFR from mild-moderate to severe. The decrease in GFR is caused by the amount of OHG consumed and comorbid hypertension
FORMULASI MASKER GEL PEEL OFF EKSTRAK BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTIOKSIDAN ALAMI Aulia Rahmi Azizah; Rasidah, Ananda Imroatur; Wilujeng, Firdianty Lestari; Piya, Nor; Yuliani, Siska Dwi; Adhila, Ghina; Sundu, Reksi
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.477

Abstract

Natural ingredients containing antioxidant compounds can be made in the form of a peel-off gel mask which can help care for facial skin. Butterfly pea flowers (Clitoria ternatea L.) contain flavonoid anthocyanin compounds which can break the chain reaction of free radicals. The aim of this research is to determine the antioxidant activity of butterfly pea flower extract and the preparation of butterfly pea peel off gel mask. The peel off gel mask formulation uses butterfly pea flower extract with a concentration of 5%. Testing for antioxidant activity uses the DPPH method. Physical characteristics assessment includes organoleptic tests, homogeneity observations, spreadability tests, viscosity tests, drying time tests, and preparation pH tests. Based on the research results, the IC50 value of telang flower extract is 43.68 ppm in the very strong category and the IC50 value of the peel-off gel mask preparation is 307.71 ppm in the inactive category. This research shows that the ethanol extract of butterfly pea flowers has potential as a natural antioxidant.
EVALUASI KESESUAIAN WAKTU TUNGGU PELAYANAN RESEP DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT UMUM KABUPATEN TANGERANG NOVEMBER 2022 Sabrina, Alifa; Rianto, Leonov; Tuahuns, Farida; Savitri, Fitri; Yulianto, Fery
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.482

Abstract

       Service Standards in hospitals related to pharmaceuticals are divided into several criteria, one of which is the waiting time for prescription services. Tangerang Regency general hospital is one of the type B government hospitals, being a referral makes RSU Tangerang Regency experience a buildup of patients in each polyclinic which results in many prescriptions entering outpatient pharmacies so that they often experience a buildup of prescriptions that cause discomfort to patients. The purpose of this study was to determine what is the average waiting time for outpatient prescription services at Tangerang Regency General Hospital and the percentage of conformity of non- concoction or concoction prescriptions with prescription service standards in accordance with the ministry of health. This study is a descriptive study using primary data, namely waiting time data recorded directly. Waiting time data obtained from direct observation during prescription services in outpatient pharmacy installations with research instruments using excel computer waiting time, data with a total population of 5087 outpatient prescriptions. The data that has been obtained is then analyzed using the mean formula (average value). The results of the research show that the average service for non-concocted drug prescriptions is more than 30 minutes and the average service for prescriptions of concocted medicines is more than 60 minutes, so that the suitability of waiting times for non-concocted and concocted prescriptions is still greater than that which does not comply with the minimum service standards.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT DAN DAGING BUAH NAGA MERAH (Hylocereus polyrhizus) DANPENENTUAN PARAMETER NON SPESIFIK Aliya, Nuska; Riyanta, Aldi Budi; Muldiyana, Tya
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.485

Abstract

Red dragon fruit is one of the fruits that is often consumed by the Indonesian people because it is rich in properties and benefits. In addition to the fruit, red dragon fruit skin can also be used as a natural colorant in food and cosmetics. One of the beneficial compounds contained in the skin and flesh of red dragon fruit is antioxidant. This study aims to determine the differences in antioxidant activity and non-specific parameters of red dragon fruit skin and flesh extracts. The samples used are skin and flesh of red dragon fruit, in addition to comparing fresh samples and dried simplisia of each skin and flesh, dried simplisia samples from each skin and flesh. Method extraction method used in this study is reflux method with 70% ethanol solvent. Antioxidant activity was determined by IC50 value. From the IC50 calculation, it was found that red dragon fruit peel extract with fresh samples and dry simplisia included strong antioxidants while antioxidants in red dragon fruit flesh were lower with weak antioxidant activity. The difference in the use of simplisia also affects the antioxidant activity of the extract, extracts using dry simplisia have higher antioxidant activity than extracts using fresh samples. While in the test of non-specific parameters of the extract there is no significant effect.

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