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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 215 Documents
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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL RIMPANG KUNYIT HITAM (Curcuma caesia Roxb.) ASAL LUWU UTARA DENGAN METODE DPPH Hasan, Tahirah; Ida, Nur; Qifni, Septi Firqiana
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.397

Abstract

The ethanol extract of black turmeric (Curcuma caesia Roxb.) contains flavonoids compounds which are thought to have antioxidant activity.The purpose of this study was to determine the class of chemical compounds and determine the IC50 value of the ethanol extract of black turmeric (Curcuma caesia Roxb.)rhizome from North Luwu using the DPPH method. The research method included extraction by maceration using 70% ethanol solvent. Phytochemical screening using specific reagents and antioxidant activity testing using the DPPH method using a visible spectrophotometer at a wavelength of 515 nm. The results of the phytochemical screening showed that the ethanol extract of black turmeric rhizome contained flavonoids, alkaloids, tannins and triterpenoids. The results of the antioxidant activity test showed that the ethanol extract of black turmeric (Curcuma caesia Roxb.) rhizome had an IC50 value of 108.8304 ± 1.24 μg/mL and ascorbic acid of 2.39 ± 0.04 μg/mL.
FORMULASI KAPSUL ANTIDIABETES EKSTRAK UMBI BAWANG DAYAK (Eleuhterine palmifolia (L) Merr.) DENGAN VARIASI KONSENTRASI AVICEL 101 DAN PREGELATINIZED STARCH Indriawan, Kadek Agus; Sa'adah, Hayatus; Helmidanora, Rusdiati
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.402

Abstract

Diabetes Mellitus is a heterogeneous disease characterized by improvement glucose levels in the blood. Several studies have shown that Dayak onions have hypoglycemic activity or lowering blood glucose levels which may be very useful for treatment of diabetes mellitus. Flavonoids contained in Dayak onions are in position to restore the characteristics of pancreatic tissue by increasing insulin release through β cells, so that it can lower blood sugar levels and can also increase sensitivity peripheral cells to insulin. Given the great potential of Dayak onions as antidiabetic, it is very important to develop more practical preparations that can carrying out weight uniform measurements of the products used, of course, one of them is in pharmaceutical preparations capsule form. This examination aims to determine the physical properties and antioxidant activity of Dayak onion extract capsules in large quantities concentration of Avicel PH 101 and pregelatinized starch as fillers. Look was carried out experimentally using three formulas with various concentrations fillers with a ratio between Avicel PH 101 and pregelatinized starch, in particular formula I (1:0), formulation II (0.5:0.5) and method III (0:1). body residence and drug stability is checked and then tested for antioxidant hobby spectrophotometric use. The research results show that the formula with the composition of Avicel PH 101 and pregelatinized starch in the ratio (0:1) is given the best wet house physical test results were 3.4%, sliding houses 12.82 gram/second, angle of repose 29.85⁰, compressibility 8%, density 0.544 and destroyed time 3 minutes 37 seconds. along with antioxidant effects activity examination showed that the drug Dayak onion extract proved to be moderate antioxidant activity, specifically 228.78 ppm.  
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN KATANG (Ipomoea pes-caprae L.) ASAL WOLU PROVINSI MALUKU MENGGUNAKAN METODE DPPH Hasan, Tahirah; Irfayanti, Nur Alfiah; Arifin, Arfiani; Muhammad, Andila Sari
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.413

Abstract

Ipomoea pes-caprae (L.) is a plant that comes from the convolvulaceae family and is known to have benefits as antioxidant. This study aims to determine the antioxidant activity of ethanol extract of Maluku's katang leaf (Ipomoea pes-caprae L) against DPPH free radicals. Katang leaves simplicia was extracted using 70% ethanol by maceration Testing of antioxidant activity against DPPH free radicals was analyzed using a viable spectrophotometer at a wavelength of 515 nm. The results of the analysis showed that the antioxidant activity of ethanol extract of katang leaves (Ipomoea pes-caprae L.) had an IC50 value of 92.5266±1.83 pg/mL The antioxidant activity ability of katang leaf extract is 0.066 times compared to ascorbic acid with an IC50 value of 6.12810.07 μg/mL
UJI EFEK ANTIPIRETIK  EKSTRAK ETANOL BIJI KORO BENGUK (Mucuna pruriens L.) DENGAN METODE SOKHLETASI PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) Putri, Alifa Ayuanti Santosa; Kusuma, Eka Wisnu
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.417

Abstract

Mucuna pruriens L is a plant that lives in a tropical climate and is widely found in Indonesia. Public knowledge on how to use velvet bean is still limited. Mucuna pruriens L plants have benefits such as antibacterial, gout, cancer, diabetes, kidney stones. The purpose of this study was to determine the effectiveness and antipyretic effect of Mucuna pruriens L  ethanol extract. This study used the socleation method as an extraction method. Velvet Mucuna pruriens L  ethanol extract was given orally to male white rats. The administration of extracts was divided into 5 groups, namely group 1 given CMC-Na as a negative control, group II paracetamol 45 mg / kg BB, group III 200 mg / KgBB and group IV 300 mg / KgBB and group V 400 mg / KgBB. The body temperature of the rats was measured at intervals of 30 minutes to 150 minutes when they were given the test substance orally. Based on research analysis showed that at a dose of 400 mg / KgBB mhad a comparable entipyretic effect strength in positive controls. Therefore, Mucuna pruriens L have potential as antipyretic drugs.
RENDEMEN EKSTRAK ETANOL HERBA RUMPUT AKAR WANGI  (Polygala paniculata L) PADA PERBANDINGAN KONSENTRASI PELARUT Pradana, Anugerah Riska; Wahyudi, Hendra; Lestari, Dwi
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.418

Abstract

Rumput akar wangi (Polygala paniculata (L)) belongs to the Polygalaceae family. One of the extract yields is influenced by solvent concentration. The aim of the research is to determine the effect of variations in concentration on the yield of Polygala paniculata extract and the groups of compounds in the extract. This research includes determination, collection, and plant preparation, processing of Polygala paniculata simplicia, extraction, screening, and determination of yield. In this study, 50 grams of Polygala paniculata powder were extracted with different solvent concentrations, namely 70% and 95% ethanol using the maceration method. Replication was carried out on each solvent three times. Data were analyzed using descriptive methods and processed using SPSS (Statistical Product and Service Solutions) tools. The results of phytochemical screening showed that the extract contained flavonoids, tannins, saponins, and terpenoids. The calculation results of the ethanol extract of Polygala paniculata were 70% ethanol (17.77% ± 1.34) and 95% ethanol (12.59% ± 0.86). The SPSS test results on the Independent Samples Test show that there is a significant difference (p < 0.05). The highest yield of Polygala paniculata extract was obtained using 70% ethanol for filtration.
KARAKTERISASI DAN SKRINING FITOKIMIA BUAH LABU KUNING (Cucurbita moschata Duch.) Budiman, Hariyadi; Supriningrum, Risa; Sundu, Reksi
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.420

Abstract

Pumpkin (Cucurbita moschata Duch.) is one of the plants that contain carotenoids, water-soluble vitamins, phenolics, flavonoids polysaccharides, mineral salts. Pumpkin is a vegetable that has many health benefits. Empirically, the pulp is used to treat diabetes, hypertension, tumors, immunomodulators and antibacterials. The benefits of a natural material with medicinal properties need to be proven scientifically through research. As a first step, characterization of simplisia and ethanol extract of pumpkin fruit and secondary metabolite content were carried out.  This study aims to determine the characteristics of simplisia and pumpkin fruit flesh extract and its secondary metabolite content. Characterization includes specific and non-specific parameters. Pumpkin fruit was extracted by maceration with 70% ethanol and obtained an extract yield of 29.68%. Specific characterization results include organoleptic observations in the form of thick blackish brown extract, bitter taste, and distinctive smell. Organoleptic simplicia simplicial piece, odorless, yellow, and bitter taste. The average level of soluble compounds in water extract is 47.33% and simplisia is 22%, while the average soluble compound in ethanol extract is 51.77% and simplisia is 31.33%. Non-specific characterization results include the average total ash content of extracts of 6.52% and simplisia of 8.33%, acid insoluble ash content test averaged 0.31% extracts and 0.22% simplisia. The average water content was 17.55%. The average specific gravity of the extract was 1.02 g/mL and the results of the total microbial contamination in the extract were 4.2 × 103 colonies/g and simplisia were 4.6 x 103 and the yeast mold number in the extract was 1.3 × 102 colonies/g and simplisia was 1.7 × 102 colonies/g. Pumpkin fruit extract and simplisia contain secondary metabolites including alkaloids, flavonoids, saponins, and terpenoids.
PERBANDINGAN TOTAL SENYAWA FLAVONOID EKSTRAK ETANOL KULIT DAN BIJI BUAH OKRA HIJAU (Abelmoschus esculentus L.) Yanti, Dharma; Putri, Indah Ananda
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.424

Abstract

Green okra (Abelmoschus esculentus L.) is a plant belonging to the Malvaceae family. Green okra fruit contains many secondary metabolites, one of which is flavonoids, which have potential as antioxidants to stabilize free radicals. This study aims to determine and compare the total flavonoid content of seeds and skin, so that it can be ascertained which part of the fruit has the highest total flavonoid content. The okra fruit extraction process was carried out by maceration with 70% ethanol solvent. Phytochemical screening and thin layer chromatography tests were performed on green okra seeds and skin extracts. The total flavonoid content was determined using the colorimetric-aluminum chloride method with UV-Vis spectrophotometry. The results of the phytochemical screening showed that the ethanol extract of green okra fruit peels contained alkaloids, flavonoids, tannins, and steroids, while the ethanol extract of green okra fruit seeds contained alkaloids, flavonoids, saponins, and tannins. The results of the thin layer chromatography test showed that the ethanol extract of green okra fruit skin and seeds contained a flavonoid compound as quercetin. The results of the total flavonoid content of the ethanol extract of green okra fruit skin : okra fruit seeds were 6.4589 mg QE/g extract ± 0.86 : 27.7583 mg QE/g extract ± 0.36. Based on statistical results with an Independent T test using SPSS, the significance value (2-tailed) of both samples was < 0.05, which means that there is a real difference between the total flavonoid compounds of skin ethanol extract and ethanol extract of green okra fruit seeds.
GAMBARAN TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK EMPUNALA PERIODE MARET – MEI 2023 Priyoherianto, Andri; Fitriany, Erna; Legowo, Deny Budi; Arif, M. Rizky
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.426

Abstract

 Pharmaceutical services are health services that have an important role in realizing health quality. Pharmaceutical services apart from being a 2 demand for professionalism such as a factor that attracts consumers' interest in purchasing drugs at pharmacies in order to obtain patient satisfaction. The purpose of this study was to describe the level of patient satisfaction with pharmaceutical services at the Empunala Drug store and to improve the quality of pharmaceutical services at the Empunala Drug store. This Research is descriptive non-experimental with incidental sampling, data collection using a questionnaire. The results of the study on the level of patient satisfaction with pharmaceutical services at the Empunala Drug store period March until May 2023 concluded on the Reliability dimension is 76%, the Responsiveness dimension is 78%, the Assurance dimension is 78%, the Emphaty dimension is 77%, and the Tangible dimension is 80%.
GAMBARAN PENGADAAN OBAT E-PURCHASING UNTUK PASIEN PROGRAM RUJUK BALIK DI APOTEK KIMIA FARMA SAMARINDA Islami, Vita Hani; Ansyori, Achmad Kadri; Helmidanora, Rusdiati
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/0whwam97

Abstract

Procurement plays an important role in the drug management cycle. Efforts to improve performance and efficiency in the drug procurement process, both for the JKN program and other health programs, procurement of drugs and medical devices must use an e-catalogue. The Refer Back Program (PRB) is BPJS Health's flagship program. Kimia Farma Pharmacy is a network pharmacy for the Refer Back Program. Kimia Farma Samarinda Pharmacy, in the procurement of PRB medicines has used e-purchasing and there are still obstacles found in the procurement system such as long lead times, unavailability of medicines at distributors, and price uniformity resulting in shortages of medicines which have a negative impact on the availability of medicines for patients referral program. This research aims to determine the management of drug availability using e-purchasing for referral program patients at Kimia Farma Samarinda Pharmacy. This research is qualitative research with a case study approach. The research was carried out by collecting primary data obtained through in-depth interviews with respondents who were deemed to know and be involved in the procurement and/or management process of medicines at Kimia Farma Pharmacy No. 114 Samarinda. Secondary data was obtained through observing documents related to drug procurement at Kimia Farma Pharmacy No. 114 Samarinda. Research results obtained from Kimia Farma Pharmacy No. 114 Samarinda show that the level of drug availability at Kimia Farma Pharmacy No. 114 Samarinda is still low (14.33%). The availability of PRB drugs in pharmacies is not sufficient to meet the needs of PRB participants. Drug vacancies are mostly caused by vacancies from distributors. To avoid patients not getting medicine, pharmacies borrow medicine from other Kimia Farma pharmacies or reduce the amount of medicine given to patients.
PENGEMBANGAN FORMULASI EMULGEL FRAKSI n-HEKSAN DAUN MIANA (Coleus scutellarioides) SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acnes PENYEBAB JERAWAT (Acne vulgaris) Auliah, Nielma; Bachri, Nurjannah; SR, Muhammad Asri; Nurfatma, Nurfatma
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.431

Abstract

Acne (Acne vulgaris) is a condition where the skin experiences inflammation in the polysebaceous unit which is triggered by Propionibacterium acnes. Miana leaves (Coleus scutellarioides) contain alkaloid and terpenoid compounds which can act as antibacterials. This research aims to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) can be formulated in the form of a physically and chemically stable emulgel preparation, to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) has activity against P. acnes. as a cause of acne (A. vulgaris) and to determine the formula with an effective concentration in inhibiting the growth of P. acnes. This research is a form of laboratory experimentation. The n-Hexane fraction of miana leaves was obtained by fractionation. Antibacterial activity testing was carried out using the well method. The results obtained were physically and chemically stable emulgel formulas, namely F0 and F1. The inhibition zone of F1 is 16.46 mm (strong), F2 is 14.40 mm (strong), F3 is 16.78 mm (strong) and F0 has no antibacterial activity. The formula with a concentration of 12.5% was the most effective in inhibiting the growth of P. acnes, namely 16.78 mm. From the results of this research, it was found that the n-Hexane fraction of Miana leaves (C. scutellarioides) has strong antibacterial activity against P. acnes and can be formulated in the form of an emulgel dosage form.

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