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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 121 Documents
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PENETAPAN KADAR FENOLIK TOTAL FRAKSI POLR DAN NONPOLAR DAUN RAMBAI LAUT (Sonneratia caseolaris L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis Jubaidah, Siti; Sundu, Reksi; Sabriningsih, Nur
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.019 KB) | DOI: 10.33759/jrki.v1i2.23

Abstract

Rambai laut (Soneratia caseolaris L.) is a type of tree that grows in riverbank swamps or mangrove forests which contains one of the secondary metabolites in the form of phenolic compounds. The purpose of this study was to determine the total phenolic content of polar and nonpolar fractions of sea rambai leaves using UV-Vis spectrophotometry method. Research conducted is non-experimental. The stages of the study included the determination of plants, sampling, making samples, making extracts, determining the water content of extracts, fractionation using polar and nonpolar fractions, phytochemical screening test of ethanol extract and fractionation results and determination of total phenolic levels by UV-Vis spectrophotometry. The results showed that rambai laut leaf in polar fraction had a total phenolic content of 213.49 ± 1.2227 mg GAE / g, which means that in each gram the polar fraction is equivalent to 213.49 mg of gallic acid, whereas in the nonpolar fraction of rambai laut leaves is obtained 55.79 ± 1.0809 mg GAE / g which means that in each gram the nonpolar fraction is equivalent to 55.79 mg of gallic acid. Total phenolic content is greater in the polar fraction.
UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Auliah, Nielma; Lotuconsina, Ari Aprianto; Thalib, Muthmainnah
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.66 KB) | DOI: 10.33759/jrki.v1i2.24

Abstract

Research has been carried out with the title "Test of the Analgetic Effect of Ethanol Extract of Jackfruit Leaves (Artocarpus heterophyllus Lam.) On Acetic Acid-induced Mice (mus musculus). Analgesics or painkillers are drugs that reduce or eliminate taste without losing consciousness. One of the traditional plants commonly used empirically is jackfruit leaves (Artocarpus heterophyllus Lam.). This study aims to determine the analgetic effect of ethanol extract of jackfruit leaves (Artocarpus heterophylus Lam.) At a dose of 100 mg / kgBB, 300 mg / kgBB and 600 mg / kgBW on acetic acid induced male mice (Mus musculus). This research is an experimental study and uses the chemical induction method. The results obtained in the form of% protection inhibition stretching ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) At a dose of 100mg / kgBB (28.79%); 300mg / kgBB (53.31%); 600mg / kgBB (60.70%). From the results of the research that has been done it can be concluded that the ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) Has the highest analgesic effect at a dose of 600mg / kgBW having a percentage of protection of 66.70%.
PERBANDINGAN UJI DAYA HAMBAT ANTARA EKSTRAK AKAR BELUNTAS DENGAN KULIT BUAH MAHKOTA DEWA TERHADAP PERTUMBUHAN BAKTERI E.COLI Agustina, Ika; Efrilia, Mega; Lisnawati, Nia
Jurnal Riset Kefarmasian Indonesia Vol 1 No 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.604 KB) | DOI: 10.33759/jrki.v1i3.31

Abstract

When this has been much studied extracts of herbs or traditional medicines, among other crops beluntas (Pluchea indica Less) and mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) As an antibacterial. Previous research has suggested that the rind of the gods crown and root beluntas known to have antibacterial activity, but please be more certain with the same methods and evaluation in testing the antibacterial activity of both plants against bacteria Escherichia coli. Are both these plants have a vigorous activity the same or different from one another. The method used to test the antibacterial activity is using the disc. The results showed beluntas root extract has inhibitory activity against Escherichia coli was higher than fruit skin extracts gods crown with a minimum concentration of 6%, while the fruit skin extracts crowns a new god looks at a concentration of 12%. Based on the paired t-test showed that there is a significant difference between the antibacterial activity of root extracts beluntas with fruit leather crown god.
FORMULASI MASKER GEL PEEL-OFF PERASAN LIDAH BUAYA (Aloe vera L.) DENGAN GELLING AGENT POLIVINIL ALKOHOL Santoso, Ivan; Prayoga, Tria; Agustina, Ika; Rahayu, Wiwit Setya
Jurnal Riset Kefarmasian Indonesia Vol 2 No 1 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.986 KB) | DOI: 10.33759/jrki.v2i1.33

Abstract

Aloe vera (Aloe Vera L.) is a plant which commonly used by local people as moisturizer. The usage of aloe vera can be applied in form of peeled off gel mask with polyvinyl alcohol as gelling agent. The goal of this research is to determine the influence of increase of polyvinyl alcohol as gelling agent to the formulation of peeled off mask from aloe vera juice. The formulation was made in a few concentration, 10%, 12%, and 14% by adding 0,5% of aloe vera juice. After that, the formulation evaluated for 4 weeks about the organoleptics, homogenity, pH, drying time and viscosity. The date of pH test and drying time analyzed by using one way ANOVA statistically and then followed by Tukey HSD test and the viscosity analyzed by using Kruskall Wallis statistically which result in the significantcy less than 0,05 that mean there are difference in drying time and viscosity, on the other hand there is no difference in pH.
PENENTUAN NILAI SPF EKSTRAK ETIL ASETAT DAUN MANGGA GEDONG MENGGUNAKAN SPEKTROFOTOMETRI UV - VIS Lisnawati, Nia; N.U, M Fathan; Nurlitasari, Dwi
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.5 KB) | DOI: 10.33759/jrki.v1i2.35

Abstract

One way that is done to reduce the negative impact of sunlight is by using sunscreen. Sunscreen can protect the skin by spreading sunlight or absorbing sunlight radiation energy that is about the skin. Phenolic compounds especially flavonoid groups have the potential as a sunscreen because of the chromophore group (single conjugated double bond) capable of absorbing UV light both UV A and UV B, thus reducing the intensity of the skin. Flavonoids have three properties of photoprotektor that is UV absorption, antioxidant properties, and modulate some DNA signaling pathways. The potential of sunscreen can be expressed with Sun Protection Factor (SPF). SPF is designated as UV protection B and is not specifically intended to resist UV A and UV C. The purpose of this research is to know the value of SPF (Sun Protection Factor) of ethyl acetate extract of mango gedong leaves using UV-Vis spectrophotometry. Simplicia gedong mango leaves were extracted using ethyl acetate solvent by reflux. Gedong mango leaf extract identified flavonoid compound using 10% NaOH and H2SO4 (concentrated). Determination of SPF (Sun Protection Factor) value of med gedong leaf extract using UV-Vis spectrophotometry method. The concentration of ethyl acetate extract of mango gedong leaves used was 120 ppm, 240 ppm and 360 ppm. The SPF (Sun Protection Factor) values were analyzed using Mansur method. The result of identification of flavonoid compound showed that the extract of ethyl acetate of mango gedong leaves positively contain flavonoids, while the result of SPF (Sun Protection Factor) extract of ethyl acetate of mango gedong leaves was 5,556; 16,675 and 22,243. The SPF (Sun Protection Factor) extract of 5,556 muddy ethyl acetate leaves including moderate protection type, 16,675 and 22,243 including ultra-protection type when tested using UV-Vis spectrophotometry by Mansur method
FORMULASI SEDIAAN GEL EKSTRAK ETANOL 96% RIMPANG JAHE MERAH (Zingiber officinale Rosc. Var. Rubrum) DENGAN HIDROKSIETIL SELULOSA SEBAGAI GELLING AGENT L, Pricillya M; Falestin, Senny Listy Kartika; Julisna, Siska
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.862 KB) | DOI: 10.33759/jrki.v1i2.36

Abstract

Zingiber officinale Rosc. Var. Rubrum is a plant that has been determined to have antibacteria activity for Propionibacterium acnes which serve as one of the cause of acnes. Gel is the topical form used to acne’s medication. Hydroxiethyl Cellulose is used as gelling agent in gel of red ginger’s root’s ethanol 96% extract. The goal of the research is to determine the influence of increased concentration of hydroxiethyl cellulose to the formulation of red ginger’s root’s extract of ethanol 96%. The gel was made into 3 formulas with each concentration of 2%, 2.5%, and 3%. Each formulas wastested about the organoleptics, homogenity, pH, and viscosity. The result shows that on organoleptic test, the gels don’t have any change, they are homogen and their pH were stable. Based on the viscosity test, 1st, 2nd and 3rd formulas have some increase with the addition of storage’s time. The formula 1 have less viscocity with the concentration of about 2%. Based on this research, we can conclude that the 1 st formula was the best one based on the physical, chemical quality and the organoleptic test.
UJI Brine Shrimp Lethality Test (BSLT) UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) DAN UJI TOKSISITAS AKUT FRAKSI AKTIF Lestari, Dwi; Kartika, Rudi; Marliana, Eva
Jurnal Riset Kefarmasian Indonesia Vol 1 No 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.051 KB) | DOI: 10.33759/jrki.v1i1.43

Abstract

Eleutherine bulbosa (Mill.) Urb come from the Iridaceae family, this species contains secondary metabolites in the form of flavonoids and quinones. This research method includes Brine Shrimp Lethality Test (BSLT) toxicity using Artemia salina Leach larvae to determine the LC50 value. This study used experimental methods pharmacologically using a completely randomized design in the same direction pattern in the selection of test animals, 25 animals used were white mice divided into 5 groups with 5 mice per group, with 4 hours observed to find out toxic symptoms and continued observation every 24 hours to see death. Testing of BSLT results showed that ethanol extract had LC50 toxicity = 66.68 ppm (very toxic category), n-hexane fraction had LC50 toxicity = 47.64 ppm (very toxic category), chloroform fraction had LC50 toxicity = 295.1 ppm ( toxic category), and the water fraction has a toxicity of LC50 = 194.54 ppm (very toxic category). The chloroform fraction is an active fraction. Acute toxicity test LD50 value according to the calculation method of Miller Tainter Probit (187,499 mg/KgBB), the method of calculation of Thompson Weil (182,810 mg/KgBB), how to calculate Indonesian Pharmacopoeia (187,068 mg/KgBB). Based on the three calculations, the LD50 value is in the medium category (50-500 mg/kgBB).
OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.) Saryanti, Dwi; Setiawan, Iwan; Safitri, Romadona Ayu
Jurnal Riset Kefarmasian Indonesia Vol 1 No 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.503 KB) | DOI: 10.33759/jrki.v1i3.44

Abstract

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.
PENETAPAN KADAR FLAVONOID EKSTRAK DAUN KELAKAI (Stenochlaena palustris (Burm. F.) Bedd.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Syamsul, Eka Siswanto; Hakim, Yana Yunita; Nurhasnawati, Henny
Jurnal Riset Kefarmasian Indonesia Vol 1 No 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.064 KB) | DOI: 10.33759/jrki.v1i1.46

Abstract

Kelakai (Stenochlaena palustris (Burm F.) Bedd.) is a medicinal plant of Borneo. The purpose of this research is to determine the level of flavonoid in crude extract of kelakai leaf by UV-Vis Spectrophotometer. The research was conducted by collection of the kelakai leaves and plant determination. The ethanolic extract of kelakai leaves was collected using macceration methode. The determination of flavonoid level was conducted by UV-Vis Spectrophotometer using quersetin as standard compound. The study showed that the rendemen of crude extract of kelakai leaf was (22,92%). The moisture content in viscous extract was (19,71%). The level of Flavonoids in extract was (2,2159±0,083%).
EVALUASI TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI KLINIK X MENGGUNAKAN APLIKASI E-SERVQUAL BERBASIS WEB Rianto, Leonov; Al'Qarana, Gilang; Sabrina, Alifa
Jurnal Riset Kefarmasian Indonesia Vol 1 No 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.304 KB) | DOI: 10.33759/jrki.v1i3.52

Abstract

In an effort to improve the quality of service, patient satisfaction can be measured by the SERVQUAL (SERVICE QUALITY) method by making a comprehensive customer satisfaction assessment survey for services in the field of goods and services that prioritize pharmaceutical services. Customer satisfaction analysis is based on five dimensions of service quality, namely responsiveness, reliability, assurance, empathy, and tangible. The formulation of the problem in this study wanted to find out how patient satisfaction with pharmacy services in clinic X. The purpose of this study was to describe patient satisfaction with pharmacy services in clinic X. Using descriptive quantitative methods to determine the level of patient satisfaction with pharmaceutical services using questionnaires as instruments Study data on patient visits were treated at 3 months beginning in 2018 in January 2,970 patients, February 2,868 patients, and March 3,304 patients. Based on data that has been recapitulated in a system by web-based e-SERVQUAL application and its validity has been tested, the percentage of each variable is evenly distributed in the range of 70%, on the dimensions of attitude and appearance. , 20% of patients were satisfied, in the dimension of drug waiting time, 73.90% of patients were satisfied, on the assurance dimension 74.45% of patients were satisfied, on the dimensions of empathy satisfied patients were 73.50%, on the dimensions of facilities and patient facilities were satisfied , 87%. From these results, the patient is satisfied with the overall dimensions of service, the greatest level of satisfaction is in the dimensions of attitude and appearance, and the smallest level of satisfaction is on the dimensions of facilities and facilities, it can be concluded that the percentage of 74.14% is in the predicate satisfied.

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