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International Journal of Clinical Inventions and Medical Sciences (IJCIMS)
Published by Lamintang Education & Training Centre
ISSN : 27214737     EISSN : 27217302     DOI : https://doi.org/10.36079/lamintang.ijcims
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
The aims are to disseminate the conceptual thoughts or ideas and research results that have been achieved in the area of Clinical Inventions and Medical Science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 58 Documents
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Phytochemical Insights and Medicinal Potential of Panax notoginseng: A Comprehensive Study from Chiang Mai Sriariyanun, Chaiyavat; Kunwadee, Chalidabhongse; Samarakoon, Malinee; Thinzar, Shwe; Win Lin, Myo
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 1: March 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0601.612

Abstract

Panax notoginseng, a prominent medicinal plant, was studied to evaluate its phytochemical composition, cultivation practices, and therapeutic potential using samples from Chiang Mai, Thailand. Phytochemical analysis revealed high concentrations of bioactive compounds, including ginsenosides (notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1), with average levels of 2.5 mg/g, 3.8 mg/g, and 3.1 mg/g, respectively. UV-visible spectrophotometry indicated total flavonoid and polysaccharide contents of 7.4 mg/g and 6.1 mg/g, respectively. These findings suggest that the Chiang Mai region offers an optimal environment for cultivating Panax notoginseng, potentially enhancing its antioxidant and immune-modulatory properties. Surveyed local farmers identified key factors influencing phytochemical composition, including consistent irrigation, pest management, and soil quality. A positive correlation (r = 0.72, p < 0.05) was observed between organic farming practices and higher concentrations of ginsenoside R1, indicating that sustainable cultivation methods may improve medicinal quality. Despite promising results regarding the therapeutic potential of ginsenosides, especially for cardiovascular conditions, there is a need for further research to address safety concerns and drug interactions. Clinical trials are recommended to evaluate the long-term effects of Panax notoginseng in diverse populations. This study underscores the potential of Chiang Mai as a significant source of high-quality Panax notoginseng, with implications for improving cultivation practices and meeting global herbal medicine demands. Future research should focus on refining cultivation techniques and assessing the plant's safety profile.
Effectiveness of Using the Calendar Method of Self-Monitoring Medication Side Effects in SLE Patients Yuwindry, Iwan; Yusri; Tangkas, Hansel Hens
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 1: March 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0601.623

Abstract

An autoimmune rheumatic disease that produces widespread inflammation, affecting organs or systems in the body is known as Systemic Lupus Erythematosus (SLE). In a previous study, data were obtained from the results of an analysis based on the Naranjo algorithm obtained were that most respondents fell into the Probable category (Most likely to occur ROM) as many as 14 respondents or 35%, followed by the Definite category (Definite ROM occurs) as many as 12 respondents or 30%. Then the Possible category (Possible ROM occurs) as many as 9 respondents or 22.5% and finally the No ES category as many as 5 respondents or 12.5%. The type of research used was quantitative research with experimental methods through a pretest-posttest control group design by taking a sample and then conducting a pretest first to find out which samples are classified namely interventions experiencing side effects, interventions with no side effects, controls experiencing side effects and controls with no side effects. Based on the results of the Wilcoxon analysis with a p value <0.05, it states that the calendar has an effect on reducing the incidence of side effects in patients. Mann Whitney test showing a p value of 0.000 smaller than 0.05, so it can be interpreted that there are significant differences in side effects in patients with Systemic Lupus Erythematosus (SLE) in the intervention group and control group. The provision of functional calendar media is effective for reducing the incidence of side effects in taking Systemic Lupus Erythematosus (SLE) drugs.
Superoxide Dismutase from Marine as a Cytotoxic Agent Apriani, Dwi Wulan; Indrayati, Ana; Herdwiani, Wiwin; Rendati, Hema Novita; Zulfah, Khairina
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.680

Abstract

The prevalence of cancer in Indonesia has shown an increase from 1.4 per 1000 population in 2013 to 1.79 per 1000 population in 2018. 70% of our planet is covered by unparalleled air and marine biodiversity. Therefore, medical researchers have focused on the marine world which has great potential, in the last six decades (Sagar et al. 2010). To find out other uses of biota, it is necessary to study the SOD of marine biota that reacts with their metal cofactors, to determine the specific SOD of some biota, to determine the SOD cytotoxic activity of several marine biota, to determine the mechanism of SOD of marine biota as anticancer. This literature review was carried out in several stages: formulating problems, collecting, evaluating, analyzing, and synthesizing data. The data sources used are international journals from publishers such as Science Direct, Elseiver, and SpringerLink between 2010 and 2021. The literature results obtained for the SOD classification of marine biota based on metal cofactors are 1,092 articles. The articles obtained will be selected and 52 articles that meet the inclusion criteria will be reviewed. The results of the search for specific SOD activities from marine biota were obtained by 1,243 articles. 13 articles that meet the inclusion criteria and will be reviewed. The results of the search for SOD cytotoxic activity from marine biota obtained 2,199 articles. 7 articles that met the inclusion criteria will be reviewed. The search results for specific SOD activities from marine biota were 2,496 articles. 8 articles that meet the inclusion criteria and will be reviewed. The results showed that SOD from marine biota had cytotoxic activity.
Epidemiological Dynamics and Public Health Challenges of Mpox in Southern Thailand Ismail, Andi Almeira Zocha; Rahman, Siti Zulaikha; Anchana, Bamrungsap; Chantanee, Namuangruk; Bamrungsap, Pongkarn
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.707

Abstract

Mpox, a zoonotic viral disease, has emerged as a significant public health concern globally, especially since its spread beyond Central and West Africa in 2022. This study focuses on the epidemiological patterns of mpox in Southern Thailand, a region characterized by frequent human-wildlife interactions and cross-border activity. The findings reveal a high concentration of mpox cases in rural areas, with a prevalence rate of 15.4 per 100,000 population. The majority of cases occurred among males aged 25-40, highlighting a demographic trend linked to occupational and travel-related exposure. Transmission patterns indicate that close contact with infected individuals and wildlife are critical factors, with occupational exposure in rural areas posing significant risks. Public health interventions, such as isolation, hygiene promotion, and education, have been somewhat effective in urban settings but face challenges in rural areas due to limited healthcare access and low public awareness. The study emphasizes the need for targeted interventions, improved surveillance, and expanded vaccination efforts to mitigate the spread of mpox, particularly in regions with significant wildlife contact. Understanding these dynamics is essential for future outbreak control efforts in Southeast Asia and beyond.
Prevalence and Risk Factors of Obesity in Saudi Arabia Mahmood, Alsalme; Elwakeel, Niazi; Khaled, Abdel Salam; Mehedi, Qadri; Claudiu, Pierre; Gosselin, Cojocaru
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.710

Abstract

Obesity has become a pressing global health issue, marked by a rapid increase in prevalence and linked to serious health complications such as diabetes, cardiovascular diseases, and certain cancers. In Saudi Arabia, the obesity epidemic is particularly pronounced, with adult obesity rates at approximately 35% and childhood obesity exceeding 20%. This significant rise is driven by shifts in lifestyle and dietary habits, notably in urban areas like Riyadh and Jeddah, where high-calorie food consumption and sedentary lifestyles are prevalent. Key risk factors for obesity in Saudi Arabia include dietary habits characterized by high consumption of fast food and sugary beverages, as well as a sedentary lifestyle influenced by urbanization and technological dependence. Socio-economic factors, including limited access to healthy foods and gaps in health education, exacerbate the problem. Cultural resistance to dietary changes and ineffective public health strategies further complicates the fight against obesity. To combat this epidemic, several recommendations are proposed: implementing community-based exercise programs, enhancing school meal plans, subsidizing healthy foods, and enforcing stricter regulations on unhealthy food marketing. Future research should focus on evaluating the effectiveness of these public health initiatives, exploring genetic predispositions, and understanding the impact of socio-economic and cultural factors on obesity. These efforts are crucial for developing targeted, culturally appropriate interventions to address obesity and improve public health outcomes in Saudi Arabia.
Optimized Nano Hydrogels for Tropical Wound Care: Integrating Chromolaena odorata and Carbopol 980 for Enhanced Healing Chalidabhongse, Praneet; Sripanidkulchai, Rameshprabu; Tinakon, Suttajit; Rajchakit, Ramaraj; Tennakoon, Wongpakaran
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 1: March 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0601.714

Abstract

This study focuses on the formulation and evaluation of nano hydrogels containing Chromolaena odorata leaf extract, using Carbopol 980 as a gelling agent. Chromolaena odorata, known for its antimicrobial and anti-inflammatory properties, is traditionally used in Southeast Asia for wound healing. The primary objective was to determine the optimal concentration of Carbopol 980 for nano hydrogel formulations with desirable physical and chemical properties suitable for wound care, particularly in tropical climates like Thailand. The hydrogels were prepared with varying concentrations of Carbopol 980 (0.5%, 1.0%, 1.5%, and 2.0%). Evaluations were conducted on particle size, pH, viscosity, spreadability, and adhesion. The results demonstrated that the 0.5% concentration of Carbopol 980 yielded the most favorable properties, with a particle size of approximately 412.9 nm, optimal viscosity, and high spreadability, making it suitable for wound dressing applications. Nano hydrogels offer several advantages, such as controlled release of active substances and improved drug delivery, which are crucial for wound healing in tropical regions. The study highlights the potential of Chromolaena odorata as an affordable and effective ingredient in wound care products, leveraging local resources and traditional medicinal knowledge in Thailand. The findings suggest that these nano hydrogel formulations could enhance wound healing, and future research should focus on clinical trials to further assess their effectiveness in real-world applications.
Evaluating the Impact of Healthcare Access on Maternal and Child Mortality in a Rural Region of Myanmar Kwee, Than Phyu; Thet, Hnin; Khaing, Yaung Hlaing
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.716

Abstract

This study evaluates the impact of healthcare access on maternal and child mortality rates in the rural region of Kayin State, Myanmar, where disparities in healthcare services significantly affect vulnerable populations. Utilizing a cross-sectional study design from February to July 2024, the research employs both quantitative and qualitative methodologies. Quantitative data is gathered from government health records and local healthcare facilities, including maternal and child mortality rates, healthcare facility availability, and healthcare worker distribution. Qualitative insights are obtained through semi-structured interviews with healthcare providers, mothers, and local stakeholders, focusing on barriers to healthcare access. The findings reveal alarming maternal mortality rates of 250 per 100,000 live births and child mortality rates of 80 per 1,000 live births in rural areas, compared to urban counterparts. Major barriers identified include geographic isolation, economic challenges, and cultural factors limiting healthcare utilization. This study underscores the urgent need for targeted interventions to improve healthcare access in rural communities. Future research should investigate longitudinal impacts of healthcare interventions and the effectiveness of health education programs to further understand and mitigate healthcare disparities in rural Myanmar.
Unveiling Antimicrobial Resistance Trends in Malaysia: A Comparative Study with Global Pattern Ismail, Andi Regina Acacia; Lisa, Guymer; Diana, Katharina; Vasso, Nicola; Kylie, Anna
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.725

Abstract

This research explores the patterns of antimicrobial resistance (AMR) in Malaysia, with a focus on major bacterial strains such as MRSA, E. coli, Klebsiella, and Pseudomonas. Data from clinical microbiology laboratories in both public and private hospitals was collected using a cross-sectional, observational study design. Analysis of resistance rates indicated that MRSA showed a resistance rate of 45%, which was notably greater than the global standard of 30% (p < 0.01). Likewise, E. coli, Klebsiella, and Pseudomonas displayed resistance rates of 55%, 40%, and 35%, respectively. These results emphasize the increasing problem of AMR in Malaysia, especially in urban healthcare settings, where resistance rates were higher than in rural areas. In the future, researchers need to enhance AMR monitoring systems and encourage responsible use of antibiotics in Malaysia. Comparison with worldwide databases like WHO GLASS and CDDEP indicates that focused efforts in urban areas are needed to address the increasing resistance rates. This research highlights the need to tackle AMR promptly by collaborating among policymakers, healthcare providers, and public health institutions. Additional research is required to assess the efficiency of existing methods and discover innovative ways to address AMR within the area.
Comprehensive Analysis to Address the Spread of Tuberculosis Aung, Theint Myo; San, Min Htun; Khan, Win Latt; Thet, Myint Sein
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 7 No 1: March 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0701.764

Abstract

This research explores the elevated incidence of tuberculosis (TB) in Myanmar, where the burden of the disease dramatically surpasses the worldwide average of 500 cases per 100,000 individuals. The research seeks to investigate elements leading to TB prevalence, recognize obstacles to control measures, and suggest practical recommendations. A mixed methods strategy was employed, integrating quantitative information from health statistics in Yangon, Mandalay, and the rural regions of Chin and Shan States with qualitative information gathered from interviews with healthcare professionals and impacted communities. The study results indicate that poverty, malnutrition, limited access to health services, and a lack of awareness are major factors contributing to elevated TB rates, exacerbated by the rise of multidrug-resistant TB (MDR-TB). Insufficient health care systems and cultural prejudices also hinder successful TB management. The research emphasizes the necessity for focused interventions, such as enhancing access to healthcare services, boosting public awareness, and establishing thorough TB screening initiatives. The research highlights the importance of tackling the underlying causes of poverty and malnutrition to lower TB vulnerability. These results have important consequences for expanding TB control initiatives, not just in Myanmar but also in other nations encountering comparable socio-economic issues. Future studies ought to concentrate on assessing the efficacy of the suggested interventions and investigating creative approaches to enhance access to TB treatment while decreasing stigma.
Strengthening Global Health Through One Health Svensson, Anna; Winder, Marie; Bjorkman, Cleveland Monika; öderholm, Minguez
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 7 No 1: March 2025
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0701.772

Abstract

This study examines the implementation of the One Health paradigm in Sweden, which integrates human, animal, and environmental health sectors to address global health challenges. The primary research objective is to explore how Sweden has applied the One Health approach to manage zoonotic diseases, antimicrobial resistance (AMR), and the health impacts of climate change. Using a descriptive case study methodology, data were collected through documentary analysis and semi-structured interviews with 17 respondents from key institutions such as Karolinska Institutet, the Swedish University of Agricultural Sciences (SLU), and the Swedish National Veterinary Institute. The findings reveal that Sweden has made significant strides in cross-sectoral collaboration, enhanced surveillance systems, and improved policy responses, particularly in managing zoonotic diseases and controlling AMR. Sweden’s framework for data sharing and coordination between sectors serves as a model for other nations facing similar health challenges. The study identifies Sweden's approach to addressing climate change as part of the One Health framework as a critical contribution to global health. Future research should focus on overcoming barriers to local-level collaboration, improving data-sharing mechanisms, and developing real-time coordination strategies to further strengthen the One Health approach globally.

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