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SCRIPTA SCORE Scientific Medical Journal
Published by Universitas Sumatera Utara
ISSN : 20888686     EISSN : 26860864     DOI : https://doi.org/10.32734/scripta.v1i2
Core Subject : Health,
Medicine & Pharmacology
SCRIPTA SCORE Scientific Medical Journal is a journal aimed to provide a forum for publishing scientific articles in the field of medical or health science. The main focus of SCRIPTA SCORE Scientific Medical Journal is tropical medicine and oncology medicine also the rest of medical fields as the additional focus. To achieve its aim, SCRIPTA SCORE Scientific Medical Journal publishes research articles, review articles, and case reports especially manuscript with a regional or national data to raise the interest of the reader in tropical medicine or oncology medicine as the main focus and the rest of medical fields as the addition focus.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
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Broken Heart Syndrome: Berawal dari Stres Menuju Gagal Jantung Sukma, Alshafiera Azayyana Mawadhani; Balatif, Ridwan
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v3i2.7742

Abstract

Background: When stress conditions can be the root of various diseases, one of which is Broken Heart Syndrome (BHS). It is estimated that 90% of cases of BHS occur in women who have entered postmenopause. The mortality from BHS cases is quite high, reaching 2-5% with the main cause of death due to cardiogenic shock and ventricular fibrillation. Objective: To provide the latest information about BHS from various literatures. Methods: Writing this article using a literature searching method. Search for articles using the help of search engines in the form of Google Scholar, Pubmed and Clinicalkey with articles that have been published in the last 10 years and in English. Discussion: Prolonged physical stress conditions can trigger BHS. Risk factors associated with BHS conditions include age over 55 years, smoking, excessive alcohol consumption, a history of anxiety and hyperlipidemia. Complications can occur in 52% of cases of BHS. Mortality in BHS cases tended to be higher in BHS cases that was triggered by physical factors than that triggered by emotional factors. Conclusion: BHS is a condition that occurs after emotional stress or physical stress, so controlling the stress triggers is expected to prevent the occurrence of BHS. Keywords: broken heart syndrome, stress, heart failure   Latar belakang: Kondisi stres saat dapat menjadi akar dari berbagai macam penyakit salah satunya Broken Heart Syndrome (BHS). Diperkirakan 90% kasus BHS terjadi pada perempuan yang sudah memasuki postmenopause. Mortalitas dari kasus BHS cukup tinggi yakni mencapai 2-5% dengan penyebab kematian utama dikarenakan shok kardiogenik dan ventrikular fibrilasi. Tujuan: Memberikan informasi terkini seputar BHS dari berbagai literatur. Metode: Penulisan artikel ini menggunakan metode literature searching. Pencarian artikel menggunakan bantuan mesin pencari berupa Google Scholar, Pubmed, dan Clinicalkey dengan artikel yang telah dipublikasikan dalam 10 tahun terakhir dan berbahasa Inggris. Pembahasan: Kondisi stres fisik yang berkepanjangan dapat mencetuskan BHS. Faktor risiko yang berkaitan dengan kondisi BHS berupa usia diatas 55 tahun, merokok, konsumsi alkohol berlebih, riwayat ansietas dan hiperlipidemia. Komplikasi dapat terjadi pada 52% kasus BHS. Mortalitas pada kasus BHS cenderung lebih tinggi pada kasus BHS yang dipicu oleh faktor fisik dibandingkan yang dipicu oleh faktor emosi. Kesimpulan: BHS ini adalah kondisi yang timbul pasca stres emosional atau fisik sehingga dengan mengendalikan faktor pencetus stres ini diharapkan dapat mencegah terjadinya BHS. Kata Kunci: broken heart syndrome, stres, gagal jantung
Pengetahuan dan Sikap Santri mengenai Personal Hygiene terhadap Kejadian Skabies di Pesantren Modern Ta’dib Al Syarikin Medan Simanjuntak, Anju Marlina; Andriyani, Yunilda
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v3i2.8080

Abstract

Background: Scabies is a transmissible skin infection caused by infestation of parasite Sarcoptes scabiei with intense nocturnal itching as the most presented clinical manifestation and prone to happen under crowded conditions. Estimated worldwide prevalence of scabies is 200 million with highest rate of occurrence on children. One of the proponent factor on scabies’s transmission is living together in a crowd. Objectives: to determine the relationship of student’s knowledge and attitude about personal hygiene towards number of scabies infection in Pesantren Modern Ta’dib Al Syarikin Medan. Methods: an analytical study was conducted using cross sectional design. Samples were taken using total sampling method. Primary data was used in this study. The data was collected by utilizing history- taking, physical examination, as well as conducting burrow ink test and skin scrapping, and questionnaires to observe student’s knowledge and attitude related to personal hygiene. All of the collected data was analyzed using the fisher’s exact test. Results: Incidence of scabies, was found in Pesantren Modern Ta’dib Al Syarikin Medan, is 9 out of 60 people (15%). There is no contrast between personal hygiene’s knowledge towards incidence of scabies (p = 0,547) and personal hygiene’s attitude towards incidence of scabies (p = 0,24). Conclusion: There is no difference between knowledge and attitude of personal hygiene with the incidence of scabies in Pesantren Modern Ta’dib Al Syarikin Medan. Keywords: attitude, knowledge, personal hygiene, pesantren, scabies   Latar Belakang: Skabies merupakan infeksi menular kulit yang disebabkan oleh parasit Sarcoptes scabiei dengan manifestasi klinis utama berupa rasa gatal yang dominan terjadi pada malam hari dan rentan terjadi pada lingkungan ramai penduduk. Estimasi kejadian skabies didunia terjadi pada sekitar 200 juta orang dengan persentasi tertinggi terjadi pada anak-anak. Salah satu faktor pendukung penyebaran skabies adalah tinggal bersama dalam suatu kerumunan penduduk. Tujuan: Penelitian ini bertujuan untuk mengetahui pengetahuan dan sikap santri mengenai personal hygiene terhadap kejadian skabies di Pesantren Modern Ta’dib Al Syarikin. Metode: Penelitian ini merupakan hasil penelitian analitik dengan desain studi cross sectional. Sampel diambil dengan menggunakan metode total sampling. Data yang diambil merupakan data primer dengan melakukan anamnesis, pemeriksaan fisik, serta melakukan burrow ink test dan kerokan kulit, dan angket untuk mengetahui pengetahuan dan sikap santri mengenai personal hygiene. Data yang telah dikumpulkan dianalisis menggunakan uji fisher’s exact. Hasil: Angka kejadian skabies di Pesantren Modern Ta’dib Al Syarikin Medan adalah berjumlah 9 dari 60 orang (15%). Tidak terdapat perbedaan antara pengetahuan mengenai personal hygiene dengan kejadian skabies (p = 0,547) dan sikap mengenai personal hygiene dengan kejadian skabies (p = 0,24) di Pesantren Modern Ta’dib Al Syarikin Medan. Kesimpulan: Tidak terdapat perbedaan antara pengetahuan dan sikap santri mengenai personal hygiene terhadap kejadian skabies di Pesantren Modern Ta’dib Al Syarikin Medan. Kata Kunci: kebersihan personal, pengetahuan, pesantren, sikap, skabies
Front & Back Matter
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Spontaneous Pneumothorax Sebayang, Abed Nego Okthara; Kurniawan, Setiadi Drajad
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8118

Abstract

Background: Pneumothorax is a medical emergency which is defined as an abnormal condition where there is air in the pleural cavity which physiologically contains only a small amount of fluid. Pneumothorax can arise spontaneously or as a result of trauma. Method: The method used in this study is a literature review. The literature study conducted by the author is by searching various written sources, whether in the form of books, archives, magazines, articles and journals, or documents that are relevant to the problem being studied. Discussion: Pneumothorax is classified as primary spontaneous if it occurs in the absence of basic lung disease or thoracic trauma. Pneumothorax is classified as secondary spontaneous if it is caused by basic lung disease. The etiology of primary spontaneous pneumothorax is pleural bleb and bulla. A bleb (air pocket) or bulla is a small air-filled pocket that forms between the lung and pleural tissues. The risk factors associated with pneumothorax are smoking and body thinness. Conclusion: The initial management of spontaneous pneumothorax includes emergency management. Furthermore, management can be divided into conservative and invasive management
Penggunaan SGLT2-i Sebagai Inovasi Terapi Preventif Stroke Pada Pasien Diabetes Mellitus Tipe 2 Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Patresia, Putri Leony
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8347

Abstract

Diabetes merupakan faktor resiko stroke iskemik sebesar 2,5 kali dan 1,5 kali lipat menderita stroke hemoragik. Hal ini memicu meningkatnya angka mortalitas baik yang disebabkan oleh diabetes, stroke maupun diabetes yang berkomplikasi pada stroke. Sodium Glucose cotransporter 2 inhibitor (SGLT2-i) diketahui dapat mengurangi permasalahan kardiovaskular pada diabetes sehingga penulis akan menelaah lebih lanjut mengenai mekanisme SGLT2-i terhadap vaskular yang dihubungkan terhadap stroke. Literature Review ini dilakukan dengan menelusuri artikel penelitian yang terdapat pada mesin pencarian. Mesin pencarian jurnal yang digunakan berupa PubMed dan Science Direct. Dari 551 artikel diidentifikasi berdasarkan judul, duplikasi, abstrak dan kesesuaian dengan kriteria inklusi dan dilaksanakan review untuk artikel terpilih. SGLT2-i memiliki mekanisme untuk menghambat progresivitas atheroma. Mekanisme yang terjadi berupa penurunan reaksi inflamasi sistemik, penurunan stress oksidatif, pengurangan ukuran ateroma hingga menjaga kestabilan plak ateroma. Oleh karena itu SGLT2-i merupakan kandidat terapi yang potensial dalam mengurangi risiko stroke pada pasien DMT2. SGLT2-i dapat digunakan sebagai inovasi terapi preventif untuk stroke pada pasien DMT2.
Identification of Victims Who Have Experienced Advanced Decay Sembiring, Asan Petrus
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8361

Abstract

Background. In the process of investigating a criminal offense, knowing the identity of the victim is something that has a very important meaning, namely as an initial step of the investigation that must be made clear before the next steps can be taken in the investigation process. Objectives. to prove that the skeleton is a human skeleton, race, gender, estimated age, height. Case Illustration. Reported cases of a group of bones thought to have originated from human bones. Taken to the hospital to identify who the victim was. Discussion. Examination found a collection of 196 human bones, in the form of head, neck and the whole body remains bones as well as the right upper limb and lower limb still found skin and muscles that began to dry, blackish brown, foul smelling , a black cocoon (pupa) with a length of 3 cm, and a white maggot (instar I larvae) with a length of 0.5 cm.. Conclusion. Collection of bones derived from humans, with an estimated Mongoloid race (Asian), male sex, age 15-25 years, height 157-165 cm, duration of death 10-20 days, with signs of violence in the form of blood infiltration on the left head bone and right skull fracture that extends to the back. the cause of death of the victim is blunt trauma to the head that causes a skull fracture. Keywords: Victim Identification, Further Decay
The Scanographic Profile Of Pancreatic Tumors In 3 Radiology Departments In Kinshasa Antoine, Molua; Eric, Matondo; Michel, Lelo; Jean, Mukaya; Angele, Mbongo; Stéphane, Yanda; Bernard, Bazeboso; Mazoba, Tacite
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8373

Abstract

Objective . Our objective was to describe the scanographic profile of pancreatic tumors in 3 radiology departments in Kinshasa. Methods . Comparative study conducted in 3 radiology departments in Kinshasa from January 2016 to June 2021, having retained 86 reports of abdominal CT-scans of patients with pancreatic pathology including 62 cases of pancreatic tumors. Results . Male patients were in the majority (sex-ratio M/F=1.6) with a mean age of 55.7±14.7 years (16 to 92 years). The frequency of pancreatic tumors was higher (62 cases/86) compared to that of inflammatory pathologies (20 cases/86). Cholestasis syndrome (50%) and abdominal (epigastric) pain were the most common indications. In tumors the contours were lobulated (56.1%) compared to pancreatitis, where they were blurred in 80% (p<0.05). In 45% of pancreatitis the peripancreatic fat was infiltrated, against 16.7% in tumors (p=0.01). The Wirsung duct was dilated in most tumors compared to pancreatitis where it was irregular with calcifications (p<0.05). The tumors were resectable in 26% of cases. Conclusion . The abdominal CT-scan contributes to the diagnosis of pancreatic pathologies. Tumors are the most common, most of them unresectable . It is often an elderly male subject with a clinical indication.
The Potential Of Antisense Oligonucleotides (ASO) Through Inhalation Based On Gold Nanoparticle (AuNP) Delivery System In Inhibiting SARS-CoV-2 Replication And Transcription Deanasa, Raehan Satya; Afladhanti, Putri Mahirah; Syafira, Fara
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8384

Abstract

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This virus infects the respiratory, digestive, and nervous systems with a rapid transmission and a fairly high mortality rate. However, there has been no specific therapy to treat COVID-19. Previous studies have shown that antisense oligonucleotide (ASO) has good efficacy in DNA and RNA viral infections. This literature review aims to investigate the potential of inhaled ASO based on gold nanoparticles (AuNp) delivery system in inhibiting the replication and transcription of SARS-CoV-2. Literature searching using several databases, such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria are used to eliminate the journals that does not match the criteria, thus 28 journals are obtained. The results show that ASO has the potential to inhibit the replication and transcription of the SARS-CoV-2 virus through different mechanisms by binding to the target RNA and modulating the viral protein synthesis. One form of ASO modification that is often used is LNA GapmeR. LNA GapmeR stimulates viral RNA cleavage and can be administered by inhalation with nebulized ASO solution. AuNP as an ASO delivery system through inhalation can reduce toxicity and increase ASO concentrations in reaching target cells. Therefore, ASO therapy with AuNP through inhalation needs to be considered for COVID-19 treatment. Further clinical study about the ideal delivery system and optimal dosage of ASO based AuNP via inhalation for COVID-19 are needed to investigate soon.
The Potency of Oral L-Arginine Suplementation Based on Chitosan-Coated Gold Nanoparticles (c-AuNPs) as Preeclampsia Prevention in Pregnant Women Syafira, Fara; Deanasa, Raehan Satya Deanasa; Afladhanti, Putri Mahirah Afladhanti
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8392

Abstract

Preeclampsia is a multi-systemic hypertensive disorder in pregnant women after two weeks of gestation and can cause complications in about 6-10% of all pregnancies. The incidence of preeclampsia in Indonesia is 128,273/year or about 5.3%. However, the handling of preeclampsia in Indonesia is still not optimal. This disease is difficult to detect and often appears suddenly, so prevention efforts need to be taken as an essential step in reducing morbidity and mortality due to this disease. Previous studies have shown that L-Arginine exhibits potential properties in preventing preeclampsia. This literature review aims to determine the potential for oral L-Arginine supplementation to prevent preeclampsia in pregnant women. Search for literature using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria are used to eliminate unrelated journals so 38 journals are obtained. L-Arginine has great potential as a preventive supplementation of preeclampsia by increasing the vascular NO synthesis where NO deficiency in pregnant women can induce changes in the uteroplacental structure. Supplementation of the dietary L-Arginine at a low dose of 3 g/day for three to four weeks is required in early pregnancy. The use of chitosan-coated gold nanoparticles (c-AuNPs) as encapsulation on a protein increases the bioavailability of oral supplementation and improves the patient's clinical state. Further research regarding the effectiveness of L-Arginine supplementation orally with c-AuNPs and the optimal dosage as a preeclampsia preventive supplement is needed.
Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 Afladhanti, Putri Mahirah; Romadhan, Muhammad Despriansyah; Hamzah, Haidar Ali; Putri, Safa Nabila; Angelica, Ellen Callista
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8399

Abstract

COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2. This study aims to identify the potential compounds derived from Ginkgo biloba as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of twenty-one compounds of Ginkgo biloba and comparative drugs were used in this study. The materials were downloaded from rcsb for protein targets and pubchem for comparative drugs and compounds. In this study, Lipinski rule of five using Swiss ADME web tool was used. Moreover, toxicity analysis using admetSAR 2.0 online test also used to predict toxicological profile of compounds. Dockings were carried out on Mpro, TMPRSS2, RdRp, and ACE2 protein targets by AutodockTools 1.5.6 and Autodock Vina. The visualization of molecular interaction was carried out by Discovery Studio v16. Nine compounds met the criteria as drug-like components and were safe. Docking results showed that ginkgolide-C and bilobetin showed strong molecular interactions to all protein targets compared to the comparative drugs and other compounds. In RdRp, ginkgolide-C showed the highest binding energy with -12.7 kcal/mol. Moreover, in TMPRSS2, ACE2 and Mpro, bilobetin also showed the highest binding energy with -12.7, -9.7 and -10 kcal/mol, respectively. Ginkgolide-C and bilobetin have the potential to be developed as SARS-CoV-2 inhibitors. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.

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