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Andika Aliviameita
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Medicra (Journal of Medical Laboratory Science/Technology)
Published by Universitas Muhammadiyah Sidoarjo
ISSN : 25807730     EISSN : 25807730     DOI : https://doi.org/10.21070/medicra
Core Subject : Health,
Health Professions Public Health
Focus : to facilitate scholar, researchers, and lecturers for publishing the original articles of review articles. Scope : Medicra publishes research articles in the field of “medical laboratory (science/technology)” with the following scope: Clinic Chemical Hematology Microbiology Parasitology Immunology Food and beverage analysis Chemical Molecular Diagnostics Toxicology Cytology Histology Epidemiology Laboratory Management Laboratory Quality Control
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 8 Documents
 1 
Search results for , issue "Vol. 8 No. 2 (2025): December" : 8 Documents clear
Journal Review: Potential of Gotu Kola Leaves (Centella asiatica) as Antibacterial Against Staphylococcus aureus: Jurnal Review: Potensi Daun Pegagan (Centella Asiatica) Sebagai Antibakteri Terhadap Staphylococcus aureus Ernanda, Hafid; Mukhtar, Diniwati; Purwaningsih, Endang; Hakim, Jasir
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1779

Abstract

Herbal substances used worldwide include pegagan (Centella asiatica). Triterpenoids and saponins found in this plant have various medicinal benefits. Staphylococcus aureus has long been the most common cause of diseases present in society globally. The aimof this study is to outline the results of a literature review on the effectiveness of pegagan leaves (Centella asiatica). A literature review is the method used in this research. The selected journals are sourced from several national journal databases, resulting in 10 articles that meet the inclusion and exclusion criteria. The review findings indicate that pegagan leaves possess antibacterial activity against Staphylococcus aureus. Pegagan leaves have the potential to act as an antibacterial agent against Staphylococcus aureus with an effective extract concentration, specifically a high concentration of pegagan leaf extract.
The Effectiveness Of Crystal Guava (Psidium guajava Linn) Leaf Extract As An Insecticide Againts Aedes aegypti: Efektivitas Ekstrak Daun Jambu Kristal (Psidium Guajava Linn.) Sebagai Insektisida Nyamuk Aedes aegypti Utomo, Satriyo Siswo; Yauwan Tobing Lukiyono; Irwan Sulistio; Agus Aan Adriansyah
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1787

Abstract

Aedes aegypti is a species of mosquito that acts as a vector for the dengue virus. Currently, control of this viral vector has been carried out using synthetic insecticides. However, continued use can lead to the emergence of resistance, necessitating efforts to address this issue. One possible approach is to use natural insecticides derived from plants. One plant considered suitable as a natural insecticide is the extract of crystal guava leaves (Psidium guajava Linn) because it contains bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. The purpose of this study was to determine the effectiveness of using crystal guava leaf extract as a spray insecticide against Aedes aegypti mosquitoes. This study used an experimental method with a Control Group Post-Test Design. Ethanol extract of crystal guava leaves (Psidium guajava Linn) was prepared in several concentrations: 22.5%, 45%, and 90%. The spray was then observed on Aedes aegypti mosquitoes for 3, 6, and 24 hours. The concentration was then determined to determine the mosquito-killing power. Analysis was then performed using SPSS to determine the LC50 and LT50 values.
Utilization of Parijoto (Medinilla speciosa Blume) Fruit Extract as a Counterstain in Gram Staining of Escherichia coli: Pemanfaatan Ekstrak Buah Parijoto (Medinilla speciosa Blume) Sebagai Counterstain Pada Pewarnaan Gram Escherichia coli Pratiwi, Sisilia; Sari, Indah; Aristoteles, Aristoteles; Veronneca, Rossa; Amantasya, Tesa
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1788

Abstract

The use of Gram staining using synthetic dyes such as safranin has the disadvantage of being more expensive and can be harmful to health and damage organs if exposed repeatedly. Parijoto fruit has an anthocyanin content of 0.43 ppm. In terms of quality, Parijoto fruit contains active compounds such as flavonoids, tannins, saponins, and alkaloids. The anthocyanin content in Parijoto fruit is a secondary metabolite compound that can produce red color in Parijoto fruit so that it can be used as a natural dye. This research to determine the difference in interpretation of staining results using parijoto fruit extract as a substitute for safranin in Gram staining. This research method using a cross-sectional research design, posttest-only control group design research type, this study was conducted in the microbiology laboratory of Muhammadiyah Ahmad DahlanUniversity, Palembang. The sample used in this study was 32 preparations. Data analysis was carried out using the Wilcoxontest. The study results showed good quality results in preparations using safranin as much as 81%, less good (18%), and not good (0%). Meanwhile, good quality was obtained in preparations using parijoto fruit extract as much as 75%, less good (25%), and bad (0%). Based on statistics, there was no significant difference between parijoto fruit extract and safranin in gram staining of 0.705 (p>0.05). The conclusion of this study is parijoto fruit has good quality to be used as a natural dye.
Toxicity Test Of Burdock (Arctium lappa L) Root Extract On Renal Histopathological Profile And Granulocyte Response In Wistar Rats : Uji Toksisitas Ekstrak Akar Burdock (Arctium lappa L) Terhadap Profil Histopatologi Ginjal Dan Respon Granulosit Tikus Wistar Nisa, Dwi Faizatun; Faizal, Imam Agus; Puspodewi, Dini
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1790

Abstract

Burdock (Arctium lappa L) is a medicinal plant widely used in traditional therapy due to its active compounds, including arctigen, and phenolic acids, which possess antioxidant and anti inflammatory pro penties. The study aims to investigate the histopatholohical profile of the kidneys and granulocyte levels in wistar rats after administration of burdock root extract. This study employed an experimental method using 8 male and female wistar rats divided into four groups, an negative control group and treatment groups whith doses 0f 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB. The extract was orally for 28 days. Was performed using Periodic Acid Schiff (PAS) sataining, and granulocyte counts were using a hematology analyzer. The results of kidney tissue examination showed no significant histopatological damage in all treatment groups, some sampeles showed the presence of adipocytes, but without indication of kidey damage. PAS staining showed no glycogen or mucopolysaccharides, which indicate tissue damage. Granulocyte levels in the treatment groups showed varying changes, depending on dose and gender, whit a significant increase in high doses in females. It can be mucopolysaccharides indicating tissue damage. Granulocyte counts in the treatment groups showed varying changes depending on dose and gender, whit a significant increase at high doses in famales. It can be concluded that burdock root extrack dose not cause histopathological kidey tissue damage and is relativeky safe use at low to high doses, but it affects granulocyte counts in a dose and sex dependent manner. 
Relationship of Candida albicans Urinary Colony Count and Glucosuria in Elderly Diabetics: Hubungan Jumlah Koloni Candida albicans Urin dan Glukosuria pada Lansia Penderita Diabetes Fadhilla, Nadyah Saffana; Qurrohman, Muhammad Taufiq
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1800

Abstract

Diabetes mellitus is a global health problem with a high prevalence in the elderly and is associated with an increased risk of opportunistic infections. One of the common accompanying conditions is glucosuria, caused by elevated urinary glucose excretion, which may promote the growth of Candida albicans. This study aimed to examine the relationship between urinary glucosuria and the number of Candida albicans colonies in elderly patients with diabetes mellitus at Griya Sehat Colomadu Clinic. Urine samples were tested for glucosuria using the dipstick method, while urine cultures were performed on CHROMagar Candida medium to identify and quantify Candida albicans colonies. Data were analyzed using the Spearman correlation test. Most respondents were negative for glucosuria (57,14%), while the remainder were positive with varying degrees. The colony counts of Candida albicansranged from 0 to 319.000 CFU/mL, with median counts increasing alongside the degree of glucosuria. Statistical analysis revealed a strong and significant positive correlation between glucosuria and Candida albicans colony counts (r = 0,700; p < 0.01). Higher levels of glucosuria are associated with increased Candida albicans colony counts in the urine of elderly patients with diabetes mellitus. These findings highlight the importance of controlling blood glucose levels and routinely monitoring urine cultures to prevent opportunistic fungal infections in elderly diabetic patients. 
Cellular Immune Responses and Hepatitis B Surface Antigen (HBsAg) in Alcohol-Consuming Fishermen : Respon Imun Seluler dan HBsAg pada Nelayan Pengonsumsi Alkohol Purwaningsih, Nur Vita; Saputro, Tri Ade; Azizah, Fitrotin; Maulidiyanti, Ellies Tunjung Sari; Budiman, Waras; Anggraini, Lukita
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1803

Abstract

Hepatitis B infection remains a global health problem with long-term complications such as cirrhosis and hepatocellular carcinoma. Alcohol consumption is known to impair immune function and exacerbate hepatitis B virus (HBV) infection. Fishermen represent a high-risk occupational group due to alcohol consumption habits and limited healthcare access. This study aimed to analyze the relationship between alcohol consumption levels and hepatitis B infection status through HBsAg testing and lymphocyte count among fishermen. This was a descriptive observational study with a cross-sectional approach involving 40 fishermen in Gresik Regency. Data were collected through alcohol consumption questionnaires and laboratory tests, including HBsAg examination using a Rapid Test and lymphocyte count using a hematology analyzer. Data were analyzed using Chi-square and ANOVA tests with a significance level of p < 0.05. A total of 30% of respondents were HBsAg reactive, with the highest proportion found in the heavy alcohol consumption group (50%). The mean lymphocyte count decreased with increasing alcohol intake: 2.580 ± 420 cells/µL in the light group, 2.120 ± 390 cells/µL in the moderate group, and 1.780 ± 360 cells/µL in the heavy group (p = 0.012). There was a significant relationship between alcohol consumption level, HBsAg status, and lymphocyte count among fishermen. High alcohol consumption may reduce cellular immunity and increase the risk of persistent hepatitis B infection. HBsAg testing and lymphocyte count can serve as early indicators for health screening in high-risk occupational groups such as fishermen. 
The Effectiveness Of a Combination Of Rosella (Hibiscus sabdariffa) and Red Ashoka (Ixora javanica) Extracts as an Eosin Substitute For Parasite Examination in Feces: Efektivitas Kombinasi Ekstrak Rosella (Hibiscus sabdariffa) dan Asoka Merah (Ixora javanica) Sebagai Pengganti Eosin Untuk Pemeriksaan Parasit pada Feses Munawwaroh, Ahsanatul; Lukiyono, Yauwan Tobing; Sulisti, Irwan; Adriansyah, Agus Aan
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1805

Abstract

Stool examination is an important diagnostic method for detecting intestinal helminths, particularly in tropical regions like Indonesia. Eosin 2% is commonly used to enhance microscopic visualization of helminth eggs but raises concerns regarding toxicity and environmental impact. This study aimed to evaluate the effectiveness of combining roselle (Hibiscus sabdariffa) and red ixora (Ixora javanica) flower extracts as a natural substitute for eosin in stool examination. This experimental research used a post-test-only control group design with four treatment groups: eosin (positive control), and three extract concentration combinations (60%:40%, 50%:50%, and 70%:30%). The results showed that all extract combinations produced comparable contrast and clarity to eosin in visualizing helminth eggs. The Kruskal–Wallis test indicated no significant difference between treatments (p>0.05). The combination of roselle and red ixora extract can therefore be considered a potential natural alternative to eosin for stool examination without reducing microscopic effectiveness.
Estimation of Blood-Borne Virus Infections in Beta Thalassemia Major Patients Sayah, Mohammed Abdulkadhim
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1815

Abstract

Thalassemia is a heterogeneous inherited anemia caused by mutations affecting globin-chain synthesis in hemoglobin, leading to ineffective erythropoiesis and hemolytic anemia. Patients commonly require lifelong blood transfusions, which increase the risk of transfusion-transmitted infections such as hepatitis B and C, potentially worsening health outcomes. This cross-sectional study aimed to determine the frequency and distribution of hepatitis viruses among thalassemia patients and their association with thalassemia type, transfusion history, splenic status, and sociodemographic factors. The study was conducted at the Hematology Center of Al-Diwaniyah Health Department from February to August 2024 and included 328 patients. Blood samples (3–5 mL) were tested for hepatitis viruses using ELISA, and data were analyzed with SPSS 20. Results showed HCV positivity in 3/328 (0.9%) patients and HBsAg positivity in 1/328 (0.3%), with equal distribution between sexes and higher prevalence in urban areas and the 16–25-year age group. All infected patients received twice-monthly transfusions, most had low educational and income levels, and only one had undergone splenectomy. The study confirms the presence of HBV and HCV infections in multi-transfused thalassemia patients, with infection risk increasing with age and number of transfusions, particularly for HCV.

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