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Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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Uji Efektivitas Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Sebagai Antihiperurisemia Pada Tikus Putih Jantan Yang Di Induksi Kalium Oksonat Gultom, Evi Deviana
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1546

Abstract

Kersen plant (Muntingia calabura L.) is a plant that has many properties and is useful as medicine. Hyperuricemia is a condition where there is an increase in uric acid levels above normal. The leaf part of this plant is widely used by the community as a traditional medicine because of its metabolite compounds. Flavonoid compounds in cherry leaves can reduce uric acid levels through inhibition of the xanthine oxidase enzyme, an enzyme that acts as a catalyst in the oxidation process of hypoxanthine to xanthine and then to uric acid. By inhibiting the work of the xanthine oxidase enzyme, the formation of uric acid will also be inhibited. This study aims to determine the effectiveness of cherry leaf ethanol extract in reducing uric acid levels in male white rats induced by potassium oxonate. This study used an experimental method using 25 male white rats induced by potassium oxonate. The test animals were divided into 5 groups: negative control (CMC Na 1%), positive control (Allopurinol), EEDK dose of 300 mg/kgBB, EEDK dose of 400 mg/kgBB, EEDK dose of 500 mg/kgBB. Measurement of uric acid levels in rats using the point of care testing (POCT) method. All data obtained were analyzed statistically using the One Way Anova test. The results of the analysis showed that there were significant differences between the negative control, positive control, EEDK 300 mg/kg, EEDK 400 mg/kg, and EEDK 500 mg/kg (P<0.05). The most effective dose of cherry leaf ethanol extract as an antihyperuricemia is the EEDK dose of 500 mg/kg BW. There was no significant difference between EEDK 400 mg/kgBW, EEDK 500 mg/kgBW and positive control (P>0.05). Based on the results of the analysis that has been done, it can be concluded that the ethanol extract of cherry leaves has an antihyperuricemia effect in rats. Keywords: Cherry leaves, Hyperuricemia, Potassium oxonate
linta meliala,roito yuliana UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitisgracilis BL) PADA TIKUS JANTAN PUTIH Meliala, Linta
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1555

Abstract

Abstract Diarrhea is the abnormal passage of loose or watery stools, with a frequency of more than three times a day. Diarrhea can be caused by bacteria. Gagatan Harimau leaves are known to have antibacterial properties. This research was conducted using an experimental method in the field of pharmacology at the Pharmacology Laboratory, Faculty of Pharmacy, Deli Husada Health Institute Delitua, using 25 rats induced with castor oil and divided into 5 treatment groups: negative control (1% CMC Na), positive control (Loperamide HCl), and treatment groups with ethanol extract of Gagatan Harimau leaves at doses of 50 mg/kg body weight (BW), 100 mg/kg BW, and 200 mg/kg BW. The sample used was Gagatan Harimau leaves (Vitis graillis BL), which were extracted by maceration using 96% ethanol as the solvent and concentrated using a rotary evaporator. The phytochemical screening results of Gagatan Harimau leaves showed the presence of flavonoids, saponins, alkaloids, and tannins. The results of the antidiarrheal effect test showed that the ethanol extract of Gagatan Harimau leaves at doses of 50, 100, and 200 mg/kg BW had antidiarrheal effects on male rats. The 200 mg/kg BW dose of ethanol extract showed the most effective antidiarrheal effect compared to the 50 and 100 mg/kg BW doses. The extract from Gagatan Harimau leaves (Vitis gracillis BL) exhibited antidiarrheal effects on male white rats induced with castor oil.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR KOMBINASI EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum) DAN KULIT JERUK LEMON (Citrus limon) TERHADAP BAKTERI Streptococcus mutans DAN Streptococcus viridans PENYEBAB KARIES GIGI DAN BAU MULUT Harahap, Nina Irmayanti; sari, rika puspita; Harnis, Zola Efa
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1557

Abstract

Dental caries is an infectious disease and is a process of progressive demineralization of the hard tissue surface of the crown and tooth roots caused by bacterial activity. microorganisms in the mouth. Plaque inhibition can be done with anti-microbial agents to suppress the activity of bacteria such as Streptococcus mutans. Streptococcus mutans is a cariogenic bacterium that causes cavities and is the most dominant in dental plaque. These bacteria can convert sucrose into lactic acid so that it can cause tooth demineralization (Haniyah, 2019). Lemon peel (Citrus limon) is known as an antibacterial ingredient. To facilitate the use of lemon orange peel extract, namely by making it into mouthwash preparations. Mouthwash is a solution that contains antibacterial substances to reduce the number of microorganisms in the mouth, is used as an oral rinse, and is easy to use (Ririn et al., 2019). Research using clove flower extract and lemon peel as antibacterial against Streptococcus mutans and Streptococcus viridans made in mouthwash preparations is still limited, therefore researchers are interested in conducting further research with the title test of antibacterial activity in mouthwash preparations combination of clove flower ethanol extract (Syzygium aromaticum) and lemon peel (Citrus limon) in inhibiting the growth of Streptococcus mutans and Streptococus viridans bacteria that cause bad breath can be formulated into mouthwash preparations and meet the evaluation test requirements for mouthwash preparations and the average diameter of the largest inhibition zone is 12, 31 mm for Streptococcus mutans at a concentration of 2%:0.5% and for Streptococcus viridans at a concentration of 2%:0.5%, namely 11.31.
AKTIVITAS ANTIOKSIDAN DAN KEMAMPUAN ANTIBAKTERI EKSTRAK KULIT BUAH KENITU (Chrysophyllum cainito L) TERHADAP Staphylococcus aureus Rahayu, Lina Oktavia
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1564

Abstract

Kenitu (Chrysophyllum cainito L) has strong antioxidant properties both in vitro and in vivo. The presence of this high antioxidant can be used as a natural agent to prevent and treat diseases associated with an imbalance of antioxidant levels in the body, such as diabetes. Some research results state that kenitu can be used as an antidiabetic. One type of complication in people with diabetes mellitus is the occurrence of bacterial infections of the skin. One type of bacteria that infects the most is Staphylococcus aureus. So far, the skin of the kenitu fruit has only been thrown away and has not been used. The purpose of this study was to determine the antioxidant activity of kenitu peel extract and to determine the ability of kenitu peel extract as an antibacterial against Staphylococcus aureus. Research methods included extracting kenitu peel by maceration using 70% ethanol, testing antioxidant activity using the DPPH method, and testing the antibacterial activity of kenitu peel extract against Staphylococcus aureus. The results of the antioxidant activity test showed an IC50 value of 126.96 ppm. Antibacterial activity testing showed a MIC value of 250 ppm and a MBC value of 500 ppm. The conclusion of this study is that kenitu peel extract has moderate antioxidant activity and kenitu peel extract is able to inhibit the growth and kill Staphylococcus aureus bacteria.
ANALISIS ANTIOKSIDAN EKSTRAK DAUN NANGKA (Artocarpus heteropyllus L ) DENGAN MENGGUNAKAN METODE FRAP sulasmi, sulasmi
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1672

Abstract

Background: Antioxidants are compounds that are able to counteract or reduce the negative effects of oxidants in the body. The activity of antioxidants is the ability of jackfruit leaves to ward off free radicals. Jackfruit leaf (Artocarpus heteropyllus L.) belongs to the Moraceae family which contains secondary metabolites. The results showed that jackfruit leaves are used as natural antioxidants because they contain secondary metabolites, namely flavonoids, saponins and tannins. Purpose : of this study was to determine the level of antioxidant activity of jackfruit leaf extract using ferric chloride reagent using Ultraviolet-Visible (Uv-Vis) spectrophotometry. Methods : This study used an experimental method, simplicia was extracted by maceration using 96% ethanol and the filtrate obtained was evaporated with the help of a rotary evaporator. Jackfruit leaf extract was analyzed for antioxidant activity with ferric chloride reagent using UV-Vis spectrophotometry in the range of 400 nm-800 nm. Results : of phytochemical screening of jackfruit simplicia powder obtained flavonoid compounds, saponins and tannins. The of the determination of antioxidant levels of ascorbic acid at a wavelength of 236 nm with levels of 87.4712 mgQE/g and levels of jackfruit leaves at a wavelength of 400 nm with levels of 1.2736 mg AAE/g. Conclusion : The results showed that the IC50 value of jackfruit leaves had a value of 74.6 ppm.
ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO Khoirunnisa, Azka; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1686

Abstract

Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.
Formulasi Sediaan Pomade Ekstrak Daun Meniran (Phyllanthus niruri L.) Sebagai Perangsang Penumbuh Rambut Pada Kelinci Syafitri, Anggun; Marbun, Viktor Edyward; Laia, Sardamai
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1688

Abstract

Background: Meniran petroleum ether extract 2% which contains lignans and terpenoids can increase hair growth activity by inhibiting 5α-reductase. In addition, the ethanol extract of candlenut seeds from the same family as meniran Flavonoids and phenols can also stimulate hair growth. Previous studies have also shown that quercetin also has activity to increase hair growth. Meniran is also known to contain the flavonoids quercetin, nirurin, rutin, quercitrin, astragalin and galocatechin. So meniran ethanol extract was chosen for this study. Based on a literature search about this research, the researcher was interested in formulating meniran leaf extract pomade (Phyllanthus niruri L.) as a hair stimulant in rabbits (Oryclolagus cunucilus). Purpose: To determine the formulation of meniran leaf extract pmade (Phyllanthus niruri L.) which is good in stimulating hair growth in rabbits. Methods: The method used was an experimental study to test the characteristics of pomade preparations with meniran leaf extract concentrations of 5%, 7.5% and 10% with organoleptic, homogeneity, spreadability, pH, irritation and freeze-thaw parameters. Results: From the results of the research on the characteristic test of pomade preparations on formulations of formula I, formula II and formula III it was found that they fulfilled the characteristics of pomade while F0 did not meet the spreadability requirements. Conclusion: Among the three formulations, it was found that pomade with formula III had the effectiveness of a good hair growth stimulant and could compete with the positive control.
A FORMULATION OF HAND BODY LOTIO FORMULATION OF HAND BODY LOTION EXTRACT ethanol from lily leaves (Crinum asiaticum L.) AS A SKIN MOISTURIZER barus, bunga rimta
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1701

Abstract

Lily leaves (Crinum asiaticum L.) have bioactivity as antioxidants and contain chemical compounds such as glycosides, flavonoids, saponins, tannins and triterpenoids. This study aims to formulate daffodil leaf extract into a hand body lotion dosage form and observe the effectiveness on volunteer skin for 4 weeks. This research was conducted experimentally. Samples were taken from daffodil leaves (Crinum asiaticum L.), then extracted by maceration with 96% ethanol and concentrated using a rotary evaporator. The ethanol extract of daffodil leaves was formulated with concentrations of 5%, 8% and 11%. The preparation evaluation test includes homogeneity, organoleptic, pH, emulsion type, irritation test, and effectiveness test of the preparation to moisturize the skin. The results showed that the ethanol extract of daffodil leaves could be used to make homogeneous grated emulsion preparations which were stable during 4 weeks of storage, pH 7.52-7.25, oil-in-water emulsion type and did not disappear. Any hand cream product that contains narcissus leaf ethanol can increase skin moisture. The composition of the most effective hand and body cream in the treatment of dry skin is a preparation with a concentration of 11% ethanol extract of lily leaves, which increases skin healing by 40.35% and is applied to the skin within 1 month.
FORMULASI DAN EVALUASI SEDIAAN SERUM WAJAH EKSTRAK ETANOL KOMBINASI DARI EKSTRAK KULIT JERUK NIPIS (Citrus aurantiifolia) DAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) Simorangkir, Delisma; Irmayanti, Nina
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1707

Abstract

Background: The skin of the key orange (Citrus aurantiifolia) contains kuersetin, miristin, routinely, tangerine, naringin and hesperine, while the skin of the red dragon fruit (Hylocereus polyrhizus) contains betaalanin, anthocyanin, vitamin a, vitamin a, vitamin e, turnioid, flavonoid, tiamin, niacin, piridoine, kobalamin, carotene, and fitoalbumin. The research was intended to formulate it in a availability of facial serum and then evaluate its quality formula for a better facial serum from 16-4954-1998. Methods : This method of research is experimental in the laboratory by making 4 formulas consisting of F1 as serum bases, F2 ratio EKJN and EKBNM (1:1), F3 ratio EKJN and EKBNM (1:2) ,F4 ratio EKJN and EKBNM (2:1).Results : The results of all the formulas for existing existing face-serum EKJN ethanol and EKBNM viscers show a clear, clear, yellowish color, a gel-based, characteristic and homogenous odor. pH and viscosity scores on each condensed formula. No irritation test on the formula showed irritation to the skin.Conclusion : Based on this, it can be concluded that the combined ethanol extract of lime peel extract and red dragon fruit peel extract can be formulated into a facial serum cosmetic preparation and meets the quality requirements according to SNI.
Uji Efektivitas Formulasi Sediaan Lipstik Menggunakan Bahan Pewarna Alami Dari Ekstrak Etanol Gambir (Uncaria Gambir (Hunteri)Roxb.) Dan Ekstrak Etanol Buah Stroberi (Fragaria Vesca). Simorangkir, Delisma; Puspita, Rika; Harnis, Zola Efa
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1708

Abstract

Abstract: Lipstick is a form of lip coloring preparation which is a cosmetic preparation used to color the lips, to improve aesthetics in facial make-up. Lipstick preparations are available in various forms such as liquid, crayon, liptin, lipbam and cream. Lipstick consists of a coloring agent dispersed in a carrier made from a mixture of wax and oil, in such a composition as to provide the desired melting temperature and viscosity. The aim of the research is to determine the physical stability of lipstick preparations made from gambier extract and strawberry fruit extract as coloring agents. Sampling was carried out using a purposive sampling method, namely a random sampling methodology. The samples used were Gambir (Uncaria Gambir (Hunteri) Roxb.) and Ethanol Extract of Strawberries (Fragaria Vesca). then extracted by maceration using 96% ethanol solvent, concentrated by rotary. The combination of gambier ethanol extract and strawberry ethanol extract was formulated with a concentration of F1: 5%:5%, F2 :10%:10%. F315%:15%. Examination of the quality of the preparation includes organoleptic, homogeneity, pH, irritation, preference and continues with statistical analysis tests using One Way Anova. The results of normality tests with the Shapiro-Wilk test and homogeneity test, produce a value for each data > 0.05, so the data is normally distributed. The results of the One Way Anova test for each formulation group showed that the Sig value was <0.05, so the formulations had a significant difference.

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