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Medfarm: Jurnal Farmasi dan Kesehatan
Published by Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo
ISSN : 23548487     EISSN : 27159957     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Jurnal MEDFARM merupakan terbitan dari lembaga jurnal dibawah naungan Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo. Topik atau pembahasan dari Jurnal MEDFARM lebih terfokus pada bidang Farmasi, Obat Tradisional, Makanan, Minuman dan Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 154 Documents
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Computational Investigation of α-Glucosidase Inhibition by Phytochemical Compounds from Muntingia calabura L. Leaves: Insights into Potential Antidiabetic Agents Prayogi, Syaiful; Rahman, Aulia; Mahbubah, Tsaiatul; Maisaan, Nabilla Defira Putri
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.682

Abstract

Diabetes Mellitus (DM) is a degenerative disease that poses a major global health problem. It is characterized by increased blood glucose levels (hyperglycemia). Common therapeutic agents for DM include sulfonylureas, biguanides, and α-glucosidase inhibitors. However, the use of α-glucosidase inhibitors is often associated with several issues such as the presence of non-intestinal α-glucosidase in various body cells, gastrointestinal side effects (diarrhea, bloating, abdominal discomfort), and high IC₅₀ values indicating low potency and efficacy against the α-glucosidase enzyme. This study aims to explore the potential of flavonoid compounds from Muntingia calabura L. (kersen) leaves as α-glucosidase inhibitors through in silico analysis. The study was conducted using molecular docking to evaluate the binding affinity and interaction of flavonoid compounds with the α-glucosidase enzyme. The docking results showed that 8 ligands test exhibited strong binding affinities, inhibitors constants, and stable interactions with the active site of α-glucosidase, comparable to standard inhibitors (acarbose). The two most promising ligands as α-glucosidase inhibitors were identified as 20,40-Dihydroxy-30-methoxydihydrochalcone (50) and (-)-30-Methoxy-20,40,β-trihydroxydihydrochalcone (51), exhibiting binding affinities and inhibition constants of –7.33 kcal/mol; 4.27 μM and –7.30 kcal/mol; 4.45 μM, respectively, have promising potential as natural α-glucosidase inhibitors and may serve as lead compounds for the development of new antidiabetic agents. Their inhibitory potential was further supported by favorable ADMET parameters and compliance with Lipinski’s rule of five. Further in vitro and in vivo studies are needed to confirm these findings.
Anticholesterol Activity of Combined Binahong and Keji Beling Leaf Extracts in Mice (Mus musculus) Rizky, Eka Septia Nur; Aina, Ganea Qorry; Kusumawati, Nursalinda; Farpina, Eka
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.684

Abstract

Cholesterol is a type of lipid found in the human body, with approximately 80% produced endogenously by the liver and the remaining 20% obtained from dietary sources. Elevated total cholesterol levels in the blood increase the risk of various health conditions such as cardiovascular disease, obesity, hypertension, and even stroke. Prolonged elevation can lead to plaque formation in blood vessels, resulting in impaired circulation and potentially life-threatening complications. The use of synthetic cholesterol-lowering drugs is often associated with unwanted side effects, including liver toxicity, muscle pain, and gastrointestinal disturbances. This has prompted increasing interest in safer, natural alternatives such as herbal medicine, which is perceived to provide fewer side effects and additional health benefits. This study aimed to investigate the anti-cholesterol activity of a combination of Binahong (Anredera cordifolia) and Keji Beling (Strobilanthes crispus) leaf extracts in mice (Mus musculus) induced with a high-cholesterol diet. The extraction method employed was maceration, using 96% ethanol as the solvent to ensure optimal phytochemical yield. The experimental design consisted of five groups: a negative control group, a positive control group, and three treatment groups receiving combinations of Binahong and Keji Beling extracts in ratios of 1:1, 1:3, and 3:1. Total cholesterol levels were measured using the Point of Care Test (POCT) method. The results showed that all treatment groups experienced a significant reduction in total cholesterol levels (p = 0.001 < 0.05). The most effective reduction was observed in the 1:1 ratio group, with a decrease of 45.39%, followed by the 3:1 group (27.80%) and the 1:3 group (14.17%). These findings indicate strong potential for development as an effective and safe herbal alternative for lowering cholesterol levels.
Formulation and Characteristic Effervescent Tablets of Water Gourd (Lagenaria siceraria) With Variation Sodium Bicarbonate Concentration Pradini, Silvia Triana; Ambarwati, Nadya; Nur, Fikria Marfuatin; Rachmawati, Nur
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.686

Abstract

Lagenaria siceraria, commonly known as bottle gourd, is a plant from the Cucurbitaceae family that contains bioactive compounds such as flavonoids, vitamin C, and saponins with potential antioxidant properties. This study aimed to develop effervescent tablets from Lagenaria siceraria using varying concentrations of sodium bicarbonate based on a Full Factorial Design method. The independent variable was the concentration of sodium bicarbonate, while the dependent variables included flow properties, angle of repose, moisture content, organoleptic characteristics, weight and size uniformity, hardness, friability, and dissolution time. Results showed that flow rate ranged from 5.1 ± 0.007 to 5.49 ± 0.025 seconds (p = 0.004), angle of repose from 25.21 ± 0.42 to 25.5 ± 0.024 degrees (p = 0.026), and moisture content from 3.08 ± 0.09 to 4.71 ± 0.027% (p = 0.080). The tablets met the requirements for weight and size uniformity. Tablet hardness ranged from 6.44 ± 1.42 to 7.75 ± 0.56 kP (p = 0.016), friability from 0.16 to 0.81% (p = 0.055), and dissolution time from 1.82 ± 0.02 to 1.96 ± 0.01 minutes (p = 0.047). In conclusion, variations in sodium bicarbonate concentration significantly affected flow properties, angle of repose, hardness, and dissolution time, but had no significant effect on moisture content and friability. Keywords: Lagenaria siceraria; sodium bicarbonate; effervescent tablet
Optimization Of Extraction Conditions For Total Phenols, Flavonoids, And Antioxidant Activity Of Avocado Seeds (Persea Americana Mill.) Using Simplex Lattice Design tomi, rizqika bastian; Iswandi, Iswandi; Saptarini, Opstaria
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.691

Abstract

Avocado pits contain a diverse array of bioactive substances, such as procyanidins, phenolic compounds, triterpenoids, acetogenins, fatty amino acids, and mild acids, all exhibiting antioxidant properties. Antioxidants function by preventing oxidation, reducing the formation of harmful compounds, and protecting against aging, inflammation, and cancer. This research centers on assessing the impact of solvent proportions, pinpointing the ideal solvent mixture, and measuring the overall phenolic and flavonoid levels, along with the antioxidant capacity, of the top-performing solvent applied for extracting compounds from avocado seeds. The research method used the SLD (Simplex Lattice Design) Design Expert method. The extract formula was prepared using sonication, with the results showing 17 formulas for three solvents: acetone, distilled water, and 70% ethanol. Test parameters included phytochemical screening tests, specific and non-specific parameter tests, total phenol tests, total flavonoid tests, and antioxidant activity tests using the DPPH method. Statistical data analysis was performed using Design Expert with ANOVA (Analysis of Variance) output according to the designed experimental design. The results obtained based on the research are the 12th run formula with a solvent ratio of acetone, distilled water, and 70% ethanol (100:0:0) has an extract yield of 3.25%, total flavonoids of 17.302 mgQE/g extract, total phenols of 46.274 mgGAE/g extract, and antioxidant activity of 81.68 ppm, the optimisation results show that the optimum solvent composition is 100% Acetone, without a mixture of 70% Ethanol or Distilled Water.

Page 16 of 16 | Total Record : 154

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