cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Chairunisa Ayu Saputri
Contact Email
jurnalmedfarm@gmail.com
Phone
+6287859041641
Journal Mail Official
jurnalmedfarm@gmail.com
Editorial Address
Jl. Batoro Katong No. 32 Ponorogo
Location
Kab. ponorogo,
Jawa timur
INDONESIA
Medfarm: Jurnal Farmasi dan Kesehatan
Published by Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo
ISSN : 23548487     EISSN : 27159957     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Jurnal MEDFARM merupakan terbitan dari lembaga jurnal dibawah naungan Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo. Topik atau pembahasan dari Jurnal MEDFARM lebih terfokus pada bidang Farmasi, Obat Tradisional, Makanan, Minuman dan Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 154 Documents
 12   13   14   15   16 
ANALYSIS OF DEXAMETHASONE AND PARACETAMOL CONTENT IN HERBAL MEDICINES FOR MUSCLE PAIN IN TERNATE CITY USING UV-VIS SPECTROPHOTOMETRY Trisiani, Dessy; Maulani, Maghfira; Abdullah, Abulkhair; Nasir, Muh.
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.600

Abstract

Jamu Pegal Linu (herbal medicines for muscle pain) is one of the most commonly consumed traditional herbal drinks to relieve muscle soreness and pain caused by fatigue. The high demand for jamu has led to some irresponsible producers adding Active Pharmaceutical Ingredient (API). The APIs commonly found are paracetamol and dexamethasone. This is a violation of the Indonesian Ministry of Health Regulation Number 007 of 2012 concerning Traditional Medicine Registration, which states that traditional medicine must not contain pharmaceutical chemicals. To detect the presence of paracetamol and dexamethasone in jamu pegal linu in Ternate City, 10 samples were analyzed qualitatively using Thin Layer Chromatography (TLC) with a mobile phase of chloroform:methanol (9:1), and quantitatively using validated UV-Vis spectrophotometry methods, including linearity, precision, accuracy, LOD, LOQ, and determination of content. Based on TLC testing, 5 samples were suspected to contain paracetamol, and 3 were suspected to contain dexamethasone. The validation results showed that all parameters met the requirements: R² ≥ 0.99, recovery 85.289–92.541%, RSD ≤ 0.79%, LOD 0.204–0.336 µg/mL. Based on qualitative analysis using TLC and quantitative analysis using UV–Visible spectrophotometry, several jamu pegal linu products sold in Ternate City were found to contain active pharmaceutical ingredients. Of the ten samples analyzed, 30% were suspected to contain dexamethasone and 50% were suspected to contain paracetamol. These findings indicate a significant presence of pharmaceutical adulterants in herbal medicines marketed in Ternate City. However, confirmatory analysis using more specific techniques such as High Performance Liquid Chromatography (HPLC) or Liquid Chromatography–Mass Spectrometry (LC-MS) is recommended to strengthen the validity of the results.
Improvement of Mother’s Knowledge to Common 65s`Cold Treatment in Children Using Leaflet Through CBIA Method In Tamansari Village Pratiwi, Yulia; Rahayu, Evitri Yuliana; Pratitis, Mera Putri; Wildayanti, Wildayanti; Tunggadewi, Aprillia Puspitasari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.612

Abstract

The common cold is a frequently occurring disease in children. An approach to control the disease is through health education using the Cara Belajar Ibu Aktif (CBIA) method alongside a leaflet media. Family knowledge, particularly that of the mother, plays a crucial role in preventing the transmission of the common cold in children. Knowledge is formed as a result of new understanding. This study used quantitative quasi-experimental design with a one-group pretest–posttest approach. The study population consisted of mothers in Tamansari Village, Tlogowungu Subdistrict, Pati Regency. Samples were selected using simple random sampling based on predefined inclusion and exclusion criteria. Data were collected door-to-door using structured questionnaires administered before and after the educational intervention. The results showed that maternal knowledge was generally poor before the intervention. Following the CBIA-based health education, maternal knowledge significantly improved. The proportion of mothers with good knowledge increased from 58.6% to 73.7%, while the proportion with poor knowledge decreased from 32.3% to 9.0% Statistical analysis using Wilcoxon Signed-Rank Test revealed a significant difference in maternal knowledge before and after the intervention (p = 0.000 < 0.05). Health education using the CBIA method supported by leaflet media is an effective approach for improving maternal knowledge regarding the treatment of the common cold in children.
The Relationship Between Pregnant Women’s Knowledge, Attitudes, and Behaviors Toward Tetanus Toxoid Immunization Andri, Sofyan; noviardi, Noviardi; Oktama, Nizan Dani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.613

Abstract

Tetanus Toxoid (TT) immunization remains a critical strategy in preventing maternal and neonatal deaths caused by tetanus. Despite its proven effectiveness, TT immunization coverage in Indonesia including in Pekanbaru City remains below target. Among the contributing factors are pregnant women's levels of knowledge, attitudes, and behaviors, which are believed to significantly influence immunization uptake. Objective: This study aimed to assess the relationship between pregnant women’s knowledge, attitudes, and behaviors and their participation in TT immunization programs across three health center areas in Pekanbaru: Simpang Tiga, Rejosari, and Okura. Methods: A descriptive analytic quantitative study with a cross-sectional design was conducted, involving 111 pregnant women who attended antenatal care (ANC) visits in May 2025. Data were analyzed using the Chi-Square test, Spearman Rank correlation, Cramer’s V, and logistic regression, with a significance level set at p < 0.05. Results: The study found statistically significant differences in knowledge, attitudes, and behaviors among the three health center areas (p < 0.05). Notably, good knowledge did not always correspond to positive attitudes—many well-informed respondents still exhibited negative attitudes. However, a strong correlation was observed between attitude and behavior (Cramer’s V = 0.552). Logistic regression revealed that knowledge (OR = 0.201; p = 0.005), attitude (OR = 2.068; p = 0.036), and behavior (OR = 5.660; p < 0.001) significantly influenced TT immunization uptake, with behavior emerging as the most dominant factor. Conclusion: Efforts to improve TT immunization coverage must go beyond knowledge-based education and focus on fostering positive attitudes and reinforcing supportive behaviors. Behavior-centered interventions and effective communication by health workers are essential to strengthen immunization outcomes.
Relationship of Knowledge and Motivation with Compliance in Taking Anti-Tuberculosis Drugs in TB Patients at North Bontang Health Center 1 husna, Husna husna; Leswana, Nurillahi Febria; Butar-Butar, Maria Elvina Tresia
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.619

Abstract

Tuberculosis (TB) treatment requires six months of continuous Anti-Tuberculosis Drug (OAT) therapy; non-compliance leads to treatment failure and Multi-Drug Resistant TB. This study aimed to analyze the relationship between patient knowledge and motivation with medication compliance among TB patients at the North Bontang Health Center 1, Indonesia. This cross-sectional study involved tuberculosis patients at North Bontang 1 Health Center. From a total registered population of 325 patients, a strict purposive sampling technique was applied based on inclusion and exclusion criteria, resulting in 30 eligible patients who participated in this study during the period of December 2024 to January 2025. Data on knowledge and motivation were collected using structured questionnaires; compliance was determined via triangulation (interviews, TB Form 01, PMO). Bivariate analysis used the Fisher's Exact Test (n=30). Results showed the majority demonstrated good knowledge (83.3%) and high motivation (90.0%), resulting in a high overall compliance rate (93.3%). Statistical analysis revealed a significant relationship between knowledge and compliance (p=0.006). No statistically significant relationship was found between motivation and compliance (p=0.193), likely due to data homogeneity
In Silico Evaluation of Cinnamaldehyde and Its Analogues as Potential Alpha-Glucosidase Inhibitors for Antidiabetic Therapy Ahwan, Ahwan; Muhtadi, Muhtadi; Munawaroh, Rima
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.622

Abstract

Diabetes mellitus (DM) is a chronic disease that can impact the health and well-being of patients in the long term. According to the International Diabetes Federation (2025), DM sufferers in Indonesia numbered 20.4 million in 2024. This figure is expected to increase to 28.6 million in 2050, DM treatment by inhibiting the alpha-glucosidase receptor. Cinnamaldehyde compounds have antidiabetic activity. This in silico study aims to determine the potential of cinnamaldehyde compounds and their analogs against alpha-glucosidase receptors as antidiabetics. Data on cinnamaldehyde compounds and their analogs were collected through the PubChem database and the alpha-glucosidase structure from the PDB database with the code 3TOP. This study evaluated cinnamaldehyde and its six analogs using molecular docking simulations on alpha-glucosidase receptors with tools such as PyRx 0.8, AutoDockTools-1.5.6, and Biovia Discovery Studio 2024, as well as pharmacokinetic and toxicity predictions using the pkCSM web tools and Lipinski's Rule of Five. The Lipinski's Rule of Five prediction results indicate that acarbose does not meet Lipinski's criteria. In contrast, cinnamaldehyde and its derivatives meet these criteria. Docking analysis shows that acarbose (7.1 kcal/mol) has the highest binding affinity for α-glucosidase, but cinnamaldehyde and its analogs (6.0–6.4 kcal/mol) still exhibit strong interactions at the enzyme's active residues. The ADMET profile supports the potential of cinnamaldehyde as an antidiabetic candidate with a broader systemic action range and a better pharmacokinetic profile than acarbose.
Phytochemical Screening and Antibacterial Activity of Ethyl Acetate, n-Hexane, and Aqueous Fractions of White Teak (Tectona grandis Linn. f.) Leaves against Escherichia coli herman, herman; Setyawan, Ferdinta Daniasta; Dhafin, Anis Akhwan; Prasetyawan, Fendy
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.628

Abstract

This study aims to conduct a phytochemical screening and evaluate the antibacterial activity of ethyl acetate, n-hexane, and aqueous fractions of white teak (Tectona grandis Linn f.) leaves against Escherichia coli bacteria. Phytochemical screening was performed to identify active compounds with potential antibacterial properties, such as flavonoids, tannins, saponins, alkaloids, and terpenoids. The antibacterial activity was tested using the disk diffusion and broth dilution methods to determine the inhibition zone, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC). The diffusion test results showed that ethanol extract (11.3 ± 1.02 mm) and the ethyl acetate fraction (18.1 ± 2.46 mm) exhibited significant antibacterial activity, whereas the n-hexane and aqueous fractions did not show any inhibition zones. Statistical analysis using ANOVA indicated a significant difference in antibacterial activity among the treatment groups (F = 163.29; p < 0.05). The broth dilution test revealed that the ethyl acetate fraction had an MIC at a concentration of 12.5%, with an MBC at 25%.
Analysis of Drug Use and Potential Interactions in Type 2 Diabetes Inpatients at a Type C Hospital, Kediri (2024) dhafin, anis akhwan; Wiryani, Luh Santhi Utami; Putri, Elsa Mahardika; Herman, Herman; Prabowo, Pulung; Yuniarto, Prayoga Feri; Winartiana, Winartiana
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.641

Abstract

Bachelor of Pharmacy, Universitas Mahasaraswati Denpasar, Indonesia Corresponding Author: anisdhafin13@unik-kediri.ac.id ABSTRACT Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a high prevalence and frequent comorbidities, particularly hypertension, which often require multidrug therapy and increase the risk of drug interactions. This study aimed to analyze the pattern of antidiabetic drug use and the potential for drug interactions in hospitalized patients with T2DM at a type C hospital in Kediri City during June–December 2024. The research employed a retrospective descriptive design using medical record data of 44 patients who met the inclusion criteria. Data were analyzed descriptively and presented in frequency distribution tables. Results showed that the most commonly prescribed drug class was biguanides (26.25%), followed by sulfonylureas (21%), insulin (21%), and α-glucosidase inhibitors (12.5%). Combination therapy was widely used, particularly the combination of two oral antidiabetic agents. Potential drug interactions were identified in 72.73% of patients, with moderate interactions being the most frequent (78.13%), followed by minor (12.5%) and major (9.38%) interactions. The most common interactions included metformin with amlodipine or ramipril (moderate severity), captopril with hydrochlorothiazide (minor severity), and simvastatin with amlodipine (major severity). However, in this study polypharmacy was defined as the concomitant use of ≥5 medications. These findings indicate that such polypharmacy in T2DM patients with hypertension substantially increases the likelihood of drug interactions, underscoring the importance of careful monitoring and rational prescribing to improve patient safety
Antibacterial Activity of Siam Weed Extract (Chromolaena odorata L.) Against Streptococcus mutans and Pseudomonas aeruginosa Bacteria Hita, I Putu Gede Adi Purwa; Kusuma, Putu Padmidewi Wijaya; Rullyansyah, Subhan; Arinatha, Bagus Lanang
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.645

Abstract

Infectious diseases are one of the main health problems in developed and developing countries. The prevalence of nosocomial infections reaches 15.74% and dental caries infections reach 88.8% caused by Pseudomonas aeruginosa and Streptocuccus mutans bacteria. To overcome bacterial infections, people usually use antibiotics, however, the use of antibiotics that are not appropriate and appropriate to the indications can cause antibiotic resistance or Antimicrobial Resistance (AMR). Therefore, this study aims to test the effectiveness of siam weed leaf extract (Chromolaena odorata L.) in inhibiting the growth of bacteria that cause infections. Siam weed leaf extract was prepared using the maceration method with 96% ethanolic solvent accompanied by extract quality control and active compound content testing. Antibacterial activity testing was carried out using the disc diffusion method to see and measure the area of inhibition zone. The results founded that siam extract has good water content, total ash content and weed acid insoluble ash content, which are below 10%, 16.6% and 0.7%. The antibacterial activity test of siam weed leaf extract obtained an inhibition zone diameter of 15.1 mm in Streptococcus mutans bacteria and 18.2 mm in Pseudomonas aeruginosa. In addition, siam weed extract also qualitatively contains active secondary metabolite compounds such as alkaloids, flavonoids, saponins, steroids, phenols and tannins. This concluded that siam weed leaves extract of has a characteristics that meet the requirements, containing secondary metabolite compounds and has antibacterial activity against the growth of Pseudomonas aeruginosa and Streptococcus mutans bacteria.
In-Silico Analysis And Molecular Dynamics Simulation Analysis of Sida rhombifolia Compounds as Candidate Antibacterial Agents Against Methicillin-Resistant Staphylococcus aureus firdaus, alshol; Herowati, Rina; Rahmawati, Ismi; Prasetiyo, Andri; Herman, Herman
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.646

Abstract

Antibiotic resistance has become a critical issue in global health, one of which is MRSA. The dynamic problem related to the increasing MRSA infections is clear evidence that the treatment and management of this disease have not been optimally resolved, requiring the development of effective antimicrobial agents against MRSA. An exploratory method was used to assess the antibacterial activity, interaction patterns, and stability of sidaguri compounds. A total of 15 potential compounds from sidaguri were docked onto four molecular targets: PBP2a (4JCN), MecR1 (609S), FtsZ (8HTB), and SCCmec (4FAK), using the molecular docking methods AutodockTools and PyMol, followed by analysis of the amino acid residue similarity of each test ligand. The molecular docking results predicted that the compounds with the best binding affinity and interaction patterns similar to the natural ligand for their respective molecular targets were quercetin, ecdysone, and 24-methylenecholesterol. The validation parameters are calculated from RMSD and RMSF based on the In-Silico predictions. MD simulations were performed using YASARA Dynamics. The MD simulation results showed that, from the RMSD and RMSF graphs of the MRSA target molecules, quercetin, ecdysone, and 24-methylenecholesterol exhibited binding stability close to that of the natural ligand. The predicted pharmacokinetic profiles show that all three compounds have a good ADMET profile, with optimal absorption potential, adequate distribution, appropriate metabolism, and relatively low toxicity, making them promising candidates for development as antibacterial drugs against MRSA
Evaluation of the Use of an Electronic Prescription System Using the HOT-Fit Approach at the Pharmacy Installation of UNS Hospital Surakarta Pratama, Rio Adwika; Inandha Dewi, Lucia Vita; Harsono, Samuel Budi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.648

Abstract

The e-Prescribing system has become an essential part of the digitalization of healthcare services aimed at improving accuracy, efficiency, and patient safety. Despite being adopted in many hospitals, the implementation of this system in Indonesia still faces challenges, including limited user understanding, uneven organizational support, and limited technological infrastructure. This study aims to evaluate the implementation of the e-Prescribing system at the Pharmacy Installation of UNS Hospital Surakarta using the HOT-FIT model, which assesses the Human, Organization, and Technology dimensions, as well as the Fishbone diagram to identify the root causes of the challenges faced. A mixed-methods approach was used, with quantitative data collected through questionnaires distributed to 30 pharmacy staff, analyzed using descriptive statistics, Pearson validity tests, and Cronbach’s Alpha reliability tests. The results showed that all questionnaire items were valid, with Pearson correlation values ranging from 0.518 to 0.898 and Cronbach’s Alpha of 0.918, indicating a very high level of internal consistency. The Human Fit dimension had a mean score of 4.2 (SD 0.5), Organization Fit 4.3 (SD 0.4), Technology Fit 4.5 (SD 0.3), and Net Benefit 4.6 (SD 0.2), indicating a positive impact on efficiency and user satisfaction. However, challenges related to inadequate training, slow system access, and limited integration with other systems remain. Fishbone analysis identified six key factors affecting system performance. The study concludes that while the e-Prescribing system shows positive results, improvements in training, infrastructure, and system integration are needed to enhance its effectiveness.

Page 14 of 16 | Total Record : 154

 12   13   14   15   16 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan Vol 13 No 2 (2024): Medfarm: Jurnal Farmasi dan Kesehatan Vol 13 No 1 (2024): Medfarm: Jurnal Farmasi dan Kesehatan Vol 12 No 2 (2023): Medfarm: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 2 (2022): Medfarm: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 2 (2021): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 1 (2021): MEDFARM: JURNAL FARMASI DAN KESEHATAN Vol 9 No 2 (2020): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 9 No 1 (2020): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 8 No 2 (2019): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 8 No 1 (2019): MEDFARM : JURNAL FARMASI DAN KESEHATAN More Issue