cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Chairunisa Ayu Saputri
Contact Email
jurnalmedfarm@gmail.com
Phone
+6287859041641
Journal Mail Official
jurnalmedfarm@gmail.com
Editorial Address
Jl. Batoro Katong No. 32 Ponorogo
Location
Kab. ponorogo,
Jawa timur
INDONESIA
Medfarm: Jurnal Farmasi dan Kesehatan
Published by Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo
ISSN : 23548487     EISSN : 27159957     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Jurnal MEDFARM merupakan terbitan dari lembaga jurnal dibawah naungan Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) Akademi Analis Farmasi dan Makanan Sunan Giri Ponorogo. Topik atau pembahasan dari Jurnal MEDFARM lebih terfokus pada bidang Farmasi, Obat Tradisional, Makanan, Minuman dan Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 154 Documents
 10   11   12   13   14 
The Determinants of Drug-Resistant Tuberculosis Incidence at the Special Lung Hospital, Health Department of the Provincial Government of North Sumatera, 2021-2024 Dalimunthe, Mawaddah Sri Rezeki; Susanti, Nofi; Aidha, Zuhrina; Batubara, Abdul Karim
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.539

Abstract

Along with the increase in tuberculosis (TB) cases, there has also been a rise in the number of Drug-Resistant Tuberculosis (DR-TB) cases, which poses a serious threat to global TB control efforts. Globally, there are 400,000 DR-TB cases according to the WHO report in 2024, with Indonesia contributing 7.4% of the total cases. In North Sumatra, the incidence of DR-TB cases reached 54%. This study aims to analyze and identify the factors influencing the incidence of DR-TB among DR-TB patients at the Special Lung Hospital of the Provincial Government of North Sumatra. The study uses a quantitative approach with a case-control design utilizing secondary data from the SITB application at the Special Lung Hospital of the Provincial Government of North Sumatra from 2021-2024. The sample consists of 204 individuals with a 1:1 ratio, comprising 102 individuals with DR-TB and 102 controls with non-DR-TB. The sampling technique used is purposive sampling. This study sets DR-TB incidence as the dependent variable, while independent variables include sex, employment status, age, treatment outcome, access to health service facilities, residence, contact examination, TB treatment history, diagnosis type, diabetes mellitus status, and HIV status. Data were analyzed using three tests: univariate analysis, bivariate analysis, and multivariate analysis with the use of statistical software version 22. The results show that factors significantly influencing DR-TB incidence include age (CI 95%: 4.7 [2.3-9.5]), employment (CI 95%: 3.4 [1.7-6.6]), and a history of previous TB treatment (CI 95%: 14.7 [5.5-39]).
The Effect of Boiling Duration on The Antioxidant Activity of Green Mustard (Brassica rapa L.) Prasetya, Landung Wahyu; Wahyuni, Sri; Mahmudah, Nur; Fithriya, Sa’idatul
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.546

Abstract

Background: A study stated that one of the contents of green mustard is phenolic which acts as an antioxidant. Antioxidant activity is influenced by the processing method, especially boiling. The duration of boiling can cause damage to antioxidant compounds. Outcome: This study was to determine the effect of the duration of boiling green mustard on the antioxidant activity contained in it. Method: This study used a laboratory experimental method with a post-test only controlled group. Results: The results of testing on fresh green mustard, green mustard boiled for 2-4 minutes showed an increase in IC50 value from 4,414.03E + 48 ppm to 5.3805E + 138 ppm. Green mustard boiled for 6 minutes experienced a decrease in IC50 value from 5.3805E + 138 ppm to 2,505.23E + 45 ppm. The IC50 value of green mustard boiled for 8 minutes increased again to 5,051.02E + 48 ppm. Boiled mustard greens for 10 minutes had a significantly decreased IC50 value to 0.0469 ppm. Conclusion: The effect of the duration of boiling green mustard greens (Brassica rapa L.) on the antioxidant effects contained there in. The duration of boiling green mustard greens (Brassica rapa L.) which has good antioxidant activity in green mustard greens boiled for 10 minutes.Keyword: Green Mustard, Phenolic, Antioxidant, Post Test Only Controlled Group
Pharmacophore Identification Through Molecular Docking of Scopoletin as a PFKFB3 Receptor Inhibitor for Anticancer Drug Development Ilafi, Nadhifa; Da’i, Muhammad
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.557

Abstract

Cancer is one of the leading causes of death worldwide. Current therapies often have limited effectiveness and significant side effects. The ability of cancer cells to utilize glycolysis for their growth is one of the challenges in the development of cancer therapies. This study aims to identify the pharmacophore of scopoletin molecules and its derivatives as inhibitors of the PFKFB3 receptor, which plays an important role in cancer cell metabolism through the glycolysis process. The method used is in silico molecular docking. The results showed that of the 12 scopoletin derivative compounds tested, compound C1 (modified by removing double bonds in the carbonyl group and hydroxyl group) showed the best performance with a binding energy value of -7.07 kcal/mol, an inhibition constant of 5.35 μM, and the highest pharmacophore fit value of 48.63. Molecular interaction analysis identified amino acid residues TYR424, LYS168, ALA44, LYS47, and THR48 as important binding sites on the PFKFB3 receptor. All test compounds meet Lipinski's rule and show good ADMET profiles, with Human Intestinal Absorption (HIA) values of more than 89%. The removal of the hydroxyl group at the C-7 position provides better binding values for each class of scopoletin derivative compounds, while the methoxy group plays an important role in the interaction with the target protein.
The Potential of Aegle marmelos as a Co-Chemotherapeutic Antimetastatic Agent for Ovarian Cancer : a Review wahyuni, Sri; Sutrisna, E.M.; Maryati, Maryati
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.558

Abstract

Aegle marmelos, commonly known as bael, has long been utilized in traditional medicine due to its diverse pharmacological activities, including antioxidant, antimicrobial, and anticancer properties. Recent studies have highlighted its potential as an anticancer agent through mechanisms such as apoptosis induction, proliferation inhibition, and suppression of metastasis. Ovarian cancer remains a significant cause of morbidity and mortality, primarily due to late-stage diagnosis, chemoresistance, and rapid metastatic progression. Co-chemotherapeutic agents derived from natural products, such as A. marmelos, may enhance standard chemotherapy efficacy, reduce resistance, and mitigate adverse effects. This review explores the potential of A. marmelos as a co-chemotherapeutic agent against metastatic ovarian cancer. The discussion covers its phytochemical composition, molecular mechanisms, cytotoxic activity across various cancer types, and its synergistic role in modulating resistance and tumor microenvironment. The therapeutic promise of A. marmelos in integrative cancer treatment strategies is emphasized as a research direction for future translational and clinical applications.
Combination of Secang (Caesalpinia sappan L.) and Glibenclamide in Mice (Mus Muscullus) Hyperglycemia Salsabilla, Salma Febriani Nur; Safitri, Cikra Ikhda Nur Hamidah
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.562

Abstract

Diabetes is a disease whose sufferers continue to increase in Indonesia. The International Diabetes Federation (IDF) in 2019, estimated around 463 million people with the disease. This figure is likely to continue to increase, up to 578 million in 2030 and 700 million in 2045. The use of herbal medicines is now growing, one of which comes from the secang woods (Caesalpinia sappan L.). The plant is rich in active bioactive components such as flavonoids and tannins. The flavonoids contained in secang have the ability to inhibit the enzyme α-glucosidase which plays a role in lowering the reabsorption of sugar into the blood. This study aims to determine the antihyperglycemia activity of the combination of sappang (Caesalpinia sappan L) and glibenclamamide in hyperglycemic mice. This research was carried out by providing treatment to the grouped mice. This study was experimental using a pretest-posttest with control group design. The results showed a significant difference in the average blood sugar levels of mice induced by alloxan in the group given a combination of secang and glibenclamide, namely a decrease in blood sugar levels from 227 mg/dL to 116.50 mg/dL after treatment.
Adherence Level to Antihypertensive Medication Among Internal Medicine Outpatients at Anna Medika General Hospital Madura Wulandari, Tri Wahyuni
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.567

Abstract

Hypertension is one of the chronic diseases known as a “silent killer” because it often presents without symptoms but can lead to serious complications such as stroke, kidney failure, and even death. The main challenge in hypertension treatment is patient non-adherence to regularly taking medication as prescribed, which can reduce treatment effectiveness and increase the risk of complications. A high level of adherence is essential to achieve optimal therapeutic outcomes and prevent harmful long-term effects. This study aims to determine the level of adherence to antihypertensive medication among patients at the internal medicine outpatient clinic of Anna Medika General Hospital Madura. The research used a descriptive quantitative method with a survey approach, employing the 8-item Morisky Medication Adherence Scale (MMAS-8) as the data collection instrument. The questionnaire was distributed to 96 respondents who met the inclusion criteria. Data were analyzed using the Guttman scale, and statistical processing was performed using SPSS version 16.0. The results showed that all respondents fell into the adherent category, with an average adherence rate of 94%. This indicates that most patients are aware of the importance of taking medication regularly, even while traveling or feeling well. The study concludes that the level of adherence to antihypertensive medication at Anna Medika General Hospital is high, serving as a positive indicator for the long-term effectiveness of therapy.
The Relationship Between Registration Time and Outpatient Satisfaction at Dr. Tengku Mansyur Tanjungbalai Hospital Hafidzah, Fidiana; Hasibuan, Rapotan; Agustina, Dewi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.571

Abstract

The registration unit serves as the initial point of contact in healthcare services, shaping patients’ first impressions of a hospital’s service quality. This study aimed to examine the correlation between registration service time and outpatient satisfaction at RSUD Dr. Tengku Mansyur Tanjung Balai. A quantitative research approach was utilized with a cross-sectional design and correlation analysis. A total of 105 respondents were selected through a random sampling method. Data were collected using a questionnaire adapted from prior studies and validated for reliability. The results of the Pearson correlation test showed a significant relationship between registration service time and patient satisfaction (p = 0.000). The correlation coefficient was -0.806, indicating a strong negative association. Additionally, the coefficient of determination (R²) was 0.646, which means that 64.6% of patient satisfaction was influenced by registration waiting time—categorized as a strong correlation. These findings indicate that longer registration times are associated with lower levels of patient satisfaction. The study emphasizes the importance of optimizing the registration process as a strategic step to improve overall hospital service quality.
THE THE EFFECT OF ADDING TOMATO EXTRACT (Solanum lycopersicum L.) to APPLE-BASED SHEET JAM (Malus sylvestris L.) AS AN ANTIOXIDANT SARI, BINA LOHITA
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.572

Abstract

Antioxidants are substances that can prevent or reduce oxidative stress in physiological systems. The natural antioxidants found in our food are substances that can protect cells from the dangers of free radicals produced by the body's metabolism. Tomato (Solanum lycopersicum L.) and apple (Malus sylvestris L.) are natural compounds with strong antioxidant capacities which can be used in functional food. Both natural compounds will be made into jam sheets, a modified jam printed in sheet which is very easy to serve on bread and cakes. This research aimed to find the best formula of apple puree sheet jam added with differences of tomato juice concentration. There are 4 sheet jam formulas which are F1, F2, F3, and F4 use 100 g of apple puree and add tomato juice as 0 g, 60 g, 75 g, and 90 g respectively. The parameter test used for this research were hedonics test for panelists, water content test, pH value, total plate count, mold/yeast test, and antioxidant activity. The results showed that F4 was the best formula preferred by the panelists. The water content, pH value, total plate count, and mold/yeast test were 21.62%, 4.23, and 7.5 x102, respectively. The antioxidant activity value with an IC50 value of 87.14 ppm. The addition of 90 g of tomato juice on 100 g of apple puree produces sheet jam with strong antioxidant activity.
Phytochemical Composition of 70% Ethanol Extract of Noni Fruit (MorindacitrifoliaL.) Using Ultrasound-Assisted Extraction Method and LC-MS Q-ToF Kurniawati, Evi; Lestari, Tri Puji; Kristianingsih, Ida; Purwani, Asih Imulda Hari; Nurhayati, Rachma
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.573

Abstract

Noni (Morinda citrifolia L.) is a traditional medicinal plant that is widely used in the treatment of various degenerative diseases. However, scientific data regarding the composition of its bioactive compounds are still limited, especially those analyzed using a high-precision instrument approach. This study aims to identify the phytochemical composition in 70% ethanol extract of noni fruit using Liquid Chromatography-Mass Spectrometry (LC-MS) method. Extraction was performed by Ultrasound-Assisted Extraction (UAE) method and compound analysis using Q-ToF type LC-MS instrument with positive ionization mode. The results showed that noni extract contained 28 compounds, with 13 compounds successfully identified consisting of 7 alkaloids, 3 glycosides, 1 phenolic, 1 amino acid, and 1 aminoglycoside. The major compound identified was Methyl (5R)-2,3,4-tris-O-(methoxymethyl)-5-{2-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-piperidinyl]ethyl}-α-D-xylopyranoside, belonging to the glycoside group with a molecular weight of 485.25 g/mol. These results indicate that noni fruit contains diverse secondary metabolite compounds with the dominance of alkaloid and glycoside compounds. This study contributes to providing primary data based on LC-MS technology on the chemical composition of Indonesian natural ingredients and can be a scientific basis for the development of medicinal plant-based pharmaceutical preparations with noni active ingredients.
Green Synthesis Of Silver Nanoparticles Of Leaf Extract Of Senduduk Bulu (Clidemia Hirta (L) D.Don) And Exploration Of The Antibacterial Activity Arvian, Dias Wahyu; Rahmawati, Ismi; Ikasari, Endang Diyah
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.574

Abstract

Senduduk bulu wild plant contains secondary metabolite compounds which used natural reducing agent on synthesis of silver nanoparticles (AgNPs). This research determine the optimum extract concentration and temperature in the process synthesis of silver nanoparticle, characteristics of silver nanoparticles and antibacterial activity of silver nanoparticles against S.aureus and E.coli. Synthesis of silver nanoparticles senduduk bulu leaf using variations extract concentration and temperature variations. The characteristics of silver nanoparticles senduduk bulu leaf were carried out using a UV-Vis Spectrophotometry, Particle Size Analyzer (PSA) and Scanning Electron Microscopy – Energy Dispersive X-Ray Spectroscopy (SEM-EDS). Antibacterial activity testing used the disc diffusion method. The results of research showed the silver nanoparticles of senduduk bulu leaf were successfully synthesized under optimal conditions an extract concentration of 1% and temperature of 60ºC indicated the colloid color changing to brown and maximum wavelength value of 413 nm with absorbance value of 2.9987. The size of colloidal AgNPs of senduduk bulu leaf was 59.2 ± 1.03 nm; zeta potential value -39.3±0.509 mV. The morphology of the AgNPs of senduduk bulu non uniform shape, the crystal size distribution is 50 – 230 nm with an average of 136 nm. The chemical composition of AgNPs crystals shows that silver (Ag) dominates with a weight concentration of 37.688% and atomic concentration of 7.605% at the peak of the 3 KeV spectrum. Feathered AgNPs had antibacterial activity against S.aureus of 14.1 ± 0.3 mm and E. coli of 13.5 ± 0.2 mm. Keywords: Green Synthesis, Silver Nanoparticle, Senduduk Bulu Leaf, Staphylococcus aureus and Escherichia coli.

Page 12 of 16 | Total Record : 154

 10   11   12   13   14 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan Vol 13 No 2 (2024): Medfarm: Jurnal Farmasi dan Kesehatan Vol 13 No 1 (2024): Medfarm: Jurnal Farmasi dan Kesehatan Vol 12 No 2 (2023): Medfarm: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 2 (2022): Medfarm: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 2 (2021): MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 1 (2021): MEDFARM: JURNAL FARMASI DAN KESEHATAN Vol 9 No 2 (2020): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 9 No 1 (2020): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 8 No 2 (2019): MEDFARM : JURNAL FARMASI DAN KESEHATAN Vol 8 No 1 (2019): MEDFARM : JURNAL FARMASI DAN KESEHATAN More Issue