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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 24 Documents
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Search results for , issue "Vol 4 No 2 (2023): June 2023" : 24 Documents clear
Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan Mawandha Sari Harahap; Urip Harahap; Panal Sitorus
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3262

Abstract

Experimental research in the field of hepatology on the development of traditional medicine into a potential pharmacological solution to protect the liver from cirrhosis. Accordingly, this study investigated the effect of ethanol extract of temu kunci rhizome on liver cirrhosis. The rats were divided into six groups, the normal control group was given nothing but pellets and sufficient water, the negative control group was given orally CMC-Na 0.5%, 200 mg acetylcysteine (dose converted to rat) was given to the positive control group, and the treatment group was given ethanol extract of temu kunci rhizome doses of 250, 500, 750 mg/kg BW, given daily for 10 days. Then on the 10th day after 1 hour of extract administration, induction was carried out with paracetamol 800 mg/kg BW orally; 16 hours after induction, rats were sacrificed, blood was taken for ALT and AST enzyme examination, then liver organs were taken for histopathological examination. The administration of ethanol extract of temu kunci rhizome can prevent liver damage by reducing ALT and AST enzyme levels in rat blood serum. The best dose in reducing ALT and AST enzymes was produced by giving 500 mg/kg BW of temu kunci rhizome ethanol extract every day for 10 days. At a dose of 500 mg/kg BW ethanol extract of temu kunci rhizome morphologically (evaluation with H&E staining) can also repair liver tissue damaged by paracetamol induction. The development of liver damage can be interpended by using ethanol extract of temu kunci rhizome, so that the status of liver morphology, structure and function of the liver can be maintained.
Uji Toksisitas Makroskopis Pada Organ Ginjal, Hati, Jantung dan Limpa Mencit Hiperglikemia yang Diberi Ekstrak Etanol Kulit Buah Rambai (Baccaurea motleyana) Ria Ceriana; Dwi Putri Rejeki
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3366

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia. Plants that can reduce blood sugar levels in alloxan-induced mice are Rambai peel (Baccaurea motleyana). The safety of the use of plants as herbal medicine must be known so as not to cause unwanted harmful effects. In this study, the relative weight of organs and changes in organ appearance were observed macroscopically. The design in this study was a completely randomized design with 24 male mice divided into 6 treatments and 4 replications. The treatment consisted of a negative control (Aquadest), a positive control (glibenclamide), peel Rambai ethanol extract with graded doses of 200 mg/kg, 400 mg/kg, 800 mg/kg and 1600 mg/kg. , given orally. The results showed that the ethanol extract of Rambai peel had no significant effect on the relative weight of the heart, kidneys and spleen, but had a significant effect on the relative weight of the liver. The results of this study also showed that no color changes were seen in any of the mice organs. So, this study showed no visible macroscopic changes in the organs, so that administration of Rammbai ethanol extract gradually causes fewer toxic effects and is still considered safe in experimental animals.
Identification of Avian Influenza with the Real-Time Polymerase Chain Reaction (RT‒PCR) Method Anak Agung Ayu Sauca Sunia Widyantari; Fauzi Rahmat Kurniawan
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3399

Abstract

Avian influenza is a zoonotic disease transmitted from poultry to humans. The prevalence of AI disease in Indonesia is likely to be a global health threat because of the ease of mutation in each generation, which makes pathogenicity higher. However, detection efforts still use conventional methods, so a more sophisticated detection search is needed. This research aims to identify the DNA amplification process and the results of detecting avian influenza virus using real-time PCR. Qualitative research using samples from BBVet Denpasar in May 2022. The samples were analyzed using the real-time polymerase chain reaction (RT‒PCR) method, and the results obtained were analyzed descriptively. The results show that the RT‒PCR method is very effective for detecting the presence of AI quantitatively and molecularly. A graph that crosses the threshold on cycles lower than 40 indicates that a positive sample will show nominal Ct. No nominal Ct was detected in this study, and the graph did not cross the threshold, so the model tested negative for the AI virus. The DNA amplification process of the avian influenza virus begins with an amplification process of 40 cycles, with each cycle stage in the form of denaturation at 94 °C for 30 seconds, annealing at 64 °C for 60 seconds, and DNA synthesis at 76 °C for 30 seconds. One cycle is declared if the amplification process has passed these three stages.
Formulasi Masker Gel Peel Off Ekstrak Daun Tanaman Porang (Amorphophallus muelleri Blume) yang Stabil Secara Farmaseutik Vina Purnamasari M; Hamsinah Hamsinah; Anifatul Mu’awanah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3452

Abstract

Porang leaves (Amorphophallus muelleri Blume) have strong antioxidant activity with an IC50 97.054 µg/mL which often used in the development of cosmetics. Purpose of the research was to obtain a pharmaceutically stable formulation of porang leaf extract gel peel-off mask (Amorphophallus muelleri Blume). The research was laboratory experimental. Porang leaf extract peel-off masks were made in 4 formulas with variations in PVA concentrations of 7.5%, 10%, 12.5% and 15%. The peel-off masks obtained were tested for stability including organoleptic testing, homogeneity, syneresis test, adhesion test, spreadability test, dry time test, viscosity and flow properties. The conclusion from the results obtained that porang leaf extract can be formulated in a gel peel-off mask formula. The gel peel-off mask formula of porang leaf extract (Amorphophallus muelleri Blume) with pharmaceutical stability test is formula 3 with a concentration of 12.5% polyvinyl alcohol and formula 4 with a concentration of 15% polyvinyl alcohol. The gel peel-off mask formula is porang leaf extract that qualifies the pharmaceutical stability test.
Formulasi dan Uji Aktivitas Sediaan Hair Tonic Kafein untuk Menstimulasi Pertumbuhan Rambut pada Hewan Uji Marmut Aztriana Aztriana; Nurlina Nurlina; Dian Safitri Achmad; Vina Purnamasari; A Hasrawati
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3453

Abstract

Hair loss occurs in many people, so it can reduce the cosmetic function and protect the body and head from the environment. Hair loss is a disorder in which the number of hairs is less or more than normal. Hair tonic includes cosmetic preparations that have a liquid form with the function of maintaining hair health, stimulating hair growth, and strengthening hair. Caffeine is a substance that can stimulate hair growth. The purpose of this study was to determine the activity of a hair tonic preparation containing caffeine that can stimulate hair growth in guinea pigs. The results showed that hair tonic caffeine Formula 1 with a concentration of 0.001% with an average hair length of 18.294 mm had high effectiveness in stimulating hair growth compared to Formula 2 with a concentration of 0.005% with an average hair length of 16.610 mm.
Pengaruh Konsumsi Sari Kacang Hijau Terhadap Kelancaran Asi Ibu Menyusui Dewi Parwati
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3490

Abstract

ASI (Air Susu Ibu) merupakan satu-satunya makanan yang terbaik untuk bayi yang bersifat alamiah. ASI mengandung berbagai zat gizi yang dibutuhkan dalam proses pertumbuhan dan perkembangan. Dalam 100 gram kacang hijau mengandung 124 mg kalsium dan 326 mg fosfor, bermanfaat untuk memperkuat kerangka tulang. Serta 19,7-24,2 % protein dan 5,9-7,8 % besi dapat menghasilkan ASI dalam jumlah yang maksimal. Jenis penelitian yang digunakan adalah Quasi Experimental, disebut juga dengan eksperimen semu. Quasi Eksperimental adalah jenis penilitian eksperimen yang memiliki perlakuan dampak, unit eksperimen, namun tidak menggunakan penugasan acak untuk menciptakan perbandingan dalam rangka menyimpulkan perubahan yang disebabkan oleh perlakuan. Populasi dalam penelitian ini adalah seluruh ibu nifas di Wilayah Kerja Puskesmas Keang Maros bulan 10 April s/d 06 Mei 2018. Kemudian sampel sebanyak 30 responden yang di ambil menggunakan tekhnik purposive sampling. Uji yang digunakan dalam penelitian ini adalah uji Chi-Square dengan menggunakan nilai α = 0,05. Berdasarkan hasil penelitian pengaruh konsumsi sari kacang hijau terhadap kelancaran ASI pada ibu nifas maka didapatkan nilai ρ = 0,00 < α = 0,05 maka Ho ditolak sehingga terdapat pengaruh konsumsi sari kacang hijau terhadap kelancarann ASI pada ibu nifas di Wilayah Kerja Puskesmas Keang Maros tahun 2018. Saran kepada ibu nifas agar dapat mengkonsumsi makanan yang bergizi selama menyusui, karena dapat berpengaruh pada perkembangan anak. Kemudian kepada petugas, dengan adanya hasil penelitian tersebut, diharapkan bidan memberikan penyuluhan pada ibu post partum tentang manfaat mengkonsumsi sari kacang hijau yang dapat melancarkan ASI.
Pengetahuan Remaja dan Peran Teman Sebaya dengan Pencegahan Infeksi Menular Seksual Kartini Massa; Stendy Ali
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3530

Abstract

Lack of adolescent knowledge about sexually transmitted diseases and their dangers, especially to health and the role of peers, which contributes badly to the increase in sexually transmitted diseases, especially among adolescents. This study aims to determine the relationship between adolescent knowledge and the role of peers with the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. The research design uses an analytic survey with a cross sectional approach. The sampling technique with probability sampling is simple random sampling on a sample of 92 teenagers. Data analysis used the Chi Square statistical test. The results showed that most adolescent knowledge was in the good knowledge category with a percentage of 57.6%, the role of peers was mostly in the good role category with a percentage of 63% and the prevention of sexually transmitted infections was mostly in the good prevention category with a percentage of 52.2 %. The conclusion is that there is a relationship between adolescent knowledge and the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. There is a relationship between the role of peers and the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. It is recommended to increase the role of counseling guidance through health education to add insight into knowledge so as to change the behavior of adolescents in preventing sexually transmitted infections and for adolescents to seek information about infectious diseases from various information media sources, to be active in various positive activities such as extracurricular activities held at school or other activities. other social activities and hang out with friends who have good behavior.
Uji Efektivitas Antidiare Obat Herbal X pada Mencit (Mus musculus) galur Swiss Webster yang diinduksi Minyak Jarak (Oleum ricini) Nita Salsa Nuraprilia; Baiq Rilda Erliana Zahara; Putri Oktaviati Riadi; Tity Afriliani; Kerthika Ayu Wandeni; Muhamad Zainul Fajri Awwalin; Siti Rahmatul Aini
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3547

Abstract

Drug X is one of the herbal medicines used as anti-diarrhea that is known to have been circulating in the community. This medicine contains extracts of pomegranate peel, areca nut seeds, gambir leaves, and guava leaves. Its use is only based on empirical data, so further studies are still needed to prove its effectiveness as an antidiarrheal. The purpose of this study was to determine the effectiveness of herbal medicine X as an anti-diarrhea agent in male mice (Mus musculus) induced by castor oil (Oleum ricini). Testing the anti-diarrhea effect was carried out using the method of protection against diarrhea induced by castor oil. Mice were randomly divided into five groups (n = 15). Mice in the normal group were only given the preparation carrier, namely Na-CMC suspension, and were not induced by castor oil. Mice in the positive control group were given Diapet® suspension at a dose of 156 mg/kg BW, while the negative control mice were given Na-CMC suspension, and then both groups were induced with castor oil. Mice in both treatment groups were given X herbal medicine with different doses (128.7 mg/kg BW and 386.1 mg/kg BW) and then induced by castor oil. Diarrhea parameters, including the frequency of defecation and stool consistency, were observed and then statistically analyzed using the ANOVA test, Kruskal-Wallis, and Mann-Whitney. The results showed that the treatment dose of 128.7 mg/kg had comparable antidiarrheal effectiveness with the positive control (p≤0.05) and was significantly different from the negative control (p≤0.05). The dose of 386.1 mg/kg showed no significant difference with the negative control (p≤0.05) and showed a significant difference with the dose of 128.7 mg/kg and the positive control. From this study, it can be concluded that herbal medicine X has an anti-diarrheal effect and that a dose of 128.7 mg/kg BW shows the best anti-diarrheal effect.
Formulasi Sediaan Masker Peel Off dari Ekstrak Buah Alpukat (Persea Americana Mill.) dengan Variasi Konsentrasi Polivinil Alkohol (PVA) Ririn Ririn; Vina Purnamasari M; Nurfajeriani Ulfah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3605

Abstract

Face mask peel off is a skin care product that when applied to the skin will dry out which can be peeled off from the skin of the face. Avocado Flesh (Persea americana Mill.) has powerful antioxidants that can be used in moisturizing and anti-aging products. This study aims to produce mask preparations to peel off gel from avocado fruit extract (Persea americana Mill.) to moisturize facial skin. This study used the maceration method to obtain a thick extract from avocado fruit. Mask formulation peel off made in a variety of polyvinyl alcohol (PVA) bases, namely 10% (F1), 12% (F2) and 14% (F3) as a film-forming agent. The evaluation is based on physical parameters including organoleptic, homogeneity, spreadability, pH, viscosity, flow properties, drying time and measurement of facial skin moisture levels. The evaluation results on the pH test, homogeneity and drying time showed that all formulas met the standard parameters, namely the PVA pH test 10% = 6.46; PVA 12% = 6.4; PVA 14% = 6.35, in the long test the drying time of 10% PVA = 18.97 minutes; PVA 12% = 20.82 minutes; and 14% PVA = 24.66 minutes. Meanwhile, in the organoleptic test,viscosity, the three formulas were pharmaceutically unstable, namely in the organoleptic test the three formulas experienced a change in consistency, in the spreadability test the spreadability value of PVA 10% = 5.41; PVA 12% = 4.75; PVA 14% = 4.03, in the viscosity test of the three formulas after forced conditions = E (error: the viscosity value exceeds the maximum limit of the viscometer). Based on the results of the facial skin moisture test, it shows that Avocado fruit extract with a concentration of 0.6% can provide effectiveness as a moisturizer for facial skin.
Hubungan Tingkat Pengetahuan Ibu Tentang Perawatan Gigi Dengan Karies Gigi Anak Usia Pra Sekolah 4-5 Tahun Arsad Arsad; Yulistina Yulistina; Sulastri S; Sultan Amin Yasin; Utari Zulkaidah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3641

Abstract

Pre-school age children are a period of child growth. Caries is a case experienced by pre-school age children. The 2018 Basic Health Research, the prevalence of dental caries in children aged 3-4 years in Indonesia is 36.4%, the prevalence of dental caries in pre-school children in South Sulawesi is 73.6%, the prevalence of dental caries in East Luwu is 82.8%, and the prevalence of dental caries at the age of pre-children as in Nuha District 89.2%. This condition is very concerning considering that pre-school children still need the role of parents in caring for their health, especially dental health. In this case, parental knowledge is needed in guiding and giving more attention so that children do not experience caries. This study aims to determine the relationship between the level of knowledge of mothers about dental care and dental caries in pre-school aged children 4-5 years at Al-Ikhwan Kindergarten. The research method used is analytic observational with a retrospective approach. This research was conducted in May 2023 with the subjects of this study being parents, especially mothers whose children attended TK Al-Ikhwan as many as 89 people. Collecting data using a questionnaire sheet. Analysis of research data using Univariate and Bivariate Test analysis. The level of parents' knowledge about dental health is mostly in the sufficient category (47, 21%). The majority of respondents experienced media caries (61.79%). Ha is accepted with ƿ Value – 0.006, correlation coefficient -0.946. There is a relationship between the level of parental knowledge about dental health and the occurrence of caries in preschool children aged 4-5 years at TK-Al Ikhwan, East Luwu Regency.

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