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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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The Omega-3 Fatty Acids can Significantly Increase the Height of Children Under Five with Stunting Lewi Jutomo1, Bambang Wirjatmadi2, Rudi Irawan3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3088

Abstract

Children with stunting are a global public health problem that has implications for impaired physical growth, which has an impact on increasing morbidity and mortality. This study aims to study the role of omega-3 fatty acid supplementation on anthropometric measures of toddlers with stunting, especially height. This type of research was an experimental randomized clinical trial design, in the form of pre-post test control group design. Subjects who participated in this study were toddlers aged 12-36 months, consisting of 12 children as a control group who received placebo, and 12 children as a treatment group who received omega-3 fatty acid supplementation for 2 months. The parameters observed was height. The collected data were analyzed using t-test. The results of the study showed that there was a difference in changes in the subject’s height in the treatment group compared to the control group (p-value = 0.009294). It was further concluded that supplementation of omega-3 fatty acids in children under five with stunting could significantly increase height.
Relations Exposure to Dust Inhalation Against Impaired Lung Function in Worker Unloading at the Port of Manado, North Sulawesi Lili Sutanti1, Zikri Fathur Rahman1, Nur lailatul Masruroh2, Abdul Rohim Tualeka3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3090

Abstract

Upper respiratory tract infection has been one of the top ten illness the last three years. In 2014 (28,579 cases), in 2015 (39,110 cases) and in August 2016 (27,068 cases). In the community health service of the Manado Port area, the upper respiratory tract infection is on the top list. The problem of loading and unloading is the problem of loading and unloading. The problem is loading and unloading. workers in Manado Port. The problem of loading and unloading workers in Manado Port. The research was observational with analytical approach and cross sectional design, with 60 samples of respondents. It consists of 9 variables and data was collected by interview, observation and measurement. (P = 0.195; PR = 0.648 (95% CI = 0.533 - 0.789). Smoking habit (p = 0.786; PR = 0.788 (95% CI = 0.361 - 1,719) Working period (p = 0,143; PR = 1,959 (95% CI = 0,896 - 4,283). Working duration (p = 0,838; PR = 0,831 (95% CI = 0,390 - 1,771) With potential variables. Affecting lung function impairment of loading and unloading workers is use of mask (p = 0.195) and period of work (p = 0.143). There is no significant correlation between use of mask, smoking habit, period of work, working duration, inhaled dust exposure and lung function disorder.
Urinary Tumor Markers for Detection and Surveillance in Non-Muscle Invasive Bladder Cancer Mohamed Jamal Saadh1, Abeer Mohammad Kharshid1, Hala Mousa Sbaih1, Khalil Altaif1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3091

Abstract

Objectives: Cystoscopy still remains the gold standard for diagnosis and follow-up monitoring of bladder cancer (BC). Unfortunately, it is an invasive, and the urine cytology is a highly specific, sensitivity for detection of low grade tumors is only 4% to 31%. The advent of noninvasive urine-based markers as well as other novel modalities has yielded improved diagnostic accuracy. Material and method: Pubmed/Medline search was conducted to identify original articles, review articles, and editorials regarding urine-based biomarkers for screening, early detection, and surveillance of urothelial carcinoma of the bladder. Results: urinary marker shave shown higher sensitivity compared with cytology, and most markers suffer from lower specificity than cytology. In this review, we aimed to summarize the current knowledge on commercially available and promising investigational Urinary tumor markers for detection and surveillance in Non-Muscle Invasive BC. Conclusions: biomarkers into clinical decision making will be of value for BC detection and screening in the future.
Relationship between QT Interval Dispersion and Degree of Coronary Artery Disease Mohammed Almyahi1, Tahseen A., Alkinani2, KadhumMajdi3, Falah Shaheed Azzawi 4, Ahmed Basheer5
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3092

Abstract

Background: It has been shown that QT dispersion (QTD) increases during episodes. Currentstudyhas been done in order to determine QTD in patients with stable angina, assess myocardial ischemia and infarction. Aims of Study: This study aiming to determine the relationship between severity of coronary artery disease (CAD) and degree of QTD. Patients and Method: A 214 patients (177 men and 37 women) underwent diagnostic coronary angiography because of suspected CAD. Standard resting 12 lead electrocardiogram (ECG) were recorded within 24hrs before coronary angiography. QT intervals were measured manually by ruler method and QTD were gauged as (QT maximum – QT minimum). A 184 patients had CAD and control group (30 persons) had a normal coronary angiogram Interestingly, QTD has increased significantly as there was sever increment of CAD. QTD was in 1 vessel disease, 2 vessel disease, in 3 vessel disease, and in left main stem disease. Left ventricular dysfunction has raised QTD significantly in patients with 1,2 vessels, as well as left main stem disease. QTD clearly elevated as Gensini score increased. Involvement of proximal left anterior descending artery did not increase QTD significantly in patients with CAD. Multiple regression analysis demonstrated that severity of CAD, left ventricular dysfunction and previous myocardial infarction were independently associated with increased QTD. QTD increased significantly in patients with stable angina compared to the controls.Severity increase of CAD resulted in significant increase in QTD, and presence of LV dysfunction has caused further increase.
Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients Mohammed.T. Alaanzy1, Jinan .MJ.Alsaffar2, Ahmed AbdulBari3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3093

Abstract

The study was done in January – may 2018, For measuring interleukin concentration 17-A and transforming growth factor-?1 in the serum of syst.emic lu.pus erythrmatosus (SLE) female patients(52 female) compared to the control group (36 healthy female). An E?zyme- Link ed Immun?s orbent Assay (ELISA) was used to diagnose both IL-17A and TGF ?1 in SLE patients and control. In case of IL-17A High significant in.crease (P < 0.0001) in SLE patients (38.54 pg / mL) compare d with he althy co.ntrol (20.24 pg / mL) was observed, while in patients with SLE, the transforming growth factor-? was (70.90 pg / mL) compared to healthy control (116.66 pg / mL) (P < 0.0001). To all SLE patients and control, The laboratory features include full blood count ,ery.throcyte sedimentation rate ESR, ,an.d immunological tests like C3,C4,ANA and anti ds-DNA were done. ESR , WBC , ANA and Urea were significantly higher in SLE patient than con trol group (p.value 0.0001, 0.0001, 0.024, 0.0001 respectively) whereas Hemoglobin were significantly lower in SLE Patient than control group (p.value 0.0001) .C3&C4 were lower in SLE patients but with no significance value.
Device-associated Infections (DAIs) in ICU: Using new CDC/ NHSN definitions Mostafa Mohammadi1, Arash Seifi2, Maryam Mokhtaryan3, Azam Ghahan4, Sara Ghaderkhani3, Esmaeil Moham
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3095

Abstract

Surveillance of device-associated infections (DAIs) in intensive-care units (ICUs) is essential for a suitable healthcare strategy-planning. This study was conducted to determine the DAIs rate, microbial epidemiology, and antimicrobial resistance pattern (AMR) in ICU. Three major DAIs, ventilator associated pneumonia (VAP), catheter-associated urinary tract infection (CAUTI), and central line-associated bloodstream infection (CLABSI) were assessed prospectively during 6 months (2018 March 21 to September 22) in an 18-bed ICU of a tertiary teaching hospital in Tehran according to new CDC/NHSN definitions for surveillance of DAIs. The incidence of VAP, CAUTI, and CLABSI were 38.2, 8.9, and 13.5 per 1000 device-days respectively. The most organisms were Acinetobacter baumannii (34.9%), Klebsiella pneumonia (19%), E.coli (10.7%), Candida (10.7%), Enterococcus Spp. (8.7%), Pseudomonas aeruginosa (8.7%), and Staphylococcus aureus (2.9%). Klebsiella pneumoniae carbapenemase (KPC)-producing was 47.4%. Acinetobacter resistance to Ampicillin-sulbactam and carbapenems was 80.6% and more than 90% respectively. Methicillin resistant Staphylococcus aureus (MRSA) was 66.6% and Vancomycin-resistant Enterococcus (VRE) was 88.9%. This study showed high incidence of DAIs and resistant organisms in the ICU. Preventive measures are essential to decrease the rates.
NOAEL Benzene in White Mice as the Basis for Determining the Safe Limit of Benzene Concentration in the Pulogadung Shoe Industry Home in Jakarta Muh. Arfandi Setiawan1, Herman Bagus1, Aisy Rahmania1, Cut Suci1, Carmelita Agustin1, Abdul Rohim Tu
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3096

Abstract

The shoe industry in its operational activities is very dependent on the quality of the material, one of which is glue containing benzene, the industrial workers have a risk of exposure to benzene. The purpose of this study was to determine the safe concentration of benzene in the leather shoe industry in the small industrial village of Pulogadung, Jakarta. This research is descriptive research. The population in this study were shoe workers who worked on the installation of solee 1 and solee 2, which amounted to 16 people. The results of the study were quantitatively analyzed to determine the safe concentration of benzene for workers obtained from data on benzene concentrations in the workplace, worker height, worker weight, rats’ weight, worker respiration rate, length of work, worker body surface area, surface area mice body, highest dose of toxin without effect on experimental animals (NOAEL), Km factor in animals (Animal Km), factor Km in workers (Human Km), and safe limit for toxin dose for workers (RfC). The measurement results of the concentration of benzene in the sole 1 section were 0.19 ppm and in the sole 2 part was 0.06 ppm, which means that the concentration of benzene is still below the Threshold Value according to Minister of Manpower Regulation Number 13 of 2011 at 0.5 ppm. Based on the calculations that have been done, the safe limit value is 0.021 ppm. Based on the minimum risk level (MRL), the concentration of benzene every day that can cause acute effects is 0.009 ppm and that can cause chronic effects is 0.003 ppm. From these standards, it can be seen that the concentration of benzene in the leather shoe industry has the potential to have an impact on the health of workers. Control measures are needed to see potential health problems that workers can experience because of the benzene. Recommendations to the leather shoe industry are to periodically monitor benzene levels in the air, conduct health checks on workers, and use personal protective equipment on workers such as masks to reduce levels of inhaled benzene into workers’ bodies
The Relationship between Heat Stress and Dehydration in the Continous Casting Machine Section of Pt X Muhammad Cahya Nur Siddiq1, Mulyono1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3098

Abstract

One of the hazards in the CCM (Continuous Casting Machine) section of PT X is the heat stress. The heat stress is predominantly caused by hot metal liquids processed before being compacted into billets. Heat Stress causes workers sweating a lot and leads to dehydration. The purpose of this study is to find the correlation between heat stress and dehydration in CCM (Continuous Casting Machine) section of PT X. It is an observational study and a cross sectional study due to time examined. The tools to measure heat stress is Heat Stress Apparatus Quest Temp 36 and measurement of work dehydration is by observing the color of the respondent’s urine compared to the urine color table. This study has a sample of 30 workers exposed to the hot work climate in CCM (Continuous Casting Machine) section of PT X. The data analysis techniques used are univariate and bivariate analysis techniques. The results show that the highest working climate in the place is 42.3 oC and of the 30 respondents studied, there are 28 respondents who are dehydrated, ranging from mild to severe. By using the chi-square test statistical calculations to see the correlation, p is 0.045 where p <?, means there is correlation between the work climate and work dehydration. Suggestions that can be given to companies to overcome heat stress problems are by adding fan blowers in the workplace and providing electrolyte salts added to the workers’ drinks.
The Effect of CHOP Chemotherapy Implementation Towards Reduced Global Longitudinal Strain in Non-Hodgkin Lymphoma Muhammad Perdana Airlanga1, Rochmad Romdoni1, Ami Asharianti2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3100

Abstract

Background: Doxorubicin in CHOP regimen is still the golden standard of first-line chemotherapy in patients with NHL (Non-Hodgkin Lymphoma); however, it has enormous cardiotoxicity side-effects. Objective: This study aims to investigate the effect of CHOP chemotherapy implementation towards the GLS reduction in cumulative dosage of doxorubicin ? 100 mg/m. Method: This study was pre experimental analysis with modified cohort. The subjects were observed for 1 month, since the first chemotherapy until 1 week after the second chemotherapy. The echocardiogram procedure with ejection fraction and global longitudinal strain was conducted twice which was before the first chemotherapy and 1 week after the second chemotherapy. Results: The implementation of CHOP therapy with the cumulative dosage of ?100 mg/m2 has resulted in reduced GLS from 19.62% to -18.03%. The reduction of GLS>10% was 40% while the LVEF has not been obtained any reduction > 10%. The case of subclinical left ventricular dysfunctions was attained 16%. Conclusion: The implementation of CHOP chemotherapy with the dosage of ?100mg/m2 has been proved to cause reduced GLS and subclinical left ventricular dysfunctions.
Effect of Metronidazole on Clopidogrel Bisulphate Efficacy in Male Albino Rats Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3101

Abstract

The data about this combination effect on platelet function and hematological parameters are sparse, but there is only mention in many medical science websites such as Medscape, there are possible interaction between it, in which metronidazole cause inhibition to cytochrome CYP3A4 which responsible on clopidogrel metabolism, this may put the patients that on clopidogrel bisulphate therapy at risk of clot formation and may be progress, this may occur because clopidogrel is at inactive form and need to activation by cytochrome mention above, so this study was performed in order to achieve the following aims: studying the efficacy of clopidogrel bisulphate on coagulation process by measuring bleeding time when giving clopidogrel alone and in combination with metronidazole and studying the possible effect of two drug alone and in combination on hematological parameters in male albino rats

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