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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 22 Documents
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Search results for , issue "Vol 6 No 1 (2023)" : 22 Documents clear
Pengaruh Pelarut N-Heksan, Etil Asetat, Dan Etanol 96% Terhadap Kadar Flavonoid dan Aktivitas Antioksidan Kulit Buah Lamtoro (Leucaena leucocephala) ina bulu, atalia tamo; Novembrina, Metrikana
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p81-86

Abstract

Lamtoro rind waste in Indonesia is produced in large quantities so it can become a problem for the environment if not managed properly. Lamtoro rind extract contains chemical compounds such as flavonoids, alkaloids, saponins, phenolics, and tannins. Flavonoid compounds, one of the phenolic groups widely found in plant tissues, can act as antioxidants. This study aims to examine the effect of N-hexane, ethyl acetate, and 96% ethanol on the levels of flavonoids and the antioxidant activity of lamtoro rind (Leucaena leucocephala). Lamtoro rind was made simplicial and extracted by maceration method using N-hexane, ethyl acetate, and 96% ethanol separately for 3x24 hours. Each extract was analyzed to determine the levels of flavonoids by UV-Vis spectrophotometry method and antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhidrazyl) method. The results of the analysis showed that 96% ethanol gave the extract with the highest levels of flavonoids, followed by ethyl acetate and N-hexane of 15.345 µg/g, 14.899 µg/g and 10.234 µg/g respectively. In addition, the antioxidant activity of lamtoro rind extract was also shown to be higher in 96% ethanol extract compared to ethyl acetate extract and n-hexane extract calculated with IC50 values of 39.914 ppm, 30.788 ppm, and 164.304 ppm respectively. Based on this study, it can be concluded that 96% ethanol resulted in lamtoro rind extract with higher levels of flavonoids and stronger antioxidant activity compared to using N-hexane or ethyl acetate as solvents. These results indicate that lamtoro rind has the potential as a useful source of flavonoids and antioxidants.
PENETAPAN KADAR FLAVONOID EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) Ayuningtyas, Nurista; Ayu Ina, Ayu Ina; Setyopuspito, Anastasia; Trisina, Jessica; Mardiyono, Amida Kesya
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p93-97

Abstract

Noni fruit has traditionally been used for treatment due to its secondary metabolite content, one of which is flavonoid. This research aims to determine the secondary metabolite content of 96% ethanol extract of noni fruit and total flavonoids in the extract. The research method was conducted experimentally. Noni fruit extract was obtained by maceration method, phytochemical screening was performed to determine the content of secondary metabolites in qualitatively. Total flavonoids were analyzed by colorimetric method with quercetin as standard. Quercetin levels were measured by Spectrophotometry Uv-Vis. The results obtained yield of noni fruit extract 3.60% + 0.31. Phytochemical screening of noni fruit extract contains flavonoids, alkaloids, tannins, steroids, and saponins. The quercetin standard curve equation obtained y = 0.0067 x - 0.0148 with r = 0.9959. The result of total flavonoids in ethanol extract of noni fruit was 0.166% + 0.004.
PROFIL PENGGUNAAN OBAT TRADISIONAL PADA MASYARAKAT DESA PEGANDON KENDAL Suwarni, Sri; Septiyana, Ria; Fajaryanti, Nita; Indrasari, Ferika
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p87-92

Abstract

This study discusses the profile of the use of traditional medicine in Pegandon Village, where this study aims to obtain an overview of traditional herbal medicine producers in the Pegandon village area and an overview of the use of traditional medicine in traditional herbal medicine businesses in the Pegandon village area. This research was conducted using a descriptive method with a questionnaire as a data collector. The respondents in this study were the Pegandon village community. The results of the study showed that the highest use of traditional medicine in Pegandon village was women (100%), aged 31-40 years (40%), housewife (92%), last high school education (47.7%). Most of the types of illness were diarrhea (30%) and menstrual pain (30%) with a duration of illness that was mostly experienced less than one week (96%), most of the actions taken when sick by respondents were to see a doctor, health center or hospital (68%), most of the purpose of using traditional medicine is to cure a sudden/mild illness (34%) by buying traditional medicine at a traditional herbal medicine seller (42%), the dosage form most respondents use is in the form of herbal medicine (46%) with the average duration of use is 1 day (46%), the most sources of information are obtained from family (30%) on the grounds that they are made from natural ingredients (90%), the amount of use is mostly one tablespoon (40%) , the traditional medicine that is used mostly does not cause side effects (92%), when side effects appear some respondents still continue traditional medicine (2%), but there are those who go to the doctor or switch to modern medicine (40%), and there are who stopped using traditional medicine (58%). Keywords: traditional medicine, pegandon village
Potensi Anti Bakteri Hard Candy Ekstrak Asam Jawa (Tamarindus indica L.) dengan Minyak Sereh Wangi (Oleum Citronellae) Saptawati, Tunik; Handayani, Dwi Nurul; Gloria, Fransisca; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p98-103

Abstract

Tamarind and Sereh wangi (Citronellae winterianus Jowitt) are widely planted in Indonesia. Citronella oil is widely used as an anti-bacterial because of its secondary metabolite content. This study aims to determine the anti-bacterial potential of hard candy with active ingredients of tamarind extract and citronella oil. Tamarind fruit extract was prepared by maceration method using 96% ethanol solvent. Hard candy is made in 3 formulas with tamarind extract and citronella oil 0,1% (F1), citronella oil 0,2% (F2), and citronella oil 0,2% (F3). Antibacterial activity of hard candy examined using the disc diffusion method by measuring the diameter of the inhibition zone for the growth of Staphylococcus aureus and Escherichia coli bacteria. The result of the diameter of the inhibition zones F1, F2, and F3 for Escherichia coli were 4.25, 4.38, and 5.35 mm, respectively. The the diameter of the inhibition zones F1, F2, and F3 for Staphylococcus aureus were 2.30, 2.67 and 2.90 mm, respectively . It was showed that hard candy with active ingredients of tamarind extract and citronella oil was able to inhibit the growth of bacteria. The difference in the diameter of the inhibition zone between the formulas was analyzed using One Way Anova. The significance value is <0.05, so there is a significant difference in anti-bacterial activity between formulas. The concentration of citronella oil influence on antibacterial activity where the greater the concentration of citronella oil, the antibacterial activity to Staphylococcus aureus and Escherichia coli will increase. Keywords: Citronella oil, Tamarind, Hard Candy, Antibacterial.
EFEKTIFITAS IMPLEMENTASI BUDAYA KAIZEN DALAM PENINGKATAN CUSTOMER SATISFACTION DI PUSKESMAS BANGETAYU KOTA SEMARANG Suwarni, Sri; Arfiyani, Aulia; Septiyana, Ria; Gloria, Fransisca
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p126-132

Abstract

Pemerintah telah mengawal mutu pelayanan kefarmasian dalam Standar Pelayanan Kefarmasian. Kualitas pelayanan meliputi teknis dan proses pelayanan dengan mengukur kepuasan pasien, yang dilakukan dengan angket secara periodik. Kaizen merupakan salah satu upaya perbaikansecara terus menerus untuk peningkatan kualitas mutu. Penelitian ini bertujuan mengetahui efektifitas implementasi budaya kaizen dalam peningkatan customer satisfaction di Puskesmas Bangetayu Kota Semarang. Penelitian eksperimental metode observasional kuantitatif menggunakan instrument kuesioner. Sampel diambil 350 responden pasien yang mendapatkan Pelayanan Kefarmasian dibagi sebelum dan sesudah Implementasi suatu budaya perbaikan kaizen dengan teknik purposive sampling. Tahapan analisis menggunakan DMAIC (Define, Measure, Analyze, dan Control). Perlakuan yang diterapkan adalah budaya kaizen (5S) yaitu seiri, seiton, seiso, shitsuke, seiketsu. Hasil improve penerapkan budaya kaizen berupa perbaikan sistem layanan dengan pembiasaan budaya resik, rajin, rapi, ringkes, rawat dalam teknis pelayanan kefarmasian menunjukkan bahwa terjadi peningkatan kepuasan pasien sebesar 1,67%. Hasil uji Wilcoxon p = , upaya perbaikan dengan adanya perbedaan signifikan antara sebelum dan sesudah penerapan budaya kaizen pada peningkatan costumer satisfaction dengan nilai keefektifan setiap indikator dengan uji N-Gain memiliki nilai keefektifan 52% yang berarti kurang efektif untuk pemilihan strategi budaya kaizen yang diterapkan di instalasi farmasi Puskesmas Bangetayu Kota Semarang sehingga dibutuhkan alternatif pembiasaan budaya kaizen lainnya.
DETERMINATION OF PIPERINE ISOLATE FROM JAVA CHILLI (Piper Retroofactum Vahl.) Using the High Performance Liquid Chromatography (HPLC) method Christina, Odilia Dea; Mahesa, Sandi; Elsa, Limpat
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p104-108

Abstract

Java chili fruit (Piper Retroofactum Vahl.) can be used in concoctions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite. In the traditional medicine industry in Indonesia, Java chili is one of the most needed raw materials, 9.5% of the total simplicia. Javanese chilies are round and dark green to brown in color. The content of the main secondary metabolites in chili plants is piperine, pipernaline, guineensine and essential oils. The purpose of this study was to determine the piperine content isolated from Java chili using the HPLC method. The column used is a C-18 type column, 2489 UV/Visible detector light. The mobile phase used was Acetonitrile : Methanol : Aquabidest (65:5:30) v/v. The isolation results obtained yield of 0.20% piperine isolate has a spicy taste, needle-shaped blackish brown color, difficult to dissolve in water and easily soluble in ethanol.From the results of the assay, the piperine content data was obtained at 37.48%
Potensi Beberapa Tanaman Herbal di Indonesia Sebagai Antidiare Berdasarkan Penelitian In Vivo Hartanti, Yesiska Kristina; Rosa, Dela; Mailinda, Putri; Elleanore, Angeline; Deis, Friska
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p114-119

Abstract

The gastrointestinal tract facilitates the primary function of the body, such as food digestion and absorption. Disruption of the process will lead to digestive tract disorder. One disorder of the digestive tract is diarrhea. Diarrhea is a condition of loose and watery stool that excretes more frequently than normal, accompanied by abdominal cramps. Herbal plants research as a therapy alternative has been continuing to develop for herbal medicine potential discovery. From the literature study, it was found 9 species of plants have activity to inhibit diarrhea based on in vivo study. This article will expose the various natural properties found in Indonesia.
Aktivitas Ekstrak Etanol Daun Akar Kucing (Acalypha indica L.) Sebagai Pengawet Alami Pada Buah Tomat (Lycopersium esculentum Mill.) Solichah, Ayu Ina; Sawal, Rizky Ardian Hartanto; Auliya, Fitri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p120-125

Abstract

The presence of preservatives in food is a common thing to extend the shelf life of foods. The bad effects appliying chemical preservatives cause both environmental pollution and health disturbing. Consuming chemical preservatives for a long time will will cause cancer. Natural preservatives is needed to reducing the bad effects. One of the Plants can be applied as natural preservatives is cat root leaves (Acalypha indica L. The study aims were to determine the activity and effective concentration of cat root leaf extract as a natural preservative on tomatoes and to identify the its phytochemical content. Activity of cat root leaf extract as a preservative was subjected by organoleptic, meanwhile the phytochemical content by tube-test. The results showed 8% cat root leaf extract effective as natural preservative according to organoleptic observation with observed time for 20 days. The result of tube-test showed cat root leaf extract contain compounds likes alkaloid, flavonoid, saponin, tannin, and terpenoid.
Efek Tonikum Ekstrak Etanol Daun Randu (Ceriba Pentandra (L.) Gaertn) Terhadap Mencit Jantan Galur Swiss Dengan Metode Natatory Exhaustion Karol Giovani Battista Leki, Karol; Permatasari, Desi
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p109-113

Abstract

Randu leaves are used traditionally to relieve fatigue and increase stamina. This study aims to determine the tonic effect of ethanol extract of randu leaves on male Swiss strain white mice. Tonic effect research was carried out using the Natatory Exhaustion method. This study used 5 test groups, namely negative control (CMC Na 0.5%), positive control (caffeine 100 mg/kgBW), ethanol extract of randu leaves with various doses of 500 mg/kgBW, 1000 mg/kgBW and 2000 mg/kgBW. The research results were analyzed using One Way Anova. The results showed that the ethanol extract of randu leaves had a tonic effect on male white mice.
PENGGUNAAN GLUKOMANAN DARI UMBI PORANG (Amorphophallus oncophyllus Pr.) SEBAGAI BIODEGRADABLE FILM DENGAN PENAMBAHAN SORBITOL DAN GLISEROL SEBAGAI PLASTICIZER Sudarsono, Agustina Putri Pitarisa; Sari, Clara Evita; Ayuningtyas, Nurista Dida
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p133-138

Abstract

Plastic waste that is not handled properly will cause disaster. Glucomannan is a type of hemicellulose polysaccharide from porang flour with an extraction method to extract glucomannan compounds in porang flour. The addition of plasticizer as an additive is useful for forming a film layer in this study. Biodegradable film is a type of film coating as a food wrapper that is environmentally friendly and safe to eat which can be decomposed by microorganisms made from processed starch compounds. Porang tubers have the potential as a biodegradable film material with high glucomannan content. This study aims to make a biodegradable film from Porang tubers and to determine the performance of sorbitol and glycerol as plasticizers. The research method begins with the extraction of porang flour with 50% and 80% ethanol twice in a ratio (1:6) stirred using a homogenizer for 30 minutes, then to form a biodegradable film with the addition of sorbitol and glycerol plasticizers using a magnetic stirrer for 45 minutes. minutes with a stirring temperature of 80ºC followed by an evaluation of the biodegradable film characterization, swelling test, FTIR test, biodegradation test using One Way Anova statistical analysis. The results showed that the biodegradable film with the addition of 10% glycerol plasticizer showed good results with the characteristics of the biofilm being slightly viscous, the evaluation degree of swelling was 76.13%, degraded for 20 days.

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