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Open Access Indonesian Journal of Medical Reviews
Published by HM Publisher
ISSN : -     EISSN : 28076257     DOI : https://doi.org/10.37275/oaijmr
Core Subject : Health,
Health Professions Medicine & Pharmacology
Open Access Indonesian Journal of Medical Reviews (OAIJMR) is a bi-monthly, international, peer-review, and open access journal dedicated to various disciplines of medicine, biology and life sciences. The journal publishes all type of review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 200 Documents
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Analysis of Studies on the Role of Hormones in Micropenis Disorders: A Systematic Literature Review Amal, Rizki Jaya; Irfansyah; Muhammad Arif Hasan; Aulia Putra Rahman
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 6 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i6.420

Abstract

A deep understanding of the role of specific hormones in genital development is key to designing effective therapeutic approaches. Factors such as testosterone deficiency, growth hormone disorders, or other hormonal imbalances can be targets for hormonal interventions that can affect penis size. This study aimed to explore the role of hormonal aspects in micropenis disorders. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the role of hormonal aspects in micropenis disorders. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Aspects of the hormonal role in micropenis include several key elements that influence the development of genital organs in men. Hormones, such as testosterone, growth hormone, estrogen, and dihydrotestosterone (DHT), play an important role in stimulating penis growth and development. Proper hormonal balance is necessary for normal genital development, and disturbances in the production of or response to these hormones may contribute to conditions such as micropenis.
Development of a Reliable Information System for Medical Device Inventory in Hospitals: A Systematic Literature Review Suryati
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 6 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i6.421

Abstract

Developing an information system for medical equipment inventory in hospitals not only includes technical aspects but also involves an in-depth understanding of the operational needs of the hospital itself. By utilizing the latest technology, such as the Internet of Things (IoT), and efficient data integration, hospitals can ensure that the information systems developed can adapt to the dynamics of future technological needs and developments. This study aimed to explore the development of a reliable information system for inventory of medical equipment in hospitals. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the development of a reliable information system for the inventory of medical devices in hospitals. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Developing an information system for medical device inventory in hospitals is a crucial step in improving the efficiency, availability, and management of health resources. Developing an information system for medical device inventory in hospitals is not just about recording and monitoring but also providing a holistic solution to improve operational efficiency and patient service.
Evaluation of Drug Management and Improvement Strategies Using the Hanlon Method in the Pharmacy Installation of Dr. Moewardi General Hospital, Surakarta, Indonesia Imelia, Lanny; RA.Oetari; Samuel Budi Harsono
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 6 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i6.446

Abstract

A hospital pharmacy (FRS) is a unit in a hospital that carries out health efforts by providing quality health services. Medication management in FRS is an important management aspect in achieving service quality. Therefore, IFRS must be managed effectively and efficiently. Inefficiency in use can have a negative impact on hospitals both medically and economically. The aim of this study was to evaluate drug management, including selection, procurement, distribution, and use, based on the 2020 National Formulary standards and improvement strategies using the Hanlon method at the pharmacy installation of Dr. Moewardi General Hospital in 2020. This research is a type of descriptive research with retrospective and concurrent data collection. Data was taken from retrospective data in 2020 and data at the time the research was conducted. Research materials include primary data obtained from observation of research data in the form of document selection, procurement, distribution, and use of medicine in the IFRS Dr. Moewardi General Hospital. Secondary data was obtained from interviews with the head of the pharmacy installation at Dr. Moewardi General Hospital Surakarta, the head of planning, and the head of ULP (procurement services unit). The results of the research show that 1) Medication management in the pharmacy installation at Dr. Moewardi General Hospital Surakarta is not yet efficient at this stage of selection. It is known that the availability of existing medicines does not comply with FORNAS standards in 2020. then, in stage procurement, there is 1 out of 5 indicators that meet the standard; in stage distribution, 5 indicators were obtained, or all of them were not standard, and in staged use, it was found that 1 of the 5 indicators met the standard. 2) The improvement strategy uses the Hanlon method in drug management, namely prioritizing problem repairs sequentially, starting from the percentage of conformity with the number of drug items available with FORNAS to the number of drug items per prescription sheet.
Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations Sukarno; Ilham Kuncahyo; Endang Dyah Ikasari
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.451

Abstract

Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.
Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations Farrah Bintang Sabiti; Sukarno
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.461

Abstract

Mefenamic acid is included in BCS (biopharmaceutical classification system) class II, namely high permeability and low solubility. This research aims to obtain a good formula for oleic acid oil, tween 80, and PEG 400 according to the characterization test of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research was an experimental study by formulating mefenamic acid in the form of SNEDDS which was made 1 formula was made in the form of SNEDDS with the composition of oleic acid, tween 80, and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, globule size, zeta potential. The yield of the oleic acid formula is 1%, tween 80 is 8%, and PEG 400 is 1%. The emulsification time characterization test resulted in 17 seconds, % transmittance of 97%, drug loading of 179.81 mg, globular size of 85.8 nm and zeta potential of -1.6 mV.
Management Evaluation of Expired and Slow-Moving Medications at Hospital X in Batam City Putri Meisa Anggesta; Heldi Candra; Oktaviani, Fifin
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.504

Abstract

Efficient drug management necessitates a well-structured supply chain to ensure the smooth functioning of health services. The objective of this study is to ascertain the strategies employed for the disposal of expired medications and the handling of slow-moving pharmaceuticals at Hospital X in Batam City. This research is characterized as descriptive-observational, employing a retrospective methodology. Data analysis involves doing qualitative analysis to assess the degree of rationality, followed by quantitative analysis using a formula. The findings of this study indicate that the highest proportion of expired pharmaceuticals occurred in September 2021, accounting for 25.011%. Additionally, the Regional Public Service Agency (RPSA) allocated 17.020% of the budget expenditures, while the Regional Budget (RB) allocated 28.904%. The pharmaceuticals that have the highest expiration rate are injectable preparations, with a proportion of 63.340%. Among these, 41.299% are funded by RPSA, and 74.075% are funded by RB. The highest proportion of expired pharmaceuticals, categorized by therapeutic class, is 16.500% in the antibiotic group. In addition, RPSA allocates 6.729% of the budget funds and RB allocates 37.123% of the budget for this purpose. The highest proportion of expired pharmaceuticals, categorized by therapeutic class, is 16.500% in the antibiotic group. In addition, RPSA allocates 6.729% of its budget funds and RB allocates 37.123% of its budget towards these expired drugs. In the first quarter, there were 57 slow-moving medications, accounting for 84.594% of the budget money from RPSA and 15.406% from RB. The findings of this study indicate that the management of expired pharmaceuticals does not meet the research criterion of less than 1%; however, the management of slow-moving drugs aligns with the research criterion of less than 1%.
Evaluation of Vaccine Stock Management at the Karanganyar Regency Health Service Indonesia Kurniawan, Andre; Jason Merari Peranginangin; Samuel Budi Harsono
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.506

Abstract

Vaccines are very susceptible to damage, so vaccine management requires special handling, this is done to maintain vaccine quality. The aim of this research is to find out the description and evaluate suitability vaccine management at the Karanganyar Regency Health Service (DKK) in 2022 based on Minister of Health Regulation No. 12 of 2017. This research is a qualitative descriptive non-experimental research. These research methods cross sectional by using approach, observation or data collection. The sampling technique uses accidental sampling by reviewing and evaluating vaccine management, which includes planning, procurement, receipt, storage, and distribution at the Karanganyar Health Service. The method used for data collection uses checklist suitability and in-depth interviews with the Head of Installation and pharmacy officers. Vaccine planning is adjusted to the usage index and needs in the previous year using a combined method system top to bottom and bottom up. Vaccine procurement is centralized at the Provincial Health Service, where requests are made by method bottom up. Receiving the vaccine is not immediate drop from the center/province, but the Karanganyar DKK takes the needed vaccines to the Provincial Health Service using the provisions for good drug distribution methods. Vaccine storage and distribution at DKK Karanganyar is in accordance with Minister of Health Regulation number 12 of 2017 and also in accordance with vaccine management guidelines from the Ministry of Health in 2021. Vaccines at DKK Karanganyar are in accordance with Minister of Health Regulation number 12 of 2017 and also in accordance with vaccine management guidelines from the Ministry of Health in 2021, both in planning, procurement, receipt, storage and distribution.
Smartphone Application for Self-Care in Type-2 Diabetes Mellitus Patients with Contextual Learning Model Bagus Santosa, Winanda Rizki; Nisha Nambiar; Erlina Abdullah; Sheylla Septina Margaretta
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.528

Abstract

Type-2 diabetes mellitus (T2DM) is an emergency problem that can cause death and disability worldwide. By using contextual learning models, smartphone applications can be an innovative solution for improving self-care and health condition management. This research aims to know the effectiveness of smartphone applications for self-care in type-2 diabetes mellitus patients with contextual learning models. Pre-test and post-test control group design was used by researchers. The study was conducted in the period October 2nd, 2023 - January 2nd, 2024. The number of samples collected using the G Power formula was 110 intervention groups and 110 control groups. To select samples, researchers used a purposive sampling method. This research involved T2DM patients treated at nine Health Centers in Kediri, Indonesia. In the smartphone application educational intervention group with the contextual learning model, there was an increase in self-care from a mean of 43,03 to 81,53, and a p-value result of 0,008 was obtained. In the control group using the booklet, there was an increase in self-care from a mean of 37,19 to 52,62, and a p-value result of 0,000 was obtained. Smartphone applications with contextual learning models are more effective in improving self-care than education using booklets; however, both types of education can improve self-care in T2DM.
Analysis of Drug Management and Improvement Strategies Using the Hanlon Method at the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital, Surakarta, Indonesia Vidya Dharma, Cakka Kumara; Titik Sunarni; Ika Purwidyaningrum
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.530

Abstract

Medication management is an important factor in ensuring the level of drug availability. The aim of this research is to analyze and provide strategies for improving drug management in the Pharmaceutical Installation of Dr. Oen Kandang Sapi Hospital Surakarta using the Hanlon method. This research uses a descriptive design, with data taken retrospectively and concurrently. Data was obtained from the selection, procurement, distribution, and use stages. In the selection stage, the results obtained were drug suitability with the National Formulary (65.14%) and suitability with the Hospital Formulary (75.07%); Procurement stage: frequency of procurement per year (96 times), frequency of delayed payments from hospitals (0 time). In the distribution stage, the percentage of expired date medicines damaged (0.15%), the accuracy of the data on the number of medicines on the stock card was (95.78%), and the percentage of dead stock (3.61%). Stage of use: number of items per prescription sheet (3.18 sheets), percentage of antibiotic drug prescriptions (8.53%), percentage of injection drug prescriptions (29.86%), the average time to serve prescriptions (non-concocted 8.88 minutes and concocted 17.52 minutes), the percentage of drugs that can be submitted (99.95%), percentage of drugs that are fully labeled (100%). Percentage of prescriptions with generic names (49.26%). The results of analysis using the Hanlon method show that drug management in the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital Surakarta is quite good but needs to be improved continuously.
Cytotoxic Activities and Expression of Protein p53 and Bcl-2 Extract and Fraction of Inggu Leaf (Ruta angustifolia [L.] Pers) to T47D Breast Cancer Cells Ariasti, Mia; Titik Sunarni; Wiwin Herdwiani
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.538

Abstract

Inggu leaves are plants that have been traditionally used as an alternative to cancer treatment. The aim of this study was to determine the cytotoxic activity of extracts, water fraction, ethyl acetate fraction and inggu leaf n-hexane fraction (Ruta angustifolia [L.] Pers) on T47D cells and to determine the effect of protein expression of P53 and Bcl-2 genes on inggu leaf active fraction (Ruta angustifolia [L.] Pers). Extract was obtained through maceration method with ethanol 96% solvent. Ethanol extract was then fractionated with liquid-liquid partition. Cytotoxic tests were performed using T47D breast cancer cells and Vero cells with the MTT assay test method and read the absorbance on ELISA reader. To determine the effect of expression of p53 and Bcl-2, an immunocytochemistry test was carried out. The results showed that the n-hexane extract and fraction of inggu leaves had cytotoxic activity against T47D breast cancer cells with IC50 values of 54,210 and 84,118 µg/mL, while the fraction of water and ethyl acetate fractions had no cytotoxic activity with IC50 value > 100 µg / ml. Inggu leaf extract (Ruta angustifolia [L.] Pers) is able to increase the expression of p53 and inhibit the expression of Bcl-2 at concentrations of 30,19-45,54 µg/mL and n-hexane fraction can increase the expression of p53 and can inhibit the expression of Bcl-2 at concentration 49,96-75,82 µg/mL.

Page 10 of 20 | Total Record : 200

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