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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 133 Documents
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Effect of The Water Origin on The Biological Properties of Sage (Salvia officinalis L.) Aqueous Extracts Irina Korotkova; Tamila Romashko; Oleg Khakhel'; Tamila Zvenihorodska; Tetiana S Yaprynets; Viktor Liashenko
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.230

Abstract

Plant extracts, due to the high content of various biologically active compounds, have found their wide application in the foods, pharmaceutical industries, and agricultures, for the production of valuable and useful bioproducts. The aqueous plant extracts are most often used. The effect of the water origin used in their preparation on the extract’s composition has not been studied enough, which limits their use. The study was aimed to compare the biological effect of sage (Salvia officinalis L.) extracts prepared using water of different origins (distilled, tap, spring, bottled). The preparation of aqueous extracts was carried out in two ways, differing in the extraction temperature. In the first method, boiling water was used to prepare the extract; in the second, cooled boiled water was used. The sage leaves mass for extract preparation was 1.65 and 3.30 g. The biological activity of the extracts was assessed by testing them for radish germination. It was shown the sage leaves extracts prepared using various waters origin can differ by one and half times in their allelopathic effect on radish seeds. It was proved the qualitative composition and mass of the substance extracted from the plant depend on the water origin used for extracts preparation. Thus, using the same amount of plant material to prepare extracts, you can increase their biological activity by fifty percent with the right choice of water.
Evaluation of Xanthone and Cinnamoylbenzene as Anticancer Agents for Breast Cancer Cell Lines through In Vitro and In Silico Assays Yehezkiel Steven Kurniawan; Hanif Amrulloh; Ervan Yudha; Nela Fatmasari; Faris Hermawan; Anggit Fitria; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Jumina Jumina
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.231

Abstract

Breast cancer is a severe global disease for women as the number of deaths increases annually. Therefore, attempts to find new anticancer agents are critical and inevitable. In this work, we report the investigation on the anticancer activity of xanthone and cinnamoylbenzene compounds against two breast cancer cell lines, i.e., T47D and MCF-7, through experimental in vitro and theoretical in silico assays. Xanthone and cinnamoylbenzene exhibit anticancer activity with a half-maximal inhibitory concentration (IC50) of 136.7–194.3 and 235.8–262.4 µg/mL against T47D and MCF-7 cancer cells, respectively. Cinnamoylbenzene generates less cytotoxicity to normal Vero cells with a selectivity index of 1.095–2.102. The molecular docking studies agree with the experimental data in which cinnamoylbenzene is more active against T47D with an IC50 of 136.7 µg/mL due to Topoisomerase II inhibition through π-π stacked interactions with Adenine12 and Guanine13 nitrogen bases. Meanwhile, xanthone is more active against MCF-7 with an IC50 of 235.8 µg/mL due to EGFR inhibition through van der Waals interaction and hydrogen bond with Glutamic acid767 and Methionine769 amino acid residues, respectively. Additionally, the pharmacokinetic parameters of xanthone and cinnamoylbenzene are predicted through absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis, and they show better suitability than doxorubicin as the commercial anticancer drug.
Residential Environment and Parental Lifestyle as Risk Factors of The Co-Occurrence of Cleft Lip and Palate Birth Defect Cases in Indonesia Katharina Oginawati; Intan Nur’azizah Rahman; Nurul Fahimah; Rinaldy Jose Nathanael; Imtiyaz Olaf Jatmy; Taqya Izdihar Muhanandi; Ida Latifah; Andi Tajrin; Ikeu Tanziha; Shinta Silvia; Farah Asnely Putri; Ida Ayu Astuti; Asri Arumsari; Utriweni Mukhaiyar
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.232

Abstract

Cleft lip and palate (CLP) are multifactorial birth defects, and the etiology behind their occurrence remains insufficiently understood. This case-control study aimed to investigate the association between residential environmental factors, parental lifestyle, and the risk of CLP in Indonesia. A total of 213 participants from 14 provinces were selected using stratified random sampling. Multivariable logistic regression was employed to determine the odds ratios (ORs) with 95% confidence intervals (CIs) for each risk factor. The study identified significant associations between several residential environmental factors and CLP. Proper kitchen ventilation was found to be protective (OR = 0.245, 95% CI: 0.096–0.624, p = 0.003), while proximity to industrial sites significantly increased the risk (OR = 3.595, 95% CI: 1.029–12.558, p = 0.045). Additionally, using treated drinking water showed a protective effect (OR = 0.39, 95% CI: 0.16–0.95, p = 0.038), whereas concerns about water sources displayed a marginally significant risk increase (OR = 2.841, 95% CI: 0.876–9.211, p = 0.082). Regarding parental lifestyle factors, maternal active smoking exhibited a marginal protective association (OR = 0.052, 95% CI: 0.002–1.09, p = 0.057), while paternal passive smoking presented a marginally significant risk (OR = 2.309, 95% CI: 0.897–5.942, p = 0.083). Furthermore, paternal radiation exposure was associated with an elevated risk of CLP (OR = 3.489, 95% CI: 0.828–14.703, p = 0.089). These findings highlight the need for targeted public health interventions to mitigate environmental exposures and promote safer parental lifestyle behaviors in Indonesia.
Screening of Sugarcane Commercial GMP Varieties Tolerant to Drought Stress Based on Molecular Detection of P5CS Gene Mahfut Mahfut; Maulidya Ananda; Endah Susiyanti; Rochmah Agustina
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.233

Abstract

Sugarcane (Saccharum officinarum L.) requires sufficient a water supply to produce optimal productivity. The selection of the superior varieties of sugarcane that are tolerant to drought can be done by molecular detection of the presence of the pyrroline-5-carboxylate synthetase (P5CS) gene. The research is aimed at molecular detection of P5CS gene in a commercial varieties at PT Gunung Madu Plantations (GMP), Indonesia that are potentially drought resistant. Similar research has never been conducted at PT GMP, as evidenced by the absence of official publications. The varieties used are GMP 3, GMP 5, RGM 06-654, PS 864, RGM 08-1026, PSJT 941, RGM 01-1834, GP11, RGM 07-099, and RGM 02-108. The research phases include DNA isolation, quantitative and qualitative DNA amplification, and PCR product visualization. Molecular data analysis is based on DNA band scoring results in the form of binary data which is then used to calculate the level of polimorphism information content (PIC) on the primary data used. The results of the study showed that nine out of ten varieties had P5CS-specific band sizes of ±167 bp, namely GMP 3, GMP 5, RGM 06-654, PS 864, PSJT 941, RGM 01-1834, GP 11, RGM 07-099, and RGM 02-108. A total of four of the nine varieties showed P5CS gene band thicknesses of RGM06-654, PSJT 941, PS864, and RGM 01-1834 which indicates the selected varieties most resistant to drought. The result of the PIC calculation has a value of > 0.25 which indicates the primary P5CS used is quite informative. The molecular detection was continued on one selected variety is PSJT 941, which showed that the relationship analysis of P5CS gene shows close affinity with the isolates from China and Bogor.
The Effect of Modifiers on the Strength and Impact Toughness of Carbon Fiber Reinforced Plastics Laura Mustafa; Marat Ismailov; Indira Tashmukhanbetova; Ilyas Ablakatov; Venera Zhumakanova
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.234

Abstract

This study utilized epoxy resin, three types of fabric (carbon fiber, glass fiber, and Kevlar), and two plasticizers – tricresyl phosphate (TCP) and oleic acid (OA) – to enhance the impact toughness of carbon fiber-reinforced plastics (CFRP). The polymer matrix used in the experiments was a hot-cured epoxy compound "Etal Inject-T" consisting of two components: A – epoxy resin and B – hardener, in a mass ratio of 100:49.9. For the fabrication of CFRP plates, both manual and vacuum molding techniques were employed. Combined reinforcement of carbon fiber was achieved using one of two types of fabrics: Ortex 360 glass fiber or Kevlar. Accordingly, two compositions were prepared for the experiments: carbon fiber/glass fiber and carbon fiber/Kevlar. Layer stacking in each composition was performed at ratios of 10:10 and 14:6, consisting of 20 layers in total. The greatest strengthening effect for CFRP in the case of carbon fiber/glass fiber was observed with a layer ratio of 14:6 and matrix modification using 10% TCP plasticizer. The strength of the CFRP increased from 425 to 451 MPa, and the impact toughness (α) improved from 192 to 280 kJ/m². A key feature of this technology is the achievement of high-performance dual-purpose CFRP. This enables the reduction of CFRP structures in aerospace applications by 3 to 5 times, while simultaneously enhancing resistance to impact loads.
Antidiabetic Activity Test of Fe(III) Complex Compound with Arginine Ligand in Male Mice (Mus Musculus L.) Yuli Ambarwati; Nurhasanah Nurhasanah; Nisa Karima; Hari Purnomo
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.235

Abstract

Diabetes mellitus is characterized by high blood sugar levels in the body. Treatment for type 1 diabetes mellitus is with insulin injections while treatment for type 2 diabetes mellitus generally uses oral medication. Currently, people are looking for diabetes drugs made from complex compounds using metals. The development of research and utilization of Fe(III) complex compounds is still limited, thus, in this study the synthesis of Fe(III) complex compounds with arginine ligands was carried out. The results of the research obtained a complex compound of Fe(III)-arginine with 96%, in the form of a brown gel with a sample weight of 0.5601 g. Characterization using a UV-Vis spectrophotometer showed absorption at a wavelength of 203 nm which indicated the absorption of the Fe(III)-arginine complex. The results of FTIR analysis showed a typical absorption of Fe–O and Fe–N bonds at a wavelength of 500–600 nm. The results of the calculation of the mice's body weight decreased when induced by alloxan. After 3 and 4 weeks, the mice's body weight returned to stability. The highest decrease in glucose levels was in dose 2, namely 100 μg/kg bw with a decrease in %GL of 66.72%. The results of this study show that the complex compound Fe(III) arginine can reduce blood glucose levels in mice.
Profiling and Antibacterial Activity Assay of Secondary Metabolites from Streptomyces Isolated from Mangrove Sediment Sample Dwi Marwati Juli Siswanti; Kasta Gurning; Winarto Haryadi; Chairil Anwar; Respati Tri Swasono
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.236

Abstract

Bacterial infections pose significant threats to human health, particularly due to the rise of antibiotic-resistant strains. Identifying new sources of effective antibiotics is therefore crucial for combating these resistant pathogens. This study aims to isolate novel Streptomyces species and profile their secondary metabolites through extraction and high-resolution mass spectrometry (HRMS) analysis. Furthermore, the antibacterial activity of the extract containing the secondary metabolites was assessed through the in vitro agar well diffusion method and supported by the molecular docking, molecular dynamics simulations, and drug-likeness analysis. Sediment samples were collected from mangrove forests in Yogyakarta. The bacteria were then isolated, purified, and characterized using 16S rRNA sequencing. The isolates were then cultured to enrich the secondary metabolites, and their secondary metabolites were extracted using methanol and dichloromethane solvents in a 1:1 volume ratio. The results showed that the isolated bacteria of Streptomyces sp. were obtained with a 95.44% similarity rate, which produced several secondary metabolites. The in vitro antibacterial assay of the extract resulted in an inhibition zone of 14, 14, and 15 mm against Propionibacterium acnes, Staphylococcus aureus, and Escherichia coli, respectively. The molecular docking and molecular dynamic simulations for 100 ns revealed that compound SB236057A could inhibit the function of thymidylate kinase protein through a carbon-hydrogen bond with Glu37 residue. Furthermore, drug-likeness analysis showed that the secondary metabolites of Streptomyces sp. exhibited preferable drug-likeness and pharmacokinetic properties. This research focuses on the understanding of microbial biodiversity in mangrove sediments, particularly focusing on the genus Streptomyces and its potential to produce novel antibiotics.
Canonical Correlation Analysis of Lead Concentration in Hair Impacted With IQ, Antisocial Behavior, and Hand Strength at High School Students Community Sri Harini; Indah Tri Susilowati; Noviana Dewi; Tri Harningsih; Endang Widhiyastuti; Purwati Purwati; Dewi Saroh; Angga Dwi Mulyanto; Muhammad Saefi
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.237

Abstract

Lead is widely found in the environment and it is a heavy metal element that has a neurotoxic effect. Unlike other elements, lead does not provide its benefits in the human body. Neurotoxicity describes the neurophysiological changes caused by exposure to toxic agents, which can be manifested by changes in various functions of the nervous system. The aim of this research was to examine the associations between high school students' lead hair levels, intelligence quotient (IQ) scores, propensities for antisocial behavior, and hand grip strength. This research used canonical correlation analysis. Lead levels were detection by flame atomic absorption spectrometry (AAS). Antisocial behavior tendency data was measured using a 21-item antisocial tendency scale using the aspects listed in diagnostic statistical mental disorder (DSM) V which had previously been tested for validity and the reliability. The IQ level was measured using the Wechsler adult intelligence scale (WAIS) test, while the hand muscle strength test was measured using a hand grip dynamometer. Based on the results of the canonical correlation analysis, the research results showed that there was no correlation between lead levels in hair and antisocial behavior tendencies, but there was a relationship between lead levels in hair and IQ levels and hand muscle strength.
Chemical Profile of The Ethyl Acetate Extract of Aspergillus sydowi, 22-PLP1-F1, as Antibacterial Agent Against Clinically Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa Andi Setiawan; Fendi Setiawan; Susianti Susianti; Wawan Abdullah Setiawan; Peni Ahmadi; Riski Pangestu; John Hendri; Ni Luh Gede Ratna Juliasih
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.238

Abstract

Mangrove endophytic fungi can produce bioactive substances with diverse  biological functions. This study aims to evaluate the chemical profile of mangrove fungal endophytic extracts that inhibit clinical pathogenic bacteria resistant to various antibiotics. The fungi were collected from Petengoran mangrove forest, Lampung Province. Fungal isolates were grown on shrimp shell media using solid-state fermentation for 14 days. The fungal biomass was extracted using ethyl acetate, and the active components were evaluated using thin layer chromatography. The extract was partitioned with dichloromethane/water and its bioactivity was tested using TLC-bioautography and agar diffusion methods. The active fraction was identified using LC-MS/MS. The LC-MS/MS data was interpreted with SIRIUS 5.8.6, and the drug-likeness and toxicological characteristics were assessed using ADME/Tox and STopTox machine learning tools. Morphological analysis showed that isolate 22PLP1F1 was an Aspergillus sp., with spherical conidia at the hyphae tips. Through phylogenetic analysis it was confirmed that isolate 22PLP1F1 is Aspergillus sydowii with similarity 98.9%. Initial TLC examination indicated the production of alkaloids, polypeptides, and steroids. Antibacterial assays showed that the polar portion inhibited multi-drug resistance (MDR) Staphylococcus aureus, while the active fraction at 2 mg/mL inhibited MDR Pseudomonas aeruginosa. LC-MS/MS analysis revealed a major chromatogram peak at a retention time of 8.67; m/z 488.2196, suggesting a novel derivative of a compound at a retention time of 7.82; m/z 446.208. ADME/Tox analysis indicated that the compounds do not penetrate the BBB but remain in the GI absorption region. Further research is needed to elucidate the active compounds’ mechanism of action and conduct bioengineering studies.
Community Social Capital in Supporting Ecosystem Recovery in Rawa Kidang of Way Kambas National Park Christine Wulandari; Lutfi Nur Latifah; Hari Kaskoyo; Yulia Rahma Fitriana; Zeda Erdian; Vinanda Arum Tri Kurniawan; Aryanti Rizki Adinda; Fadela Yunika Sari; Mhd Zaidi
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.241

Abstract

Ecosystem recovery plays a central role in environmental and forest conservation efforts, including efforts made in a conservation area that is a national park. This effort requires support from the communities living around the national park. Therefore, the presence of the community can become a form of capital, which is generally referred to as social capital and will determine the success of a program. Elements of social capital consist of trust, norms, and networks is one form of capital that is very valuable in addition to economic capital, physical capital, and human capital. The purpose of this research is to analyze the level of social capital that exists in the community and how the characteristics of respondents affect social capital. This research is located in Labuhan Ratu VII Village, Labuhan Ratu Subdistrict, East Lampung Regency from November to December 2023. Based on the results of the analysis, it is known that the trust element and the social network element are in the medium category, while the norm element is in the high category. Education and length of stay are respondent characteristics that influence community social capital in supporting ecosystem recovery in Rawa Kidang, Way Kambas National Park (WKNP). Increasing social capital can be done through two characteristics that affect community social capital in the form of informal education such as training. People who live for a long time will affect the sustainability of WKNP so training can be carried out for a long period of time in a structured and intensive manner towards sustainable WKNP management. The results of this study can be a consideration for WKNP managers in implementing Permen LHK policy no 14 of 2023 concerning business and/or activity arrangements in nature conservation areas, nature reserve areas and hunting arks because they must have a strong social foundation.

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