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Perum Sarimadu II B3 No.09, Pakisaji, Kab.Malang, Jawa Timur, Indonesia 65162
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INDONESIA
Indonesian Journal of Medical Sciences and Public Health
Published by Future Science
ISSN : -     EISSN : 27461971     DOI : https://doi.org/10.11594/ijmp
Core Subject : Health, Engineering,
Engineering Health Professions Medicine & Pharmacology Public Health Veterinary
Indonesian Journal of Medical Sciences and Public Health (IJMP) Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Subject areas include, but are not limite to the following fields: Medicine Surgery Ophthalmology Gynaecology and Obstetrics Psychiatry Anaesthesia Paediatrics Orthopaedics Microbiology Pathology and Laboratory Medicine Medical Education Research Methodology Forensic Medicine Medical Ethics Community Medicine and Public Health Anatomy Physiology Biochemistry Nutrition Pharmacology Biophysics, etc.
Arjuna Subject : Kedokteran - Mikrobiologi (Medis)
Articles 16 Documents
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Attitude and Knowledge Relationship with Sexual Behavior at Risk of Sexually Transmitted Infection (STI) in Male Adolescents in Indonesia (IDHS Data Analysis 2017) Nur Asiah; Agnes Yohana Sondi; Nining Parlina; Della Raymena Jovanka
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.638 KB) | DOI: 10.11594/ijmp.02.01.02

Abstract

Introduction: Indonesia Population Demographic Survey in 2017 recorded that 8% of teenage boys and 2% of teenage girls admitted to having sexual intercourse. This certainly worries all of us who hope today's youth will be a demographic bonus. Sexual behavior is at risk of impacting the issue of Unwanted Pregnancy (KTD), abortion, Sexually Transmitted Infections (STIs), and the ongoing incidence of HIV and AIDS. Objective: to confirm the relationship of attitudes and knowledge with risky sexual behavior in adolescent boys in Indonesia. Methods: This type of research is quantitative analytics using a cross-sectional design and sourced from secondary data of the Indonesian Health Demographic Survey 2017. The population in this study was 13,079 adolescent men aged 15-24, sampling 10,710 with saturated sampling techniques. Bivariate data analysis using the chi-square test (0.05). Results: were obtained by adolescents with a positive attitude of 52.1%, knowledgeable 77.8%, and 13.1% risky sexual behavior. Test results showed there was an attitude relationship with risky sexual behavior with p-value = 0.000 and there was a knowledge relationship with risky sexual behavior with p-value = 0.000. Conclusions: This study are expected to be used as input for the creation of risky sexual behavior prevention programs in adolescents and form the basis for the creation of an educational model related to adolescent reproductive health for parents and educational institutions.
RETRACTION NOTICE: Curcumin as an Anti-Proliferative Agent in Breast Cancer through RASSF1A, Bax, and Caspase-3 Protein Nunung Ainur Rahma; Harliansyah; Fransiscus D. Suyatna; Mpu Kanoko; Primariadewi Rustamadji; Joedo Prihartono; Arleni Bustami; Samuel Johny Haryono; Bethy Suryawati Hernowo
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.023 KB) | DOI: 10.11594/ijmp.02.01.03

Abstract

Introduction: Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specific mechanism of curcumin cytotoxicity remains controversial because of many anti- and pro-apoptotic signaling pathways in various cell types. This study aims to examine the relationship among curcumin on RASSF1A, Bax protein levels, and caspase-3 activity in supporting the apoptotic mechanism in CSA03 breast cancer cells. Method: Curcumin administration to cancer cells is based on differences in dosage with 24-hour incubation. Cytotoxicity after curcumin administration was determined using MTS. RASSF1A and Bax protein levels were tested through ELISA. Caspase-3 activity was used to determine apoptosis and was tested using flow cytometry. Results: The results indicated that curcumin had a cytotoxicity effect of 40.85 µg/mL. At concentrations of 40 µg/mL and 50 µg/mL, curcumin increases levels of protein RASSF1A (∆ = 26.53% and 47.35%, respectively), Bax (∆ = 48.79% and 386.15%), and caspase-3 (∆ = 1,678.51% and 1,871.889%) significantly. Conclusions: Curcumin exhibits anti-proliferative activity and apoptotic (Caspase-3) effects through activation of RASSF1A and Bax.
Anti-Cancer Assessment of a Ramie (Boehmeria nivea L. Gaud.) Leaf Extract Using Mcf-7 Cell Line and a Yeast-Based Bioassay Asri Peni Wulandari; Annisa Abdiwijaya Qaromah; Karen Kezia Lolowang; Desi Harneti Putri Huspa; Ade Zuhrotun
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (562.518 KB) | DOI: 10.11594/ijmp.02.01.01

Abstract

Introduction: One strategy for molecular cancer therapy is to know the key mechanism of cytotoxic compounds that can kill cancer cells. Ramie (Boehmeria nivea L. Gaud.) leaves contain active compounds that have important effects on cancer chemoprevention. Objective: To obtain the active fraction of a Ramie leaf extract in inhibiting the proliferation of MCF-7 breast cancer cell lines and to determine the mechanism of apoptosis induction using MCF-7 and Saccharomyces cerevisiae strains 1140, 1353, and 1138. Method: Fractions were prepared using n-hexane, dichloromethane (CH2Cl2), ethyl acetate, and n-butanol as solvents. All fractions were tested qualitatively through phytochemical. The MTT-based cytotoxicity assay used MCF-7 (in vitro) to obtain the IC50 value, whereas the model system that targets the enzymatic (topoisomerase) used a yeast-based bioassay to obtain the IC12 value. Apoptotic induction of the active fraction in MCF-7 was performed using flow cytometry and qPCR (2-ΔΔCt method). Results: The phytochemical analysis indicated that the extract fraction consisted of alkaloids and steroids. The smallest IC50 value was obtained from the CH2Cl2 fraction as 3.79 g/mL, potentially act as an anticancer. A higher percentage of apoptosis than that of necrotizing cells and live cells was observed through flow cytometry. The CH2Cl2 fraction with an IC12 value < 8000 in strains 1140, 1353, and 1138 consistently showed the mechanism of apoptosis induction as topoisomerase I and II inhibitors. Also, another mechanism could be through the intrinsic pathway, indicated by the highest expression level in p53. Conclusions: The CH2Cl2 fraction of Ramie leaves can inhibits the proliferation of MCF-7 cells in the active and strong categories. The CH2Cl2 fraction induces apoptosis by increasing p53 gene expression and inhibiting topoisomerase I and II. Thus, it showed potential as an anticancer drug candidate.
Prevalence of otomycosis in patients with cerumen impaction due to ear-phone usage during COVID-19 Sunethra Suresh; Suraj Suresh; Sudha Sivasamy
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.822 KB) | DOI: 10.11594/ijmp.02.01.04

Abstract

Background: Otomycosis affects about 9% of patients with otitis externa. One of the predisposing factor is impacted cerumen. Earphone usage causes cerumen impaction. In the light of the recent COVID-19 pandemic, people are housebound due to prolonged lockdown. Hence people are more technology dependent as working from home and studying online has become the norm. Therefore, usage of earphones has proportionately increased, and the impacted cerumen cases have increased. Methods: This cross-sectional study aimed to analyze data from questionnaire to assess the prevalence of otomycosis among patients with impacted cerumen due to excessive earphone usage, establish associations between otomycosis and symptoms such as pain and hearing loss as well as the correlation between fungal growth and the long hours of earphones usage. The relationship between the age of participants and the usage of earphones during the pandemic was also explored. The data was collected from 100 individuals aged 14 to 51 years who sought treatment for symptomatic impacted wax at an ENT clinic in Malaysia. Results: The mean age of participants was 25.9 years. There was a 31% prevalence of otomycosis among these patients. Otalgia was present in 60% of patients with otomycosis (t value 2.94, coefficient 0.27). Approximately 37% of patients had a large air-bone gap indicating conductive hearing loss. There was an insignificant correlation between otomycosis and the longer hours of earphones usage (t value 1.51, coefficient 0.00015). No correlation was found between age of participants and the total hours of earphone usage (t value 0.63, coefficient 0.0012). Conclusion: This study offers initial evidence that earphone usage could be a predisposing factor in developing otomycosis. However, there was no evidence of longer hours of earphones usage increasing the chances of developing otomycosis. Additionally, symptoms like otalgia and conductive hearing loss could be present in both earwax impaction and otomycosis.
Relationship Between Maternal Education and Knowledge on Coverage of Exclusive Breastfeeding in Ten Stunting Locus Villages in Pandeglang District, Banten Sri Wuryanti; Himmi Marsiati
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 1 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.174 KB) | DOI: 10.11594/ijmp.02.01.05

Abstract

Introduction: Until now, the practice of exclusive breastfeeding is still far from the national target. The success of exclusive breastfeeding is determined by many factors, including the mother’s education, knowledge, and awareness about the importance of breastfeeding for child growth. This study aims to determine the relationship between the mother’s level of education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten, Indonesia. Methods: This study uses a cross-sectional design with data collection methods through interviews and direct observation. The population consists of mothers who have children under 2 years of age. The study was conducted for 6 months from November 2019. The variables studied included the mother’s age, occupation, number of children, education, and knowledge of exclusive breastfeeding. Result: As many as 99.6% of respondents have a good level of knowledge about exclusive breastfeeding. The level of education is low at 44.6%, medium at 50.9%, and high at 4.4%. The results showed there was no significant relationship between the mother’s last education and exclusive breastfeeding (p = 0.860) and there was no significant relationship between the mother's level of knowledge and exclusive breastfeeding (p = 0.558). Conclusion: No significant relationship was observed between the mother’s education and knowledge on exclusive breastfeeding in ten stunting locus villages located in Pandeglang Regency, Banten.
Disseminated Herpes Zoster in an Immunocompromised Geriatric Patient: Disseminated Herpes Zoster in Geriatric Patient Muhtady, N.F.A; Nurasrifah , D.I; Indraswari , A; Reza, N.R; Alinda, M.D; Widia, Y; Agusni , R; Hidayati, A. N
Indonesian Journal of Medical Sciences and Public Health Vol 2 No 2 (2021)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Disseminated Herpes Zoster (DHZ) was defined as the presence of 25–50 or more blisters outside the primary or near the dermatomal area that usually occurred within a week of the onset of the primary lesion. It is rare and occurs much less frequently than generalized herpes zoster infection, with most cases developing in immunocompromised patients. Case: A 60-year-old woman complained of grouped multiple blisters with an erythematous base three days before. She came to ER and noticed a stabbing pain and burning sensation on the external ear and left neck. The patient also complained of fever one day before the lesion occurred. The blisters were already ruptured the next day, and some erosion was seen and covered by black crust. On day 5, she also complained of blisters spreading on her back and felt itchy but no pain. She has been suffering from a mild cough for more than a year. Chest X-ray found ground glass opacity paracardial right and left, indicating pneumonia. She has had a history of hearing impairment since 15 years ago. She is unmarried and lives alone. The result of the Tzanck smear examination indicated several multinucleated giant cells. Acyclovir 800 mg 5 times daily was administered to the patient for ten days. Ceftriaxone 1g twice a day and Antrain 1 g 3 times daily. Debridement therapy with normal saline 0,9% were also included. Conclusion: A DHZ case can affect immunocompromised geriatric patients.

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