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JIFI (Jurnal Ilmiah Farmasi Imelda)
Published by Universitas Imelda Medan
ISSN : 26553147     EISSN : 25977164     DOI : https://doi.org/10.52943/jifarmasi.v5i1.623
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
JIFI (Imelda Pharmacy Scientific Journal) Imelda Imelda College of Health Sciences (STIKes) which is now Imelda University Medan received related articles: 1. Clinical Community Of Pharmacy 2. Pharmaceutical Technology 3. Pharmacy Management 4. Herbal medicines and Chemistry 5. Biology & Pharmacology JIFI (Jurnal Scientific Pharmacy Imelda) also accepts all writings with various disciplines on the condition that the core points remain in the path and scope of pharmaceutical science.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 119 Documents
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SUNSERUM WAJAH SARI RIMPANG TEMU GIRING (Curcuma heyneana) TERFERMENTASI Lactobacillus bulgaricus Andriani, Irma; Mardianingrum, Richa; Susanti
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 1 (2023): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i1.1491

Abstract

Long-term sun exposure can cause a variety of skin disorders, including sunburn and skin cancer. Sunscreen products containing antioxidants can help to prevent unwanted effects and protect the skin from free radicals. The rhizome of sleigh meeting (Curcuma heyneana) has chemicals 1,4- napthalenedione, 2-hydroxy-3-(-2-methyl-prophenyl), or other names Norlapachol, which has the potential as a suya screen and has strong antioxidant action. The study's goal is to see if the juice of fermented rhizome of Lactobacillus bulgaricus can be created as a sun serum face preparation, and then compare the value of antioxidant activity and sunscreen. Making fresh juice, fermented juice, phytochemical screening, preparation making, preparation evaluation, and SPF test are all part of the procedure. creating fresh juice, fermented juice, phytochemical screening, creating preparations, evaluating preparations, in-vitro SPF testing using a UV-Vis spectrophotometer, and antioxidant testing with the DPPH (2,2-Dyphenyl-1- Pycrylhydrazyl) method are all part of the approach. SPF F1 test value: 27.40 (ultra protected); F2: 27.84 (ultra protected); antioxidant activity test results: the IC50 value of fresh juice is 15.92 ppm (very strong); fermented juice is 11.02 ppm (very strong); and all preparation evaluations met the requirements according to the test standards. According to the findings, fresh and fermented ginger rhizome juice can be prepared as a sunscreen and antioxidant-rich facial sun serum preparation.
FORMULASI DAN EVALUASI PEMBUATAN PRODUK NUTRASETIKAL SIRUP DARI EKSTRAK BUAH JERUK KUKU HARIMAU (Citrus medica L.) SERTA UJI AKTIVITAS ANTIOKSIDANNYA DENGAN MENGGUNAKAN METODE DPPH (2,2-DIFENIL-1-PIKRILHIDRAZIL) Gultom, Roby; Gulo, Septi Kristina; Siagian, Hartika Samgryce
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 1 (2023): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i1.1501

Abstract

Syrup nutraceutical product has been made from the fresh extract of Tiger Nails fruit (Citrus Medica L). This research is a laboratory experimental. Fresh extracts were divided into FI (10%), FII (20%) and FIII (40%). The formulations were compounds of extracts, sugars and waters. Organoleptic’s test results were color is yellow, orange’s aroma, sweet taste and thick textures. Hedonic’s test showed the color of Formulations were not like by panelists (60%) and aroma test of FII showed panelists like it (60%). The texture test of formulations showed the panelists like it (70%) and the taste test of FI showed the panelists were very like it (70%). The pH values were ranged from 4-5. The fastest dissolving time test showed from FI (8 seconds). The highest viscosity test was showed by FII (6,08 poise). The determination of vitamin C levels using UV-Vis Spectrophotometry showed FIII the highest levels of vitamin C (0.828%). But all antioxidants activity had low activity. FIII has the highest IC50 value (454172,74 ppm). Anova test value showed 0,1505>0.05 that means the antioxidant activity were not significantly different. Tukey test showed the comparison of antioxidant properties between the formulations groups showed a significance value of 0,135 > 0.05.
IDENTIFIKASI BAKTERI Escherichia Coli PADA SAUS MAKANAN ATAU JAJANAN CILOK DI SEKOLAH DASAR (SD) KECAMATAN INDRALAYA SELATAN KABUPATEN OGAN ILIR Hikmah, Al; Prasetyo, Dani; Ernia, Rima
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 1 (2023): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i1.1505

Abstract

Food poisoning often occurs in elementary school children due to the lack of personal and environmental hygiene. According to children tend to choose unhealthy foods because regardless of the physical/chemical properties of food, taste, brand, availability and environment. The environment such as personal hygiene from food vendors is one of the factors that influence food conditions. This study aims to determine whether there is Escherichia coli bacteria on cilok sauce in Junior High Schoolab So1th Indralaya District. The results of the study by identifying Escherichia coli bacteria in cilok sauce, namely the isolation test of bacteria on LB media, obtained 8 out of 10 samples contaminated with bacteria. The EMB test results obtained 3 out of 8 samples that were positive for Escherichia coli. For bacterial tests with biochemical tests, SIM, MR, citrate, 3 positive samples of Escherichia coli bacteria were obtained where there was a color change. Citrate changes from green to blue, SIM is indicated by the formation of a pink indole ring and the MR test changes the solution to a pink color.
LITERATUR REVIEW: BEBERAPA FORMULASI DARI ASAP CAIR Zebua, Nilsya Febrika; Nadia, Syarifah; Elviana, Elviana
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1253

Abstract

Liquid smoke is the result of condensation or direct combustion produced from materials containing lignin, cellulose, hemicellulose and other carbon compounds. Based on the literature read, it turns out that there are many contents of liquid smoke, one of which is as a preservative. The method used in this research is the literature review method where this method can help in terms of inputting data in detail and clearly. The results of this study state that liquid smoke can be used in preservative, antibacterial and deodorizing latex preparations. The purpose of this research is to find out how many uses for liquid smoke so that it can be used in everyday life. The conclusion in this study is that liquid smoke is most widely used in preservatives which distinguishes the method used in the form of a literature review.
UJI EFEKTIVITAS ANTIOKSIDAN DARI KOMBINASI EKSTRAK DAUN STEVIA (Stevia rebaudiana (bertoni) bertoni) DAN DAUN TEH HIJAU (Camellia sinensis (L.) Kuntze) DENGAN MENGGUNAKAN METODE DPPH (1,1- Difenil-2-Pikrilhidrazil) Samosir, Sri Rezeki; Auliafendri, Novycha; Naibaho, Marlina Iva
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1502

Abstract

The stevia plant is known to have various benefits in the pharmaceutical field and is used as a health medicine because of its antioxidant, antifungal and non-carcinogenic effects. Green tea is a plant that contains various antioxidant compounds that are beneficial for health. The aim of this research is to determine whether the combination of stevia leaf extract and green tea leaves is effective as an antioxidant. Ethanol extract of stevia leaves and green tea leaves is made by maceration with 96% ethanol solvent, combination extract has blackish green. The ethanol extract of stevia leaves and green tea leaves was screened for phytochemical compounds. Antioxidant effectiveness was tested using the DPPH (1,1 Diphenyl-2-Picrylhydrazyl) method, with varying concentrations of 10 ppm, 20 ppm, 30 ppm, 40 ppm and 50 ppm. Then Antioxidant activity test by DPPH measured using a UV-Vis spectrophotometer. The results of screening for phytochemical compounds show that stevia leaf extract contains alkaloids, saponins, flavonoids and tannins. Meanwhile, the results of screening for phytochemical compounds in green tea leaf extract contain alkaloids, steroids, saponins, flavonoids and tannins. The research results showed that antioxidant levels in the combination of Stevia leaf extract and green tea leaves with concentrations of 10 ppm, 20 ppm, 30 ppm, 40 ppm, 50 ppm with a ratio of (1:1) had an IC50 analysis result of 10 ppm of 19.90 mg/L, 20 ppm is 12.90 mg/L, 30 ppm is 9.60 mg/L. 40 ppm is 6.80 mg/L. 50 ppm is 6.60 mg/L where a concentration of 50 ppm is classified as a very strong antioxidant. The antioxidant effect of the combination of stevia leaf extract and green tea leaves is still higher than vitamin C. The combination of stevia leaves xtract and green tea leaves has antioxidant effectiveness.
UJI EFEKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETIL ASETAT DAUN RIMBANG (Solanum torvum Sw.) DAN DAUN KECOMBRANG (Etlingera elatior (Jack) R.M.sm.) TERHADAP Staphylococcus Aureus dan Escherichia Coli Samosir, Sri Rezeki; Siagian, Hartika; Purba, Sefniarta
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1504

Abstract

The rimbang plant is one of the traditional plants used in the treatment of infectious diseases. The kecombrang plant has long been known and used by the public, several studies have shown that kecombrang flowers and leaves have antibacterial activity against gram-positive and gram-negative bacteria. To determine whether the combination of rimbang leaf extract and kecombrang leaf has antibacterial effectiveness against Staphylococcus aureus and Escherichia coli bacteria, use the disc method. Ethyl acetate extract of rimbang leaves and kecombrang leaves is made by maceration. The ethyl extract of rimbang leaves and kecombrang leaves was screened for phytochemical compounds. Antibacterial activity was tested using the paper disc diffusion method with varying concentrations of 30%, 40% and 50%. The results of screening for phytochemical compounds show that rimbang leaf extract contains alkaloids, terpenoids, flavonoids and tannins. Meanwhile, the results of screening for phytochemical compounds in kecombrang leaf extract contain alkaloids, saponins, flavonoids and tannins. The antibacterial effectiveness test of the combination of rimbang leaf and kecombrang leaf extracts from 3 concentration variations, namely 30%, 40% and 50%, has antibacterial effectiveness against staphylococcus aureus and Escherichia coli, the most effective concentration for staphylococcus aureus bacteria is at a concentration of 30% with a ratio of 3 :1 with a result of (13.2) while Escherichia coli bacteria were found at a concentration of 30% with a ratio of 1:3 with a result of (10.3). The combination of ethyl acetate extract of rimbang leaves (Solanum torvum Sw.) and kecombrang leaves (Etlingera elatior (Jack) R.M.sm.) has been proven to have antibacterial effectiveness against Staphylococcus aureus and Escherichia coli bacteria. Based on the one way ANOVA data analysis test, there is a significant difference in antibacterial inhibition power.
OPTIMASI FORMULA DAN UJI EVALUASI FISIK SEDIAAN ESSENCE KOMBUCHA DENGAN VARIASI KONSENTRASI PROPYLENGLIKOL DAN GLISERIN Ayu Ningrum, Yuyun Darma; Sholeh, Aries Badrus; Ramadhini, Amelianingrum
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1518

Abstract

Skin problems can be treated with several cosmetic products such as essence. Essence is a skin care product that is part of skincare. Essence is a cosmetic product that has added value and optimal effects, namely as a humectant, ultraviolet protector, whitening agent, antioxidant, anti-inflammatory and skin rejuvenator. This Research using experimental method and aims to determine the optimal concentration of propylene glycol and glycerin in the optimum preparation of kombucha essence. In the results of the SLD method, 28 solutions were obtained, then for formula optimization the composition ratio between Propylene glycol and Glycerin was chosen as 11.5: 8.25 with a desirability value of 1.00. The resulting predicted values ??are a pH test of 5.255 and a viscosity test of 546.7. The analysis used a parametric sample t-test which showed that the results were not significantly different. This is shown by the value (p>0.05), so the results above indicate that the kombucha essence formula before and after the stability test was carried out obtained stable pH and viscosity values ??during storage based on the parametric sample t-test. The research results showed that the essence preparation made had an optimal formula in formula 3, namely transparent white, had a pH within the range so it was safe for the skin, was homogeneous and a viscosity value of 528.7 cp.
HUBUNGAN PENGETAHUAN DENGAN SIKAP PENGGUNAAN TABLET Fe PADA WANITA DALAM PENCEGAHAN STUNTING DI RW 012 DESA SUKAMEKAR Suryanih, Anisa; Yanti, Silfera Indra; Shoaliha, Maratun
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1523

Abstract

Iron or Fe deficiency is still a micronutrient problem in the world, especially in Indonesia. The cause of iron deficiency is lack of knowledge and unsupportive attitudes. The aim of the research is to determine the relationship between the level of knowledge and attitudes towards using Fe tablets among women in preventing stunting in RW 012 Sukamekar Village. The research uses an analytical survey method through a cross sectional approach, namely collecting data all at once or at one time. The data collection technique is through distributing questionnaires, the technique used to determine the sample in this research is Non Random Sampling, using a Purposive sampling technique. The results of this research from 75 respondents showed knowledge of the use of Fe tablets in women in preventing stunting in RW 012 Sukamekar Village, 30 (40%) had sufficient knowledge, 29 (38.7%) people had a good attitude. Bivariate analysis obtained a p value of 0.024 (<p=0.005). The conclusion from this research is that there is a relationship between knowledge and attitudes towards using Fe tablets among women in preventing stunting in RW 012 Sukamekar Village with a p-value of 0.024.
PENGARUH KONSENTRASI PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN SEDIAAN SERUM EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus Polyrhizus) Fatah, Muhammad Ilman; Muldiyana , Tya; Kusnadi , Kusnadi
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1562

Abstract

The skin of red dragon fruit (Hylocereus Polyrhizus) contains active substances that are useful for extracting in making natural serums. Antioxidants, one of the important compounds in serum that can protect the skin and capture free radicals. This study aims to prove the presence of antioxidants in serum made from red dragon fruit peel extract, and to compare the effect of using 70% and 96% ethanol solvents on the physical properties and antioxidant activity of the serum. The extraction method used was maceration extraction, by testing the flavonoid content and free ethanol content in the extract. The physical properties of the serum were tested including organoleptics, pH, homogeneity, viscosity, spreadability and stickiness. Meanwhile, antioxidant activity was tested using the UV-VIS spectrophotometric method. The research results show that red dragon fruit peel extract contains flavonoids with orange and red colors, and does not have an ester odor. Serum preparations from 70% and 96% ethanol extracts have semisolid form, characteristic odor, color differences, pH 5, homogeneous, with viscosities of 464 cPs and 341 cPs respectively. The spreadability of the serum is 7.1 cm and 9.7 cm, while the adhesive power is 0.88 and 0.93. The serum antioxidant activity of 70% and 96% ethanol extracts was 39.59 µg/mL and 45.87 µg/mL. The 70% ethanol extract serum meets the standard physical properties of serum and has stronger antioxidant activity compared to the 96% ethanol extract serum, indicated by the lower IC50 value. Flavonoids, as antioxidant compounds, have various types and different polarities depending on the position and number of hydroxyl groups.
UJI AKTIVITAS ANTIKOLESTEROL EKSTRAK DAUN KETEPENG CINA (Cassia alata L.) TERHADAP PENURUNAN KADAR KOLESTEROL MENCIT PUTIH JANTAN (Mus musculus L.) Khoirila, Nisa; Walid, Muhammad
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1569

Abstract

High levels of cholesterol in the blood can increase the risk of hypertension, coronary heart disease (CHD), stroke, peripheral artery disease (PAD), and type 2 diabetes. One potential plant for traditional medicine to lower cholesterol levels is Cassia alata L. Cassia alata L. is known to contain flavonoid compounds, suspected to act as cholesterol-lowering agents in the body. This study aimed to determine the anti-cholesterol activity of Cassia alata L. in reducing cholesterol levels in male white mice (Mus musculus L.). The research employed an experimental design, utilizing the maceration method with 96% ethanol as the solvent for extraction. Male white mice aged 3-4 months, weighing 20-30 grams, were used as test subjects. The first group served as the positive control using simvastatin suspension, the second group as the negative control using 0.5% Na CMC solution, the third group received Cassia alata L. extract at a concentration of F1 (10%), F2 (20%), F3 (30%). Data analysis was performed using One Way Anova. The results of the One-way Anova test obtained F count 31.192 > F table 3.48 and sig. value of 0.000 <0.05, so Ho is rejected and Ha is accepted which can be concluded that there is an effect of anticholesterol activity on Cassia alata L. extract. concentration of 10%, 20%, and 30%. Then in the Post Hoc Test using LSD, K (+) showed the same results as F3 (30%) with a significant value of 0.54 so that p>0.05 which showed no significant difference in anticholesterol effectiveness between K (+) and F3 (30%). The results revealed that Cassia alata L. extract at concentrations of 10%, 20%, and 30% exhibited activity in reducing cholesterol levels, which is F3 (30%) demonstrating the most significant cholesterol-lowering effect. This is attributed to the presence of flavonoid compounds in the Cassia alata L. extract.

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