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JIFI (Jurnal Ilmiah Farmasi Imelda)
Published by Universitas Imelda Medan
ISSN : 26553147     EISSN : 25977164     DOI : https://doi.org/10.52943/jifarmasi.v5i1.623
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
JIFI (Imelda Pharmacy Scientific Journal) Imelda Imelda College of Health Sciences (STIKes) which is now Imelda University Medan received related articles: 1. Clinical Community Of Pharmacy 2. Pharmaceutical Technology 3. Pharmacy Management 4. Herbal medicines and Chemistry 5. Biology & Pharmacology JIFI (Jurnal Scientific Pharmacy Imelda) also accepts all writings with various disciplines on the condition that the core points remain in the path and scope of pharmaceutical science.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 119 Documents
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GAMBARAN TINGKAT PENGETAHUAN MAHASISWA PROGRAM STUDI SARJANA FARMASI TENTANG OBAT GENERIK DAN OBAT PATEN DI UNIVERSITAS IMELDA MEDAN Samgryce Siagian, Hartika; Samosir, Sri Rezeki; Gultom, Roby Pahala Januario
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1577

Abstract

Obat Generik adalah obat dengan nama resmi International Non Propietary Name (INN) yang ditetapkan dalam Farmakope Indonesia atau buku standar lainnya untuk zat berkhasiat yang dikandungnya. Obat paten adalah obat baru yang ditemukan berdasarkan riset industri farmasi yang diberi hak paten untuk memproduksi dan memasarkannya setelah melalui berbagai tahapan uji klinis. Mutu obat generik tidak berbeda dengan obat paten karena bahan bakunya sama. Pada umumnya konsumen atau masyarakat lebih tertarik untuk mengkonsumsi produk obat bermerek/produk dagang dibandingkan produk generik, hal itu disebabkan adanya anggapan bahwa obat generik mutunya lebih rendah daripada produk yang bermerek/dagang. Tujuan dari penelitian ini adalah untuk mengetahui gambaran tingkat pengetahuan mahasiswa sarjana farmasi di Universitas Imelda Medan tentang obat generik dan obat paten. Metode yang digunakan adalah metode deskriptif dengan menggunakan kuesioner dibagikan kepada responden. Sampel berjumlah 67 mahasiswa aktif dari tingkat 1, 2, 3 dan 4. Teknik sampling dalam penelitian ini menggunakan metode probability sampling yaitu stratified random sampling. Analisa data dilakukan secara deskriptif dengan menampilkan persentase tingkat pengetahuan 76-100% tingkat pengetahuan baik, 56-75% tingkat pengetahuan cukup dan <55% tingkat pengetahuan kurang. Hasil penelitian menunjukkan bahwa gambaran pengetahuan mahasiswa sarjana farmasi tentang obat generik dan obat paten di Universitas Imelda Medan dikategorikan baik. Hal ini disebabkan dari data yang diperoleh sebanyak 66 responden (98,5%) memiliki pengetahuan baik dan 1 responden (1,5%) memiliki pengetahuan cukup.
POTENSI NIOSOMAL GEL SEBAGAI PENGHANTARAN OBAT ANTIINFLAMASI MELALUI SISTEM PENGHANTARAN TRANSDERMAL Nursal, Fith Khaira; Nining, Nining
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1612

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most popular drugs used, and the WHO model lists essential medicines due to their efficacy in reducing pain and inflammation. Orally administered is prone to causing adverse reactions, while injections administered are not conducive to self-administration of the drug because the patient feels uncomfortable, thereby reducing patient compliance. Transdermal delivery is one solution because it has the potential to improve the safety profile and increase the drug's bioavailability. The use of drug delivery systems based on colloidal particulate carriers such as niosomes has advantages over conventional dosage forms because these particles can act as a reservoir containing the drug and can increase penetration. Based on the discussion presented, gel-based niosomes formulations in various research results show better drug release and permeation through the skin compared to conventional formulations. The presence of cholesterol and surfactant components plays an important role in helping drug permeation through the skin in terms of increasing the number of permeating drug molecules and the depth of permeation that occurs. Hydrogel-forming polymers are the first choice for loading niosomes because they are biocompatible and easy to obtain. Carpobol is the polymer most chosen because of its ability to spread easily, forming homogeneous and transparent preparations.
PEMBUATAN DAN EVALUASI GRANUL EFFERVESCENT VITAMIN C Faidah, Anis; Na'imah, Janatun
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1617

Abstract

Vitamin C is a compound with the molecular formula and the chemical name 2-oxo-L-threo-hexono-1,4-lactone-2,3-enediol. Vitamin C can improve the immune system and as an antioxidant can prevent and treat infections and various other diseases, by fighting bacteria, viruses and fungal diseases. Vitamin C in the form of effervescent granules is an alternative to consuming vitamins for someone who has difficulty swallowing medication in tablets, pills or capsules. This research aims to determine the evaluation results of making vitamin C effervescent granules through several evaluations including determining the real specific gravity, compressible specific gravity, compressibility, and dispersion time tests for effervescent granules. The research method was experimental which was carried out at the Pharmacy Laboratory, Faculty of Health, Muhammadiyah University, Gresik. Based on the evaluation results, the real specific gravity was 0.58 g/mL, the compressible specific gravity was 0.67 g/mL, the compressibility was 13.4% and the dispersion time was ± 4.31 minutes. Based on these results, the vitamin C effervescent granule formula that has been made has very good flow properties as seen from the compressibility of the effervescent granules below 15%, and the granule dispersion time is in the good category because the time required is ? 5 minutes.
GAMBARAN MEREK DAGANG DARI SEDIAAN SUNSCREEN YANG DIGUNAKAN SELURUH MAHASISWA PROGRAM STUDI DI UNIVERSITAS IMELDA MEDAN Dini, Dea Aprian; Maya Syari, Dina; Siahaan, Mutiara
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1693

Abstract

Sun exposure can cause damage to the skin due to ultraviolet radiation. Skin needs special protection from ultraviolet rays, especially on skin organs, namely by using sunscreen. Sunscreen is a compound that functions to protect the skin from excessive exposure to ultraviolet rays. The type of research used is qualitative research using questionnaires to obtain student data. The population in this study was Imelda University Medan students at levels 1, 2, 3 and 4, totaling 1,333 people from 9 study programs. The data collection technique is using a questionnaire. The results of this research after data collection was carried out using a questionnaire and analyzed via SPSS, the results showed that there were 145 males at Imelda University in Medan who used sunscreen, while there were 715 females at Imelda University in Medan who used sunscreen, while sunscreen products the most popular one used by female students is Wardah 259 (19.4%). And the most popular product used by male students is Nivea Men 66 (4.9%). From this research it can be concluded that Wardah and Nivea Men products are the most popular at Imelda University Medan, and there are still many students who do not use sunscreen 473 (35.4%), consisting of male students 115 (8.6%) and 358 female students (26.8%), included in Imleda University, Medan. Even though sunscreen is really needed for the skin to protect it from ultraviolet rays.
INTERAKSI OBAT ANTIDIABETES DENGAN OBAT ANTITUBERKULOSIS (OAT) PADA PASIEN DIABETES MELLITUS TIPE 2 YANG TERINFEKSI TB PARU DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN Auliafendri, Novycha; Sinaga, Alex Handani; Gea, Kiki Restini
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1716

Abstract

Diabetes is a medical condition that can worsen the severity of pulmonary tuberculosis (TB) infection. Combining Antidiabetic Drugs with Antituberculosis Drugs (OAT) in type 2 DM patients who have pulmonary TB can cause undesirable pharmacological interactions. The aim of this study is to explain the relationship between Antidiabetic Drugs and OAT. The research design used in this study is a cross-sectional observational design, with a focus on descriptive statistical analysis. The research sample consisted of 72 patients. Data collection was carried out retrospectively using medical records and doctor's prescription forms. The Medscape (Drug Interactions Checker) tool was used for drug interaction analysis, while SPSS (Statistical Product and Service Solution) 21.0 for Windows was used for data processing. Research findings revealed that the occurrence of drug interactions between Antidiabetic Drugs and OAT varied based on gender characteristics, with 56.9% observed in men and 43.1% in women. Pharmacodynamic interactions reached 25.5% based on the mechanism of action, while pharmacokinetic interactions reached 5.7%. The remaining 68.9% were classified as unknown interactions. In contrast, minor types of drug interactions reached 68.9% in terms of severity, while moderate types of interactions reached 31.1%, and there were no significant interactions. This study concludes that the combination of antidiabetic drugs and OAT mainly causes pharmacological interactions both in the pharmacodynamic and pharmacokinetic pathways, with varying levels of severity, ranging from minimal to moderate.
PEMANFAATAN MORINGA OLIEFERA DAN ESSENTIAL OIL MENJADI MASKER PEEL OFF KESEHATAN KULIT WAJAH DENGAN KONSEP ECOFRIENDLY Samosir, Sri Rezeki; Elnovreny, Jane; Siagian, Hartika Samgryce; Mardiah, Ainun
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1745

Abstract

A peel-off mask cosmetic product has been made from the ethanol extract of the leaves of the Moringa oliefera plant. The research method is experimental. Moringa leaf extract was obtained by the maceration method using 75% ethanol solvent. The extract is divided into six formulations, namely FI (0.5%), FII (1%), FIII (1.5%) and FIV (0.5%), FV (1%), FVI (1.5%) . The formulation for making peel off mask products uses a mixture of green tea essential oils (FIV, FV, FVI). Evaluation of Peel Off mask product preparations consists of organoleptic tests, homogeneity tests, pH tests, Hedonic tests, Irritation tests, spreadability tests. Based on the results of organoleptic tests, non-essential oil preparations in FI have a yellow color, FII has a brown color, and FIII has a brown color, where all three formulations have the aroma of Moringa leaves, while the formulation with the addition of essential oil in FIV has a white color, FV has a brown color, and FVI Brown in color, all three formulations have the aroma of green tea essential oil. The homogeneity test results of all formulations have a homogeneous texture and have a pH of 7. The hedonic test uses 10 panelists to determine the panelists' level of preference. The hedonic test results for color are 40% FI, 50% FII, 60% FIII, 100% FIV, 90% FV and 90% FVI. The hedonic test for texture is 50% FI, 60% FII, 50% FIII, 80% FIV, 100% FV, and 90% FVI. The hedonic test for aroma obtained 20% FI, 40% FII, 50% FIII, 80% FIV, 90% FV and 90% FVI. The Moringa leaf extract peel off mask does not cause irritation to the skin and has a spreadability of around 3.9 – 6.2 cm.
PENGARUH KUALITAS PELAYANAN DAN HARGA TERHADAP KEPUASAN PELANGGAN APOTEK CANGKIRAN Lestari, Nadia Anggi; Erki Arfianto; Ningtyas, Ery Ardiyanti
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1756

Abstract

Health is an important factor in life because with health, everyone is able to carry out activities smoothly without any interference (Kuniano, 2015). To support this health, health facilities are needed, one of which is a pharmacy. A pharmacy is one of the pharmaceutical service facilities as a place of practice for pharmacists. Pharmacy practitioners must know how to make pharmaceutical activities provide satisfaction and benefits for patients or consumers by providing complete drug information, comfortable facilities, communicating in easy-to-understand language, being able to understand consumer needs, appearing polite and courteous, friendly in conveying information, and providing fast and precise service to patients or consumers. Customer perceptions of prices, for example expensive, cheap or appropriate, have a strong influence on purchasing interest and purchase satisfaction (Herlina & Tugiono, 2021). The aim of the research was to ascertain how customer satisfaction at Cangkiran Pharmacy is impacted by pricing and service quality. However, it should be based on an Islamic perspective for pharmaceutical service activities to run with blessings and goodness. This research uses a quantitative approach method, which is a process of seeking knowledge with data in the form of numbers as a tool in analyzing information related to something to be known. Data is collected through the use of written questions (questionnaires).
IDENTIFIKASI STRUKTUR SENYAWA FLAVONOID DARI DAUN KESUM (Polygonum minus Huds.) MENGGUNAKAN METODE PEREAKSI GESER Inayah, Ita; Saepudin, Syumillah; Mudrikah Ramdhani, Humairo
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1761

Abstract

Polygonum minus Huds atau tanaman kesum merupakan tanaman khas Kalimantan Barat. Kandungan metabolit sekunder pada tanaman ini yaitu fenol, terpenoid, alkaloid, flavonoid, saponin, dan tanin. Penelitian sebelumnya menunjukkan bahwa adanya isolat senyawa kimia golongan flavonoid. Dalam penelitian ini bertujuan untuk mengidentifikasi struktur senyawa flavonoid pada daun kesum menggunakan metode pereaksi geser. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut metanol selama 7x24 jam. Setelah itu, dilakukan skrining fitokimia menggunakan pereaksi Wilstater, H2SO4, dan NaOH 10%. Pemantauan ekstrak dilakukan menggunakan plat KLT dengan eluen n-heksan : etil asetat : asam asetat 98% (8 : 1 : 1). Kemudian dilakukan fraksinasi kromatografi cair vakum dengan eluen n-heksan (100%), n-heksan : etil asetat (50% : 50%), etil asetat (100%), etil asetat : metanol (50% : 50%), metanol (100%) dan kromatografi kolom dengan eluen n-heksan : etil asetat : asam asetat 98% (8 : 1 : 1). Tahap selanjutnya, isolasi menggunakan kromatografi lapis tipis preparatif dan dilakukan uji kemurnian dengan kromatografi lapis tipis dua dimensi. Identifikasi struktur senyawa flavonoid menggunakan pereaksi geser dilakukan dengan penambahan pereaksi geser seperti NaOH 2N, AlCl3 5%, NaOAc, NaOAc/H3BO3 dilakukan untuk menentukan kedudukan gugus hidroksil fenol bebas pada inti flavonoid. Berdasarkan hasil interpretasi menggunakan spektrofotometer UV-Vis (metode pereaksi geser) menunjukkan adanya flavonoid golongan flavonol (flavonoid 3-OH tersubstitusi). Berdasarkan teori kemotaksonomi, tumbuhan dalam satu famili umumnya mempunyai senyawa kimia yang serupa, sehingga kemungkinan mempunyai potensi yang serupa untuk pengobatan penyakit.
REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari; Larasati, Rizky Dwi; Ramadhana, Irma Hazira Awalinda; Putranti, Inneke Nurul Dwi; Kholifatuzzahroh; Shafwa, Mayra
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1767

Abstract

The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Several tests were conducted to evaluate the preparation of paracetamol syrup, namely organoleptic test, content determination test, pH test, viscosity test, and specific gravity test. Data was obtained from relevant literature sources such as Google Scholar, ResearchgateNet and Science direct and obtained 10 journals that met the criteria. The use of different cosolvents in syrup will produce different physical values. Paracetamol syrup with PEG 400 and glycerin cosolvents had greater viscosity than paracetamol syrup with propylene glycol and Ryoto sugar ester cosolvents. Paracetamol syrup with PEG 400 and glycerin cosolvents had a greater specific gravity than paracetamol syrup with propylene glycol cosolvents and Ryoto sugar ester surfactant. Based on the results of a review of 10 journal articles, it appears that the use of different cosolvents in paracetamol syrup preparations can modify the preparation and affect the level of stability of the resulting syrup preparation.
FORMULASI SABUN CAIR ANTISEPTIK SARI AIR KULIT BUAH PISANG AMBON (MUSA PARADISIACA VAR SEPIENTUM L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Ramadani, Muhammad; Gunawan, Muhammad; Fitriani, Enny; Kusumastuti, Melati Yulia
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1770

Abstract

Cleanliness of the skin, hands and body is a state of being free of dirt, dust and microorganisms that can cause infection. The existence of these microorganisms can be overcome by using soap containing chemical compounds that have antibacterial activity. In the market there are many circulating antiseptic soaps containing synthetic antibacterials, but they often cause side effects, so it is necessary to make soaps containing natural antibacterials, for example, Ambon banana peel contains polyphenolic compounds and saponins have antibacterial activity. The study conducted a phytochemical screening of Ambon banana peels, made liquid soap containing water extract of Ambon banana peels as a cleanser and antibacterial and carried out antibacterial activity tests. Research stages: phytochemical screening of Ambon banana peel and water extract, liquid soap formulation containing 10%, 20% and 30% Ambon banana peel water extract (SKPA), evaluation of liquid soap including: stability, foam height, pH, irritation and preference test . Antibacterial activity test against Staphylococcus aureus, Escherichia coli and bacteria from volunteer hand washing water specimens. The results showed that the water extract from Ambon banana peel contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides, which can be formulated into liquid soap (SKPA) fulfilling the physical quality requirements. SKPA 30% liquid soap is the best because it is very liked by researchers, has strong antibacterial activity, diameter of inhibition against Staphylococcus aureus (17.23 ± 0.66) mm, and Escherichia coli (15.83 ± 0.66) mm. The total plate number for volunteer hand washing specimens, 10% SKPA resulted in a reduction of bacterial colonies of 49.78%, 30% SKPA obtained the greatest reduction in bacteria, namely 82.79, almost the same as Dettol liquid soap. What is circulating in the market is 83.02%.

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