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JIFI (Jurnal Ilmiah Farmasi Imelda)
Published by Universitas Imelda Medan
ISSN : 26553147     EISSN : 25977164     DOI : https://doi.org/10.52943/jifarmasi.v5i1.623
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
JIFI (Imelda Pharmacy Scientific Journal) Imelda Imelda College of Health Sciences (STIKes) which is now Imelda University Medan received related articles: 1. Clinical Community Of Pharmacy 2. Pharmaceutical Technology 3. Pharmacy Management 4. Herbal medicines and Chemistry 5. Biology & Pharmacology JIFI (Jurnal Scientific Pharmacy Imelda) also accepts all writings with various disciplines on the condition that the core points remain in the path and scope of pharmaceutical science.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 128 Documents
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FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN BODY SCRUB DARI EKSTRAK DAUN SRIKAYA (Annona squamosa L.) DENGAN METODE ABTS Ucik Susilowati; Tiara Ajeng Listyani; Danang Raharjo
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2038

Abstract

IDENTIFIKASI ADVERSE DRUG REACTION (ADR) OBAT ANTI TUBERKULOSIS PADA PASIEN TB DI RSUD PASAR REBO JAKARTA TIMUR Dini Permata Sari; Julita Silitonga; Farisa Luthfiana; Ria Anggraeni
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2044

Abstract

Tuberculosis (TB) remains a major public health problem in Indonesia, ranking second globally in TB burden. Although Anti-Tuberculosis Drugs (ATDs) are effective in curing TB, prolonged treatment and combination regimens may lead to Adverse Drug Reactions (ADRs), potentially affecting patient adherence and treatment outcomes. This study aimed to identify the types of ADRs experienced by TB patients undergoing ATD therapy at Pasar Rebo General Hospital, East Jakarta, and to analyze the relationship between age, gender, and duration of drug use with ADR occurrence. This research employed a descriptive-analytic retrospective design conducted from June to July 2025. A total of 60 adult TB patients receiving first-line ATD therapy (Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol) were included. Data were collected using questionnaires and analyzed using univariate and multivariate statistical methods with SPSS. Causality assessment of ADRs was performed using the Naranjo algorithm. The results showed that 88.33% of patients experienced ADRs. The most frequently reported symptoms were nausea (48.33%), rash/itching (28.33%), and joint pain (26.67%). Most ADRs were categorized as “Probable” based on the Naranjo score. Multivariate analysis revealed that gender was significantly associated with ADR occurrence (p = 0.041), while age and duration of drug use were not statistically significant. In conclusion, ADRs are common among TB patients receiving ATD therapy, with gastrointestinal and dermatological symptoms being the most prevalent. Gender appears to be an important predictor of ADR risk. Therefore, close clinical monitoring and gender-sensitive pharmacovigilance strategies are essential to ensure patient safety, improve adherence, and optimize TB treatment outcomes.
FORMULASI DAN UJI MUTU FISIK SABUN PADAT MENGANDUNG EKSTRAK LAVENDER (Lavandula angustifolia Mill.) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii) Sri Rezeki Samosir; Dina Maya Syari; Mawarni Atika Sari
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2177

Abstract

The manufacture of solid soap combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) has been carried out. The research method is experimental in the laboratory with a quantitative analysis approach. The sample of this research is from lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii). The research stages include making simplicia, evaporation extraction, phytochemical screening, making solid soap preparations and testing the physical quality of solid soap. The extraction stage uses the maceration method for 3 days with 96% ethanol solvent, the extract obtained using a rotary evaporator. Solid soap from a combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) is made in 3 formulations, namely 1%, 2%, 3%. Physical quality testing includes organoleptic test, pH test, foam height test, water content test. The results of the organoleptic test showed a brown colored preparation and a solid texture with a distinctive cinnamon aroma. The results of the pH test showed a pH of 11 for all three formulas. The results of the foam height test showed an initial foam height of 6cm – 7cm and a final foam height of the three formulas of 1cm. The results of the water content test at (F1) 1.29%, (F2) 1.03% and at (F3) 1.86%. The results of the study can be concluded that the combination of lavender leaf & flower extract (Lavandula angustifolia Mill) and cinnamon bark extract (Cinnamomum burmanii) can be formulated as a solid soap preparation.
PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH Nurhadijah Sibagariang; Roy Indrianto Bangar; Refi Ikhtiari
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2181

Abstract

UJI AKTIVITAS ANTIOKSIDAN METODE DPPH DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis L.) MENGGUNAKAN METODE MASERASI Cindy Kurnia Sari; Razoki Razoki; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2193

Abstract

Breadfruit leaves (Artocarpus altilis L.) area plant with various health benefits due to their natural chemical compounds, one of which acts as an antioxidant. Antioxidants are compounds that can halt the oxidation process by donating electrons, there by protecting normal cells, fats, and proteins from damage caused by free radicals. The concentration of an antioxidant that causes a 50% reduction in DPPH activity is referred to as the IC50.  The objective of this study was to determine the effectiveness of ethanol extract from breadfruit leaves in combating oxidation using the DPPH method. The results showed an IC50 value of 6.66 ppm for the extract, indicating very strong antioxidant activity, although it was more effective compared to vitamin C, which served as a positive control with an IC50 value of 1.15 ppm. This difference in effectiveness is influenced by the amount of phenolic compounds present and the potential pro-oxidant effects at higher concentrations. In summary, breadfruit leaves have high potential as asource of natural antioxidants and can be used to develop pharmaceutical products to treat degenerative diseases.
EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN MINDI (Melia Azedarach L.) Casey Dola Rebeca br Pinem; Razoki Razoki; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2203

Abstract

Microencapsulation is a technology used to protect active ingredients from environmental influences and enhance their stability. This study aimed to evaluate the formulation of microencapsulated ethanol extract of mindi leaves (Melia azedarach L.), which possesses pharmacological activities as an antioxidant, antibacterial, and antidiabetic agent. The extraction of mindi leaves was performed using the maceration method with 80% ethanol, yielding a 10.4% extract. Microencapsulation was prepared using sodium alginate and chitosan as coating materials, with three different extract concentrations (0.25%, 0.5%, and 0.75%). Formulation evaluation included moisture content testing, stability testing using cycling test, and floating test on rat gastric mucosa. The results showed that moisture content ranged from 0.37% to 0.63%, with the 0.75% formulation having the lowest moisture content (0.37%). Stability testing over six cycles demonstrated that all formulations remained stable without significant changes in color, texture, and shape. The floating test showed a lag time of less than 2 minutes for all formulations with floating time ranging from 3 to 6 hours, where the 0.25% concentration exhibited the longest floating time (6 hours). It can be concluded that microencapsulation technology successfully produced mindi leaf ethanol extract preparations with stable characteristics, low moisture content, and good floating capability, making it potential as an oral drug delivery system.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI Pseudomonas aeruginosa Suci Della; Muhammad Yunus; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2228

Abstract

Formulation and Antibacterial Action Assessment of Celery Leaf Extract Gel (Apium graveolens L. ) Against Staphylococcus aureus and Pseudomonas aeruginosa Bacteria Celery (Apium graveolens L.) is a plant recognized for its ability to fight bacteria because of substances like flavonoids, saponins, and tannins, which offer promising natural antibacterial alternatives. This study aimed to create a gel from celery leaf extract and test its antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. The celery leaves were extracted using the maceration method with 96% ethanol, achieving a yield of 17.25%. Four distinct gel formulations were produced with varying levels of extract: 0% (F0), 5% (F1), 10% (F2), and 15% (F3), utilizing HPMC as the gel base. Evaluations of the physical properties, which included sensory testing, uniformity, pH, spreadability, and viscosity, showed that all formulations met the quality criteria for gel products. The pH values ranged from 6. 63 to 6. 81, the spreadability was recorded between 5-6 cm, and the viscosity varied from 15,567 to 18,325 cPs. The antibacterial effectiveness test on Staphylococcus aureus, conducted through the disc diffusion method, revealed inhibition zones of 9.2 mm (moderate), 10.3 mm (moderate), and 11.48 mm (strong) at concentrations of 2.5%, 5%, and 10%, respectively. These results indicate that the gel made from celery leaf extract shows antibacterial effects against Staphylococcus aureus, with the highest efficacy observed at a concentration of 10%.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA SECARA IN VITRO Wahyuni Sihombing; Muhammad Yunus; Edy Fachrial
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2230

Abstract

Celery leaves (Apium graveolens L) are plants with various properties according to people's beliefs, one of which is functioning as an antibacterial for skin infections. The skin on the largest human body organ located on the external part of the body whose function is to protect the body parts underneath. This skin disease is caused by bacteria, namely Pseudomonas aeruginosa bacteria, this bacteria is a gram-negative bacteria. The purpose of this study was to determine the effectiveness of celery leaves (Apium graveolens L) against pseudomonas aeruginosa bacteria In Vitro, with concentrations of 2.5%, 5%, 7.5%, 10%, 15%, 20%. In the negative control using 10% DMSO solution, and in the positive control using chloramphenicol disk This study is an experimental study. The research method uses the maceration method using 96% ethanol solvent, sterilization of tools, bacterial rejuvenation, media preparation, test solution preparation, and measurement of inhibition zones after incubation for 24 hours at 37 ° C. The results of this study showed that celery leaf extract (Apium graveolens L.) could inhibit bacterial growth at all tested concentrations. The conclusion is that celery leaf extract (Apium graveolens L) is effective in inhibiting bacterial growth.

Page 13 of 13 | Total Record : 128

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