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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 17 Documents
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Search results for , issue "Vol 6 No 1 (2021): JIIS" : 17 Documents clear
OPTIMASI SINTESIS DAN KARAKTERISASI SABUN CAIR DARI KEMIRI (Aleurites moluccana) DENGAN BANTUAN GELOMBANG ULTRASONIC Aman Santoso Santoso; Syafiuddin Syafiuddin; Dedek Sukarianingsih; Sumari Sumari; Rini Retnosari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.552 KB) | DOI: 10.36387/jiis.v6i1.545

Abstract

Liquid soap has become a basic necessity, especially during the Covid pandemic. The quality of soap is influenced by the type of raw material used. Candlenut oil saponification with potassium hydroxide produces liquid soap which has the potential to be anti-bacterial. Ultrasonic waves (US) produce cavitation which speeds up the reaction. This study aims: (1) Synthesis and characterization of liquid hazelnut oil soap, (2) to determine the antibacterial activity of liquid soap. The stages in this study were: (1) isolation and characterization of hazelnut oil, (2) making liquid soap at various alkaline concentrations with US (3) characterizing liquid soap (4) testing for antibacterial activity. The results showed that liquid soap can be made by saponification with KOH hazelnut oil, obtained physical properties of viscous liquid form, yellowish white color, distinctive aroma. The chemical properties of liquid soap have a pH of 8.46, a density of 1.10 g/mL, a free fatty acid content of 0.34%, a free alkaline content of 0.05%, a viscosity of 1,460 cSt and a surface tension of 4.33 x 10-4 N/m. Candlenut liquid soap has antibacterial activity in the weak category against E. coli bacteria and in the moderate category against S. aureus bacteria
VARIASI EKSTRAK ETANOL BIJI KEBIUL (Caesalpinia bonduc (L). Roxb) PADA FORMULASI SEDIAAN EMULSI M/A Densi Selpia Sopianti; Abdul Ricki; Aina Fatkil Haque
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.506 KB) | DOI: 10.36387/jiis.v6i1.568

Abstract

Indonesia is an archipelago state that is the nature have provides raw materials from medicinal plants, it is not yet used cause medicinal plants usually lived in the forests that have difficult access. Kebiul seed (Caesalpinia bonduc (L.) Roxb.) is an empirically medicinal plant belonging to the Caesalpiniaceae family which has great potential to be used as an prevent from free radicals or as an antoxidants cause kebiul seeds contains alkaloids, flavonoids, saponins, and steroids.The aims of this research to make a M/A emulsion substance. The sample that have been used in this study is kebiul seeds that have extracated by maceration and then evaporated with a waterbath. The extract was made in four formulas with each concentration 10%, 20%, 30%. The evaluation of the M/A have perfect result which were done, stability test (odor, color and shape / texture and pH test) flow properties test, viscosity test, emulsion type test, and microscope cross-section test. After analyzing the M/A emulsion substance the results from all of the evaluations that have been done from the 4 formulas, the kebiul seeds could be made into M/A Emulsion. Variation in contents of Caesalpinia bonduc (L.) Roxb extract which have the requirements evaluation, namely: organoleptic test, pH test, stability test, emulsion type test, viscosity test, and microscope cross-section test.
OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN Joko Santoso; Heru Nurcahyo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.432 KB) | DOI: 10.36387/jiis.v6i1.569

Abstract

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software. Keywords: hand sanitizer gel, carbomer, aloe vera, TEA, Simplex Lattice Design.
MOBILE HEALTH APPLICATION UTILIZATION AND E-HEALTH LITERACY AMONG MEDICAL AND HEALTH STUDENTS Julaeha Julaeha; Devi Solikhati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.811 KB) | DOI: 10.36387/jiis.v6i1.571

Abstract

Fast changing technology application in industry 4.0 technology era implicated on teaching and health services face to face paradigm to virtual services. Excellence health services influenced by good health literacy. The propose of this study is to evaluation knowledge, attitude, and practice medical and health students toward mobile health application and e-health literacy.The study adopted a descriptive cross sectional survey design was conducted in medical and health students in Indonesia during March-July 2020. An Indonesian Electronic Health Literacy Scale (IEHLS) was developed to evaluate Knowledge, Attitude, and Practice (KAP) about e-health literacy and mobile health apps among medical and health students. The full response rate was 99% (n=301). Half of respondents are mobile health apps active user (52.6%). Hallodoc apps was th e most mobile health apps used (60.5%), followed by Medscape (41.5%) and MIMS (23.6%). Diseases information, side effect, indication, and regimen dose of drugs were the most favourite information accessed among medical and health students. Around 80% of medical and health students agree that mobile health apps improve patient’s knowledge on their own disease and medication and helped healthcare professionals on giving education and counseling. In other hand, only 60% medical and health students agree mobile health apps might be use full in learning process and healthcare services. Knowledge, attitude, and practice medical and health students toward mobile health application will be elevated with improving level of health literacy.
PENGARUH VARIASI KONSENTRASI AMPROTAB SEBAGAI DESINTEGRANT TERHADAP SIFAT FISIK TABLET EKSTRAK BUAH PARE (MOMORDICA CHARANTIA L.) Sri Rahayu; Nor Anisah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.008 KB) | DOI: 10.36387/jiis.v6i1.572

Abstract

Bitter melon (Momordica charantia L.) is a type of medicinal plant that is widely used by the public. Charantin is one of the nutritious compounds contained in bitter melon. Charantin compounds can be used to reduce glucose levels in the blood so that it is widely used as a diabetes medicine. The research aims to determine the effect of variations in the concentration of amprotab as a desintegrant on the physical properties of Pare (Momordica charantia L.) extract tablets has been conducted. Viscous extract was made by maceration method by using ethanol 96%. Tablets made by wet granulation method in two different desintegrant concentration of 9,6% and 18%. Dried granule tested with flowability, angle of repose and indeks of compressibility. Tablet evaluation includes uniformity of weight test, friability test, hardness test and disintegration test. The results showed that formula with amprotab as desintegration at 9,6 % concentration was able to produce tablets that met the requirements. Variation in concentration of desintegrant material take effect on the uniformity of weight, hardness friability and disintegration time.
AKTIVITAS ANTIKANKER EKSTRAK ETANOL TANAMAN TAPAK LIMAN (Elephantopus scaber L.) TERHADAP SEL T47D MELALUI INDUKSI APOPTOSIS Panji Ratih Suci; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.223 KB) | DOI: 10.36387/jiis.v6i1.605

Abstract

Breast cancer is the most dominant type of cancer in Indonesia. Traditional medicine using tapak liman (Elephantopus scaber L.) as an anticancer becomes an option because it contains compounds such as sesquiterpenes. The purpose of this study was to know the cytotoxic activity of ethanolic extract of tapak liman on T47D cells through induction of apoptosis. The extraction method uses maceration with 96%. Total flavonoids were tested using quercetin as a spectrophotometric standard. ethanol solvent, cytotoxic test using microtetrazoliom (MTT assay), and apoptosis test using double staining test (ethidium bromide-acrydine orange) under a fluorescence microscope. The results showed the linear regression equation y = 0.0934x-0.0292 with the resulting flavonoid levels of 0.979% w / w calculated against quercetin (QE) The concentration of the compound used was 1000 µg/ml; 500 µg/ml; 250µg/ml; 125 ?g/ml, 62.5 ?g/ml; 31.25 µg/ml. The MTT assay results are the values of IC50 which are analyzed using probit analysis and apoptosis tests which are analyzed descriptively. The results of the research show that the ethanol extract of tapak liman using MTT method has IC50 value of 59 µg/ml, while the testing of double staining method shows the color of bright green which indicates early apoptosis and the color orange in the cells which undergoing final apoptosis. DNA fragmentation results shows that Tapak Liman extract induces DNA fragments. The conclusion of this study is that tapak liman textract has the potential for cytotoxic activity against T47D breast cancer cells through the induction of apoptosis
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN RACUN AYAM (Brucea javanica [L.] Merr.) ASAL KALIMANTAN SELATAN Sutomo Sutomo; Fahriah Fahriah; Arnida Arnida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.647 KB) | DOI: 10.36387/jiis.v6i1.607

Abstract

Racun ayam is one of the plants which has several activities in its fruits, one of which is an antibacterial. This study aims to determine the antibacterial activity of ethanol extract of racun ayam leaves. The extraction was done by maceration method using ethanol as a solvent. Antibacterial activity assay was carried out on S. aureus, E. coli, and P. aeruginosa bacteria by disk diffusion method at the concentrations of 80, 100, and 120 ppm. The results showed that the ethanol extract of B. javanica leaves had the greatest inhibition zone on E. coli with inhibition zone diameter values ​​at 80, 100, and 120 ppm were 11.7 mm, 14.5 mm and 19.67 mm respectively. Inhibition zones in S. aureus could only be seen at 100 and 120 ppm which had inhibition zone diameters at 1.17 mm and 2.17 mm respectively, whereas in P. aeruginosa they did not have any inhibitory zone values. The results of statistical analysis showed a significance of the inhibition zone diameter values ​​of E. coli bacteria starting at 80 ppm with a sig value of 0.034. Due to a sig value was <0.05, it was categorized as significantly different from the negative control. The bacteria of S. aureus which had ​​<0.05 for sig values only found on 100 ppm and 120 ppm. Bacteria P. aeruginosa which had sig value >0.05 was not significantly different at all concentrations
UJI TOKSISITAS DENGAN METODE BSLT PADA NANOPARTIKEL KOMBINASI OBAT CISPLATIN, BOVINE SERUM ALBUMIN DAN ASAM FOLAT Ersalina Nidianti; Ary Andini
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.575 KB) | DOI: 10.36387/jiis.v6i1.609

Abstract

Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. Cancer treatment is important in reducing the high number of deaths (mortality) due to cancer sufferers. One of the cancer treatments is using chemotherapy drug cisplatin. However, cisplatin drug has side effects, namely nephrotoxicity, ototoxicity, neurotoxicity, hemotoxicity, cardiotoxicity, and hepatotoxicity. Therefore, the combination of cisplatin in albumin nanoparticles and modification of the bond using folic acid as an alternative solution minimizes the resulting toxic effects. This study aimed to determine the toxicity effect of the cisplatin drug formulation with a combination of bovine serum albumin (BSA) nanoparticles and folic acid through the Brine Shrimp Lethality Test (BSLT) method. The research methods used were BSA nanoparticle synthesis (NP-BSA), NP-BSA Synthesis with Cisplatin Drug (CP-NP-BSA), Folic Acid Synthesis with CP-NP-BSA Combination (As-CP-NP-BSA). Then, a toxicity test was carried out using the BSLT method to determine the toxicity level of BSA nanoparticles and the effect of adding folic acid in the cisplatin drug in the nanoparticles. The results showed that the absorbance of the 358 nm As-CP-NP-BSA UV-Vis spectrophotometer was 0.86. The toxicity level of the NP-BSA with the LC50 value was 69.23 ppm while the As-CP-NP-BSA LC50 toxicity level was 56.56 ppm. Nanoparticles consisting of a combination of bovine serum albumin, cisplatin and folic acid can be used as candidates for anticancer drugs
PENGGUNAAN INSULIN PADA PASIEN DIABETES MELITUS TIPE 2 PESERTA JKN DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT ST. ELISABETH SEMARANG Fef Rukminingsih; Valentina Catur Nova
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.72 KB) | DOI: 10.36387/jiis.v6i1.611

Abstract

Diabetes mellitus (DM) type 2 is a chronic and progressive clinical syndrome, characterized by polyuria, polydipsi and polyphagy accompanied by increased blood glucose or hyperglycemia. Management of type 2 diabetes mellitus in patients with HbA1C values > 9% is by administering insulin or a combination of insulin with oral hypoglycemic agents. This study aims to determine the suitability of the type and dose of insulin in type 2 DM patients in the Outpatient Pharmacy Installation of St. Elisabeth Hospital Semarang. This research is a descriptive observational study using retrospective data. The data were obtained from the medical records of Universal Health Coverage participant patients with type 2 diabetes mellitus in the Outpatient Pharmacy Installation of St. Elisabeth Hospital Semarang, who only received insulin therapy in January 2020, is 26-65 years old, and has examination results for fasting blood glucose, post prandial blood glucose and HbA1C (examination results for the last 6 months). The results showed that 57 patients consisted of 29 (50.88%) male patients and 28 (49.12%) female patients. A total of 47 (82.46%) patients were more than 45 years old. A total of 38 patients (66.67%) received combination insulin and all patients had HbA1C values> 9%. The suitability of using insulin based on the type of insulin was 68.42% and most of the patients (80.70%) received inappropriate insulin doses.
AKTIVITAS REPELLENT FORMULASI SEDIAAN SPRAY KOMBINASI MINYAK ATSIRI SERAI (Cymbopogon winterianus), DAUN KEMANGI (Ocimum basilicum) DAN NILAM (Pogostemon Cablin) BESERTA UJI PREFERENSINYA Faikah Dyah Utami; Arif Budi Setianto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.085 KB) | DOI: 10.36387/jiis.v6i1.631

Abstract

Plants that are played as mosquito repellents, one of which is plants that contain essential oils, such as lemongrass, basil and patchouli. As an effort to make it easier to use, this research will make a spray repellent preparation with a combination of active ingredients from essential oils of lemongrass, basil and patchouli. The research methods included making a spray repellent using essential oils of lemongrass, basil, patchouli every 0.1 ml (5 concentrations %), 0.2 ml (10% concentration), 0.3 ml (15% concentration) and the additives 1ml Propylene glycol and 5 ml 96% Ethanol which functions as a solvent. The experiment used five treatments, namely: Negative control (Kn), Formula A (0.1ml), Formula B (0.2ml), Formula C (0.3ml), and Positive Control (Kp). The parameters tested included pH test, patch test, organoleptic, specific gravity, emulsion stability, preference and percentage of protective power. The protective power test was carried out 10 times from each treatment for 6 hours of observation (0-1 hours, 1-2 hours, 2-3 hours, 3-4 hours, 4-5 hours and 5-6 hours). The results showed that the best spray expulsion treatment was formula B with a concentration of 10% (0.2 ml)

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