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Scientific Journal
Published by CV. Akhbar Putra Mandiri
ISSN : 28100204     EISSN : 28100204     DOI : https://doi.org/10.56260/sciena
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Scientific Journal(SCIENA) published by an official of Scientific.id_considers the following types of original contribution for peer review and publication: Research Articles, Review Articles, Letters to Editor, Brief Communications, Case Reports, Book Reviews, Technological Reports, and Opinion Articles. It Is published six times a year and serves the need of scientific and non-scientific personals involved/interested in Natural Science (Physics, Chemistry, Electronics, Mathematics, Astronomy, Oceanography, Engineering), Social Science, Economics, Biology and Medicine. Each issue covers topics, which are of broad readership interest to personals from General Public, Industry, Clinicians, Academia, and Government. Scientic Journal is a must read journal for every one with curiosity in science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 188 Documents
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Marine-Lenhart Syndrome: Current Perspectives on Diagnosis and Management Kam, Alexander; Pradwi Efendi, Yanne; Aprilia, Dinda; Decroli, Eva; Syahbuddin, Syafril; Berlian Hemilton, Suci
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.264

Abstract

Marine-Lenhart syndrome (MLS) is an uncommon disorder characterised by the concurrent presence of Graves’ disease and hyperfunctioning thyroid nodules. Its global prevalence ranges between 2.7- 4.1% of Graves’ disease cases, presenting significant challenges in diagnosis and management. MLS is often difficult to detect due to limitations in autoimmune serology tests, thyroid ultrasonography, and access to nuclear medicine facilities. Diagnosis relies on a combination of clinical hyperthyroidism symptoms, the presence of specific thyroid antibodies, and scintigraphy findings that reveal "hot" or "cold" nodules. The primary therapeutic options for MLS include antithyroid drugs, radioactive iodine (RAI) therapy, and surgery. RAI is commonly employed as definitive treatment, often requiring higher doses to address the resistance of hyperfunctioning nodules. Surgery is indicated in cases involving large nodules, compressive symptoms, or suspected malignancies. Treatment strategies should be tailored to the individual clinical characteristics of each patient to minimize complications and ensure optimal outcomes. Advancing the diagnosis and management of MLS requires enhanced access to advanced diagnostic technologies and improved healthcare provider proficiency in identifying and treating the syndrome. A multidisciplinary and integrated approach is essential for achieving favorable clinical outcomes for MLS patients.
Gambaran Gejala Non Motorik Penderita Penyakit Parkinson di Poliklinik Neurologi RSUD M. Natsir Solok Asril , Asrizal; Nikmawati , Sari
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.265

Abstract

Latar Belakang: Penyakit Parkinson adalah penyakit degenerasi otak yang terbanyak kedua, setelah penyakit Dementia Alzheimers. Penyakit Parkinson ini juga merupakan penyakit yang tingkat insidensinya bertambah banyak setiap tahun. Penyakit Parkinson sendiri memiliki dimensi gejala yang sangat bervariasi antara satu pasien dengan pasien lainnya. Gejalanya pun cukup beragam, yang meliputi gejala motorik maupun gejala non-motorik. Gejala tersebut seiring waktu akan mengalami progresifitas atau perburukan, yang mana hal tersebut dapat mengganggu kualitas hidup pasien. Data gambaran gejala non motorik Penyakit Parkinson di RSUD M. Natsir belum ada. Tujuan: Mengetahui gambaran gejala non motorik Penyakit Parkinson Di Poliklinik Neurologi RSUD M Natsir Solok. Metode : Studi deskriptif  kuantitatif melalui desain cross sectional dengan menggunakan data rekam medik penderita Parkinson di Poliklinik Neurologi RSUD M. Natsir dari bulan Januari 2025 sampai Juni 2025.  Data penderita kemudian diolah dan ditampilkan dalam bentuk narasi dan tabel. Hasil : Pada penelitian ini didapatkan 30 subjek penelitian penderita parkinson dengan  gejala non motorik 22 orang (73 %) dan tanpa gejala non motorik 8 orang (27%). Mayoritas penderita parkinson adalah jenis kelamin perempuan sebanyak 17 orang (57 %), usia terbanyak 60-69 tahun sebanyak 12 orang (40 %), pekerjaan terbanyak pensiunan PNS sebanyak 11 orang (36 %) dan tingkat pendidikan terbanyak SMA sebanyak 11 orang (37 %). Gejala non motorik didapatkan  nyeri  (37 %), gangguan tidur (14 %), hipersalivasi  (14 %), demensia  (9 %), gangguan gastrointestinal (9 %), dan gangguan berkemih (9 %), depresi (4 %), dan disfagia (4 %). Kesimpulan : Pada penelitian ini didapatkan hasil gejala non motorik Penyakit Parkinson adalah  nyeri (37 %), gangguan tidur (14 %), hipersalivasi (14 %), demensia (9 %), gangguan gastrointestinal (9 %), dan gangguan berkemih  (9 %), depresi  (4 %), dan disfagia (4 %). 
Menentukan Kekompakan dari Dua Individu yang Sudah Menjadi Tulang Belulang Rosmawaty
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.266

Abstract

Identifikasi forensik suatu upaya yang dilakukan untuk membantu penyidik menentukan identitas seseorang. Informasi yang berkaitan dengan identitas seseorang seperti kedua individu korban dari kekompakan tulang belulang antara Mrs A dan Mrs B, ras, jenis kelamin, dan umur. Penemuan dari tulang belulang ini dilaporkan oleh polisi dan diidentifikasi oleh ahli forensik berdasarkan surat permohonan visum yang diberikan. Pada kasus ini diidentifikasi jumlah tulang belulang manusia lengkap dan tidak lengkap dengan perkiraan lama kematian sekitar 1 tahun dapat diperkirakan melalui penilaian kondisi tulang yang masih padat, berbau busuk, berwarna kecoklatan dan kekuningan serta masih adanya sisa jaringan lunak pada permukaan tulang belulang dan ditemukannya belatung. Berdasarkan hasil pemeriksaan tulang belulang dapat disimpulkan sebab kematian korban karena adanya trauma tumpul dan ditemukan adanya resapan darah pada tulang kepala. Pada kedua kerangka tulang terdapat kekompakan tulang yang dapat memudahkan identifikasi korban dari dua induvidu yang berbeda dan adanya pemeriksaan DNA.
Evaluation of Antioxidant Activity of Methanol Extract of Neem Leaves (Azadirachta indica) Using DPPH, ABTS, and FRAP Methods Aini, Noer; Tilaqza, Andri
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.267

Abstract

Introduction: Azadirachta indica leaves are rich in bioactive compounds with antioxidant potential. Aims: To assess the antioxidant activity of methanolic neem leaf extract using three in vitro methods DPPH, ABTS, and FRAP and to identify its major secondary metabolites. Method: Extraction was performed using Ultrasound-Assisted Extraction (UAE) with methanol as the solvent. Qualitative phytochemical screening was conducted to determine the presence of key antioxidant-related compounds. Antioxidant activity was evaluated using a microplate reader, and IC₅₀ values were calculated based on the inhibition percentage across several concentrations. Results: Phytochemical analysis confirmed the presence of flavonoids, phenolics, terpenoids, and alkaloids. The extract showed strong antioxidant activity in the DPPH assay, with an IC₅₀ value of 54.91 ppm. However, the ABTS and FRAP assays did not yield measurable IC₅₀ or RP₅₀ values, even at concentrations up to 1000 ppm, suggesting limited electron transfer-based antioxidant capacity. These results indicate that the extract’s primary antioxidant mechanism is likely through hydrogen atom transfer (HAT), rather than single electron transfer (SET). Conclusion Methanolic extract of A. indica leaves exhibits strong free radical scavenging activity through the HAT mechanism, as shown in the DPPH assay. This activity is presumably due to the presence of flavonoids and phenolics.
Hormonal Contraception and Cervical Cancer Stage: Does Duration of Use Matter? Evidence from Indonesia: Does Duration of Use Matter? Evidence from Indonesia Oktora, Meta Zulyati; Safitri, Niken; Purnama Dewi, Nadia; Fegita, Primadella; Aliefia, Desi
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.268

Abstract

Background: Cervical cancer remains a major public health problem in Indonesia, ranking as the second most common cancer among women. Hormonal contraceptives are widely used, and long-term exposure has been hypothesized to promote cervical carcinogenesis through hormonal modulation of HPV oncogene expression and epithelial proliferation. However, limited evidence is available on their association with the stage of cervical cancer at diagnosis in Indonesian populations. Objective: To examine the association between the duration of hormonal contraceptive use and the clinical stage of cervical cancer among patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: A cross-sectional analytic study was conducted involving 80 randomly selected patients from 222 cervical cancer cases in 2019. Data on age, age at marriage, parity, type and duration of contraceptive use, and cervical cancer stage (FIGO classification) were retrieved from medical records. Descriptive statistics were presented as frequencies and percentages, while bivariate associations were analyzed using the Mann–Whitney U test (SPSS v25). Results: The majority of patients were aged 46–55 years (38.6%), married after age 20 (57.1%), multiparous (80%), and predominantly used injectable contraceptives (62.9%). More than half had used hormonal contraceptives for <5 years (55.7%). Cervical cancer was most frequently diagnosed at stage III (47.1%). A statistically significant association was observed between longer duration of hormonal contraceptive use and more advanced cervical cancer stage (p = 0.008). Conclusion: Prolonged hormonal contraceptive use is significantly associated with advanced cervical cancer stage at diagnosis. These findings highlight the need for targeted counseling and routine cervical cancer screening in women using long-term hormonal contraceptives to facilitate earlier detection and improve clinical outcomes.
Liothyronine Therapy in Hypothyroidism Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Oktaviandra Siahaan, Jonggara
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.277

Abstract

Hypothyroidism is a clinical condition characterized by reduced production of thyroid hormones and is among the most common endocrine disorders, affecting about 3% of the general population, with a higher prevalence in women (5.1%) than in men (0.9%). In Indonesia, the prevalence of hypothyroidism is estimated at 5-10%. Despite achieving normal thyroid stimulating hormone (TSH) levels with levothyroxine (LT4) therapy, many patients continue to experience symptoms like fatigue, depression, and cognitive impairment, which impact their quality of life. A study of 969 hypothyroid patients found that 77.6% were dissatisfied with their treatment and reported low quality of life scores. Although LT4 has been the standard therapy for nearly 50 years due to its stability and the peripheral conversion of thyroxine (T4) to triiodothyronine (T3), recent recommendations from experts in developed countries suggest using liothyronine (LT3) monotherapy or a combination of LT3 and LT4 in selected cases.
The Role of Genomic Sequencing in Diabetes Mellitus Pradwi Efendi, Yanne; Kam, Alexander; Decroli, Eva; Aprilia, Dinda; Syahbuddin, Syafril
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.279

Abstract

Diabetes Mellitus is a chronic metabolic disorder caused by impaired insulin secretion and/or insulin resistance. Genetic testing through genomic sequencing is one of the modalities available for diabetes mellitus. Genomic sequencing is the process of analysing DNA obtained from a blood sample (or alternatively from tissue samples). Broadly, genomic sequencing plays two major roles in diabetes mellitus: supporting diagnosis and guiding therapeutic approaches. In its development, genomic sequencing has proven valuable for diagnostic investigation in type 1 diabetes and maturity-onset diabetes of the young (MODY), as well as for assessing the polygenic risk score (PRS) in type 2 diabetes. Establishing a definitive diagnosis allows for the selection of individualised therapy. Several randomised controlled trials have demonstrated that the risk of developing diabetes can be reduced by up to half if detected at an earlier stage. Moreover, genomic sequencing can identify genetic variants that influence responsiveness to antidiabetic treatments. At present, several potential antidiabetic agents targeting novel pathways are under development and in various stages of clinical trials. The application of genomic sequencing thus facilitates the implementation of individualised therapy, ultimately contributing to the realisation of precision medicine.
Case Presentation : Congenital Tuberculosis in A Premature Infant Presented with Miliary Tuberculosis Ihsan, Indra; Wahyuda Putra, Aldian Tri; Rahman, Mutia
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.280

Abstract

Congenital tuberculosis (TB) is a rare neonatal infection resulting from vertical transmission of Mycobacterium tuberculosis from mother to infant. Fewer than 500 cases have been reported worldwide, with a high mortality rate up to 40%. Diagnosis is challenging due to its nonspecific presentation and resemblance to neonatal sepsis. We report a case of a 1-month-old preterm infant admitted with worsening respiratory distress, fever, and cough. Chest X-ray revealed a “snow storm appearance” consistent with miliary tuberculosis. The infant’s mother had a history of chronic cough prior to pregnancy and later tested positive for Mycobacterium tuberculosis by sputum PCR. The sputum PCR test in the infant also returned positive. Laboratory findings included leukocytosis with neutrophil predominance and elevated transaminases.  The infant was given respiratory support with CPAP and treated with a standard four-drug antitubercular regimen (2HRZE/10HR) and corticosteroids due to severe respiratory involvement. The clinical course was favorable, with resolution of respiratory symptoms and radiologic improvement, allowing discharge after 16 days of hospitalization. The diagnosis of congenital tuberculosis in this patient was confirmed based on the mother's history of suspected pulmonary tuberculosis prior to pregnancy, along with the confirmed diagnosis of tuberculosis through a positive sputum PCR test in the mother and the infant. Liver biopsy which is gold standard of diagnosis could not be performed due to the patient's unstable condition and the consideration of the benefit invasive procedure.Awareness of maternal risk factor for TB plays a pivotal role in suspected congenital tuberculosis, enables early diagnosis and prompt treatment, reducing mortality and long-term sequelae.
Emerging Biomarkers for Prediabetes : A Review Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Deas Hadilofyani, Putri
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.278

Abstract

Prediabetes is a global health concern marked by elevated blood glucose levels that do not yet meet the threshold for type 2 diabetes mellitus (T2DM). It is often underdiagnosed despite being associated with insulin resistance, beta-cell dysfunction, and increased cardiovascular risk. Improved strategies for early detection are crucial to prevent disease progression. This review aims to explore novel biomarkers associated with prediabetes and evaluate their potential clinical applications in early diagnosis and risk stratification. A literature search was conducted on English and Indonesian language publications, including original research, case reports, and expert guidelines, focusing on emerging molecular and metabolic biomarkers related to prediabetes. Several promising biomarkers have been identified, including adiponectin, microRNAs, fetuin A, alpha-hydroxybutyrate (α-HB), and Protein Z. Adiponectin demonstrates an inverse relationship with insulin resistance. Specific microRNAs, such as miR-192 and miR-193b, are implicated in glucose metabolism and beta-cell function. Elevated fetuin A levels are linked to hepatic insulin resistance, while increased α-HB levels reflect early metabolic shifts in glucose utilization. Additionally, altered Protein Z concentrations may contribute to prothrombotic states in individuals with prediabetes. In conclusion, these biomarkers offer valuable insight into the pathophysiology of prediabetes and hold potential for enhancing early detection and prevention strategies. However, further validation through large-scale studies is needed before their integration into clinical practice
Perdarahan Intrakranial Spontan dan Perdarahan Intraventrikular pada Seorang Anak Usia 16 Tahun dengan Riwayat Konsumsi Basella alba: Laporan Kasus Wiradinata Sembiring, Wahyu; Saragih, Edwin Batara; Yulia, Maya
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.281

Abstract

Perdarahan intraventrikular (IVH) memperburuk prognosis Spontaneous Intracerebral Hemorrhage (SICH) dengan mortalitas diperkirakan mencapai 50–80%. IVH jarang terjadi pada anak-anak, mencakup sekitar 3% dari kasus perdarahan serebral spontan. Perdarahan intraventrikular primer sebagian besar terjadi pada orang dewasa; namun, telah dilaporkan sejak usia sembilan tahun. Perdarahan akut dapat menyebabkan sakit kepala, muntah, penurunan kesadaran, kekakuan leher, dan defisit neurologis. Faktor etiologi mencakup trauma, malformasi vaskular, gangguan koagulasi, serta faktor non tradisional seperti konsumsi obat herbal. Beberapa laporan literatur menunjukkan adanya kemungkinan hubungan antara penggunaan obat tradisonal tertentu seperti Basella alba, dapat menyebabkan perubahan fungsi hemostasis yang dapat meningkatkan kerentanan terhadap perdarahan intrakranial.

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