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Slamet Supriadi
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slamet.supriadi@i3l.ac.id
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Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
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INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 85 Documents
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Structure-Based Computational Screening of Indonesian Spice-Derived Compounds Targeting the Neuropeptide Y1 Receptor Woran, Blessari Tesalonika; Jollie, Jessica Angelina; Dharmasetiawan, Michael Nathanael; Kusnadi, Kevin Purwadinata
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.286

Abstract

The neuropeptide Y1 receptor (NPY1R) is a promising therapeutic target for type 2 diabetes mellitus (T2DM) due to its role in regulating appetite and insulin secretion. Indonesian spices contain diverse bioactive compounds with potential metabolic effects, yet their interaction with NPY1R remains largely unexplored. This study aimed to identify potential natural allosteric modulators of NPY1R using structure-based virtual screening and pharmacokinetic analysis. A total of 17,356 compounds from the NCBI PubChem database were pre-filtered, yielding 860 ligands for blind molecular docking. Of these, 97 showed stronger predicted binding affinities than the reference antagonist BMS-193885. Further screening based on physicochemical properties, toxicity, and ADMET parameters identified six top candidates. Among them, cis-theaspirone demonstrated the most favorable profile, including binding to an allosteric pocket (–10.0 kcal/mol; RMSD 2.658 Å), high gastrointestinal absorption, blood–brain barrier permeability, and acceptable solubility. Molecular dynamics simulations over 50 ns confirmed stable ligand–receptor interactions. Overall, cis-theaspirone emerges as a potential NPY1R modulator, highlighting the promise of Indonesian spice-derived compounds for further investigation in metabolic disease research.
Integrated Network Pharmacology and Molecular Docking Identify Neuroprotective Candidates from Nicotiana tabacum L. Against Alzheimer’s Disease Alauddin, Daffa Rizal Dzulfaqaar; Januar Wicaksono, Muhammad; Abas, Muhammad; Alkwarismi, Zubair; Abdillah Wasom, Mochamad; Madyastuti Purwono, Rini
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.288

Abstract

The neuroprotective potential of compounds from Nicotiana tabacum L. against Alzheimer’s disease was evaluated using network pharmacology, molecular docking, and ADME profiling. 25 compounds were screened, and the intersection of predicted targets with Alzheimer’s disease associated proteins yielded 90 overlapping proteins. Network topology using Degree prioritized three hub targets, IL-1β (Degree: 37), GSK3β (Degree: 25), and AChE (Degree: 19). Docking in YASARA against IL-1β (5R8Q), GSK3β (5K5N), and AChE (4EY7) produced binding energy ranges of -6.673 to -8.680, -9.769 to -10.614, and -10.349 to -12.275 kcal/mol, respectively. The β-amyrin ranked best among test ligands for IL-1β at -6.885 kcal/mol and for GSK3β at -10.178 kcal/mol, while citrostadienol ranked best for AChE at -10.881 kcal/mol. Dual-target profiles supported 28-Isofucosterol for GSK3β and AchE, and gramisterol for IL-1β and AChE. BOILED Egg analysis supported BBB-oriented prioritization of candidates with TPSA <79 Ų, while highly lipophilic sterol-type leads indicate formulation-dependent developability. Overall, Nicotiana tabacum L. provides non-nicotine sterol and triterpenoid scaffolds as multi-target chemotypes spanning inflammation, kinase signaling, and cholinergic dysfunction in Alzheimer’s disease.
The F-11 Sensory Neuron Model: A Scalable In Vitro Platform for Neuropathic Pain and Drug Screening Nazwar, Tommy Alfandy; Laksono, Ristiawan Muji; Balafif, Farhad; Wardhana, Donny Wisnu; Balafif, Fachriy
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.290

Abstract

Neuropathic pain remains a major therapeutic challenge, largely due to the translational disconnect between preclinical animal models and clinical efficacy in humans. This review critically evaluates the differentiated F-11 cell line, a hybridoma of mouse neuroblastoma and rat embryonic dorsal root ganglion (DRG) neurons, as a scalable, reproducible, and physiologically relevant in vitro platform for neuropathic pain research and analgesic drug screening. A detailed analysis of differentiation strategies highlights the critical interplay of neurotrophic factors (notably NGF), intracellular signaling modulators (such as cAMP elevators), and extracellular matrix cues in driving neuronal maturation. Functional validation via calcium imaging and electrophysiology confirms capsaicin responsiveness and action potential generation, mirroring native nociceptors. Its compatibility with medium-to-high-throughput screening and mechanistic studies including investigation of silent nociceptor sensitization in chronic pain conditions along with emerging applications in neuropathy models, makes it a valuable tool for de-risking drug candidates before animal studies.
Effectiveness of Mesenchymal Stem Cells and Their Derivatives in Modulating Oxidative Stress in Neurodegenerative Diseases: A Structured Narrative Review Ghanny, Niken Rahmah; Pradnyani, Putu Erma; Salwa, Assyafiya; Rahajeng, Herera; Radhina, Afifa; Sari, Bunga Anggreini; Baihaki, Ichwan
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.297

Abstract

Background: Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). Mesenchymal stem cells (MSCs) and their derivatives have emerged as promising therapeutic strategies due to their antioxidant, anti-inflammatory, and neuroprotective properties. Objective: This review evaluated the effectiveness of MSC-based interventions in modulating oxidative stress in neurodegenerative disease models. Methods: A structured narrative review search was conducted following PRISMA 2020 guidelines using PubMed and Scopus databases for studies published between 2020 and 2025, with the last search in December 2025. Results: 33 studies met the inclusion criteria, primarily involving Parkinson’s and Alzheimer’s disease models. Overall, MSC-based therapies reduced oxidative stress markers, enhanced antioxidant defenses, activated the Nrf2/HO-1 pathway, improved mitochondrial function, and reduced neuroinflammation in experimental neurodegenerative disease models.
Smartphone Use and Musculoskeletal Disorders: A Systematic Review of Epidemiological Evidence and Potential on Inflammatory Mechanisms Hijami, Nurul Afifah; Ulfah, Maya
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.301

Abstract

Smartphone use among adults has increased and often involves prolonged exposure with sustained non-neutral neck posture. Epidemiological studies report a high prevalence of neck and shoulder pain among frequent users. Biomechanical loading of the cervical spine is considered a main mechanism, while inflammatory processes have been proposed as an additional pathway. This systematic review evaluated the association between smartphone use and musculoskeletal complaints, focusing on inflammatory biomarkers as a potential biological mechanism. The review followed PRISMA 2020 guidelines. Searches were conducted in PubMed and ScienceDirect for peer-reviewed studies published between 2018 and 2025. Eligible studies included adults aged 18 years or older who reported smartphone use exceeding 2 to 3 hours per day. Exposure was commonly assessed using self-report questionnaires or structured surveys. Studies examining neck or shoulder outcomes, posture, or inflammatory biomarkers were included. Observational studies, randomized controlled trials, and ergonomic interventions were eligible. Thirty studies met the inclusion criteria. Most reported significant associations between prolonged smartphone use, sustained neck flexion, and musculoskeletal pain in the neck and shoulders. Prevalence ranged from moderate to high among students and workers with a daily use of 3 to 9 hours. No included study directly measured inflammatory biomarkers in general smartphone users. Related evidence indicates elevated IL-6 and C-reactive protein in sedentary populations with high device exposure.

Page 9 of 9 | Total Record : 85

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