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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 160 Documents
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The cerebrum and cerebellum of Rattus norvegicus offspring, whose mothers were exposed to a sequence of 14 Mozart compositions during pregnancy, expressed higher levels of BDNF and dendritic density, but not mTORC1 Hermanto TJ; N Cininta M; Widjiati
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.212

Abstract

Introduction: To investigate Brain-Derived Neurotrophic Factor levels, Mammalian Target of Rapamycin Complex 1 levels, and Dendritic Density in the cerebrum and cerebellum of Rattus norvegicus offspring following prenatal Mozart compositions exposure. Material and Methods: An experimental study with a randomized post-test-only control group design was conducted at the Animal Laboratory of the Faculty of Veterinary Medicine, Universitas Airlangga, following ethical clearance. A 13 healthy pregnant female Rattus norvegicus were randomly chosen and exposed to 14 Mozart compositions, beginning on gestation day 10 until delivery, while another 13 served as the control group. At day 20, the rats were sacrificed, 2 offsprings' brains (the heaviest) were extracted, and BDNF levels were analyzed using the ab203573 immunohistochemistry kit, mTORC1 levels using the pSer2448 kit, and Dendritic Density using silver impregnation. Statistical analysis was performed accordingly with a significance level of p < 0.05. Results: BDNF levels and Dendritic density in the cerebrum of the treatment group were higher (2.27 ± 1.41 vs. tr 7.44 ± 2.09, p < 0.05) and (4.42 ± 2.04 vs. 6.67 ± 1.23, p < 0.05). In the cerebellum, BDNF levels and Dendritic density in the treatment group were higher (1 vs. 8, p < 0.05) and (3.34 ± 1.94 and 7.91 ± 2.45, p < 0.05). mTORC1 levels in the treatment group were lower but not statistically significant in both areas. Conclusion: Prenatal 14 Mozart compositions exposure during pregnancy increased Rattus norvegicus offsprings' cerebrum and cerebellum BDNF levels and Dendritic Density. A correlation was found between BDNF levels and dendritic density.
Pregnancy with Bidirectional Dominant Left-To-Right Shunt due to Ventricular Septal Defect and Large Secundum Atrial Septal Defect with Left-To-Right Shunt: A Case Report Destikatari, Lovin; Prasetyorini, Nugrahanti; Putri, Valerinna Yogibuana Swastika
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.218

Abstract

Introduction: Congenital heart disease (CHD) is the most common birth defect in humans, affecting approximately 0.8% of all live births. The spectrum of defects is broad, ranging from complex defects that lead to severe disability and death in infancy, to mild defects that may only be discovered later in asymptomatic adults. Case Presentation: This case report discusses a 21-year-old female in her second pregnancy was diagnosed with complex congenital heart disease after presenting with shortness of breath. Pulmonary hypertension was established by echocardiography. The woman did not obtain proper therapy since she was not aware of her cardiac problem during her pregnancy. There were no fetal abnormalities found during prenatal exams. At 38 weeks gestation, an IUD-assisted cesarean surgery was scheduled. While a cesarean section is performed on individuals with certain problems, the majority of CHD cases may be successfully delivered vaginally. Another crucial factor to take into account is the choice of postpartum contraception. Conclusion: A personalized strategy is needed to manage congenital heart disease throughout pregnancy. This includes risk education, careful observation, and modification of interventions to guarantee the best possible results for both mother and child.
The Effect of Flavonoids from Mahkota Dewa Fruit Extract (Phaleria macrocarpa) on Inflammation Factors (IL-1β and IL-6) and Estrogen Receptor Alpha (ERα) in The Ovaries of Endometriosis Model Mice Destikatari, Lovin; Rahajeng; Baihaqi, Irfani
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.220

Abstract

Introduction: Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterus. The disease is marked by uncontrolled cell proliferation, increased cell aggressiveness, apoptosis defects, and an inflammatory microenvironment. Phaleria macrocarpaa, a native Indonesian plant, contains flavonoids that function as antioxidants and have anti-inflammatory and antimicrobial properties. Previous research has shown that flavonoids from Phaleria macrocarpa can inhibit endometriosis lesion growth by regulating cell apoptosis. Material and Methods: This study is an experimental study using a randomized post-test-only control group design. Six groups were included: a negative control, a positive control, and four treatment groups receiving Phaleria macrocarpa flavonoid extract at concentrations of 3.75%, 7.5%, 11.25%, and 15%. The primary data obtained were then examined using SPSS 26.0. Results: IL-1β, IL-6, and ERα levels in the treatment groups were lower than in the positive control group, with significant differences between each group. Higher extract doses were associated with a greater reduction in inflammatory mediators. Regression analysis demonstrated a strong correlation between Phaleria macrocarpa extract administration and decreased levels of IL-1β (86%), IL-6 (94%), and ERα (95%). Conclusion: In endometriosis model mice, administering Phaleria macrocarpa fruit extract can lower the concentration of IL-1β, IL-6, and ERα. There is a correlation between the reduction of concentration of IL-1β, IL-6, and ERα in endometriosis model mice and various doses of Phaleria macrocarpa fruit extract.
The Effect of Red Bean Extract (Phaseoulus Vulgaris L. Sp.) on T Helper 17, T Regulator Levels, and Atretic Follicle Count in Mice Models of Premature Ovarian Failure Induced by Systemic Lupus Erythematosus Effendi, Madina Paramitha; Noryanto, Mukhamad; Wiyasa, I Wayan Arsana; Arianto, Onni Dwi
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.222

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a long-term autoimmune disease that primarily impacts women of reproductive age. A major complication of SLE treatment with cyclophosphamide is premature ovarian failure (POF), leading to infertility. The imbalance between T-helper 17 (Th-17) and T-regulator (Treg) cells contributes to SLE progression. Red bean extract (Phaseolus vulgaris L. sp.), known for its antioxidant and anti-inflammatory effects, may help restore this balance and protect ovarian function. Material and Methods: Female Balb/c mice were divided into five groups: control, untreated SLE, and three treatment groups receiving red bean extract at 50, 75, and 100 mg/kg. SLE was induced using pristane, followed by cyclophosphamide to trigger POF. The treatment groups received red bean extract for four weeks. Th-17 and Treg levels were measured using ELISA, and ovarian tissues were histologically analyzed to assess atretic follicle count. Data were statistically analyzed using ANOVA and Tukey’s post hoc test. Results: Red bean extract reduced Th-17 levels and increased Treg levels, indicating improved immune balance. Additionally, a decrease in atretic follicles suggested protective effects on ovarian function. The most significant results were observed at the 75 mg/kg dose. The extract’s polyphenolic and phytoestrogenic content likely contributed to its anti-inflammatory and antioxidant activity. Conclusion: Red bean extract shows promise as a natural therapeutic agent for preventing ovarian dysfunction in SLE-induced POF by modulating immune response and reducing follicular damage. Further research is needed to explore its molecular mechanisms and clinical potential in humans.
A Study on Predicting High Achievers among Medical Students in the 4th Semester Faculty of Medicine Universitas Airlangga Hermanto Tri Joewono; Herawati, Lilik; Ummah, Fithriyah Cholifatul; Handayani, Samsriyaningsih; Chandra, Cecilia Felicia; Hasan, Helmia; Rejeki, Purwo Sri; Sakina; Heryana, Achmad Yuniari; Kuswandi, Dedi
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.223

Abstract

Introduction Student-centered learning (SCL) is based on students' needs, capacities, and other characteristics, making the method more personalized. This study aimed to analyze new questionnaires to categorize 4th-semester medical faculty students based on their characteristics. Understanding these characteristics could make the teaching and learning process more effective, potentially reducing the number of students retaking exams. Material and Methods: Subjects were 4th semester students who agreed to enroll and self-fulfilled the questionnaire. High achievers are defined as high expectations and consistent high performance (GPAs). Validity and reliability of each item were analyzed by statistical calculations accordingly. GPA in the next semester was used as threshold to confirm the participant's categorization. Results: The study commenced in March 2022, with 107 participants with Grade Point Averages (GPAs) available. The study demonstrated that the questionnaires had high validity and reliability (p-value < 0.005; Pearson Correlation Coefficient and Cronbach alpha). Among the participants, 3 (2.8%) were classified as high achievers, while 3 (28%) were categorized as low achievers. Notably, 44.86% of participants reported their passions as unrelated to medicine, while 5.61% were uncertain of their passions. Regarding vocation, 8.2% cited parental influence, and 10.3% felt their educational progress was not within their control. Conclusion: The questionnaires had high validity and reliability in item analysis. There were 2,8% of participants predicted as High Achievers and Low Achievers. Refinements of items and score presentation are needed. Follow-up activities should be given to the low achievers to prevent becoming retakers.
Maternal Mortality in Indonesia, When will it end? Sutrisno, MD, PhD, OG (REI)
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.237

Abstract

Sad news colored the arrival of this morning. Although the sky is clear, the breeze is gentle, and the sun is shining brightly, our feelings are truly troubled. This morning, the Obstetrics and Gynecology resident, with a sad face, reported a young mother passed away in the Maternal ICU, leaving behind deep sorrow. A young mother, 28 years old, post cesarean section at another district hospital, 35 kilometer away from our city, was sent due to decreased consciousness, blood pressure 180/120, shortness of breath, oedema, and diffuse lung rales. X-ray showed severe pulmonary oedema and the oximeter indicated an O2 level of only 85 percent despite using high doses of oxygen. 10 days of treatment in the ICU with a ventilator did not help, and this morning she was called back to God Almighty.
Antioxidant Supplementation Improves Lipid Profiles and Antioxidant Levels in Post-menopausal Women: Systematic Review and Meta-Analysis Tandiono, Felicia; Apriliani, Dyang Wulan; Safitri, Fadhila Permata; Gerardo, Timothy Sahala; Tarigan, Audrey Gracielle
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.179

Abstract

Introduction: Post-menopause is marked by a decline in estrogen levels around age 50, leading to unfavorable metabolic changes, including increased LDL-c and decreased HDL-c, which elevate cardiovascular disease (CVD) risk. Reduced antioxidant capacity during this phase also heightens oxidative stress, contributing to chronic diseases such as CVD, osteoporosis, and cancer. Given the limitations of conventional treatments, antioxidant supplementation has emerged as a potential alternative.   Material and Methods: Systematic Reviews and Meta-Analyses Preferred Reporting Items (PRISMA) framework was used in this study. Studies on arterial ligation techniques in placenta percreta surgery were included based on criteria focusing on estimated blood loss, operative time, and adverse events. A comprehensive literature search across multiple databases was performed, resulting in three studies that met the inclusion criteria.    Results: The three studies included in the review with a total of 193 patients. The findings show that IIAL significantly decreased the projected amount of blood loss compared to control groups. In one study, bilateral IIAL showed lower blood loss (1076 ± 545 ml) compared to other interventions, while another study demonstrated that IIAL resulted in lower estimated blood loss compared to control groups. However, hypogastric artery ligation (HAL) was associated with higher blood loss in one study. Despite its effectiveness in controlling blood loss, complications such as common iliac artery thrombosis, pseudoaneurysms, and limb ischemia were reported, though with low incidence.    Conclusion: Arterial ligation, particularly IIAL, could be a viable strategy for managing blood loss during placenta percreta surgery.
Social and Cultural Drivers Affecting The Uptake Of Maternal and Newborn Health Care Services Among Women in Their Reproductive Age in The East Mamprusi Municipality Yussif, Adam Bawa; Mahama, Smith Wayo; Abudu, Jacob Ibrahim
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.204

Abstract

Introduction: Socio-economic and cultural factors affect the use of basic maternal and newborn health care services among women in their reproductive age in Ghana. Yet, little is known about women’s choice of such preferences. This study was conducted to assess social and cultural factors that affect the uptake of maternal and newborn health care services among women in their reproductive age in the East Mamprusi municipality of Ghana. Material and Methods: The study employed a descriptive cross-sectional study design using simple random sampling technique to sample the respondents at the study setting. Structured questionnaire of a question about knowledge, cultural factors, and social factors were used to collect the data. The collected data was filled on cleared for completeness and analysed using Statistical Package for Social Science Windows version 25.0 and Microsoft Word Excel 2016. Results: 81.5% mentioned that husband determined when ANC should be initiated. It was also revealed that, pregnant women preferred to be attended to by TBAs as compared to nurses. From the results, 89% of the respondents considered distance to access maternal and newborn care services as a social factor affecting maternal and newborn care. From the results, respondents who were staying more than 2 km away from a health centre were 2.26 times more likely to be knowledgeable on social factors that affects maternal and newborn health care services as compared to those who were staying less than 2 km away from a health centre [COR = 2.26 (95% CI 2.11, 24.88); p = 0.152]. Conclusion: Cultural and social factors affect women use of maternal and newborn health care.
Correlation Between Transmission Prevention and Incidence of Filariasis: A Systematic Review Nawan; Agatha, Sinda; Handayani, Septi; Toemon, Agnes Immanuela
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.215

Abstract

Introduction: Filariasis, a chronic infectious disease caused by filarial worms and transmitted by mosquitoes, remains a global public health issue, affecting 120 million people in 72 countries. Indonesia, with cases spread across 34 provinces, is one of the endemic countries. Preventive measures such as eliminating mosquito habitats, preventing mosquito bites, and implementing Mass Drug Administration (MDA) programs in endemic areas are essential to achieve filariasis elimination. This literature review aims to explore the correlation between these prevention practices and the incidence of filariasis to support elimination efforts. Material and Methods: Secondary data were sourced from databases including Google Scholar, PubMed, ResearchGate, SpringerLink, ScienceDirect, PLOS One, and Neliti. Using keywords such as prevention practices, Mass Drug Administration (MDA), risk factors, going out at night, bed nets, anti-mosquito repellent, wire netting, and filariasis, 30 research journals meeting the inclusion criteria and quality assessment were obtained. Results: The study results showed correlations between filariasis incidence and various prevention practices: 72.22% of studies (13 journals) with avoiding going out at night, 73.33% (11 journals) with using anti-mosquito repellent, 75% (12 journals) with using bed nets, 68.75% (11 journals) with using wire netting, and 92.31% (12 journals) with participating in Mass Drug Administration (MDA) programs. Conclusion: There were a correlation between no go out at night, the habit used of anti-mosquito repellent the used of bed net, wire netting, and taking Mass Drug Administration (MDA) programs with filariasis incidence.
Systematic Review & Meta-Analysis Triple Inhaler Therapy Outperforms Dual Therapy in Moderate to Severe COPD: A Meta-Analysis of 11,477 Patients from 4 Randomized Controlled Trials Shows Improved Lung Function, Reduced Exacerbations, and Comparable Safety Profile Albab, Chabib Fachry; Habibah, Almas Talida; Wulandhari; Murteza, Faiq; Mas'udi, Achmad Fayyad
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.224

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) continues to be one of the most prevalent health conditions globally. Treatment strategies for COPD are often tailored to disease severity, beginning with single therapy and advancing to dual or triple therapy as needed. However, limited randomized controlled trials (RCTs) have explored the comparative impact of dual and triple inhaler therapies on clinical outcomes and exacerbation frequencies. Our meta-analysis aims to evaluate the effectiveness and safety of triple and double medication in moderate and severe COPD patients.    Material and Methods: A comprehensive exploration of databases was conducted to identify RCTs comparing triple and dual inhaler therapies. For binary outcomes, the pooled RR or OR was calculated; we also used weighted MD to analyze continuous outcomes, both with high CI (95%).    Results: The meta-analysis included four RCTs involving 13,574 patients, of whom 67.92% were male. Triple inhaler therapy proves lung function improvements significantly, evidenced by an increase in FEV1 (MD: 0.06; 95% CI: 0.01–0.11; p=0.02). It showed significant association with a exacerbations reduction in both moderate and severe one (RR: 0.76; 95% CI: 0.72–0.81; p<0.000001). No notable differences in adverse events were observed between combination of triple and double medication (OR: 0.99; 95% CI: 0.90–1.10; p=0.85).    Conclusion: Triple inhaler medication proves more effective than double medication in moderate and severe COPD patients, enhancing lung function and lowering exacerbation rates without a significant increase in adverse effects.

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