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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 160 Documents
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In Vivo Studies Exploring the Impact of IUGR in Rat Models on Offspring Malnutrition: A Systematic Review Sukandar, Umar Gunarsa; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.194

Abstract

Introduction: Intrauterine growth restriction (IUGR), stemming from inadequate fetal nutrition due to maternal or placental factors, affects 10–15% of pregnancies worldwide. Animal models reflect human IUGR, showing malnutrition-associated outcomes like impaired growth, reduced body weight, delayed puberty, and disruptions in genetic and hormonal processes. Despite extensive research, gaps persist in understanding how IUGR impacts fetal outcomes, particularly regarding malnutrition-related outcomes. Material and Methods: The literature search was conducted in four databases. Several outcomes were analyzed, including the timing of puberty, weight and body composition, and organ development, which represented the IUGR rat's malnutrition condition. Throughout the identification process, 11 articles were included in the systematic review. Results: Research consistently demonstrates that IUGR in rat models results in delayed puberty, characterized by delayed vaginal opening and lower body weights compared to controls across early and later developmental stages. Additionally, IUGR adversely affects organ development, with studies showing reduced brain weights, diminished ovarian and mammary gland development, and altered sizes of reproductive organs. Furthermore, IUGR disrupts hormonal and genetic profiles, as evidenced by changes in ovarian follicle counts, altered gene expressions related to testicular development, and dysregulated metabolic pathways. All malnutrition-related outcomes significantly differed between IUGR and control rats (p < 0.05). Conclusion: IUGR in rat models consistently induces developmental delays and physiological impairments in offspring, characterized by delayed puberty, reduced body weights, and compromised organ development, highlighting the adverse consequences of malnutrition associated with IUGR.
Diagnostic and Treatment Challenges of Recurrent Tuberculosis in Patient with Drug-Induced Hepatotoxicity: A Case Report Devanda, Kasilda Pasha; Avelline, Kendraadine Dheayu; Lauwis, Keziah Queency; Kharizmatika; Hayati, Khofifah Bela Rachmanu; Adiwinoto, Ronald Pratama; Nugraheni, Pramita Anindya; Rasyida, Annisa Ullya
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.195

Abstract

Introduction: Pulmonary tuberculosis (TB) remains one of the most significant global health challenges, especially complicated by cases with incomplete treatment histories. The recurrence of TB poses diagnostic and therapeutic dilemmas that significantly impact patient outcomes. Case Presentation: We report a case of a 57-year-old female patient presenting with recurrent pulmonary TB after an incomplete treatment course. The patient's history revealed gaps in adherence to the prescribed TB regimen, leading to multiple relapses. In this study, we found that patients undergoing TB treatment may experience liver damage as a result of the TB medication, also known as DIH. Comprehensive diagnostic procedures, including chest radiography, sputum culture, and molecular testing, confirmed recurrent TB. The patient's clinical manifestations, treatment plan, and response to therapy are detailed. Conclusion: Recurrent TB is common, particularly in older adults, and is influenced more by environmental factors than occupation. Additionally, ATT poses risks of hepatotoxicity, especially in malnourished patients, underscoring the importance of managing side effects and addressing factors like malnutrition to prevent complications and improve outcomes. This case underscores the importance of complete adherence to TB treatment regimens and highlights the challenges in managing recurrent TB. It emphasizes the need for robust follow-up, patient education strategies, early diagnosis, and prompt intervention to prevent recurrence and enhance patient outcomes.
Pain Management in Albania’s Health Care System Çuni, Zhenisa; Saliaj, Aurela
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.196

Abstract

Introduction: Access to pain management is a fundamental human right. Addressing pain - whether mental, emotional, psychological, or physical - should be a primary goal for medical professionals. This article provides an overview of how the Albanian Healthcare System is structured to assist patients and examines the focus of scientific research in this area. Material and Methods: Literature review of scientific articles found on PubMed, Google Scholar, Cochrane, and Elsevier.  Observation of Health Care System in Albania for 3 years. Observation of Education System in Albania for more than 15 years.   Results: After literature review it became quite clear the panorama of Pain Management in Albania which totally lacks research focused on the way pain is being evaluated and monitored by nursing staff, and on non-pharmacological methods for pain relief. Regarding pain evaluation, it is traditionally evaluated through subjective and objective evaluation and there is not a unified, standardized protocol with defined tools and a schedule on how and when to evaluate pain and to address it. Until now studies and articles are focused on identifying barriers to Palliative Care, measuring Health Care System quality, and patient satisfaction. Meanwhile, Postoperative Pain Management is quite a new topic. Conclusion: In Albania’s Health Care System standardized protocols for pain assessment and management are lacking, and there is a need for continued scientific research and development in this field to address the challenges identified and offer solutions based on developed countries’ consolidated experience in pain therapy.
Predicting Schistosoma Haematobium Risk Distribution in Zambia Using Geographic Information System (GIS) and Remote Sensing (RS) Technologies Chimfwembe, Kingford; Mutesu, Lillian Mambwe
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.198

Abstract

Introduction: This study explores the spatial distribution and climatic influences on schistosomiasis in Zambia using remote-sensed data, specifically focusing on the Normalized Difference Vegetation Index (NDVI) and maximum temperature (Tmax). Material and Methods: By analysing prevalence data over a decade (2002-2012) and employing Geographic Information System (GIS) and Remote Sensing (RS) technologies, we identified regions conducive to the transmission of the disease. Results: The findings revealed significant variability in schistosomiasis prevalence across Zambia. Climatic cut-offs for schistosomiasis transmission were established, highlighting NDVI values between 134 - 153 and Tmax ranges of 19.4 – 27.6°C as optimal for sustaining transmission. Conclusion: The study underscores the pressing need for comprehensive control strategies that extend beyond school-based treatments, addressing the broader community and targeting at-risk populations. Furthermore, the established climatic cut-offs provide a framework for future research and public health initiatives aimed at reducing the burden of schistosomiasis in Zambia. This work emphasizes the intricate relationship between climate, health interventions, and disease dynamics, calling for adaptive strategies in the face of climate change.
A 68-Year-Old Male with Giant Urethral Diverticulum Stone Rahma, Naely; Muhammad, Izbikavik; Puspitasari, Violita Ayu; Syairofi, Fajar; Medina, Aulia Shofia; Zia, Nur Khalida
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.200

Abstract

Introduction: Urolithiasis primarily affects the kidneys, ureters, or bladder, but urethral stones are rare, making up less than 1% of all urinary tract stones. Their prevalence is 0.3% to 2%, with a higher incidence in men due to the longer male urethra. Symptoms range from asymptomatic to severe pain, dysuria, and urinary retention, often complicated by fever or renal failure. Urethral diverticulum, a rare malformation, can cause recurrent infections and stone formation. Diagnosis involves imaging, urethrography, and cystourethroscopy, while treatment depends on stone size and location. Delayed diagnosis can lead to significant morbidity. Case Presentation: A 68-year-old male presented to the clinic with a painful lump in the left scrotum, which had progressively enlarged and hardened. He reported experiencing painful, incomplete urination along with right-sided back pain. The patient had a history of similar lumps that had been surgically removed. Upon examination, a tender, hard mass measuring 4x3 cm was found in the left scrotum. Urethrography revealed a solitary opaque stone in the posterior urethra, while post-contrast imaging confirmed diverticulolithiasis in the bulbo-cavernous urethra, leading to stenosis and partial obstruction, confirming urethral obstruction due to stones. Laboratory tests returned normal results. Conclusion: Urethral stones are rare, constituting less than 1% of urinary tract stones, mainly affecting men. Symptoms range from asymptomatic to severe pain, with potential complications like fever and kidney failure. Diagnosis involves imaging, and timely management is crucial to prevent morbidity.
The Effect of Curcumin Administration on p53 and Caspase-3 Expression in Cervical Cancer HeLa Cell Culture Purba, Irene Silvia; Irwanto, Yahya; Rahardjo, Bambang; Handayani, Puspita
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.201

Abstract

Introduction: Cervical cancer is a type of cancer with 605,000 new cases globally each year, with a mortality rate of 340,000. Curcuma longa, or curcumin, has the potential to enhance apoptosis in cervical cancer cells through the NF-kB-p53-caspase-3 pathway. Material and Methods: This in vitro experimental study employed a Completely Randomized Design (CRD) using HeLa cell cultures derived from cervical adenocarcinoma (ATCC® CCL2™). Cells were grown in Dulbecco's Modified Eagle Medium (DMEM) and treated with curcumin at concentrations of 25 µg/mL, 50 µg/mL, 100 µg/mL, 150 µg/mL, and 250 µg/mL. Cytotoxicity was assessed using the CCK-8 assay, apoptosis via flow cytometry, and p53 and caspase-3 expression using immunofluorescence. Statistical analysis was performed with IBM Statistics SPSS 25. Results: There was an increase in the percentage of apoptosis, p53 expression, and caspase-3 expression. At a dose of 100 µg/mL, total apoptosis increased significantly, reaching nearly 25% (p=0.000). P53 expression significantly increased at curcumin doses of 50 µg/mL and 100 µg/mL (p=0.021). There was a significant increase in caspase-3 expression, reaching approximately 86.2%, with a maximum effect at a dose of 100 µg/mL (p=0.002). Conclusion: Curcumin shows promising potential as an anticancer agent by reducing cell viability and enhancing apoptotic activity in HeLa cervical cancer cells.
The Womb: Beyond a Waiting Room – Nurturing the Future Generation Hermanto Tri Joewono
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.203

Abstract

In the intricate journey of human development, the womb emerges not merely as a waiting room, but as one of the best places to lay the foundation for the growth of the human brain and human. Pregnancy, far from being solely a period of preparing for childbirth, unfolds as a golden opportunity to shape the next generation in profound ways.
Pregnancy With Severe Thrombocytopenia Caused by HELLP Syndrome and Acute Idiopathic Thrombocytopenic Purpura: a Case Report Widowati, Ayu Rizky; Firdaus, Wildan Aulia; Hariyati, Suheni Ninik; Hermanto, Djoko Heri
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.183

Abstract

Introduction: Thrombocytopenia in pregnancy could result in a wide range of prognosis, with the worst-case being life-threatening. Thrombocytopenia in pregnancy is a rare condition which could result in bleeding, endangering both maternal and foetal components. During pregnancy, thrombocytopenia could be caused by various factors, including idiopathic thrombocytopenic purpura and preeclampsia. Case Presentation: A 28-year-old pregnant woman, primigravid, gestational age 37-38 weeks old, single pregnancy, presents with fever ongoing for 12 days. A routine blood test returned a thrombocyte count of 11000/mm3. Patient received 8 units of thrombocyte concentrate with no improvement and progressive decline of thrombocyte count. Patient was assessed with severe thrombocytopenia caused by suspected dengue fever, with differential diagnoses being HELLP syndrome and idiopathic thrombocytopenic purpura. Patient was also assessed with severe preeclampsia and severe oligohydramnios. Patient’s condition improved after termination of pregnancy by caesarean section, accompanied with gradual return to normal thrombocyte count value. Conclusion: Thrombocytopenia in pregnancy could be caused by various factors, necessitating the need for a thorough medical evaluation to determine the underlying cause. A multidisciplinary and collaborative approach is highly recommended in managing pregnant women with thrombocytopenia.
Ruptured Cavernoma Associated with Developmental Venous Anomaly: Case Report Nogarotto Cembraneli, Pedro; Brasileiro de Faria Cavalcante, Julia; Nogarotto Cembraneli, Italo; Brasileiro de Faria Cavalcante, Renata; da Silva Cavalcante, José Edison; Taveira Lopes, Leonardo; Fonseca Cardoso, Alessandro; Antônio Zanini , Marco; Fonseca Cardoso, Chrystiano
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.209

Abstract

Introduction: Cerebral Cavernous Malformations (CCMs) are rare vascular lesions, often associated with genetic mutations. The association between these malformations and Developmental Venous Anomaly (DVA) has been the focus of recent studies, as they may influence the evolution of the lesions. Case Presentation: A 26-year-old female patient presented with a sudden onset of severe headache, vertigo, and ataxia, requiring hospitalization due to cerebellar hemorrhage confirmed by CT scan. Magnetic Resonance Imaging (MRI) revealed a cavernoma in the right cerebellar peduncle with an adjacent DVA. The patient underwent surgical intervention with intraoperative neuronavigation, where the DVA was used as an anatomical landmark to locate and completely excise the cavernoma while preserving the anomalous vein. Postoperatively, the patient showed significant improvement without neurological deficits. Conclusion: CCMs can be sporadic or familial, and they are frequently associated with DVAs. DVA resection can impair venous drainage and cause infarction, making its preservation crucial during surgery. A conservative approach is recommended in most cases, with resection indicated for symptomatic lesions or those at high risk of bleeding.
Cervicothoracic Spinal Epidural Empyema Causing Tetraparesis: Case Report and Literature Review Cembraneli, Pedro Nogarotto; Cavalcante, Julia Brasileiro de Faria; Cembraneli, Italo Nogarotto; Cavalcante, Renata Brasileiro de Faria; Cavalcante, José Edison da Silva; Lopes, Leonardo Taveira; Xavier, Marcos Daniel; Cardoso, Alessandro Fonseca; Cardoso, Chrystiano Fonseca
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.211

Abstract

Introduction: Spinal Epidural Empyema (SEE) is a rare and severe central nervous system infection characterized by pus in the epidural space of the spine, often caused by bacteria such as Staphylococcus aureus. Although its incidence has increased in recent decades, diagnosis remains challenging. Risk factors include advanced age, invasive surgeries, injectable drug use, and central venous catheters. The clinical presentation typically includes spinal pain, fever, and focal neurological deficits. Diagnosis is confirmed by contrast-enhanced magnetic resonance imaging (MRI). Case Presentation: This report describes a 41-year-old female with a history of urinary tract infection who developed tetraparesis, cervicalgia, and fever. MRI revealed an extensive fluid collection in the epidural space from C5 to T6, with spinal cord compression. Urgent surgical intervention was required for decompression and purulent drainage, with Staphylococcus aureus identified as the causative pathogen. Following two weeks of intravenous antibiotics, the patient showed significant recovery of strength in both upper and lower limbs. Conclusion: Early intervention with surgical decompression and appropriate antibiotics is crucial to prevent severe neurological sequelae. Raising awareness and achieving a prompt diagnosis are key to improving patient outcomes and quality of life.

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