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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
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Phosphorylated Ataxia Telangiectasia Mutated (pATM) Enzyme-Linked Immunosorbent Assay (ELISA) for Predicting Radiation Induces Normal Tissue Toxicity in Radiotherapy Patients: A Systematic Review Sofiati Purnami; Viria Agesti Suvifan; Dwi Ramadhani; Yanti Lusiyanti; Darlina Darlina; Nastiti Rahajeng; Mukh Syaifudin; Dwi Ari Pujianto; Retno Widowati
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.971

Abstract

Background: An adverse normal tissue response, such as normal tissue toxicity (NTT), is present in radiotherapy (RT) patients and can limit the effectiveness of the RT treatment. Identifying patients with adverse tissue responses before RT had clinical benefits and individual radiosensitivity (IRS) is considered an important factor in NTT incidences. Therefore, this systematic study aimed to determine the possibility of using phosphorylated Ataxia Telangiectasia Mutated (pATM) Enzyme-Linked Immunosorbent Assay (ELISA) to predict NTT in RT patients.Methods: A comprehensive data search was conducted in three electronic databases, namely PUBMED CENTRAL, ScienceDirect, and SCOPUS. The quality of relevant publications was independently evaluated using the PICO (participants, intervention/exposure, comparison, and outcome) approach.Results: : A total of 47 articles were retrieved, 41 of which were assessed based on the titles and abstracts. Furthermore, 39 articles were excluded, and 2 were included in this study.Conclusions: The phosphorylated ATM ELISA on lymphocytes showed promising results for IRS prediction in RT patients. However, these assumptions should be validated on a larger RT patient cohort.
Proactive versus Reactive Nutrition Therapy in Head and Neck Cancer Patients Treated with Chemoradiotherapy: A Case Series Dian Araminta Ramadhania; Diyah Eka Andayani; Wina Sinaga
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.972

Abstract

Introduction: Malnutrition is frequently found in head and neck cancer (HNC) patients subjected to chemoradiotherapy. Furthermore, the condition can hinder therapy and increase patient mortality. Nutrition therapy may be given proactively and reactively before and during chemoradiotherapy, as a response to nutritional status deterioration. Early or proactive nutrition therapy is considered superior in minimizing weight loss and interruption days during chemoradiotherapy. Therefore, this study aims to explore the clinical impact of proactive and reactive nutrition therapies.Case Presentation: A total of 4 HNC patients were subjected to chemoradiotherapy and received nutrition therapy at different points. Approximately 2 patients received proactive nutrition therapy, while the other 2 underwent reactive nutrition after cancer treatment. Increased intake was achieved through administering oral nutrition supplements and supporting a nasogastric tube. Patients who received proactive nutrition therapy experienced less weight loss compared to reactive therapy. Delayed initiation of nutrition therapy resulted in a more pronounced weight loss. Therefore, it was crucial to maintain energy intake in line with established recommendations to effectively uphold the nutritional status of cancer patients.Conclusions: Proactive nutrition therapy should be provided to HNC patients before the commencement of cancer therapy.
The Role of Liquid Biopsy for Detecting Epidermal Growth Factor Receptor (EGFR) Mutations in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) – A Preliminary Study in Indonesian Population Agus Susanto Kosasih; Arif Riswahyudi Hanafi; Ninik Sukartini; Mariska Pangaribuan; Muhammad Alfin Hanif; Willy Pandu Ariawan; Sri Agustini Kurniawati; Dian Cahyanti; Kartika Anastasia Kosasih; Alyssa Diandra; Markus Yovian; Lyana Setiawan
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.1061

Abstract

Background: The development of new biomarker-targeted therapies is associated with the improvements in overall survival of advanced non-small cell lung cancer (NSCLC) sufferers. However, tissue biopsy as the gold standard to determine tumor molecular status is not always feasible in advanced diseases. Liquid biopsy, a minimally invasive technique to obtain cytological and molecular assessment from patients allows real-time monitoring of tumors and identification of resistant mechanisms. Therefore, this preliminary study aimed to compare the molecular profile of advanced NSCLC from liquid and tissue biopsy.Methods:  This cross-sectional study was conducted on patients with NSCLC undergoing diagnostic procedures at Dharmais National Cancer Center Hospital from January 2018 to December 2021. Tissue biopsy to check epidermal growth factor receptor (EGFR) mutations was performed on formalin-fixed paraffin-embedded (FFPE) tissue blocks. Analysis of mutations involved using a home-brew polymerase chain reaction (PCR) based on a high-resolution melting technique. Meanwhile, the liquid biopsy was performed using blood samples, and sequencing for circulating tumor DNA (ctDNA) was carried out with NGS.Results: : The results showed that among the 22 subjects enrolled in the study, tissue biopsy identified wild-type EGFR in 18 (81.8%), exon 19 mutations in 3, and exon 21 mutations (L861Q and L858R) in 3. Liquid biopsy found EGFR exon 19 deletions in 11 samples (50%), exon 21 mutations (L861Q and L858R) in 10, L861Q in 7, L8585 in 6, and wild type in 1 sample. Additionally, acquired EGFR mutations in exon 20 T790M were found in 5 samples.Conclusions: Liquid biopsy may be beneficial in patients for whom tissue biopsy cannot be performed or where tissue for molecular profiling is inadequate. This modality can also be used to detect molecular resistance in patients with advanced NSCLC.
A Case Report of Radiation Therapy as Definitive Treatment for Desmoid Tumor in a Young Girl Rafiq Sulistyo Nugroho; Irma Darinafitri; Eviana Norahmawati; Istan Irmansyah Irsan; Satria Pandu Persada Isma
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.977

Abstract

Introduction: Desmoid tumor is a benign growth that can exhibit aggressiveness and various patterns, resulting in a wide range of management methods. These methods include observation to active interventions, such as surgery, radiation, and systemic therapy. Therefore, this case report aimed to present the role of radiation therapy for desmoid tumors in a young girl who refused limb amputation to preserve the organ.Case Presentation: This study presented the case of a 13-year-old girl with a vast and painful desmoid tumor in the left upper arm. Magnetic resonance imaging (MRI) on the left shoulder showed an 8 x 9 x 17 cm solid soft tissue mass on the left deltoid muscle with the necrotic component that expands to adjacent cutaneous and subcutaneous tissue. In this case, the left humerus attaches to the deep brachial artery and vein. Previous pathological studies with immunohistochemicals showed desmoid fibromatosis. A multidisciplinary team discussion led to the selection of, radiotherapy for treatment because of tumor localization and proximity to the critical structure. Radiation was also selected as the definitive therapy of choice with the aim of local control and organ preservation. Furthermore, the radiation dose was 56 Gy in 2 Gy per fraction over six weeks. After six months of follow-up, the patient reported pain relief, improved range of motion, and reduced tumor size.Conclusion: Radiotherapy reduced desmoid tumor size and improved symptoms without compromising organ function in young girls.
Effect of Inhaled Peppermint Aromatherapy on Chemotherapy-Induced Acute Nausea and Vomiting among Women with Breast Cancer in Gresik Regency Istiroha Istiroha; Roihatul Zahroh; Qonitatin Wafiyah; Yuanita Syaiful
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.987

Abstract

Background: Chemotherapy-induced acute nausea and vomiting are commonly experienced by breast cancer patients. Therefore, this study aimed to determine the effect of inhaled peppermint aromatherapy on chemotherapy-induced acute nausea and vomiting among women with breast cancer.Methods: This pre-experimental study was conducted using a one-group pre-post-test design approach. The sample included 28 women with breast cancer undergoing chemotherapy at the Chemotherapy Unit of Semen Gresik Hospital, Gresik, Indonesia. Respondents were administered 0.25 cc of peppermint essential oil on a cotton ball and then inhaled for 10 minutes. Data were collected using Rhodes Index Nausea Vomiting & Retching (RINVR) and analyzed with a paired sample t-test.Results: The pre-test showed that the majority of respondents experienced a moderate level of nausea and vomiting. After the intervention, the post-test results indicated mild nausea and vomiting. The statistical analysis showed that peppermint aromatherapy significantly affected chemotherapy-induced acute nausea and vomiting with a p-value of 0.001 (α<0.05).Conclusions: There was a significant improvement in chemotherapy-induced acute nausea and vomiting after the administration of peppermint aromatherapy. Therefore, this intervention could be used as a non-pharmacological complementary therapy to reduce chemotherapyrelated nausea among breast cancer patients
Performance of Pre-Operative IOTA Three-Step Algorithm in Detecting Ovarian Carcinoma in a Referral Center in Indonesia Kurniadi, Andi; Permadi, Wiryawan; Kusuma, Aria Yusti; Kireina, Jessica; Andarini, Mia Yasmina; Winarno, Gatot Nyarumenteng Adhipurnawan; Harsono, Ali Budi
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1044

Abstract

Background: To assess the diagnostic performance of a three-step algorithm using the International Ovarian Tumor Analysis (IOTA) Group ‘simple rules’, ‘simple descriptors’, and Assessment of Different NEoplasias in the adneXa (ADNEX) model for discriminating benign and malignant adnexal masses. Methods:  This was a retrospective observational study, performed at a tertiary-care university hospital, on women diagnosed with adnexal mass on ultrasonography from January 2021 and February 2022. The examiner first classified the mass using ‘simple descriptors’ (first step) and, if not possible, using ‘simple rules’ (second step). For inconclusive masses, an assessment using the ADNEX model was done as the third step. All masses were managed surgically. Histopathology results were used as the reference standard.Results: One hundred and forty-one women were included (median age of 48 years). Histopathology results showed 104 (73.76%) mass to be malignant, and 37 (26.24%) mass to be benign. Twelve (8.51%) of 141 masses could be classified using simple descriptors, 89 (63.12%) masses were classified using simple rules, and 40 (28.37%) masses were classified using the ADNEX model. Overall accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of the three-step algorithm were 89.36%, 94.23%, 75.68%, 91.59%, 82.35%, 3.87, and 0.08 respectively.Conclusions: The IOTA three-step algorithm, based on the sequential use of simple descriptors, simple rules, and ADNEX model, performs well for classifying adnexal masses as benign or malignant
Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell Ibrahim, Sugeng; Riwanto, Ignatius; Suharti, Catharina; Putra, Agung; Budijitno, Selamat
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1211

Abstract

Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+. The study investigates the synergistic effects of combining epigallocatechin gallate (EGCG) with 5-fluorouracil (5-FU) on CR-CSCs through comprehensive cytotoxicity assessments, aiming to enhance therapeutic outcomes. EGCG is a polyphenol with anti-cancer activity in green tea. Previous studies have reported that the anti-cancer activity of EGCG involves inhibition of proliferation and induction of apoptosis thereby reducing recurrence by as much as 51.6% in patients with colorectal adenoma after polypectomy. The significance lies in optimizing treatment strategies by understanding the potential synergies between conventional chemotherapeutic agents and natural compounds. Given 5-FU's status as a cornerstone in CR-CSCs chemotherapy and EGCG's emergence as a promising natural compound, the study delves into their individual and combined cytotoxicity profiles. Methods: The single and combination assay aimed to determine the cytotoxicity of EGCG and 5-FU, including establishing the half inhibitory concentration (IC50) and combination index (CI) values. CR-CSCs colonies were disassociated, counted, and cultured in 96-well plates. Test solutions of varying concentrations were applied, and subsequent steps involved incubation, media removal, washing, MTT reagent addition, and absorbance measurement. Results: The single cytotoxicity tests established individual IC50 values, revealing 141.26 µM for 5-FU and 464.56 µM for EGCG. Subsequent combination cytotoxicity tests demonstrated a synergistic effect at specific doses, indicated by CI values below 1. Conclusions: These findings highlight the potential for increased cytotoxicity against CR-CSCs when treated with the combination of 5-FU and EGCG.
Transcatheter Arterial Chemo Infusion (TACI) for Squamous Cell Carcinoma of the Tongue: A Case Report Poedjomartono, Bagaswoto; Bangun, Alan Anderson; Frinces, Freshilla Sonia; Indrarto, Erwin Yudhistira Yasanusaraharja; Faiz, Ahmad
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1043

Abstract

Introduction: Cancers of the lip and oral cavity, with the tongue being the most common site, accounted for more than 377,700 cases and more than 177,700 deaths worldwide in 2020. Ninety percent of these oral neoplasms are squamous cell carcinomas (SCC). The main treatments for oral cancers are surgery, radiotherapy, and chemotherapy, either combined or as stand-alone therapies. Transcatheter Arterial Chemo Infusion (TACI) is considered the definitive treatment for locoregionally advanced squamous cell carcinoma of the oral cavity, aiming to preserve function after surgery while maintaining or improving locoregional control and survival rates. This case report presents the qualitative result of TACI on SCC of the tongue. The aim of this case report is to demonstrate the potency of TACI as an alternative palliative therapy for SCC of the tongue. Case Presentation: A 37-year-old man with SCC of the tongue was diagnosed and treated at Dr. Sardjito General Hospital, Yogyakarta in 2021. The patient underwent TACI procedure and subsequent radiotherapy sessions subsequently. The therapeutic response was evaluated by observing the clinical morphology of the lesions. Conclusions: TACI is a minimally invasive technique used in the management of SCC. TACI has shown its potency as an efficient and effective alternative palliative therapy.
A Case Report of Pediatric Colorectal Carcinoma in an 11-year-old Indonesian Pahlevi Adeputra Nasution, Iqbal; Fikri, Erjan; Dutra Pratama, Raka
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1016

Abstract

Introduction: Colorectal carcinoma (CRC) is a rare condition among pediatric patients and is often considered the last possible diagnosis in individuals with defecating issues. Therefore, this case report aims to present and elaborate on the identification of pediatric CRC in a center in Indonesia.Case Presentation: An 11-year-old female adolescent presented with obstipation for a week after a series of defecating difficulty episodes spanning the last three months. Furthermore, these difficulties had been progressively worsening over the past two weeks. The patient also reported recurrent colic pain in the abdominal region, but the exact location was unspecified. Positive results of goat-like stool were found for three months, without any observed diarrhea episodes and blood or mucous layer on the stool. A significant weight loss of ±10 kg was reported during the illness period. On physical examination, symmetrical abdominal distention was observed, and colon-in-loop and CT assessment results supported this. These diagnostic measures showed a malignant-suggestive mass ascending to the transverse colon. A right extended hemicolectomy procedure was then carried out as the definitive treatment, accompanied by stoma ileocolostomy to divert defecation. The histopathological analysis on the 4.0 x 4.0 cm intraluminal mass confirmed the presence of poorly differentiated adenocarcinoma. Conclusion: The identification of chronic constipation among pediatric patients must raise awareness regarding the potential for mechanical bowel obstruction due to a malignant mass, specifically in inpatients.
IInduction of G2/M Phase Block and Apoptosis by Kaempferol in Human Sarcoma Cells Ishiki, Manabu; Yoshii, Miho; Kanamori, Masahiko
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1147

Abstract

malignant cells has interested us to seek new strategies for the treatment of sarcoma. Flavonoids have been recently claimed to exert anti-cancer effects. We focused on the flavonoid kaempferol, to determine whether it induces apoptosis of sarcoma cells in vitro. Methods: We examined cell growth using a CCK-8 assay, morphology, cell cycle analysis, and the apoptosis or differentiation effects of kaempferol on cultured human osteosarcoma MG-63 cells. All experiments were performed at least three times in duplicates. The ANOVA and independent sample t-test were used for the comparison of the continuous variables Results: Kaempferol (50 μM), adversely affected the proliferation of MG-63 cells. Anti-proliferative action of kaempferol appeared to be linked to apoptotic cell death based on the morphological changes depicting nuclear fragmentation. Cell cycle analysis demonstrated the induction of G2/M phase arrest and an enhanced sub-G1 population. However, the intracellular alkaline phosphatase (ALP) activity was observed to have been stimulated. This apoptosis might be associated with cell differentiation of the cells in the early stage. Conclusions: This study demonstrates that kaempferol inhibited the growth of MG-63 cells in vitro. G2/M phase arrest and induction of intracellular ALP activities in the early phase are observed. These findings indicate that kaempferol may present as an additional pharmacological tool for the treatment of human sarcoma cells. 

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