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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
Arjuna Subject : -
Articles 270 Documents
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Meaning of life among elderly individuals with chronic diseases living with family: A qualitative study Bahtiar, Bahtiar; Sahar, Junaiti; Wiarsih, Wiwin
Makara Journal of Health Research Vol. 24, No. 1
Publisher : UI Scholars Hub

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Background: Many elderly individuals receive lifelong treatment caused by chronic diseases with symptoms that affecting them physically, psychologically, socially, and spiritually. Spirituality plays an essential role in health conditions and social relationships given that it provides meaning to the elderly individuals life by allowing them to see the wisdom of life events experienced. This research aimed to explore the meaning of life among elderly individuals with chronic diseases. Methods: This research applied descriptive phenomenology using Colaizzi’s method of thematic analysis among 13 elderly patients with chronic diseases. Results: Elderly individuals with chronic diseases found meaning through the following items: (1) surrender to God, (2) divine destiny, (3) care until death, (4) guarantee for health finance, (5) role replacement, and (6) observing the development of children and grandchildren. Conclusion: Elderly individuals with chronic diseases can obtained positive meaning in life through family support. Families are thus expected to facilitate the development of meaning in the lives of elderly individuals with chronic diseases to help them fulfill their spiritual needs.
Cervical cancer vaccination awareness and acceptance among the females of Punjab, Pakistan Minhas, Sadia; Sajjad, Aneequa; Kashif, Muhammad; Rehman, Zobaria; Idrees, Muhammad; Ansari, Farheen
Makara Journal of Health Research Vol. 24, No. 1
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Background: In developing countries like Pakistan, it is essential for health care professionals to have comprehensive knowledge regarding cervical cancer. Methods: A cross-sectional self-administered paper-based questionnaire was administered to patients from 2016 to 2018. This study included 200 females who attended the gynecological OPD of Lady Willingdon Hospital Lahore, Punjab. We evaluated cervical cancer knowledge, screening, prevention, and acceptance towards the vaccination. Data entry and analysis were performed using SPSS version 20. Results: The perception and knowledge related to cervical cancer (28%), screening (3%), prevention (3%), and vaccination (1%) among the females were poor, but a positive attitude was observed towards cervical cancer screening, vaccination, and awareness programs. An extreme lack of knowledge was observed regarding the risk factors associated with cervical cancer and the availability of the cervical cancer vaccine (99%). A significant association (p > 0.005) was noted among the level of education and awareness of cervical cancer, its mode of transmission, and screening tests. Conclusion: The knowledge and perception of cervical cancer and its vaccine among the females of Punjab, Pakistan were inadequate. Efforts should be made to prevent and control cervical cancer in Pakistan by establishing proper strategies, such as health education programs through health care providers and media support.
Serum immune profiling of patients with polycystic ovary syndrome Mobeen, Hifsa; Kashif, Muhammad; Nadeem, Ahmed; Shahzad, Faheem; Tahir, Romeeza; Abbas, Afia; Afzal, Nadeem
Makara Journal of Health Research Vol. 24, No. 2
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Background: Polycystic ovary syndrome (PCOS), the most prevalent hormonal disorder in females, is characterized by low levels of progesterone, which causes increased estrogen levels leading to production of various anti and auto-antibodies. This study aimed to estimate and compare levels of anti-nuclear antibodies (ANA), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG), and anti-islet cell antibodies (anti-ICAb) in patients with PCOS and healthy controls. Methods: The present comparative study included 82 subjects divided into two groups with 41 individuals in each group. Group I included healthy subjects, while Group II included patients diagnosed with PCOS. Blood samples were collected to determine serum levels of ANA, anti-TPO, anti-TG, and anti-ICAb using commercially available ELISA kits. Data were analyzed by using SPSS 20.0. Results: Two (4.8%) subjects in Group II had ANA, but none of the other healthy individuals had these auto-antibodies. Levels of anti-TPO were higher in Group II (6.01 IU/ml) than in Group I (5.98 IU/ml). Levels of anti-TG and anti-ICAb were higher in Group I (19.86 and 32.49 IU/ml, respectively) than in Group II (19.78 and 26.07 IU/ml, respectively). Conclusion: Levels of ANA and anti-TPO were higher in patients with PCOS than in controls. By contrast, levels of anti-TG and anti-ICAb were higher in controls than in patients with PCOS.
Chronic constipation among community-dwelling older people in the East Coast region of Peninsular Malaysia Wahab, Patimah Abdul; Kadir, Azidah Abdul; Lee, Yeong Yeh; Ali, Siti Hawa; Yusoff, Dariah Mohd
Makara Journal of Health Research Vol. 23, No. 3
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Background: This study aimed to investigate the prevalence, symptoms, and factors associated with chronic constipation among community-dwelling older people in the East Coast region of Peninsular Malaysia. Methods: A cross-sectional study was conducted in four selected health clinics using stratified cluster sampling. A face-to-face interview was carried out among the elderly outpatients, in order to complete a structured questionnaire. Results: A total of 400 participants were included in the study. The mean age was 68.7 ± 6.4 years, and 55% of the cohort were women. The prevalence of chronic constipation was 32.3% among the sample population. The most common symptom was “sensation of incomplete evacuation” (63.6%), and none of the participants reported having “less than three defecations per week,” “straining,” or “lumpy or hard stool.” Educational level (p = 0.005), number of defecations per week, stool form, time spent for defecation, and abdominal bloating were significantly associated with chronic constipation (p < 0.001). Conclusion: Chronic constipation was common in older people and associated with a low educational level. Recognition of symptoms was predominantly based on clinical features of constipation and will require the healthcare providers to consider these factors in their routine assessment of older people.
Obesity is associated with depression in Malaysian schoolchildren: A cross-sectional study Nurumal, Mohd Said; Zainal Abidin, Rohulizzat; Ibrahim, Wisam Nabeel; Md Isa, Muhammad Lokman; Che Hasan, Muhammad Kamil
Makara Journal of Health Research Vol. 24, No. 1
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Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity and depression among schoolchildren in Kuantan. Methods: This cross-sectional study was conducted in three different primary schools in Kuantan by purposive sampling. With consent from their parents/guardians, participants were given a self-administered questionnaire. Demographics and anthropometric measurement data were self-reported on the basis of the school records. Furthermore, body mass index was calculated. Data were analyzed using SPSS version 20.0, and chi-square and correlation tests were conducted for the variables. Results: Among the 300 schoolchildren who responded, 14.3% were underweight, 37.7% were normal, 11% were overweight, and 37% were obese. Statistically, obesity and ethnicity, as well as obesity and sex, were not associated. Conversely, obesity and age, as well as obesity and depression, were significantly associated. Conclusion: Depression is associated with obesity among schoolchildren. Hence, a special approach for designing and implementing prevention programs is necessary to reduce the risk of obesity-led depression and other forms of comorbidity later in life.
Influence of religion on healthcare professionals’ beliefs toward teenage sexual practices in Malaysia Abdul Hamid, Siti Hazariah; Fallon, Debbie; Callery, Peter
Makara Journal of Health Research Vol. 24, No. 1
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Background: Teenagers are influenced by their surroundings, and this may also include their sexual behavior or societal responses to this type of behavior. It is important to understand the complexity of religious mandates and sociocultural disapproval of premarital sex from the perspectives of healthcare professionals. Methods: This qualitative study aimed to explore the influence of religion on healthcare professional’s beliefs toward providing sexual and reproductive health information and treatment. An interview topic guide was used in the in-depth interview of 32 healthcare professionals in several health clinics in Malaysia. The data were transcribed and entered into the NVivo 11 software. Thematic analysis was used to evaluate the data. Results: The findings show that some healthcare professionals positively incorporated Islamic beliefs into sexual health education session but excluded the contraception information. This study also highlights the strategies used by healthcare professionals (discourse on risk, being selective, maintaining their own honor) when providing sexual health services to teenagers. Conclusion: These findings revealed how religion perpetuates a “moral” approach in the provision of sexual health services that potentially affects teenagers’ access to healthcare.
A high glucose concentration is well tolerated by colorectal adenocarcinoma and melanoma cells but toxic to normal human gingival fibroblast: Results of an in vitro investigation Mazlan, Muhammad Alif; Yusof, Afzan Mat; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 1
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Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose. Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using the Statistical Package for the Social Sciences software. Results: The hGF cells’ percentage pattern of viability showed a rapid decline of nearly 95% on the third day of treatment. Both HT29 and A375 were able to survive in the high glucose condition when the cell viability percentage was above 100% on Day 5. The data exhibited significance; the p-value was less than 0.001. Conclusion: The high glucose concentration can be toxic to hGF. In addition, HT29 and A375 might be adaptive to the hyperglycaemic condition.
Oral health related quality of life in stroke survivors at community-based rehabilitation centre: A pilot study Tew, In Meei; Goo, Chui Ling; Said, Shahida Mohd; Zahari, Hafizul Izwan; Ali, Noor Amalina; Masawi, Fatin Athirah; Abdul Aziz, Aznida Firzah; Mohd Dom, Tuti Ningseh
Makara Journal of Health Research Vol. 24, No. 1
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Background: Despite being a common problem, long-term disability following stroke often improves after survivors receive regular rehabilitative therapy. This study aimed to assess the oral health-related quality of life (OHRQoL) of stroke survivors who had access to a community-based rehabilitation centre after hospital discharge. Methods: Dentate post-stroke patients receiving regular rehabilitative care with slight to moderate dependency (Barthel Index >70) and without severe cognitive impairment were involved in this study. The OHRQoL parameters were measured using the Oral Health Impact Profile-14 (OHIP-14) and EuroQol five dimensions (EQ-5D-5L) questionnaires. Results: Thirty one patients were recruited in this study. Majority of the patients hardly ever or never had problems in all functional, physical, psychological and social domains, including eating discomfort and having to avoid eating, difficulty in chewing food and presumably having bad breath (58.1%, 61.3% and 71.0% respectively). Other than gender, age, ethnicity, co-morbidities and oral hygiene practices, education level was the only variable found to significantly affect patients’ OHRQoL (p = 0.028). Most of the patients had no or slight problem(s) in self-care (87.1%) and carrying out usual activities (57.1%), pain/discomfort (3.2%) and anxiety/depression (6.5%). Conclusion: Stroke survivors under regular rehabilitative care perceived have good oral health-related quality of life.
Effects of L-fucose supplementation on the viability of cancer cell lines Mazlan, Muhammad Alif; Yusof, Afzan Mat; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 2
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Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells. Therefore, this study aimed to evaluate the viability pattern of human cancer and normal cell lines treated with fucose. Methods: The human gingival fibroblast (HGF-1), colorectal adenocarcinoma (HT-29) and skin malignant melanoma (A375) cell lines were cultured and treated with fucose at three concentrations of 1, 5, and 10 mg/ml. Cell viability was then measured using (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using Statistical Package for the Social Sciences software. Results: The percentage of HGF-1 cell viability showed a rapid decline after day 1 of treatment. HT-29 and A375 were capable of surviving treatment with high fucose concentrations. The data were highly significant at p < 0.001. Conclusion: Whereas a high concentration of fucose is toxic to the HGF-1 cell line, the HT-29 and A375 cell lines could potentially adapt to this condition. Down- or upregulation of certain molecules that could induce or inhibit cell death may explain such adaptation. Further testing of up- and downregulated molecules should be conducted in future work.
Oral care practices of adults in Turkey Koseoglu, Merve; Bal, Ozge; Turkan, Hatice Bilge; Cetin, Beyza; Tascioglu, Muhammed Nuri; Aydin, Nurullah; Sancar, Ozgur; Altindis, Selma
Makara Journal of Health Research Vol. 24, No. 1
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Background: Information on oral health practices can play a key role in improving a community’s oral health status. The aim of this study was to determine oral healthcare practices of Turkish individuals. Methods: A questionnaire was randomly given to 351 individuals, all of them older than 18 years. This cross-sectional study data were analyzed using descriptive statistical methods and chi-square test. Statistical significance was evaluated at p < 0.05. Results: According this study, 62.1% of individuals visited the dentist only when they needed to. Furthermore, 58% of individuals brushed their teeth twice a day; 12.5% of them used miswak; 50.4% used dental floss, toothpicks, or mouthwash; and 86.6% stated that they didn’t use any other herbal/traditional tooth cleaning method. Additionally, 39.8% of the individuals reported that they ate sweetened foods 1–2 times a day, and 33.6% of them drank acidic beverages 1–2 times a month. Although the frequency of visiting a dentist and using herbal/traditional practices did not differ among individuals (p ˃ 0.05), frequency of consuming sweetened food did differ (p = 0.032). Conclusions: Toothbrushing and interdental cleaning habits differed among individuals, while frequency of dentist visits and alternative methods of cleaning teeth did not differ.

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