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Hepatotoxicity Risk Profile of Indonesian Due to Polymorphism of NAT2 and CYP2E1 in Isoniazid Metabolism Setiyo Budi Santoso; Puji Umi Chabibah; Prasojo Pribadi
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

This article presents data on drug-induced liver injury events' risk profile due to NAT2 and CYP2E1 polymorphisms in isoniazid metabolism in Indonesian populations among various populations of several countries. The research took place through a review of the literature obtained from google scholar. The library search uses three variants of the keyword: (1) "pharmacogenomic and tuberculosis and INH and NAT2 and CYP2E1 and polymorphism", (2) "isoniazid and hepatotoxicity and polymorphism and N-acetyltransferase," (3) "isoniazid and hepatotoxicity and polymorphism and CYP2E1". Analysis of hepatotoxic risk based on the odds ratio (confidence interval) using Stata MP 14th edition software. The study of drug-induced liver injury events' risk based on various NAT2 acetylation rates involved 2,140 populations from 8 countries, while the risk analysis based on CYP2E1 allele variety involved 1,530 populations from 5 countries. The literature review shows that the Indonesian population's isoniazid-induced liver injury events' risk with slow acetylator NAT2 enzymes and people with CYP2E1*c1/c2 is three times higher than other populations in various countries. Further, people who have the combination slow acetylator NAT2 and CYP2E1*c1/c2 have more drug-induced liver injury events' risk.

Tannin Analysis of Red Roselle Petals (Hibiscus Sabdariffa, L.) using Permanganometry Method Anita Agustina Styawan; Aristhasari Putri; Refida Ramadhani Nur Cholifa
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Red roselle (Hibiscus sabdariffa L.) is a plant that can be used by the community as traditional medicine. Rosella flower petals contains protein, fat, minerals, alkaloids, flavonoids, and tannins. Red rosella is effective in preventing vertigo, antihypertension, antidiabetic, anticancer, and antioxidants. Tannins are known as one of the active ingredients contained in the petals of red rosella flowers. Tannins are polyphenolic protein. This study aims to determine the levels of tannin in the extract of red rosella flower petals using permanganometry titration. The research method used was observational. This study used a sample of red roselle flower petals. The sample was tested qualitatively using FeCl3 1%. Analyzed quantitatively using permanganometry titration. The results showed that qualitatively the positive sample contained tannins which was marked by a change in color to dark blue dark. Quantitatively the sample was titrated with KMnO4, the tannin content in red roselle flower petals was 13,73 % b/b.

Gel Formulation for Hand Sanitizer from Ethanol Extract of Mulberry Leaf (Morus Alba L.) Sutaryono Sutaryono; Hendra Budiman; Anita Agustina Styawan; Nurul Hidayati; Dayah Ainus
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

During the Covid 19 pandemic, a handsanitizer product has emerged which functions as a hand washing disinfectant for the prevention of the Covid 19 virus. One of the ingredients that can be made handsanitizer gel is the mulberry plant (Morus alba L.) because it contains many flavonoids which act as antiseptics against bacteria. The research objective was to determine the handsanitizer gel formulation with the concentration of carbopol and propylenglycol which can produce good physical properties. The research design used an experiment, with the mulberry leaf preparation material macerated using 70% ethanol. Mulberry leaf ethanol extract (Morus alba L.) as the active substance and made 3 formulas with variations in the concentration of carbopol: propylenglycol formula I (0.5%: 15%), formula II (1.25%: 12.5%), formula III (2%: 10%). The three formulas were tested for physical properties and analyzed by ANOVA with a confidence level of 95%. The results showed that the handsanitizer gel formulation with carbopol increased viscosity and stickiness, while propylenglycol increased the dispersibility. The 1.25% formula: 12.5% ??produces the best physical properties, with a pH test of 6, a viscosity test of 150 dPas, a spreadability test of 6.5 cm, a sticky power test of 2.39 seconds and a protective power test without red stains.

Effect of Diabetes Exercise on Depression Score in Type II Diabetes Mellitus Patients Romadhani Tri Purnomo; Puput Risti Kusumaningrum; Fitriana Noor Khayati; H Harjana
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Diabetes mellitus is a chronic disease that occurs when the pancreas is unable to produce enough insulin. Indonesia is the 7th most DM sufferer in the world. Patients when diagnosed with DM experience psychological stress, anxiety because they are no longer like normal people, causing depression. The way to reduce depression is to do physical activity such as gymnastics. The purpose of this study was to determine the effect of diabetic exercise on the reduction of depression scores at Persadia RSI Klaten. This study used a quasy experimental pre post test design with a cross sectional approach. The study population was type II DM patients who joined Persadia Islamic Hospital Klaten. The sampling technique was purposive sampling with a total of 30 respondents. The data collection instrument used the PHQ questionnaire. Bivariate data analysis using the Wilcoxon test. The results of the research on the characteristics of respondents were dominated by women as many as 23 (76.7%). The average age of the respondents was 49 years. The ethnic group is dominated by Javanese as many as 28 (93.3%). Most of the respondents' occupation is Labor 12 (40.0%). The average score for depression before the intervention for diabetic exercise was 7,400 and after the intervention for diabetic exercise decreased to 2.166. The results of the Wilcoxon test showed that there was a significant effect of diabetes exercise on the reduction of depression scores in type II diabetes mellitus patients at Persadia RSI Klaten values ??(p = 0.000, Z = -4.813). Conclusion based on the results of the study, the average depression score in Type II DM patients before diabetes exercise was 7,400. Meanwhile, the average depression score after diabetes exercise was 2.166. The results of statistical tests showed that there was an effect of diabetes exercise on depression scores in Type II DM patients with a p value of 0.000.

Investigative Study on Self-Concept of Diabetes Mellitus Ulcer Patients Istianna Nurhidayati; Marwanti Marwanti; Susminingsih Susminingsih; Sutaryono Sutaryono
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormal insulin secretion. Uncontrolled hyperglycemia condition can cause complications in the foot neuropathy and ulcers are often associated with diabetes. Diabetic ulcers have an impact on loss of bodily function, decreased activity tolerance resulting in disruption to the individual's self-concept. The aim of this study was to analized relationship between diabetic ulcers and self-concept of diabetes mellitus patients in RSUP dr. Soeradji Tirtonegoro Klaten. The study design used case control with non-probability, sampling technique was consesecutived sampling. The number of samples used were 82 samples divided into two groups: 41 controls 41 cases. analysis of the results using bivariate test with Chi-Squere. Comparative test results with Chi-Squere between DM ulcers with self-concept in the control group and case group were adjusted p value = 0.034 (OR = 0.35). Conclusion there was a relationship between diabetic ulcers with the self-concept of diabetes mellitus patients at RSUP dr. Soeradji Tirtonegoro Klaten. Based on these findings, the proposed interventions that could be implemented was to increase self concept patient with diabetic ulcer.

Design and Implementation of Sterilization Chamber with Ozone and UV-C Light to Break the Transmission of Covid-19 Muhammad Latifur Rochman; Lilik Budiyarto; Muhammad Iqbal Al-Fikri; Khoirul Fa’i; Prasasti Bayu Aji Pramono; Riyan Tri Aditya Pamungkas; Baginda Pangidoan Tanjung; Refaldy Pristiwantoro; Widha Bagus Fahriansyah; Agung Setyo Pambudi; Ahmad Irfan; Riyan Adhy Pratama; Lalank Samudra Mukti Hidayat; Setyo Widiantoro; Darmawan Rois; Muhammad Mauludin Kharim; Wahyu Danu Romadlon; Dwi Restianto; Muji Setiyo; Budi Waluyo; Bagiyo Condro Purnomo; Suroto Munahar; Noto Widodo; Saifudin Saifudin
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

The emergence of Corona Virus Disease 19 (Covid-19) required a new method to control its spread. During this time, controlling COVID-19 was carried out by implementation of a sterilization chamber using a liquid-based disinfectant. However, the use of liquid-based disinfectants has been evaluated to be less effective because it allows disrupting the respiratory tract. Therefore, this work presents a negative pressure sterilization chamber using Ozone and UV-C lamp. Ozone has been recommended by the Indonesian Institute of Sciences (LIPI) as a substitute for liquid-based disinfectants. In addition, to maximize performance, the chambers are added with UV-C lamps. The negative pressure sterilization chamber with Ozone and ultraviolet lamps was successfully created with the main parts of the cubicle chamber, an Ozone generator, at least one ultraviolet lamp, exhaust fan, switch, and a timer. The negative pressure sterilization chamber with Ozone and ultraviolet lamps according to this work, where the Ozone supply from the Ozone generator is made automatically to the door opening and closing. The duration of the Ozone supply was regulated by a timer. Then, the ultraviolet lamp can be activated together with Ozone or independently. With the implementation of this sterilization chamber, the spread of the Covid-19 virus is expected to be suppressed in a safer way than using liquid-based disinfectants.

Baking Soda and Peroxide Formulation as Dental Whitening Gel Herma Fanani Agusta; Alfian Syarifuddin; Fitriana Yuliastuti; Misya Putri Kurnia Pradani
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Indonesian society began to make appearance as a primary need. Appearance becomes important for middle and upper social classes which reaches 60-70% in Indonesia. Researchers are trying to find a combination formula of two teeth whitening ingredients (Baking Soda and Peroxide). The study uses an experimental method, which is to make a dental gel with variety of gradient constituent formulas, including F1, F2, F3, F4, and F5. F5 is the most optimal formula with best stability test results among other. F5 with Peroxide concentration of 30% had teeth whitening activity of 38% by two months in vitro test on adult teeth samples.

Hepatotoxicity Risk Profile of Indonesian Due to Polymorphism of NAT2 and CYP2E1 in Isoniazid Metabolism Setiyo Budi Santoso; Puji Umi Chabibah; Prasojo Pribadi
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.11

This article presents data on drug-induced liver injury events' risk profile due to NAT2 and CYP2E1 polymorphisms in isoniazid metabolism in Indonesian populations among various populations of several countries. The research took place through a review of the literature obtained from google scholar. The library search uses three variants of the keyword: (1) "pharmacogenomic and tuberculosis and INH and NAT2 and CYP2E1 and polymorphism", (2) "isoniazid and hepatotoxicity and polymorphism and N-acetyltransferase," (3) "isoniazid and hepatotoxicity and polymorphism and CYP2E1". Analysis of hepatotoxic risk based on the odds ratio (confidence interval) using Stata MP 14th edition software. The study of drug-induced liver injury events' risk based on various NAT2 acetylation rates involved 2,140 populations from 8 countries, while the risk analysis based on CYP2E1 allele variety involved 1,530 populations from 5 countries. The literature review shows that the Indonesian population's isoniazid-induced liver injury events' risk with slow acetylator NAT2 enzymes and people with CYP2E1*c1/c2 is three times higher than other populations in various countries. Further, people who have the combination slow acetylator NAT2 and CYP2E1*c1/c2 have more drug-induced liver injury events' risk.

Tannin Analysis of Red Roselle Petals (Hibiscus Sabdariffa, L.) using Permanganometry Method Anita Agustina Styawan; Aristhasari Putri; Refida Ramadhani Nur Cholifa
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.31

Red roselle (Hibiscus sabdariffa L.) is a plant that can be used by the community as traditional medicine. Rosella flower petals contains protein, fat, minerals, alkaloids, flavonoids, and tannins. Red rosella is effective in preventing vertigo, antihypertension, antidiabetic, anticancer, and antioxidants. Tannins are known as one of the active ingredients contained in the petals of red rosella flowers. Tannins are polyphenolic protein. This study aims to determine the levels of tannin in the extract of red rosella flower petals using permanganometry titration. The research method used was observational. This study used a sample of red roselle flower petals. The sample was tested qualitatively using FeCl3 1%. Analyzed quantitatively using permanganometry titration. The results showed that qualitatively the positive sample contained tannins which was marked by a change in color to dark blue dark. Quantitatively the sample was titrated with KMnO4, the tannin content in red roselle flower petals was 13,73 % b/b.

Gel Formulation for Hand Sanitizer from Ethanol Extract of Mulberry Leaf (Morus Alba L.) Sutaryono Sutaryono; Hendra Budiman; Anita Agustina Styawan; Nurul Hidayati; Dayah Ainus
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.37

During the Covid 19 pandemic, a handsanitizer product has emerged which functions as a hand washing disinfectant for the prevention of the Covid 19 virus. One of the ingredients that can be made handsanitizer gel is the mulberry plant (Morus alba L.) because it contains many flavonoids which act as antiseptics against bacteria. The research objective was to determine the handsanitizer gel formulation with the concentration of carbopol and propylenglycol which can produce good physical properties. The research design used an experiment, with the mulberry leaf preparation material macerated using 70% ethanol. Mulberry leaf ethanol extract (Morus alba L.) as the active substance and made 3 formulas with variations in the concentration of carbopol: propylenglycol formula I (0.5%: 15%), formula II (1.25%: 12.5%), formula III (2%: 10%). The three formulas were tested for physical properties and analyzed by ANOVA with a confidence level of 95%. The results showed that the handsanitizer gel formulation with carbopol increased viscosity and stickiness, while propylenglycol increased the dispersibility. The 1.25% formula: 12.5% ??produces the best physical properties, with a pH test of 6, a viscosity test of 150 dPas, a spreadability test of 6.5 cm, a sticky power test of 2.39 seconds and a protective power test without red stains.

Home Page

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Contact

Reviewer

Google Scholar

Contact Name
Muji Setiyo

Contact Email
muji@unimma.ac.id

Phone
+6282330623257

Journal Mail Official
ujas.urecol@gmail.com

Editorial Address
Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Location
Unknown,

Unknown

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muji Setiyo

Contact Email muji@unimma.ac.id

Phone +6282330623257

Journal Mail Official ujas.urecol@gmail.com

Editorial Address Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Location Unknown, Unknown INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muji Setiyo

Contact Email
muji@unimma.ac.id

Phone
+6282330623257

Journal Mail Official
ujas.urecol@gmail.com

Editorial Address
Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Location
Unknown,

Unknown

INDONESIA