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Nailis Syifa
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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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Antihyperlipidemic activity and mechanism test of cashew nut shell extract in male wistar rat induced by high-cholesterol foods Era Rahmi; Poppy Dharsana
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.15077

Abstract

Nutshell is a waste of cashew nuts product which is known to contain phytosterols was tested as an antihyperlipidemic agent with two methods:  induction of hyperlipidemia and inhibition of cholesterol absorption method. In induction of hyperlipidemia, animals were induced using high cholesterol foods and induction agents (cholesterol, cholic acid, and propylthiouracil). After that were treated using simvastatin and cashew nut shell extract. Total cholesterol value was measured periodically after therapy, then aorta was isolated to examine the histology of aorta. In inhibition cholesterol absorption method, rats were given PTU and then were given ezetimibe and extracted orally. After that, all the animals were induced with exogenous cholesterol. Cholesterol level in the serum and feces was measured as well as to see the effects of inhibition of cholesterol absorption. For hyperlipidemia induction method, extract had different significance compared to the control group after 8 weeks of therapy. Atherogenic index of plasma (IAP) values of low-dose extract and high dose extract was significantly different compared to the control group. Histology of rats aorta for extract was significantly different in thickness compared to the control group. In the inhibition of cholesterol absorption method, extract 250mg/kg bw (group EKBKM 250) and 500  mg/kg bw (group EKBKM 500) inhibit the increase of total blood cholesterol within one hour after  induction and significantly different compared to the control group. N-hexane extract cashew nut shells 500mg/kg have antihyperlipidemic effects, one of them is inhibition of cholesterol absorption.
Quality of life in cancer outpatients using the EORTC QLQ-C30 questionnaire at PKU Muhammadiyah Yogyakarta Hospital Fitri Ayu Wahyuni; Woro Supadmi; Endang Yuniarti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.15219

Abstract

Cancer is a disease characterized by the uncontrolled growth of abnormal cells in the body, which can be treated using chemotherapy as one of the therapies. However, some of chemotherapy's main side effects, such as nausea, vomiting, and pain, are associated with decreased quality of life. The patient's quality of life is measured from several dimensions: dimensions of physical health, psychological well-being, social and environmental relationships. This study aims to describe the quality of life of cancer patients at PKU Muhammadiyah Yogyakarta Hospital. This study used a cross-sectional design with all cancer patients undergoing chemotherapy during the study period who had met the inclusion criteria. The patient's quality of life was measured using the EORTC QLQ-C30 questionnaire. The results showed the quality of life of cancer patients based on a functional scale from the domain of the social function (84.55 ± 24.54), emotional function (79.20 ± 24.08), cognitive function (77.23 ± 27.82), role function (73.98 ± 31.85), and physical function (69.43 ± 29.09), the symptom scale shortness of breath (9.75 ± 18.62), diarrhea (11.38 ± 25.39), financial constraints (23.57 ± 24.99), constipation (25.20 ± 33.15), pain (25.61 ± 30.29), nausea and vomiting (33.33 ± 28.13), insomnia (8.21 ± 41.87), fatigue (45.79 ± 29.93), and loss of appetite (48.78 ± 37.34). The highest score on the functional scale was the social function, and the lowest score was in the physical function. The highest score on the symptom scale was appetite loss, and the lowest score was the shortness of breath.  
Validation method for determining sodium benzoate in fruit juice drinks in Malang Engrid Juni Astuti; Roha Fakhri Naufal Ilham; Januar Rahman
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.6622

Abstract

Sodium benzoate is a preservative that is permitted to be used in food and beverages. The maximum limit for using sodium benzoate in food is 600 mg/L of ingredients calculated as benzoic acid. In this study, High-Performance Liquid Chromatography (HPLC) method using a PDA detector was used for sodium benzoate levels analysis in fruit juice drink circulating in Malang. The mobile phase composition used in this study was methanol pro-HPLC:aqua pro injection (70:30) and added glacial acetic acid to reach pH 3. The analysis was conducted at a wavelength of 245 nm, and the flow rate was set at 1.00 mL/minute. This method was validated against the parameters of selectivity, linearity, accuracy, and precision, and the results obtained to meet the validation requirements. The application of the HPLC method after being validated in the determination of sodium benzoate levels in fruit juice drink circulating in Malang resulted in selectivity Rs ≥ 1.5, linearity obtained in the range 0.1-5 μg/mL with a correlation coefficient (r) = 0,9999, recovery at a concentration of 80%, 100%, and 120% was 105.31%, and precision with an RSD value of 1.40%. Based on the results, it can be concluded that the validation method of analysis shows that the method can be used to determine sodium benzoate level using HPLC with PDA detectors for routine use in fruit juice drink samples.
Clinical study of the efficacy and safety of jamu for hyperuricemia Agus Triyono; Fajar Novianto
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.6628

Abstract

Hyperuricemia is a degenerative disease with a reasonably high prevalence and requires long-term treatment. Clinical research has been conducted to test the efficacy and safety of herbal medicine for hyperuricemia. The research involved 30 subjects who had fulfilled the inclusion and exclusion criteria and conducted with a pre-post test research design. Subjects were treated with herbal medicine for hyperuricemia three times a day for 28 days. From the research, jamu for hyperuricemia was effective in reducing blood uric acid levels from 7.43 mg/dL to 5.72 mg/dL, raising the quality of life score (SF-36) from 78.06 to 81.50, and disappeared of clinical symptoms. Use of herbal medicine for hyperuricemia for 28 days in subjects had no symptoms of severe side effects found and did not interfere with liver, kidney, and blood function.
Gel formulations containing Sumbawa's horse milk with carbomer gel base Dian Ermawati; Uswatun Chasanah; Herika Juli Andani; Khalda Nisrina
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.6892

Abstract

Peptides from Sumbawa horse milk are active as antibacterial and antioxidant. Horse milk has a higher content of vitamin C than cow or goat's milk, and cream products that contain milk can overcome dry skin. The Gel is one of the topical dosage forms suitable for acne medications and oily skin types. This study aimed to determine the effect of variations in horse milk content formulated in gel preparations with carbomer 1% base as gelling agents on physical characteristics (organoleptic, viscosity, pH) and antibacterial activity in Propionibacterium acnes. In this study, gel preparations were made with six different formulas on horse milk content, namely FI (2.5%), FII (5%), and FIII (10%), FIV (15%), FV (20%), and FVI (25%) with 1% carbomer base on each formula and well method were used for the antibacterial test. From the organoleptic test, it was found that in all of the gel formula had soft textured, thick white color, and distinctive aroma like horse milk. The viscosity test showed that was no significant difference, but the pH test showed a significant difference for each formula. In this study showed that all of the gel formulae did not have an inhibitory zone, which means that at each level there was no evidence of antibacterial activity in the P. acnes. So, it could be concluded that all gel formula had good gel characteristics but there was no inhibitory activity against the P. acnes. 
Quantitative structure-cytotoxic activity relationship of phenylthiourea derivatives from ChemBL database on sirtuin-1 receptor by in silico Anindi Lupita Nasyanka
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.7745

Abstract

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850;  P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.
In silico study of COX-2 on indomethacin and diclofenac as nonsteroidal anti-inflammatory drugs (NSAIDs) Janatun Na'imah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.7767

Abstract

Cyclooxygenase is an enzyme that plays a role in the formation of prostaglandins, which can cause inflammation and pain when overexpressed. This study aims to determine the interaction between COX-2 macromolecules (receptors) with their ligands, namely indomethacin and diclofenac in silico using the Molecular Docking method. The COX-2 receptor was downloaded in the form of a 3D structure from the RCSB GDP with code 5F19. Diclofenac Ligand and Indomethacin were downloaded in the form of a 3D structure from the RCSB GDP with 4ZBQ code and 4IK7 code. The results showed that the interaction between COX-2 and indomethacin was the interaction of hydrogen, which linked indomethacin with amino acid Leu531 and steric interactions between indomethacin and amino acids Trp387, Tyr385, Tyr355, Leu352, and Val523. The interaction of [COX-2 – Indomethacin] produces a value of ∆G of -103.136 kcal/mol, and the value of RMSD is 1.244 Å. Whereas, the interaction that occurs in COX-2 with diclofenac is the steric interaction that happens between diclofenac with amino acids Leu390, Trp387, Gln203, His388, His207, and Thr206. The interaction parameter between [COX-2-Diclofenac] obtained ∆G value of -7.843 kcal/mol and an RMSD value of 2.07851 Å. 
Medicinal plants documentation of Dayak Banuaq tribe in Intu Village, Nyuatan District, West Kutai, East Kalimantan Indah Lestari; Lailiiyatus Syafah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.7896

Abstract

The Dayak Benuaq tribe is one of the tribes in Indonesia who live in East Kalimantan. They have various knowledge related to raw materials and medical treatment traditions for generations that have never been documented, especially in Intu Lingau Village, Nyuatan District, West Kutai, East Kalimantan. This study aims to documentation of medicinal plants and herbs of the local communities. The finding shows that there are 104 plants used, which is divided into 34 families. The most common plant parts used in the treatment were leaves, the most common processing method was boiling, and the most utilized method was by drinking.
Influence of historical use of antibiotics toward antibiotic resistance Fawandi Fuad Alkindi; Rika Yulia; Fauna Herawati; Abdul Kadir Jaelani
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.7901

Abstract

A WHO’s Global Surveillance of Antibiotic Resistance showed there is an increase of antimicrobial resistance in Asia between 2013 until 2014. Many studies showed that there is a correlation between prior antibiotic use with antimicrobial resistance case. The primary objective of this study is to analyze the relationship between prior antibiotic use with antimicrobial resistance. İt was a retrospective and descriptive study conducted at Bangil Regional General Hospital. The data collected from the medical record and microbiological test from the patient at the internal ward. Chi-square analysis used for the statistic. This study showed that prior antibiotic use increased 0,399 bigger for antimicrobial resistance rate (p=0,001). 
Correlation of illness perception, asthma control, and lung function value to the quality of life of asthma outpatients Nadia Aisah Mayzika; Asri Wido Mukti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.10176

Abstract

Asthma is a heterogeneous disease and chronic inflammation of the respiratory tract that has an impact on the decreased quality of life. The design of this research is non-experimental cross-sectional. The variables of this study are illness perception, control of asthma, lung function values, and life quality of asthma patients. The relationship of asthma control, illness perception, lung function value, and life quality of asthma patients can be seen with structural equation modeling using Smart-PLS software. The results are only control of asthma affects life quality, where the coefficient value is 0.511, which is positive and significant (p = 0,000). Lung function value and asthma quality indicate that lung function has a positive relationship direction seen from the coefficient value of 0.306 but not significant (p = 0.061). The correlation between illness perception and life quality of asthma was negative, where the coefficient value was - 0.142 and not significantly different (p = 0.332). This means that the direction of the relationship is reversed; it means the quality of life of asthmatic patients, which affects illness perception by 14.2%. The conclusion is that the life quality of asthmatic patients is influenced by the control of asthma and lung function. But it’s different from illness perception, where there is a negative relationship between illness perception and life quality of asthma patients. Which means illness perception affects the life quality of asthma patients.

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